[Plastic bronchitis: report of a pediatric case]. / La bronchite plastique: à propos d'une observation pédiatrique.

Plastic bronchitis (PB) is a rare disease, characterized by the formation of obstructive branching airways tracheobronchial casts. Commonly, PB often complicates the course of cardiac or respiratory disorders. The occurrence of PB before manifestation of the underlying respiratory disease is unusual. We report on the case of a boy, aged three years and eight months, free from underlying pulmonary disease, who presented with extensive atelectasis of the left lung during an acute respiratory tract infection. Bronchoscopy revealed the obstruction of the left tracheobronchial tree with large purulent casts. After bronchoscopic removal of the casts, the boy became asymptomatic. Initial aetiological investigations were negative. Two years later, the patient developed an asthma.

Effects of excipients on the bioavailability of sodium salicylate from orally administered, oily suspensions.

The effects of various excipients, i.e. sucrose, aluminium stearate, Cab-o-sil, hydrogenated castor oil and lecithin, either alone or in combination, on the bioavailability of sodium salicylate from suspension in fractionated coconut oil have been investigated using the rabbit as the test animal. In addition an in vitro drug release study and partition and rheological measurements have been carried out. Results of the study show that the bioavailability of sodium salicylate is not affected significantly by any of the excipients other than 20% w/v of sucrose and that this effect of sucrose is nullified by the inclusion of 1% w/v Cab-o-sil. Some correlation was observed between in vitro drug release data and the apparent viscosity of the oily vehicle. However, no correlations were detectable between in vivo and in vitro bioavailability parameters.