RESUMEN
The purpose of this study was two-pronged: 1) to determine the level of concordance (agreement) between multiple records abstractors who extracted defined data elements from printed medical examiner/coroner (ME/C) death investigation records; and 2) to identify data items for which improved reporting could facilitate the effective use of ME/C reports and data. Four hundred ninety four printed death investigation records were obtained from 224 medical examiner/coroner offices throughout the United States. Trained abstractors were asked to extract information for 110 data elements from investigative reports. Additional data elements for each toxicology workup were abstracted from toxicology laboratory reports and six-digit AIS codes were also abstracted for each injury as described in autopsy reports. The ability of multiple abstractors to identify each data element and identically abstract the data was assessed using Kappa statistical methods. Level of agreement for many data elements was very good (>0.9), but for some data elements agreement was marginal to poor, especially for items related to toxicology, the nature of specific injuries, and dates, times of the occurrence of death and injury. Many data items can be easily abstracted from ME/C records. However, some data items seem difficult to abstract reliably in all cases. Standardizing the report formats used by ME/Cs and/or standardizing the electronic storage of ME/C data would make the abstraction of such data easier and improve the usefulness of ME/C data.
Asunto(s)
Indización y Redacción de Resúmenes/normas , Causas de Muerte , Médicos Forenses , Medicina Legal/estadística & datos numéricos , Bases de Datos Factuales , Humanos , Reproducibilidad de los ResultadosRESUMEN
Infant lung samples were obtained at autopsy by medical examiner pathologists in five areas of the United States regardless of the cause of death. Lung sections were stained with hematoxylin and eosin. Sixty cases were evaluated for the study. The four sections examined for each case were taken from the anterior and posterior aspects of the right and left upper lung lobes. Histologic sections were scored for the extent of alveolar hemorrhage using the following scoring system: 0, no hemorrhage; 1, focal hemorrhage but less than score 2; 2, patchy, focal hemorrhage not present throughout the section; 3, focal hemorrhage more extensive than score 2 but not meeting the criteria for score 4; 4, patchy focal hemorrhage distributed throughout the section; 5, more extensive hemorrhage than score 4 but not meeting the criteria for score 6; 6, diffuse hemorrhage throughout the section. Total possible scores ranged from 0 to 24. Intraalveolar hemorrhage was observed in 40 cases. Overall, the mean score for the 60 cases was 5 (range, 0-24); for the 40 cases with hemorrhage, 7 (range, 1-24). Scores were compared with other descriptive variables like cause of death; interval between onset of fatal events and death; whether resuscitation was attempted; and pulmonary macrophage counts and hemosiderin scores reported in earlier studies of the same cases. In none of the 60 cases was death attributed to pulmonary hemorrhage or hemosiderosis. Pulmonary hemorrhage tends to be common among deceased infants; more prominent when there is medical treatment or resuscitation during the agonal period; infant position may partially explain distribution of hemorrhage in lungs; postmortem interval may exacerbate pulmonary hemorrhage; and infant deaths caused by acute idiopathic pulmonary hemorrhage (AIPH) or pulmonary hemorrhage/hemosiderosis (PHH) probably are rare. Specific case definitions for AIPH and PHH are needed, along with further study of these conditions.
Asunto(s)
Hemorragia/patología , Mortalidad Infantil , Pulmón/patología , Muerte Súbita del Lactante/patología , Autopsia , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estados Unidos/epidemiologíaRESUMEN
As part of a public health response to severe heat waves in the midwestern and northeastern United States in the summer of 1999, the authors actively solicited the number of heat-related deaths from 38 medical examiner and coroner jurisdictions comprising 35 metropolitan areas to enumerate heat-related deaths in areas affected by heat waves. They also determined the usefulness of these data for surveillance and rapid investigation of heat-related deaths. A total of 334 heat-related deaths were reported during the study period of July 1 - August 31. Minor changes in data collection and diagnostic criteria in some medical examiner and coroner jurisdictions would allow for greater comparability among jurisdictions. The National Association of Medical Examiners' position paper on heat-related mortality diagnosis provides important guidance to medical examiners and coroners regarding the certification of heat-related deaths and may require some refinement to address certain issues. Among these are certifying manner of death and classifying potential causes of heat-related death not involving hyperthermia or heat stroke, but where heat is a potential contributing factor to death. Medical examiners and coroners are an important resource for heat-related mortality research, and improvements in data collection and reporting could yield tremendous benefits to our understanding of and interventions for heat-related deaths.
Asunto(s)
Causas de Muerte , Trastornos de Estrés por Calor/mortalidad , Ciudades/epidemiología , Médicos Forenses/estadística & datos numéricos , Certificado de Defunción , Trastornos de Estrés por Calor/diagnóstico , Humanos , Vigilancia de la Población/métodos , Estaciones del Año , Estados Unidos/epidemiologíaAsunto(s)
Vacunas contra el Cáncer/efectos adversos , Drogas en Investigación , Drogas en Investigación/efectos adversos , Neoplasias Hepáticas/secundario , Neoplasias Pulmonares/secundario , Melanoma/secundario , Neoplasias Cutáneas/terapia , Adulto , Vacunas contra el Cáncer/uso terapéutico , Causas de Muerte , Diagnóstico Diferencial , Drogas en Investigación/uso terapéutico , Femenino , Humanos , Hígado/patología , Neoplasias Hepáticas/patología , Neoplasias Hepáticas/terapia , Pulmón/patología , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/terapia , Metástasis Linfática , Melanoma/patología , Melanoma/terapia , Neoplasias Cutáneas/patologíaAsunto(s)
Accidentes por Caídas , Autopsia , Vértebras Cervicales/lesiones , Errores Diagnósticos , Leiomiosarcoma/diagnóstico por imagen , Neoplasias Pulmonares/diagnóstico por imagen , Compresión de la Médula Espinal/diagnóstico , Fracturas de la Columna Vertebral/diagnóstico , Tomografía Computarizada por Rayos X/normas , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Leiomiosarcoma/secundario , Neoplasias Pulmonares/secundario , Compresión de la Médula Espinal/etiología , Fracturas de la Columna Vertebral/etiología , Neoplasias Uterinas/patologíaRESUMEN
CONTEXT: Although standard autopsy texts and other publications discuss the general content of autopsy reports, and some provide examples of autopsy report formats, no publication to date has recommended specific headings for autopsy report organization. The College of American Pathologists Autopsy Committee decided it would be helpful to provide suggestions for autopsy report headings to foster more standardized autopsy reporting, to facilitate review of reports by third parties, and to facilitate searches of electronically stored autopsy reports. OBJECTIVES: To create a model document (named the Autopsy Lexicon), which defines standard categories of information that are useful to include in autopsy reports; to offer specific wording for the headings of various sections of the report; and to explain the rationale for including the various items of information and headings. PARTICIPANTS AND METHODS: The members of the Autopsy Committee of the College of American Pathologists prepared the document by reviewing various examples of autopsy report formats, identifying specific categories of information usually contained in such reports, and developing wording for various sections of the autopsy report that would contain specific information. A draft was submitted to 45 members (including 12 forensic pathologists) of the College of American Pathologists for review, comment, and reality testing. Reviewers included pathologists from both community and academic settings. Comments of reviewers were incorporated to the extent possible. RESULTS: The Autopsy Lexicon was prepared and is a model document for autopsy pathologists who wish to define an autopsy template of headings for consistent organization of autopsy reports. CONCLUSIONS: The Autopsy Lexicon is available to foster more uniform reporting of autopsy information, which may facilitate review of autopsy reports and retrieval of information from electronically stored autopsy reports.
Asunto(s)
Autopsia , Causas de Muerte , Documentación , Documentación/normas , Guías como Asunto , Humanos , Patología , Examen Físico , Sociedades Médicas , Estados UnidosRESUMEN
To evaluate the level of agreement between medical examiner investigators' opinion of the manner of death and what the manner of death was as certified by forensic pathologist medical examiners (MEs), we reviewed the case records stored in a database of all deaths reported to the office of the medical examiner in Fulton County, Georgia. Of 15,771 deaths reported to the office during a 10-year period, a difference exists in 1908 cases. In 900 natural deaths, the investigators recorded 135 accident, 10 homicide, 10 suicide, and 745 undetermined manners of death. In 755 accidental deaths, the investigators recorded 16 natural, 8 homicide, 13 suicide, and 718 undetermined manners of death. In 107 homicides, the investigators recorded 12 natural, 8 accident, 0 suicide, and 87 undetermined manners of death. In 70 suicides, the investigators recorded 9 natural, 9 accident, 3 homicide, and 49 undetermined manners of death. In 61 deaths classified as undetermined, the investigators recorded 25 natural, 13 accident, 17 homicide, and 6 suicide manners of death. In 15 deaths, the discrepancy exists due to an apparent error in the database information. This study confirms a high concordance between investigator and ME opinion regarding manner of death but also documents the need for case review and autopsies by forensic pathologists to confirm the investigators' opinion of the manner of death, determine the manner of death when the investigator selects undetermined, and on occasion, refute the investigators' opinion regarding the manner of death.
Asunto(s)
Causas de Muerte , Médicos Forenses , Medicina Legal , Georgia , Humanos , Variaciones Dependientes del Observador , Registros , Estudios RetrospectivosRESUMEN
Infant lung samples were obtained prospectively at autopsy by medical examiner pathologists in five areas of the United States and regardless of the cause of death. Four sections were examined for each case and were taken from the anterior and posterior aspects of the right and left upper lung lobes. Lung sections were stained with HAM-56 immunostain, which is specific for macrophages. Sixty-one cases were evaluated for the study. Three pathologists independently counted the number of macrophages per 40x field (10x ocular) in 10 contiguous fields near the center of each lung section examined. There was good agreement between pathologists on the average number of macrophages observed in each case. The mean macrophage count for all fields counted was 16.5 per 40x field (range 0-136), and the mean for individual cases was 16 (range 6.6-39.4). There was no observed difference between right, left, anterior, and posterior lung sections. There was a tendency for cases certified as sudden infant death syndrome to show lower macrophage counts than those with other causes of death, but the difference was of only marginal statistical significance. Seven of 10 cases in which infants died after a survival period in the hospital had a mean macrophage count greater than the overall mean of 16 per 40x field. These data suggest that mean pulmonary macrophage counts > 16 per 40x field may be a marker for causes of death other than sudden infant death syndrome or that there was a survival interval. These data may be useful as baseline data for further studies of infant mortality possibly involving pathologic changes in the lungs.
Asunto(s)
Mortalidad Infantil , Macrófagos Alveolares , Autopsia , Causas de Muerte , Recuento de Células , Femenino , Humanos , Lactante , Pulmón/patología , Macrófagos Alveolares/patología , Masculino , Estudios Prospectivos , Muerte Súbita del Lactante/diagnósticoRESUMEN
Infant lung samples were obtained prospectively at autopsy by medical examiner pathologists in five areas of the United States. Tissues were submitted regardless of the cause of death. Lung sections were stained with Prussian blue to detect deposits of hemosiderin. Fifty-nine cases were evaluated for the study. The four sections examined for each case were taken from the anterior and posterior aspects of the right and left upper lung. Three pathologists independently scanned the lung sections microscopically using a 10x objective lens (with 10x ocular lens) and indicated an "iron score" by indicating for each section if it showed no staining for iron-hemosiderin (Score 0), occasional staining with most fields negative (Score 1), focally abundant staining with most fields having no staining (Score 2), focally abundant staining with most fields showing positive staining (Score 3), or prominent staining throughout the section (Score 4). There was good agreement between pathologists on the iron score for each case. A total iron score was calculated by adding the scores based on each pathologist's observations. The mean total iron score was 6 (range, 1-44), with the range of possible total iron scores being 0 to 48. There was no significant difference between the four lung sections in a given case. Six cases had total iron scores that were at least twice the mean (i.e., total iron score > 12); in five of these cases death was caused by conditions other than sudden infant death syndrome, including one case in which asphyxia was the cause of death. These data are consistent with other reports that pulmonary hemosiderin in deceased infants is suggestive of a cause of death other than sudden infant death syndrome. The data may be useful as baseline data for further studies of infant mortality involving possible pathologic changes in the lungs.
Asunto(s)
Causas de Muerte , Hemosiderina/análisis , Mortalidad Infantil , Pulmón/patología , Autopsia/estadística & datos numéricos , Femenino , Hemorragia/complicaciones , Hemorragia/diagnóstico , Hemosiderosis/complicaciones , Hemosiderosis/diagnóstico , Humanos , Lactante , MasculinoRESUMEN
Several researchers in the 1950's proposed that hypernatremia causes water to leave brain cells, shrinking the brain, thus tearing the bridging veins and resulting in subdural hematomas. Although the old literature suggests mechanisms linking the two in a cause and effect relationship, there is controversy as to whether hypernatremia leads to subdural bleeding or whether the reverse is true. This issue is important for forensic pathologists who must distinguish natural disease from trauma. An etiologic link between hypernatremia and subdural hematomas was suggested recently, and was proposed originally before Kempe's 1962 paper "The Battered Child Syndrome" which widely disseminated the concepts of child physical abuse, and of subdural bleeding resulting from non-accidental injury. Our study is a multifaceted investigation of infants which includes: a literature review, retrospective chart reviews of both living and deceased hypernatremic infants, a retrospective review of infants hospitalized with subdural hematoma, and a prospective collection of head injured, hypernatremic children. We conclude that hypernatremia, if present in association with subdural hemorrhage, is most likely secondary to intracranial pathology, and that hypernatremia often develops in critically ill infants suffering from a variety of medical conditions.
Asunto(s)
Maltrato a los Niños/diagnóstico , Hematoma Subdural/etiología , Hipernatremia/complicaciones , Preescolar , Femenino , Medicina Legal , Humanos , Hipernatremia/etiología , Lactante , Recién Nacido , Masculino , Registros Médicos , Estudios RetrospectivosAsunto(s)
Autopsia , Ceguera/etiología , Traumatismos de las Arterias Carótidas/etiología , Complicaciones Intraoperatorias , Nervio Óptico/patología , Trasplante de Órganos , Neoplasias Hipofisarias/patología , Sarcoma/patología , Adulto , Arteria Carótida Interna , Constricción Patológica/diagnóstico , Trasplante de Corazón , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Hipofisarias/complicaciones , Neoplasias Hipofisarias/cirugía , Sarcoma/complicaciones , Sarcoma/cirugía , Silla TurcaRESUMEN
The Autopsy Committee of the College of American Pathologists has prepared this revised guideline to reflect changes that have occurred in the reporting of autopsies since the original guideline was published in February 1995. It is intended to be an instrument to assist pathologists in the reporting of autopsies. The guideline is to be regarded as being primarily an educational tool. Application of these recommendations on autopsy reporting is to be made on the basis of the judgment of the pathologist engaged in a specific case.