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BACKGROUND CONTEXT: The functional goals of cervical disc arthroplasty (CDA) are to restore enough range of motion (ROM) to reduce the risk of accelerated adjacent segment degeneration but limit excessive motion to maintain a biomechanically stable index segment. This motion-range is termed the "Physiological mobility range." Clinical studies report postoperative ROM averaged over all study subjects but they do not report what proportion of reconstructed segments yield ROM in the Physiological mobility range following CDA surgery. PURPOSE: To calculate the proportion of reconstructed segments that yield flexion-extension ROM (FE-ROM) in the Physiological mobility range (defined as 5°-16°) by analyzing the 24-month postoperative data reported by clinical trials of various cervical disc prostheses. STUDY DESIGN/SETTING: Analysis of 24-month postoperative FE-ROM data from clinical trials. PATIENT SAMPLE: Data from 1,173 patients from single-level disc replacement clinical trials of 7 cervical disc prostheses. OUTCOME MEASURES: 24-month postoperative index-level FE-ROM. METHODS: The FE-ROM histograms reported in Food and Drug Administration-Investigational Device Exemption (FDA-IDE) submissions and available for this analysis were used to calculate the frequencies of implanted levels with postoperative FE-ROM in the following motion-ranges: Hypomobile (0°-4°), Physiological (5°-16°), and Hypermobile (≥17°). The ROM histograms also allowed calculation of the average ROM of implanted segments in each of the 3 motion-ranges. RESULTS: Only 762 of 1,173 patients (implanted levels) yielded 24-month postCDA FE-ROM in the physiological mobility range (5°-16°). The proportions ranged from 60% to 79% across the 7 disc-prostheses, with an average of 65.0%±6.2%. Three-hundred and two (302) of 1,173 implanted levels yielded ROM in the 0°-4° range. The proportions ranged from 15% to 38% with an average of 25.7%±8.9%. One-hundred and nine (109) of 1,173 implanted levels yielded ROM of ≥17° with a range of 2%-21% and an average proportion of 9.3%±7.9%. The prosthesis with built-in stiffness due to its nucleus-annulus design yielded the highest proportion (103/131, 79%) of implanted segments in the physiological mobility range, compared to the cohort average of 65% (p<.01). Sixty-five of the 350 (18.6%) discs implanted with the 2 mobile-core designs in this cohort yielded ROM≥17° as compared to the cohort average of 9.3% (109/1,173) (p<.05). At 2-year postCDA, the "hypomobile" segments moved on average 2.4±1.2°, those in the "physiological-mobility" group moved 9.4±3.2°, and the hypermobile segments moved 19.6±2.6°. CONCLUSIONS: Prosthesis design significantly influenced the likelihood of achieving FE-ROM in the physiological mobility range, while avoiding hypomobility or hypermobility (p<.01). Postoperative ROM averaged over all study subjects provides incomplete information about the prosthesis performance - it does not tell us how many implanted segments achieve physiological mobility and how many end up with hypomobility or hypermobility. We conclude that the proportion of index levels achieving postCDA motions in the physiological mobility range (5°-16°) is a more useful outcome measure for future clinical trials.
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Vértebras Cervicales , Diseño de Prótesis , Rango del Movimiento Articular , Reeemplazo Total de Disco , Humanos , Rango del Movimiento Articular/fisiología , Vértebras Cervicales/cirugía , Reeemplazo Total de Disco/métodos , Reeemplazo Total de Disco/instrumentación , Disco Intervertebral/cirugía , Femenino , Masculino , Adulto , Persona de Mediana Edad , Artroplastia/métodos , Resultado del Tratamiento , Ensayos Clínicos como AsuntoRESUMEN
The biomechanical literature describes axial rotation occurring coupled with lateral bending and flexion in the cervical spine. Since the head is kept level during some activities of daily living, we set out to investigate the changes in total and segmental motion that occur when a level gaze constraint is applied to cadaveric cervical spine specimens during axial rotation. 1.5Nm of left and right axial rotation moment was applied to sixteen C2-T1 cadaveric specimens with C2 unconstrained and C2 constrained to simulate level gaze. Overall and segmental motions were determined using optoelectronic motion measurement and specimen-specific kinematic modeling. Without a kinematic constraint on C2, motions were as described in the literature; namely, flexion and lateral bending to the same side as axial rotation. Keeping C2 level reduced that total axial rotation range of motion of the specimens. Changes were also produced in segmental coupled rotation in all specimens. The observed changes included completely opposite coupled motion than in the uncoupled specimens, and traditional coupled behavior at one load extreme and the opposite at the other extreme. Constraining C2 during axial rotation to simulate level gaze can produce coupled motion that differs from the classically described flexion and lateral bending to the same side as axial rotation. Statement of Clinical Significance: Activities of daily living that require the head to be kept level during axial rotation of the cervical spine may produce segmental motions that are quite different from the classically described motions with implications for biomechanical experiments and implant designers.
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Actividades Cotidianas , Vértebras Cervicales , Humanos , Rotación , Fenómenos Biomecánicos , Rango del Movimiento Articular , CadáverRESUMEN
BACKGROUND: Transarticular screw fixation is a common surgical treatment for tarsometatarsal ligamentous (Lisfranc) injuries. Iatrogenic damage to articular cartilage from screw placement, however, has been thought to potentially lead to increased risk of tarsometatarsal (TMT) joint arthritis after initial injury. To date, no study has evaluated the effect of weightbearing on articular cartilage after screw fixation. The aim of this study was to create a Lisfranc injury and quantify and compare articular damage due to screw fixation before and after simulated weightbearing. METHODS: A ligamentous Lisfranc injury was created in 10 cadaveric specimens and treated with transarticular screws. Specimens were cycled for 1000 cycles at 250 N to simulate 2 weeks of physiologic weightbearing. Rotation and diastasis across the Lisfranc complex were measured. Articular injury as a percentage of total articular surface was measured using digital imaging of the first and second TMT joint before and after simulated weightbearing. Comparisons between articular damage were made and statistical analysis was performed. RESULTS: Simulated partial weightbearing increased articular injury 1.44-fold (P < .001). The second metatarsal (M2) showed the greatest increase (1.54-fold, P = .0047), whereas the first (M1) showed the least (1.35-fold, P = .0083). Increases seen at the medial (1.43-fold, P = .0387) and middle cuneiform (1.44-fold, P = .0292) were intermediate between the values seen at M2 and M1. CONCLUSION: Articular damage from transarticular screw fixation significantly increased after simulated partial weightbearing. This may increase the risk of arthritis and future morbidity when using transarticular screws for the treatment of ligamentous Lisfranc injuries. CLINICAL RELEVANCE: Iatrogenic damage to articular cartilage due to screw fixation of ligamentous Lisfranc injuries may be increased with weightbearing.
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Artritis , Huesos Metatarsianos , Humanos , Pie/cirugía , Huesos Metatarsianos/cirugía , Huesos Metatarsianos/lesiones , Ligamentos Articulares/cirugía , Ligamentos Articulares/lesiones , Artritis/cirugía , Soporte de Peso , Enfermedad IatrogénicaRESUMEN
Background: Soft tissue complications after Achilles tendon repair has led to increased interest in less invasive techniques. Various limited open techniques have gained popularity as an alternative to open operative repair. The purpose of this study was to biomechanically compare an open Krackow and limited open repair for Achilles tendon rupture. We hypothesized that there would be no statistical difference in load to failure, work to failure, and initial linear stiffness. Methods: A simulated Achilles tendon rupture was created 4 cm proximal to its insertion in 18 fresh-frozen cadaveric below-knee lower limbs. Specimens were randomized to open or limited open PARS Achilles Jig System repair. Repairs were loaded to failure at a rate of 25.4 mm/s to reflect loading during normal ankle range of motion. Load to failure, work to failure, and initial linear stiffness were compared between the 2 repair types. Results: The average load to failure (353.8 ± 88.8 N vs 313.3 ± 99.9 N; P = .38) and work to failure (6.4 ± 2.3 J vs 6.3 ± 3.5 J; P = .904) were not statistically different for Krackow and PARS repair, respectively. Mean initial linear stiffness of the Krackow repair (17.8 ± 5.4 N/mm) was significantly greater than PARS repair (11.8 ± 2.5 N/mm) (P = .011). Conclusion: No significant difference in repair strength was seen, but higher initial linear stiffness for Krackow repair suggests superior resistance to gap formation, which may occur during postoperative rehabilitation. With equal repair strength, but less soft tissue devitalization, the PARS may be a favorable option for patients with risk factors for soft tissue complications.
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BACKGROUND: Powered instrumentation is often used for bone preparation and/or removal in many orthopaedic procedures but does risk thermogenesis. This study compares biomechanical properties of a fluted burr and a novel fluteless resurfacing tool. METHODS: Twenty cadaveric metatarsals were tested with four predetermined cutting forces to evaluate heat generation and cutting rate for the fluted burr and fluteless resurfacing tool over 40 s or until a depth of 4 mm was reached. Cutting rate was calculated from displacement transducer data. Heat generation was measured by thermocouples placed in the bone adjacent to the burring site. Assuming a body temperature of 37 °C, a 10 °C increase in heat was used as the threshold of inducing osteonecrosis. FINDINGS: At 1.0 N and 1.7 N, the thermal osteonecrosis threshold was reached at comparable times between burrs, while the bone removed by the resurfacing tool was on average five times greater than fluted burr at 1.0 N and over twice as great at 1.7 N. Statistical analysis of these common cutting forces showed the resurfacing tool had significantly higher cutting rates (P < 0.01). As a result, the fluted burr produced higher temperatures for the same amount of bone removal (P < 0.01). INTERPRETATION: In a cadaveric study, the fluteless resurfacing tool demonstrated higher bone cutting rates and lower heat generation for the same amount of bone removed than a traditional fluted burr.
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Calor , Osteonecrosis , Humanos , Huesos , Instrumentos Quirúrgicos , CadáverRESUMEN
BACKGROUND: We examined the effect of Kirschner wire (K-wire) reuse and use of oscillating mode on heat generation within cortical bone. METHODS: Two trocar-tipped K-wires were drilled through the diaphysis of each of 30 human metacarpals and phalanges: one K-wire was inserted in rotary mode and another in oscillating mode. Each wire was reused once. Thermocouples placed within the dorsal and volar bone adjacent to the K-wire drill path measured temperatures throughout each test. RESULTS: Peak cortex temperatures were 25°C to 164°C. Rotary drilling achieves peak temperatures quicker (31 ± 78 seconds vs 44 ± 78 seconds, P = .19) than oscillating drilling, but insertion time is also less, resulting in lower overall heat exposure. This effect is also seen when the K-wire is reused (34 ± 70 seconds vs 41 ± 85 seconds, P = .4). The length of time that cortical bone was exposed to critical temperatures (47°C or more) was significantly higher when a wire was reused (36 ± 72 seconds vs 43 ± 82 seconds, P = .008). Peak temperatures greater than 70°C (a temperature associated with instantaneous cell death) were observed on many occasions. CONCLUSIONS: Overall heat exposure may be higher if a K-wire is reused or inserted in oscillating mode. In the absence of external cooling, K-wire insertion into cortical bone can easily expose bone to temperatures that exceed 70°C and may increase the risk of osteonecrosis.
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Huesos del Metacarpo , Procedimientos Ortopédicos , Humanos , Calor , Hilos Ortopédicos , Temperatura , Procedimientos Ortopédicos/métodos , Huesos del Metacarpo/cirugíaRESUMEN
OBJECTIVES: To biomechanically investigate a novel modified all-suture construct compared with commercially available suspensory button fixation for stabilization of the syndesmosis. METHODS: Eight matched pairs of cadaver lower limbs were obtained. We used a material testing machine and Optotrak optoelectronic 3D motion measurement system for testing. Syndesmotic injuries were simulated, and specimens were fixed with either a suspensory suture button or modified all-suture construct. Repaired specimens were then cyclically loaded for 500 cycles. Spatial relationship of the tibia and fibula were continuously monitored for the intact, destabilized, and repaired states. The results were analyzed using independent samples t test. RESULTS: There was no significant difference in sagittal or coronal plane translation between intact and either repair. Compared with the intact state, both repair techniques demonstrated significantly more external rotation of the fibula relative to the tibia and decreased construct stiffness. Cycling of the specimens did not significantly increase coronal or sagittal plane translation; however, external rotation of the fibula relative to the tibia increased and stiffness decreased with cycling for both repair techniques. CONCLUSIONS: Our data suggest that sagittal and coronal plane translation is no different from the intact state for both fixation techniques. However, rotation of the fibula relative to the tibia was increased, and construct stiffness was decreased compared with the intact state for both fixation techniques. These findings suggest that an all-suture construct could offer syndesmotic fixation comparable with proprietary suspensory button fixation in a cadaver model.
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Traumatismos del Tobillo , Tornillos Óseos , Humanos , Peroné/cirugía , Articulación del Tobillo/cirugía , Suturas , Traumatismos del Tobillo/cirugía , Técnicas de Sutura , CadáverRESUMEN
BACKGROUND: The goal was to determine the effect of addition of oblique trajectory distal interlock screws to a retrograde intramedullary femoral nail on implant stability (stiffness), cycles to failure and mode of failure. The hypothesis was that addition of oblique screws would increase implant stability and number of loading cycles to failure. METHODS: Eight matched pairs were tested; one femur implanted with a femoral nail with only transverse distal interlock screws and the other with transverse and oblique interlock screws. Axial compressive load was applied to the femoral head and the gluteal tendon was tensioned vertically to simulate standing or at 45° to the sagittal plane to simulate stair climbing. Loads were cycled to increasing amplitude until failure of fixation (10 mm displacement or 10° rotation). FINDINGS: In simulated standing, oblique screw specimen had greater sagittal bending (bowing) than transverse only specimen. Transverse (axial) plane motion was higher in simulated stair climbing in oblique screw specimen. Oblique screw specimen had higher sagittal plane translation at 600 N of load. At 300 N, oblique screw specimen had lower internal-external rotation than transverse only specimen. A larger number of cycles to failure were observed in four oblique screw of seven paired specimen. Failure (10 mm or 10 degrees of motion) was only achieved during simulated stair climbing. INTERPRETATION: Our hypothesis that adding oblique screws improves fixation was rejected. Activities of daily living other than standing may constitute a challenge to fracture fixation; fixation failure occurred at lower loads in simulated stair climbing than standing.
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Actividades Cotidianas , HumanosRESUMEN
Background: The theoretical advantages of hybrid constructs over multi-level fusion have been illustrated in clinical and biomechanical studies. However, there is no biomechanical data on hybrid constructs using load control analyses. There is also no clear data on whether there is a biomechanical difference if the arthroplasty is below or above a 1- or 2-level fusion. This work investigated the effect on segmental motion of having a cervical total disc arthroplasty implanted above or below a 1- or 2-level fusion. Methods: Segmental motions of 16 C2-T1 cervical spine specimens were measured as the specimens were tested to 1.5Nm in axial rotation and in flexion-extension under compressive preload. Tests were conducted on intact specimens, and then after arthroplasty with a 1-level and 2-level fusion. 8 specimens were in test Group 1, where the hybrid configuration had a total disc arthroplasty above a 1- or 2-level fusion. The arthroplasty was below the 1- and 2-level fusion in Group 2. Load control and displacement control analyses were conducted to determine the effect of the hybrid configurations on segmental motion. Results: In load control, compensatory motion increases were found at all non-instrumented cervical spine segments in flexion-extension and axial rotation. Flexion-extension and axial rotation ranges of motion at the total disc arthroplasty level were less than 1° different than intact.In displacement control, there was no consistent pattern of compensatory motion. Range of motion at the arthroplasty level was within 3.5° of intact. Conclusions: The total disc arthroplasty segmental level in a hybrid construct has similar amounts of motion as intact. This may shield the arthroplasty level and adjacent levels from supra-physiological motion and loading. These results suggest that a hybrid construct may be protective of adjacent segments, whether the total disc arthroplasty is above or below the fusion.
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STUDY DESIGN: This was a preclinical study. OBJECTIVE: Evaluate sex-dependent differences in the bone healing response to recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat posterolateral spinal fusion model. SUMMARY OF BACKGROUND DATA: Minimal and conflicting data exist concerning potential sex-dependent differences in rhBMP-2-mediated bone regeneration in the context of spinal fusion. MATERIALS AND METHODS: Forty-eight female and male Sprague-Dawley rats (N=24/group), underwent L4-L5 posterolateral fusion with bilateral placement of an absorbable collagen sponge, each loaded with 5 µg of bone morphogenetic protein-2 (10 µg/animal). At eight weeks postoperative, 10 specimens of each sex were tested in flexion-extension with quantification of range of motion and stiffness. The remaining specimens were evaluated for new bone growth and successful fusion via radiography, blinded manual palpation and microcomputed tomography (microCT). Laboratory microCT quantified bone microarchitecture, and synchrotron microCT examined bone microstructure at the 1 µm level. RESULTS: Manual palpation scores differed significantly between sexes, with mean fusion scores of 2.4±0.4 in females versus 3.1±0.6 in males ( P <0.001). Biomechanical stiffness did not differ between sexes, but range of motion was significantly greater and more variable for females versus males (3.7±5.6° vs. 0.27±0.15°, P <0.005, respectively). Laboratory microCT showed significantly smaller volumes of fusion masses in females versus males (262±87 vs. 732±238 mm 3 , respectively, P <0.001) but significantly higher bone volume fraction (0.27±0.08 vs. 0.12±0.05, respectively, P <0.001). Mean trabecular thickness was not different, but trabecular number was significantly greater in females (3.1±0.5 vs. 1.5±0.4 mm -1 , respectively, P <0.001). Synchrotron microCT showed fine bone structures developing in both sexes at the eight-week time point. CONCLUSIONS: This study demonstrates sex-dependent differences in bone regeneration induced by rhBMP-2. Further investigation is needed to uncover the extent of and mechanisms underlying these sex differences, particularly at different doses of rhBMP-2.
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Vértebras Lumbares , Fusión Vertebral , Humanos , Femenino , Masculino , Ratas , Animales , Vértebras Lumbares/cirugía , Caracteres Sexuales , Microtomografía por Rayos X , Ratas Sprague-Dawley , Proteína Morfogenética Ósea 2/farmacología , Factor de Crecimiento Transformador beta/farmacología , Fusión Vertebral/métodos , Proteínas Recombinantes/farmacologíaRESUMEN
BACKGROUND: Individual contributions of the rotator cuff (RC) and superior capsule (SC) to prevent superior translation of the humerus are not well understood. PURPOSE: To evaluate the relative contributions of the SC and RC to normal and pathologic shoulder biomechanics by determining their independent effects on superior humeral translation. STUDY DESIGN: Controlled laboratory study. METHODS: Twelve cadaveric shoulders were tested at 0º, 45º, and 90º of abduction under 5 conditions: intact RC/SC, RC sectioned first, SC sectioned first, both structures sectioned, and RC repair. Matched pairs were randomly assigned to the second or third testing condition (RC or SC sectioned first). Specimens were tested under 2 static conditions (40-N deltoid load [balanced load], 80-N deltoid load [superiorly directed load]) and 1 dynamic condition during active abduction. A mixed-design 2-way repeated-measures analysis of variance with Bonferroni adjustments was performed to compare testing conditions. Paired t tests were used to compare specimens in the intact state versus the repaired state. Significance was set at P < .05. RESULTS: During balanced deltoid loading at 0° and 45º, there was significantly greater humeral translation when both structures were sectioned as compared with the intact state and with both isolated sectioned states (P < .05 for all). No significant differences were observed between or within groups at 90º of abduction. These effects remained consistent with superiorly directed loading. Dynamic testing of both groups showed a significant increase in superior translation for specimens in which the RC was deficient versus the intact state (P = .027), with no difference when the SC was sectioned. The RC repair state returned translation to values similar to the intact state at all abduction angles and loading conditions (P > .05). CONCLUSION: In this cadaveric study, the SC and RC played an important role in preventing superior humeral translation; however, dynamic testing suggested preferential contribution of the RC. RC repair was effective in preventing superior humeral translation, even with a sectioned SC at the level of the glenohumeral joint. CLINICAL RELEVANCE: RC repair was effective in preventing superior humeral translation, even in the presence of a sectioned SC at the level of the glenohumeral joint in this cadaveric model. Our data lay the groundwork for future studies investigating the clinical effect of RC repair in an SC sectioned state.
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Lesiones del Manguito de los Rotadores , Articulación del Hombro , Fenómenos Biomecánicos , Cadáver , Humanos , Rango del Movimiento Articular , Manguito de los Rotadores/cirugía , Lesiones del Manguito de los Rotadores/cirugía , Articulación del Hombro/cirugíaRESUMEN
OBJECTIVE: To evaluate the individual contributions to stability of the superficial and deep deltoid ligaments in the setting of SER IV ankle fractures. METHODS: Nineteen total cadaveric specimens were used. SER IV injuries were created with the rupture of either the superficial (SER IV-S) (n = 9) or deep deltoid (SER IV-D) (n = 10). These were tested by applying an external rotation force (1 Nm, 2 Nm, 3 Nm, and 4 Nm). Changes in the position of the talus were recorded with a 3D motion tracker. Injury conditions were compared with a 4-step general linear model with repeated measures. Injury condition was also compared with the intact state and to each other using 2-tailed t tests. RESULTS: The general linear model showed that increased loading had a significant effect with axial rotation (P = 0.02) and sagittal translation (P = 0.003). SER IV-S and SER IV-D showed significantly greater instability compared with the intact state in axial rotation (1 Nm, 2 Nm, and 3 Nm). SER IV-S and SER IV-D did not significantly differ from each other. CONCLUSIONS: SER IV fracture patterns can be unstable with isolated injury to either the superficial or deep deltoid. This challenges the notion that deep deltoid rupture is necessary. Further clinical studies would help quantify the consequences of this instability.
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Fracturas de Tobillo , Ligamentos Articulares , Fracturas de Tobillo/cirugía , Articulación del Tobillo , Peroné , Humanos , Rango del Movimiento ArticularRESUMEN
Prosthesis design has an influence on the quantity and quality of postoperative motion after cervical disc arthroplasty. Prostheses with built-in resistance to angular and translational motion may have an advantage in restoring physiologic motion. The ability of a prosthesis to work with remaining bony and soft tissues to restore motion and load-sharing is a function of the kinematic degrees of freedom DOF, axis of rotation for a given motion, and device stiffness. How these characteristics allow the prosthesis to work with the patient's anatomy will determine whether the prosthesis is successful at restoring motion and mitigating adjacent-level stresses.
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Vértebras Cervicales , Disco Intervertebral , Artroplastia , Fenómenos Biomecánicos , Vértebras Cervicales/cirugía , Humanos , Disco Intervertebral/cirugía , Diseño de Prótesis , Rango del Movimiento ArticularRESUMEN
We recently developed a recombinant growth factor-free bone regenerative scaffold composed of stoichiometric hydroxyapatite (HA) ceramic particles and human demineralized bone matrix (DBM) particles (HA-DBM). Here, we performed the first pre-clinical comparative evaluation of HA-DBM relative to the industry standard and established positive control, recombinant human bone morphogenetic protein-2 (rhBMP-2), using a rat posterolateral spinal fusion model (PLF). Female Sprague-Dawley rats underwent bilateral L4-L5 PLF with implantation of the HA-DBM scaffold or rhBMP-2. Fusion was evaluated using radiography and blinded manual palpation, while biomechanical testing quantified the segmental flexion-extension range-of-motion (ROM) and stiffness of the fused segments at 8-weeks postoperatively. For mechanistic studies, pro-osteogenic gene and protein expression at 2-days and 1-, 2-, and 8-weeks postoperatively was assessed with another cohort. Unilateral fusion rates did not differ between the HA-DBM (93%) and rhBMP-2 (100%) groups; however, fusion scores were higher with rhBMP-2 (p = 0.008). Both treatments resulted in significantly reduced segmental ROM (p < 0.001) and greater stiffness (p = 0.009) when compared with non-operated controls; however, the degree of stabilization was significantly higher with rhBMP-2 treatment relative to the HA-DBM scaffold. In the mechanistic studies, PLGA and HA scaffolds were used as negative controls. Both rhBMP-2 and HA-DBM treatments resulted in significant elevations of several osteogenesis-associated genes, including Runx2, Osx, and Alp. The rhBMP-2 treatment led to significantly greater early, mid, and late osteogenic markers, which may be the mechanism in which early clinical complications are seen. The HA-DBM scaffold also induced osteogenic gene expression, but primarily at the 2-week postoperative timepoint. Overall, our findings show promise for this 3D-printed composite as a recombinant growth factor-free bone graft substitute for spinal fusion. STATEMENT OF SIGNIFICANCE: Despite current developments in bone graft technology, there remains a significant void in adequate materials for bone regeneration in clinical applications. Two of the most efficacious bone graft options are the gold-standard iliac crest bone graft and recombinant human-derived bone morphogenetic protein-2 (rhBMP-2), available commercially as Infuse™. Although efficacious, autologous graft is associated with donor-site morbidity, and Infuse™ has known side effects related to its substantial host inflammatory response, possibly associated with a immediate, robust osteoinductive response. Hence, there is a need for a bone graft substitute that provides adequate osteogenesis without associated adverse events. This study represents a significant step in the design of off-the-shelf growth factor-free devices for spine fusion.
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Fusión Vertebral , Animales , Matriz Ósea , Proteína Morfogenética Ósea 2 , Trasplante Óseo , Cerámica/farmacología , Femenino , Vértebras Lumbares , Impresión Tridimensional , Ratas , Ratas Sprague-Dawley , Proteínas Recombinantes , Factor de Crecimiento Transformador betaRESUMEN
BACKGROUND CONTEXT: Transition from standing to sitting significantly decreases lumbar lordosis with the greatest lordosis-loss occurring at L4-S1. Fusing L4-S1 eliminates motion and thus the proximal mobile segments maybe recruited during transition from standing to sitting to compensate for the loss of L4-S1 mobility. This may subject proximal segments to supra-physiologic flexion loading. PURPOSE: Assess effects of instrumented fusion versus motion preservation at L4-L5 and L5-S1 on lumbar spine loads and proximal segment motions during transition from standing to sitting. STUDY DESIGN: Biomechanical study using human thoracolumbar spine specimens. METHODS: A novel laboratory model was used to simulate lumbosacral alignment changes caused by a person's transition from standing to sitting in eight T10-sacrum spine specimens. The sacrum was tilted in the sagittal plane while constraining anterior-posterior translation of T10. Continuous loading-data and segmental motion-data were collected over a range of sacral slope values, which represented transition from standing to different sitting postures. We compared different constructs involving fusions and motion preserving prostheses across L4-S1. RESULTS: After L4-S1 fusion, the sacrum could not be tilted as far posteriorly compared to the intact spine for the same applied moment (p<.001). For the same reduction in sacral slope, L4-S1 fusion induced 2.9 times the flexion moment in the lumbar spine and required 2.4 times the flexion motion of the proximal segments as the intact condition (p<.001). Conversely, motion preservation at L4-S1 restored lumbar spine loads and proximal segment motions to intact specimen levels during transition from standing to sitting. CONCLUSIONS: In general, sitting requires lower lumbar segments to undergo flexion, thereby increasing load on the lumbar disks. L4-S1 fusion induced greater moments and increased flexion of proximal segments to attain a comparable seated posture. Motion preservation using a total joint replacement prosthesis at L4-S1 restored the lumbar spine loads and proximal segment motion to intact specimen levels during transition from standing to sitting. CLINICAL SIGNIFICANCE: After L4-S1 fusion, increased proximal segment loading during sitting may cause discomfort in some patients and may lead to junctional breakdown over time. Preserving motion at L4-S1 may improve patient comfort and function during activities of daily living, and potentially decrease the need for adjacent level surgery.
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Vértebras Lumbares , Fusión Vertebral , Actividades Cotidianas , Fenómenos Biomecánicos , Humanos , Rango del Movimiento Articular , SedestaciónRESUMEN
INTRODUCTION: Suboptimal acetabular component position can result in impingement, dislocation, and accelerated wear. Intraoperative pelvic motion has led to surgeon error and acetabular cup malposition. This study characterises the relationship between pelvic rotation and postoperative acetabular cup orientation. METHODS: A device was constructed to allow cadaveric pelvis rotation along three axes about an acetabular cup in fixed orientation. The acetabular cup was fixed in space at 40° of radiographic inclination and 15° of anteversion relative to the anterior pelvic plane to represent consistent surgeon intraoperative placement. Active marker clusters were fixed to surgical equipment while the cadaveric pelvis was cemented with passive reflective markers, both identified with the Optotrak Certus motion capture system. The reamed cadaveric pelvis was rotated along three axes from -45° to 45° of roll, -30° to 30° of tilt, and -35° to 35° of pitch. The change in component inclination and anteversion was recorded at each 5° interval. Using computed tomography 3D reconstruction, the experimental setup was duplicated computationally to assess against a greater range of pelvis and implant sizes. RESULTS: Radiographic anteversion and inclination showed a non-linear relationship dependent on pelvic roll, tilt, and pitch. Radiographic anteversion changed -0.59°, 0.76° and 0.01° while radiographic inclination changed 0.23°, 0.18° and 1.00° for every 1° of pelvic roll, tilt and pitch, respectively. Computationally, anteversion changed -0.61°, 0.75° and 0.00° while inclination changed 0.22°, 0.19° and 1.00° for every 1° of pelvic roll, tilt and pitch, respectively. These results were independent of cup and pelvis size. CONCLUSIONS: Intraoperative pelvic motion can significantly affect final cup position, and this should be accounted for when placing acetabular components during total hip arthroplasty. Based on this study, intraoperative adjustment of the acetabular component position based on pelvis motion may be implemented to improve postoperative component position.
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Artroplastia de Reemplazo de Cadera , Prótesis de Cadera , Acetábulo/diagnóstico por imagen , Acetábulo/cirugía , Humanos , Pelvis , Tomografía Computarizada por Rayos XRESUMEN
Activities of daily living require the subaxial cervical spine (C2-C7) to have substantial mobility. Cervical degenerative changes can cause abnormal motions and altered load distribution, leading to pain and limiting the ability of individuals to perform activities of daily living. Anterior cervical discectomy and fusion (ACDF) has been widely used to treat symptomatic cervical spondylosis. Clinical studies have shown cervical disc arthroplasty (CDA) to be a viable alternative to ACDF for the treatment of radiculopathy and myelopathy. The benefits of CDA are based on the premise that preservation of physiologic motions and load-sharing at the treated level would lead to longevity of the index-level facet joints and mitigate the risk of adjacent segment degeneration.This review article classifies cervical disc prostheses according to their kinematic degrees of freedom and device constraints. Discussion on how these design features may affect cervical motion after implantation will provide the reader with valuable information on how disc prostheses may function clinically.The ability of a disc prosthesis to work in concert with remaining bony and soft tissue structures to restore physiologic motion and load-sharing is a function of the following design features and surgical factors: Kinematic degrees of freedom-Prostheses that allow translation independent of rotation allow, in theory, the spinal anatomy to dictate segmental motion after CDA potentially restoring physiologic motion and load-sharing. A 6-degrees-of-freedom disc prosthesis may be best equipped to achieve the intended function of CDA.Built-in stiffness-A disc prosthesis with built-in resistance to angular and translational motion may have an advantage in restoring stability to a hypermobile segment without eliminating motion.Surgical factors related to prosthesis implantation may influence cervical segments after CDA. These factors include the amount of disc space distraction caused by the prosthesis, prosthesis placement in the sagittal and coronal planes, and integrity of the soft tissue envelope.
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Unfortunately, figures 1 and 2 have been incorrectly published in the original publication. The complete correct figures are given below with the captions.
RESUMEN
BACKGROUND: Conditions requiring cervical decompression and stabilization are commonly treated using anterior cervical discectomy and fusion using an anterior cage-plate construct. Anterior zero profile integrated cages are an alternative to a cage-plate construct, but literature suggests they may result in less motion reduction. Interfacet cages may improve integrated cage stability. This study evaluated the motion reduction of integrated cages with and without supplemental interfacet fixation. Motion reduction of integrated cages were also compared to published cage-plate results. METHODS: Seven cadaveric (C2-T1) spines were tested in flexion-extension, lateral bending, and rotation. Specimens were tested: 1) intact, 2) C6-C7 integrated cage, 3) C6-C7 integrated cage + interfacet cages, 4) additional integrated cages at C3-C4 and C4-C5, 5) C3-C4, C4-C5 and C6-C7 integrated cages + interfacet cages. Motion, lordosis, disc and neuroforaminal height were assessed. FINDINGS: Integrated cage at C6-C7 decreased flexion-extension by 37% (P = .06) and C3-C5 by 54% (P < .01). Integrated + interfacet cages decreased motion by 89% and 86% compared to intact (P < .05). Integrated cages increased lordosis at C4-C5 and C6-C7 (P < .01). Integrated + interfacet cages returned C3-C5 lordosis to intact values, while C6-C7 remained more lordotic (P = .02). Compared to intact, neuroforaminal height increased after integrated cages at C3-C5 (P ≤ .01) and at all levels after interfacet cages (P < .01). INTERPRETATION: Anterior integrated cages provides less stability than traditional cage-plate constructs while supplemental interfacet cages improve stabilization. Integrated cages provide more lordosis at caudal levels and increase neuroforaminal height more at cranial levels. After interfacet cages, posterior disc height and neuroforaminal height increased more at the caudal segments.
Asunto(s)
Vértebras Cervicales/fisiología , Vértebras Cervicales/cirugía , Discectomía/instrumentación , Fusión Vertebral/instrumentación , Fenómenos Biomecánicos , Placas Óseas , Cadáver , Femenino , Humanos , Persona de Mediana Edad , Rango del Movimiento Articular , RotaciónRESUMEN
OBJECTIVE: The authors conducted a study to determine whether a change in T1 tilt results in a compensatory change in the cervical sagittal vertical axis (SVA) in a cadaveric spine model. METHODS: Six fresh-frozen cadavers (occiput [C0]-T1) were cleaned of soft tissue and mounted on a customized test apparatus. A 5-kg mass was applied to simulate head weight. Infrared fiducials were used to track segmental motion. The occiput was constrained to maintain horizontal gaze, and the mounting platform was angled to change T1 tilt. The SVA was altered by translating the upper (occipital) platform in the anterior-posterior plane. Neutral SVA was defined by the lowest flexion-extension moment at T1 and recorded for each T1 tilt. Lordosis was measured at C0-C2, C2-7, and C0-C7. RESULTS: Neutral SVA was positively correlated with T1 tilt in all specimens. After increasing T1 tilt by a mean of 8.3° ± 2.2°, neutral SVA increased by 27.3 ± 18.6 mm. When T1 tilt was reduced by 6.7° ± 1.4°, neutral SVA decreased by a mean of 26.1 ± 17.6 mm.When T1 tilt was increased, overall (C0-C7) lordosis at the neutral SVA increased from 23.1° ± 2.6° to 32.2° ± 4.4° (p < 0.01). When the T1 tilt decreased, C0-C7 lordosis at the neutral SVA decreased to 15.6° ± 3.1° (p < 0.01). C0-C2 lordosis increased from 12.9° ± 9.3° to 29.1° ± 5.0° with increased T1 tilt and decreased to -4.3° ± 6.8° with decreased T1 tilt (p = 0.047 and p = 0.041, respectively). CONCLUSIONS: Neutral SVA is not a fixed property but, rather, is positively correlated with T1 tilt in all specimens. Overall lordosis and C0-C2 lordosis increased when T1 tilt was increased from baseline, and vice versa.