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1.
J Neural Eng ; 19(1)2022 02 14.
Artículo en Inglés | MEDLINE | ID: mdl-35100571

RESUMEN

Objective.Somatosensory perception is disrupted in patients with a lower limb amputation. This increases the difficulty to maintain balance and leads to the development of neuromuscular adjustments. We investigated how these adjustments are reflected in the co-activation of lower body muscles and are modulated by visual feedback.Approach.We measured electromyography (EMG) signals of muscles from the trunk (erector spinae and obliquus external), and the lower intact/dominant leg (tibialis anterior and medial gastrocnemius) in 11 unilateral transfemoral amputees and 11 age-matched able-bodied controls during 30 s of upright standing with and without visual feedback. Muscle synergies involved in balance control were investigated using wavelet coherence analysis. We focused on seven frequencies grouped in three frequency bands, a low-frequency band (7.56 and 19.86 Hz) representing more sub-cortical and spinal inputs to the muscles, a mid-frequency band (38.26 and 62.63 Hz) representing more cortical inputs, and a high-frequency band (92.90, 129 and 170.90 Hz) associated with synchronizing motor unit action potentials. Further, the dynamics of changes in intermuscular coupling over time were quantified using the Entropic Half-Life.Main results.Amputees exhibited lower coherency values when vision was removed at 7.56 Hz for the muscle pair of the lower leg. At this frequency, the coherency values of the amputee group also differed from controls for the eyes closed condition. Controls and amputees exhibited opposite coherent behaviors with visual feedback at 7.56 Hz. For the eyes open condition at 129 Hz, the coherency values of amputees and controls differed for the muscle pair of the trunk, and at 170.90 Hz for the muscle pair of the lower leg. Amputees exhibited different dynamics of muscle co-activation at the low frequency band when vision was available.Significance.Altogether, these findings point to the development of neuromuscular adaptations reflected in the strength and dynamics of muscular co-activation.


Asunto(s)
Amputados , Adaptación Fisiológica , Electromiografía , Retroalimentación Sensorial/fisiología , Humanos , Pierna , Músculo Esquelético/fisiología
2.
PLoS One ; 16(12): e0260795, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34855875

RESUMEN

BACKGROUND: The tenosynovial giant cell tumor (TGCT) is a usually benign lesion which arises from the synovium. It affects joints, tendon sheaths and bursae. The clinical course is often unpredictable, and local recurrences frequently occur. The aim of this study was to describe different treatment options, surgical complications, and to develop a follow-up regime based on a systematic literature review and meta-analysis of foot and ankle lesions. METHODS AND RESULTS: 1284 studies published between 01/1966 and 06/2021 were identified. 25 met the inclusion criteria, with a total of 382 patients. Of these, 212 patients had a diffuse (dTGCT) and 170 a localized (lTGCT) TGCT. Patients with a dTGCT had a mean age of 36.6±8.2 years, and 55% were female. The overall complication rate was 24% in dTGCT, irrespective of the therapeutic procedure; the mean follow-up was 37.9±27.4 months with a recurrence rate of 21%, and recurrences occurred between 3 and 144 months, the vast majority (86%) within the first 5 years following intervention. Patients with a lTGCT had a mean age of 31.2±5.7 years, and 53% were female. Complications occurred in 12%. The mean follow-up was 51.1±24.6 months, the recurrence rate was 7%, and recurrence occurred between 1 and 244 months after intervention. CONCLUSION: Diffuse TGCTs of the foot and ankle region have a remarkable recurrence rate irrespective of therapeutic procedures, and most lesions reoccurred within 5, with more than half of these in the first 2 years. The lTGCTs are well treatable lesions, with a low recurrence and a moderate complication rate. Based on these findings, we propose a follow-up regime for the dTGCT including a clinical survey and MR imaging 3 months after surgical intervention (baseline), followed by twice-yearly intervals for the first 2 years, yearly intervals up to the fifth year, and further individual follow-up due to the fact that recurrences can even occur for years later. For the lTGCT a clinical survey and MRT is proposed after 3-6 months after intervention (baseline), followed by annual clinical examination for 3 years, and in case of symptoms MR-imaging. Larger prospective multi-center studies are necessary to confirm these results and recommendations.


Asunto(s)
Tobillo/cirugía , Enfermedades del Pie/cirugía , Tumor de Células Gigantes de las Vainas Tendinosas/cirugía , Recurrencia Local de Neoplasia/patología , Complicaciones Posoperatorias/patología , Procedimientos Quirúrgicos Operativos/efectos adversos , Tobillo/patología , Estudios de Seguimiento , Enfermedades del Pie/patología , Tumor de Células Gigantes de las Vainas Tendinosas/patología , Humanos , Recurrencia Local de Neoplasia/etiología , Complicaciones Posoperatorias/etiología
3.
Radiologe ; 61(7): 649-657, 2021 Jul.
Artículo en Alemán | MEDLINE | ID: mdl-34100121

RESUMEN

CLINICAL/METHODOLOGICAL ISSUE: Bone and soft tissue tumours are often incidental findings in children. Because they are usually benign tumours, nonspecialised radiologists generally have little experience in the diagnosis and differentiation from malignant tumours. Various imaging techniques are used in the diagnosis of skeletal tumours. STANDARD RADIOLOGICAL METHODS: Imaging techniques used to evaluate bone and soft tissue tumours include sonography, computed tomography (CT) and magnetic resonance imaging (MRI). METHODOLOGICAL INNOVATIONS: An algorithm to determine malignancy of bone and soft tissue tumours in children is proposed. PERFORMANCE: By using the presented algorithms, further diagnostic procedures such as biopsies can be avoided in the majority of children with bone and soft tissue tumours. Aggressive bone lesions and unclear soft tissue tumours are guided to biopsy to confirm diagnosis. ACHIEVEMENTS: The algorithms presented are based on the proposals of European professional societies and have been adapted by the authors for use in children and adolescents. PRACTICAL RECOMMENDATIONS: In the clarification of soft tissue tumours, sonography is the first diagnostic tool; depending on the sonographic findings, MRI is the technique for further clarification. Biopsy confirmation of the diagnosis in unclear cases or in cases of probable malignancy should be carried out in a paediatric oncology centre.


Asunto(s)
Neoplasias Óseas , Neoplasias de los Tejidos Blandos , Adolescente , Neoplasias Óseas/diagnóstico por imagen , Huesos , Niño , Humanos , Imagen por Resonancia Magnética , Neoplasias de los Tejidos Blandos/diagnóstico por imagen , Tomografía Computarizada por Rayos X
4.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3815-3818, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018832

RESUMEN

The dynamics of the adjustment of center of pressure (CoP) has been utilized to understand motor control in human pathologies characterized by impairments in postural balance. The control mechanisms that maintain balance can be investigated via the analysis of muscle recruitment using electromyography (EMG) signals. In this work, we combined these two techniques to investigate balance control during upright standing in transfemoral unilateral amputees wearing a prosthesis. The dynamics of the CoP adjustments and EMG-EMG coherence between four muscles of the trunk and lower limb of 5 unilateral transfemoral amputees and 5 age-matched able-bodied participants were quantified during 30 s of quiet standing using the entropic half-life (EnHL) method. Two visual conditions, eyes open and eyes closed, were tested. Overall, the group of amputees presented lower EnHL values (higher dynamics) in their CoP adjustments than controls, especially in their intact limb. The EnHL values of the EMG-EMG coherence time series in the amputee group were lower than the control group for almost all muscle pairs under both visual conditions. Different correlations between the EnHL values of the CoP data and the EMG-EMG coherence data were observed in the amputee and control groups. These preliminary results suggest the onset of distinct neuromuscular adaptations following a unilateral amputation.Clinical Relevance - Understanding neuromuscular adaptation mechanisms after an amputation may serve to design better rehabilitation treatments and novel prosthetic devices with sensory feedback.


Asunto(s)
Amputados , Miembros Artificiales , Adaptación Fisiológica , Humanos , Proyectos Piloto , Equilibrio Postural
5.
BMC Cancer ; 17(1): 527, 2017 Aug 07.
Artículo en Inglés | MEDLINE | ID: mdl-28784104

RESUMEN

BACKGROUND: Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different types of malignancies. This study aims to evaluate a possible correlation of different microvesicle subpopulations with a positive history of venous thromboembolism (VTE) in patients with soft tissue sarcoma. METHODS: Annexin V - positive microvesicles, leukocyte (CD45-positive), platelet (CD61-positive), activated platelet (CD62P-, CD63-positive), endothelium-derived (CD62E-positive) and tissue-factor (CD142-positive) microvesicles were identified in the peripheral blood of patients with soft tissue sarcoma (n = 39) and healthy controls (n = 17) using fluorescence-activated cell sorting (FACS). RESULTS: Both the total amount of Annexin V-positive microvesicles and levels of endothelium-derived (CD62E-positive) microvesicles were shown to decrease significantly after tumor resection (n = 18, p = 0.0395 and p = 0.0109, respectively). Furthermore, the total amount of Annexin V - positive microvesicles as well as leukocyte (CD45-positive) and endothelium-derived (CD62E-positive) microvesicles were significantly higher in patients with grade 3 (G3) soft tissue sarcoma (n = 9) compared to healthy controls (n = 17) (p = 0.0304, p = 0.0254 and p = 0.0357, respectively). Moreover, patients with G3 soft tissue sarcoma (n = 9) presented higher levels of Annexin V-positive and endothelium-derived (CD62E-positive) microvesicles compared to patients with grade 2 (G2) soft tissue sarcoma (n = 8) (p = 0.0483 and p = 0.0045). Patients with grade 1 (G1) soft tissue sarcoma (n = 3) presented with significantly lower levels of platelet (CD61-positive) microvesicles than patients with G3 soft tissue sarcoma (n = 9) (p = 0.0150). In patients with a positive history of VTE (n = 11), significantly higher levels of activated platelet (CD62P- and CD63-positive) microvesicles (p = 0.0078 and p = 0.0450, respectively) were found compared to patients without a history of VTE (n = 28). CONCLUSION: We found significantly higher levels of Annexin V-positive and endothelium-derived (CD62E-positive) microvesicles to be circulating in the peripheral blood of patients with G3 soft tissue sarcoma compared to patients with G2 soft tissue sarcoma. Furthermore, we showed that high counts of activated platelet-derived microvesicles correlate with the occurrence of VTE. Thus, the detection of these microvesicles might be an interesting new tool for early diagnosis of soft tissue sarcoma patients with increased risk for VTE, possibly facilitating VTE prevention by earlier use of thromboprophylaxis.


Asunto(s)
Plaquetas/metabolismo , Micropartículas Derivadas de Células/metabolismo , Sarcoma/complicaciones , Sarcoma/metabolismo , Tromboembolia Venosa/etiología , Adulto , Anciano , Anexina A5/metabolismo , Biomarcadores , Estudios de Casos y Controles , Citometría de Flujo , Humanos , Leucocitos/metabolismo , Persona de Mediana Edad , Activación Plaquetaria , Periodo Posoperatorio , Periodo Preoperatorio , Riesgo , Sarcoma/cirugía , Tromboembolia Venosa/sangre
6.
Acta Chir Orthop Traumatol Cech ; 84(2): 91-96, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28809624

RESUMEN

PURPOSE OF THE STUDY Various spine disorders are regularly treated by orthoses, and success of treatment depends on wearing these devices. In this study we examined the compliance, wear comfort, subjective stabilization and side effects associated with spinal orthoses using an individualized questionnaire and the Compact Short Form-12 Health Survey (SF-12). MATERIAL AND METHODS In this prospective pilot study of randomized cross-over design, twelve healthy volunteers with a mean age of 31.2 years wore three different types of orthoses, each for one week: A hyperextension brace (HB), a custom-made semirigid orthosis (SO) and a custom-made rigid orthosis (RO). The daily duration of wearing the orthosis was defined as primary endpoint; contentment was measured using an individualized questionnaire and the standardized SF-12. RESULTS In the study population calculated probability of wearing the HB and RO was between 0.2 und 38.5% (95% confidence interval). No volunteer wore the SO orthosis for the predefined time. The SO and RO each displayed high subjective stabilization, while the RO was more often associated with side effects like skin pressure marks than the SO. The need for rework due to discomfort was mainly necessary with the RO. We observed no substantial differences in feeling compression and sweating. Noteworthy, eight of 12 subjects complained of uncomfortable sternal pressure due to the upper pad of the HB. The SF-12: scores ranged from 52.1 to 48.6 on the physical (PCS), and from 53.7 to 50.8 on the mental component score (MCS), demonstrating an influence on QoL. DISCUSSION AND CONCLUSIONS The design as well as the orthosis itself influence the compliance of wearing and exert a moderate negative, but acceptable impact on QoL. The SO appeared to correlate with the best overall compromise between comfort and subjective stabilization. Further investigations are necessary in patients with spinal diseases, for whom the effect of orthosis wearing may surpass the potential discomfort. Key words: thoracolumbar spine, orthoses, SF-12 - Quality of Life - QoL, comfort, compliance.


Asunto(s)
Tirantes , Cooperación del Paciente , Enfermedades de la Columna Vertebral/terapia , Adulto , Anciano , Tirantes/efectos adversos , Estudios Cruzados , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estudios Prospectivos , Adulto Joven
7.
Radiologe ; 56(6): 476-88, 2016 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-27233920

RESUMEN

Primary cartilage-forming tumors of the bone are frequent entities in the daily work of skeletal radiologists. This article describes the correlation of pathology and radiology in cartilage-forming skeletal tumors, in particular, enchondroma, osteochondroma, periosteal chondromas, chondroblastoma and various forms of chondrosarcoma. After reading, the radiologist should be able to deduce the different patterns of cartilage tumors on radiographs, CT, and MRI from the pathological aspects. Differentiation of enchondroma and chondrosarcoma is a frequent diagnostic challenge. Some imaging parameters, e. g., deep cortical scalloping (more than two thirds of the cortical thickness), cortical destruction, or a soft-tissue mass, are features of a sarcoma. Osteochondromas are bony protrusions with a continuous extension of bone marrow from the parent bone, the host cortical bone runs continuously from the osseous surface of the tumor into the shaft of the osteochondroma and the osteochondroma has a cartilage cap. Chondromyxoid fibromas are well-defined lytic and eccentric lesions of the metaphysis of the long bones, with nonspecific MRI findings. Chondroblastomas have a strong predilection for the epiphysis of long tubular bones and develop an intense perifocal bone marrow edema. Dedifferentiated chondrosarcomas are bimorphic lesions with a low-grade chondrogenic component and a high-grade noncartilaginous component. Most chondrogenic tumors have a predilection with regard to site and age at manifestation.


Asunto(s)
Neoplasias Óseas/diagnóstico por imagen , Neoplasias Óseas/patología , Condroma/diagnóstico por imagen , Condrosarcoma/diagnóstico por imagen , Osteocondroma/diagnóstico por imagen , Osteocondroma/patología , Condroma/patología , Condrosarcoma/patología , Diagnóstico Diferencial , Medicina Basada en la Evidencia , Humanos , Aumento de la Imagen/métodos , Imagen por Resonancia Magnética/métodos , Tomografía Computarizada por Rayos X/métodos
8.
Rofo ; 188(5): 479-87, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26815281

RESUMEN

PURPOSE: The interobserver-variability of radiological diagnosis of benign bone tumors (BBT) and tumor-like lesions (TLL) was examined in order to identify difficult-to-diagnose entities, to examine the frequency of advanced diagnostics and to describe the number of interdisciplinary tumor center diagnoses (IDT) in comparison with diagnoses upon referral (ED) and radiologists´ diagnoses (RD). MATERIALS AND METHODS: We retrospectively reviewed 413 patients with 272 BBT and 141 TLL, classified either histologically or through interdisciplinary consultation. Discrepancies between groups were analyzed and rates of additional imaging and biopsy to establish diagnosis were assessed. RESULTS: In BBT the number of identical radiological diagnoses was 56 (ED) and 81 % (RD) compared to the IDT, while in the latter additional imaging were obtained in 30 % cases. In 21 % (12 % to establish diagnosis) BBT were biopsied, the ED matching the histology 40 %, the RD 60 % and the IDT 76 % of the time. For TLL diagnosed through radiology, ED and RD matched IDT 31 % and 61 % of the time, with additional imaging being obtained in 21 % of cases (IDT). In 36 % (27 % to establish diagnosis) biopsy was performed, with histological diagnosis matching the IDT, RD and ED in 51, 27 and 20 %. Diagnostic challenges were apparent in enchondromas, non-ossifying fibromas (NOF), solitary (SBC) and aneurysmal bone cysts (ABC). Ganglia can be misinterpreted as a tumor. CONCLUSIONS: Establishing a definitive diagnosis for BBT and TLL can be challenging with the latter posing greater difficulties. An interdisciplinary approach involving radiologists, orthopedics and pathologists was found to improve diagnostic accuracy. KEY POINTS: • Benign bone tumors (BBT) and tumor-like lesions (TLL) present a diagnostic challenge, while enchondroma, NOF, SBC and ABC were difficult to diagnose, and ganglia can be misinterpreted as a tumor• Additional imaging studies were required for diagnosis in 29 % and 21 % of cases for BBT and TLL, respectively, biopsies in 12 % of cases for BBT and 27 % for TLL• Sound diagnoses can be made through interdisciplinary case discussion, while reducing the risk of overtreatment Citation Format: • Scheitza P, Uhl M, Hauschild O et al. Interobserver Variability in the Differential Diagnosis of Benign Bone Tumors and Tumor-like Lesions. Fortschr Röntgenstr 2016; 188: 479 - 487.


Asunto(s)
Enfermedades Óseas/diagnóstico por imagen , Neoplasias Óseas/diagnóstico por imagen , Comunicación Interdisciplinaria , Colaboración Intersectorial , Variaciones Dependientes del Observador , Derivación y Consulta , Adolescente , Adulto , Biopsia , Enfermedades Óseas/clasificación , Enfermedades Óseas/patología , Neoplasias Óseas/clasificación , Neoplasias Óseas/patología , Huesos/diagnóstico por imagen , Huesos/patología , Niño , Preescolar , Diagnóstico Diferencial , Humanos , Lactante , Recién Nacido , Imagen por Resonancia Magnética , Persona de Mediana Edad , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Adulto Joven
9.
Acta Orthop Belg ; 82(3): 474-483, 2016 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-29119887

RESUMEN

The aim of this study was to describe treatment -options and develop a follow-up regime for the -aneurysmal bone cyst, a neoplastic bone lesion with a noticeable recurrence rate. Reports of 28 patients and a mean follow-up of 42.2 months treated multidisciplinary were analysed. Data were complemented by a literature review including 790 patients. Patient age was from seven to 57 years, in line with the literature (1-69 years). Lesions most frequently affect long bones, spine and pelvis ; pain is the most common symptom. Treatment modalities vary, recurrences -occurred in 26.1% in our series, rates ranged from 0-60% in the literature, with the vast majority within 2 years. With regard to the findings we propose, irrespective of treatment, a follow-up regime including clinical survey and imaging, best with MRI, at 3 months, 6 months and at half-yearly intervals within the first two and yearly within the third to fifth year.


Asunto(s)
Cuidados Posteriores , Quistes Óseos Aneurismáticos/terapia , Trasplante Óseo , Legrado , Glucocorticoides/uso terapéutico , Adolescente , Adulto , Quistes Óseos Aneurismáticos/complicaciones , Quistes Óseos Aneurismáticos/diagnóstico por imagen , Quistes Óseos Aneurismáticos/patología , Niño , Femenino , Fracturas Espontáneas/etiología , Humanos , Inyecciones Intralesiones , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Trasplante Autólogo , Adulto Joven
10.
Acta Chir Orthop Traumatol Cech ; 81(4): 288-91, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25137500

RESUMEN

Epithelioid and epithelial neoplasms of bone are rare. They include different epithelioid variants of vascular lesions, osteoblastoma, chondroblastoma and most importantly metastatic carcinoma. Up to now, only few cases of epithelioid osteosarcoma were described. In this case the authors report a 53-year-old patient presented with a medical history of chronic shoulder pain for 3 years. Magnetic resonance imaging (MRI and computed tomography (CT) showed a destructive, partially calcified osseous lesion of the scapula with expansion into the surrounding soft tissue, suggestive of a primary bone tumor. Histologically, the tumor consisted of epithelioid cells with expression of cytokeratine and the lesion was primarily diagnosed as metastatic carcinoma. With regard to the MRI morphology untypical for metastatic disease the histopathologic slides were re-evaluated and detection of tumor osteoid led to the diagnosis of epithelioid osteosarcoma. Chemotherapy was initiated, however follow-up imaging studies showed rapidly progressive disease of both primary tumor and lung metastases. In conclusion, epithelioid neoplasms of the bone are extremetumourly rare and must be distinguished from metastatic carcinoma. Despite the presence of cytokeratine positive cells a thorough histological evaluation is mandatory and osteoid detection is essential in order to establish the correct diagnosis and further treatment. Key words: osteosarcoma, epithelioid, aneurysmal bone cyst, chondrosarcoma, pathology, immunohistochemistry.


Asunto(s)
Neoplasias Óseas/diagnóstico , Neoplasias Óseas/patología , Osteosarcoma/diagnóstico , Osteosarcoma/patología , Escápula/diagnóstico por imagen , Escápula/patología , Traumatismos del Brazo/complicaciones , Biopsia , Quistes Óseos Aneurismáticos/diagnóstico , Quistes Óseos Aneurismáticos/patología , Neoplasias Óseas/complicaciones , Contusiones/complicaciones , Contusiones/diagnóstico , Diagnóstico Diferencial , Errores Diagnósticos , Femenino , Humanos , Inmunohistoquímica , Neoplasias Pulmonares/secundario , Imagen por Resonancia Magnética , Persona de Mediana Edad , Osteosarcoma/complicaciones , Osteosarcoma/secundario , Radiografía , Dolor de Hombro/etiología , Neoplasias de la Columna Vertebral/secundario
11.
Neoplasma ; 61(4): 365-78, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24645839

RESUMEN

The Enchondroma is a common, benign, cartilage forming tumour. They usually occur as a single, asymptomatic lesion. Occasionally patients present with multiple enchondromas which is generally defined as enchondromatosis. This entity encompasses several different subtypes including Ollier disease and Maffucci syndrome (enchondromatosis associated with soft tissue haemangiomas) as the most commons. Some of them have a complicated clinical course when malignant transformation occurs. This malignant progression is a well known fact especially in enchondromatosis, but up to now there is still a lack of recommendations concerning the follow up. The aim of this article is to review the clinical and imaging features of patients with solitary enchondroma and enchondromatosis focusing on the development of secondary chondrosarcoma and the follow up.


Asunto(s)
Neoplasias Óseas/patología , Transformación Celular Neoplásica/patología , Condroma/patología , Condrosarcoma/patología , Encondromatosis/patología , Radiología , Animales , Humanos
12.
Zentralbl Chir ; 139 Suppl 2: e79-82, 2014 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-22065338

Asunto(s)
Neoplasias de las Glándulas Suprarrenales/diagnóstico , Enfermedades de la Aorta/diagnóstico , Enfermedades de la Aorta/etiología , Vasoespasmo Coronario/diagnóstico , Vasoespasmo Coronario/etiología , Displasia Fibromuscular/complicaciones , Displasia Fibromuscular/diagnóstico , Displasia Fibromuscular/cirugía , Hipertensión Renovascular/diagnóstico , Hipertensión Renovascular/etiología , Hipertensión/diagnóstico , Hipertensión/etiología , Neoplasias del Mediastino/complicaciones , Neoplasias del Mediastino/diagnóstico , Paraganglioma Extraadrenal/diagnóstico , Feocromocitoma/diagnóstico , Remodelación Vascular/fisiología , Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias de las Glándulas Suprarrenales/cirugía , Adventicia/patología , Adventicia/cirugía , Anciano , Disección Aórtica/complicaciones , Disección Aórtica/diagnóstico , Disección Aórtica/patología , Disección Aórtica/cirugía , Aorta Torácica/patología , Aorta Torácica/cirugía , Enfermedades de la Aorta/patología , Enfermedades de la Aorta/cirugía , Vasoespasmo Coronario/cirugía , Diagnóstico Diferencial , Resultado Fatal , Femenino , Displasia Fibromuscular/patología , Humanos , Hipertensión/cirugía , Hipertensión Renovascular/patología , Hipertensión Renovascular/cirugía , Neoplasias del Mediastino/patología , Neoplasias del Mediastino/cirugía , Paraganglioma Extraadrenal/patología , Paraganglioma Extraadrenal/cirugía , Feocromocitoma/patología , Feocromocitoma/cirugía , Arteria Pulmonar/patología , Arteria Pulmonar/cirugía , Arteria Renal/patología , Arteria Renal/cirugía , Túnica Media/patología , Túnica Media/cirugía
13.
Radiologe ; 53(12): 1125-36, 2013 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-24129968

RESUMEN

PURPOSE: Osteochondroma represents the most common form of benign bone tumor. Clinical manifestations include deformity of bone, compression of surrounding tissue and vascular or neurological compromise. Osteochondromas may be solitary (solitary osteochondroma, SO) or multiple (multiple osteochondromas MO). Recurrence after surgery is a known problem especially in MO and malignant transformation is rare but more common in MO than in solitary cases. Reliable recommendations regarding diagnostics and clinical follow-up are currently lacking. PATIENTS AND METHODS: A comprehensive literature review and a review of own patient files with SO/MO treated between 2000 and 2011 in this hospital were performed. The age of patients at diagnosis, tumor localization, clinical aspects, recurrence and the risk of malignant transformation in secondary (i.e. epiexostotic) chondrosarcoma were analyzed. The follow-up including patients who received surgery ranged between 2 and 127 months for patients with SO and between 2 and 84 months for MO. RESULTS: A total of 39 patients with SO from this hospital were included in the study. Out of 36 patients who received surgery 3 recurrences were registered after an average time of 62 months. In addition, 11 patients with MO were identified and all received surgery. In 5 out of 11 cases recurrences occurred after an average time of 20.6 months. Secondary chondrosarcomas were not recorded in this series. According to the literature an increased risk of malignant transformation was found for osteochondromas of the axial skeleton, in the proximal aspect of the extremities, as well as for recurrent tumors and for MO. Pain and/or increase in size of lesions after skeletal maturation were the most common clinical signs of transformation. There was a wide time interval between the initial diagnosis and the development of secondary chondrosarcoma. In MO secondary chondrosarcoma has been described before skeletal maturity. CONCLUSIONS: The risk of malignant transformation of SO is generally low. Axial lesions as well as recurrent osteochondromas and MO seem to have an increased risk of malignant transformation. The follow-up, requiring sufficient primary diagnostics, includes regular self-control and can usually be clinically carried out in more peripherally located lesions but in certain cases supplementary X-ray imaging is needed. In cases of anatomical regions which are more difficult to access manually, follow-up examination by magnetic resonance imaging (MRI) is the method of choice. Especially MO patients seem to benefit from long-term follow-up: when the tumor is located in the trunk and in (proximal) long bones MRI or whole-body MRI, respectively, should be performed once a year after skeletal maturity because of the higher risk of malignant transformation in these patients.


Asunto(s)
Neoplasias Óseas/diagnóstico , Osteocondroma/diagnóstico , Adolescente , Adulto , Anciano , Neoplasias Óseas/epidemiología , Neoplasias Óseas/patología , Neoplasias Óseas/cirugía , Transformación Celular Neoplásica/patología , Niño , Preescolar , Exostosis Múltiple Hereditaria/diagnóstico , Femenino , Alemania/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/diagnóstico , Recurrencia Local de Neoplasia/patología , Osteocondroma/epidemiología , Osteocondroma/patología , Osteocondroma/cirugía , Prevalencia , Factores de Riesgo , Adulto Joven
14.
Acta Chir Orthop Traumatol Cech ; 79(3): 275-8, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22840961

RESUMEN

Different aetiologies including the femoroacetabular impingement (FAI) may cause a painful hip, especially in young pa - tients. Two general types of femoroacetabular impingement have been described, the pincer- and the cam type impingement. The latter is characterized by a femoral deformity, usually a bump on the head-and-neck junction that impinges on the acetabular rim. The authors describe the case of a 21-year-old male, bodybuilder, suffering from progressive hip pain with impairment of exercise tolerance, gait and other daily activities. Besides limitation of hip internal rotation physical examination was normal. He had a transitory response to non-steroid anti-inflammatory drugs. Initially performed MRI of the pelvis shows predominant inflammation of the hip joint. In external performed arthroscopy the biopsies of the capsule demonstrated chronic synovitis. In the follow up hip pain remains, however, diagnosis was still unclear. Re-evaluation of the formerly performed and a follow up MRI, and of an additional CT, the findings were compatible with an osteoid osteoma in the femoral cervico-cephalic transition causing itself a cam impingement and monarthritis. The adopted therapeutic strategy consisted on arthroscopic excision of the nidus and trimming of the femoral neck, with clinical recovery after surgical intervention.


Asunto(s)
Artritis/diagnóstico , Pinzamiento Femoroacetabular/etiología , Neoplasias Femorales/diagnóstico , Osteoma Osteoide/diagnóstico , Diagnóstico Diferencial , Neoplasias Femorales/complicaciones , Neoplasias Femorales/cirugía , Cuello Femoral , Humanos , Masculino , Osteoma Osteoide/complicaciones , Osteoma Osteoide/cirugía , Adulto Joven
15.
Acta Chir Orthop Traumatol Cech ; 78(6): 501-9, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-22217402

RESUMEN

Chondrosarcoma is the third most frequent primary malignant tumor of bone, constituting up to 16% of the malignant osseous neoplasms. Up to date several genetic alterations and markers were described concerning the pathogenesis and the progression of the chondrosarcoma, which represents actually a heterogeneous group of different types including conventional intramedullary, clear cell, myxoid, mesenchymal, and dedifferentiated chondrosarcoma. The pathologic appearance varies, however, in general they grow with a lobulated pattern. Histologically the hyaline cartilage demonstrates high water content and typically enchondral ossification is apparent. Imaging reflect this while radiographic findings suggest the diagnosis when the typical "ring-and-arc" chondroid matrix mineralization, endosteal scalloping and soft-tissue extension were apparent. The CT is used for detecting the mineralization of the matrix, especially when it is subtle or when the lesion is located in complex areas. MRT is the method of choice to detect the high water content of these lesions with a high signal intensity with T2-weighting and its bone marrow extend. Surgical resection is the primary and preferred treatment modality for most individuals with localized disease. In selected cases of the Grad I conventional chondrosarcoma curettage should be discussed. Systemic chemotherapy may be considered in variant forms such as mesenchymal or dedifferentiated chondrosarcomas. In knowledge of the "many faces" of the primary chondrosarcoma individualized patient assessment and optimal clinical management is possible.


Asunto(s)
Neoplasias Óseas/cirugía , Condrosarcoma/cirugía , Neoplasias Óseas/diagnóstico por imagen , Neoplasias Óseas/patología , Condrosarcoma/diagnóstico por imagen , Condrosarcoma/patología , Humanos , Radiografía
16.
J Hand Surg Eur Vol ; 35(2): 144-5, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19828567

RESUMEN

Enchondromas are common in the hand but less frequent in the distal phalanges. Epidermal cysts are rare in the hand but when they occur can be difficult to differentiate from enchondromas both clinically and radiologically. Our review of seven distal phalangeal bone lesions treated over 7 years included four enchondromas and three epidermal cysts. The patients with epidermal cysts all had a history of previous penetrating trauma 5-8 years earlier. One patient with an enchondroma had a history of a penetrating injury. Patients presenting with distal phalangeal lesions and a history of previous penetrating injury appear more likely to have an epidermal cyst than an enchondroma. This is important as there may be a higher recurrence rate following curettage and bone grafting.


Asunto(s)
Quistes Óseos/patología , Neoplasias Óseas/patología , Dedos , Adolescente , Adulto , Niño , Condroma/patología , Diagnóstico Diferencial , Quiste Epidérmico/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
17.
Neoplasma ; 55(1): 16-22, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18190235

RESUMEN

Although primary malignant tumors of the spine and sacrum are described in all orthopedic textbooks, it is still remarkable how little attention is paid to differential diagnosis of persisting lower back pain and how to detect in special the underlying tumor disease. Chordoma, osteosarcoma, chondrosarcoma, plasmacytoma, lymphoma and Ewing's sarcoma, their radiological manifestation, age distribution and preferred location in the spine and sacrum are reviewed and discussed.


Asunto(s)
Sacro , Neoplasias de la Columna Vertebral/diagnóstico por imagen , Neoplasias de la Columna Vertebral/diagnóstico , Biopsia , Diagnóstico Diferencial , Humanos , Linfoma/diagnóstico , Imagen por Resonancia Magnética , Sacro/diagnóstico por imagen , Sarcoma de Ewing/diagnóstico , Neoplasias de la Columna Vertebral/terapia , Tomografía Computarizada por Rayos X
18.
Acta Chir Orthop Traumatol Cech ; 73(6): 400-2, 2006 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-17266842

RESUMEN

Conservative treatment of pathologic fractures of the long bones have been reported very infrequently, especially when fracture is caused by an tumour. This report highlights the possibility of an nonoperative treatment of a pathologic humerus fracture caused by an cartilaginous tumour with radiographic criterions of an chondrosarcoma.


Asunto(s)
Neoplasias Óseas/complicaciones , Condrosarcoma/complicaciones , Curación de Fractura , Fracturas Espontáneas/etiología , Fracturas del Húmero/etiología , Húmero , Femenino , Fracturas Espontáneas/terapia , Humanos , Fracturas del Húmero/terapia , Persona de Mediana Edad
19.
J Bone Joint Surg Br ; 87(3): 348-51, 2005 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15773644

RESUMEN

We treated surgically 16 shoulders with an isolated traumatic rupture of the subscapularis tendon over a six-year period. Nine patients had a total and seven a partial tear of the subscapularis tendon. Repair was undertaken through a small deltopectoral groove approach. The mean Constant score improved in total tears from 38.7 to 89.3 points (p = 0.003) and in partial tears from 50.7 to 87.9 points (p = 0.008). The total tears were significantly more improved by surgery than the partial tears (p = 0.001). The delay between trauma and surgery was inversely proportional to the improvement in the Constant score suggesting that early diagnosis and surgical repair improves outcome.


Asunto(s)
Lesiones del Hombro , Traumatismos de los Tendones/cirugía , Adulto , Diagnóstico Precoz , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Rotura , Articulación del Hombro/cirugía , Dolor de Hombro/etiología , Traumatismos de los Tendones/diagnóstico , Traumatismos de los Tendones/etiología , Resultado del Tratamiento
20.
Radiologe ; 44(10): 1013-22; quiz 1023-4, 2004 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-15448905

RESUMEN

Tumor-like bone lesions include various conditions of a non-neoplastic nature originating from or affecting the bone as solitary or sometimes multiple bone lesions. This review discusses the most important cystic tumor-like lesions, such as simple bone cyst, aneurysmal bone cyst, intraosseous ganglion, epidermoid cyst and subchondral cyst. MR is the most sensitive method of detection, and is the most accurate in depicting the extent of involvement of these lesions. MR signal characteristics may aid in differential diagnosis. Conventional radiographs are often more specific with respect to the underlying histopathology.


Asunto(s)
Quistes Óseos/diagnóstico , Neoplasias Óseas/diagnóstico , Quistes Óseos Aneurismáticos/diagnóstico , Huesos/patología , Cementoma/diagnóstico , Diagnóstico Diferencial , Quiste Epidérmico/diagnóstico , Humanos , Imagen por Resonancia Magnética , Radiografía , Cintigrafía , Sensibilidad y Especificidad
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