RESUMEN
BACKGROUND & AIMS: Many studies indicate that gallstone susceptibility has genetic components. MDR3 is the phosphatidylcholine translocator across the hepatocyte canalicular membrane. Because phospholipids are a carrier and a solvent of cholesterol in hepatic bile, we hypothesized that a defect in the MDR3 gene could be the genetic basis for peculiar forms of cholesterol gallstone disease, in particular those associated with symptoms and cholestasis without evident common bile duct stone. METHODS: We studied 6 adult patients with a peculiar form of cholelithiasis. MDR3 gene sequence was determined by reverse-transcription polymerase chain reaction amplification of mononuclear cell RNAs followed by direct sequencing. Hepatic bile was analyzed in 2 patients. RESULTS: All patients shared the following features: at least 1 episode of biliary colic, pancreatitis, or cholangitis; biochemical evidence of chronic cholestasis; recurrence of symptoms after cholecystectomy; presence of echogenic material in the intrahepatic bile ducts; and prevention of recurrence by ursodeoxycholic acid therapy. Hepatic bile composition showed a high cholesterol/phospholipid ratio and cholesterol crystals. In all patients, we found MDR3 gene mutations involving a conserved amino acid region. CONCLUSIONS: These preliminary observations suggest that MDR3 gene mutations represent a genetic factor involved in this peculiar form of cholesterol gallstone disease in adults. They require further studies to assess the prevalence of MDR3 gene defects in symptomatic and silent cholesterol gallstone disease.
Asunto(s)
Subfamilia B de Transportador de Casetes de Unión a ATP/genética , Transportadoras de Casetes de Unión a ATP/genética , Colelitiasis/genética , Colesterol/metabolismo , Adolescente , Adulto , Bilis/química , Colelitiasis/metabolismo , Colelitiasis/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Ácido Ursodesoxicólico/uso terapéuticoRESUMEN
BACKGROUND & AIMS: Hereditary hemochromatosis is associated with C282Y homozygosity. Some heterozygotes may also present with abnormal iron parameters. However, the precise role of H63D and C282Y mutations in iron overload is poorly understood. We investigated the level of expression of the mutated and unmutated HFE alleles in these heterozygous patients. METHODS: We studied the expression of HFE messenger RNAs in peripheral blood mononuclear cells from 34 heterozygotes using reverse-transcription polymerase chain reaction (PCR) followed by enzymatic digestion or sequence analysis of the PCR products, which allows relative quantification of mutated and unmutated transcripts. HFE proteins were quantified by Western blotting in Epstein-Barr virus-immortalized lymphocyte extracts from 2 C282Y and H63D homozygotes and a compound heterozygote. RESULTS: (187C > G; H63D) mutated transcripts predominated in H63D and compound heterozygotes and the normal transcripts in C282Y heterozygotes. The amount of HFE protein was increased in the H63D homozygotes and the compound heterozygote compared with the C282Y homozygotes. In addition, we found a new mutation at codon 282 (C282S) associated with severe iron overload. CONCLUSIONS: We demonstrate the existence of differential allelic expression of the HFE alleles, suggesting that the (187C > G; H63D) mutation plays a role in the disease expression in H63D heterozygotes, in particular when associated with environmental or host factors.
Asunto(s)
Antígenos HLA/genética , Hemocromatosis/genética , Antígenos de Histocompatibilidad Clase I/genética , Proteínas de la Membrana , Transcripción Genética , Adulto , Sustitución de Aminoácidos , Codón , Duodeno/inmunología , Duodeno/patología , Femenino , Ferritinas/sangre , Amplificación de Genes , Genes MHC Clase I , Genotipo , Hemocromatosis/inmunología , Hemocromatosis/patología , Proteína de la Hemocromatosis , Heterocigoto , Humanos , Hígado/inmunología , Hígado/patología , Linfocitos/inmunología , Masculino , Persona de Mediana Edad , Mutación Puntual , ARN Mensajero/genética , Reacción en Cadena de la Polimerasa de Transcriptasa InversaRESUMEN
In this single case study, paintings by a visually impaired and cognitively handicapped savant artist are evaluated. He paints his pictures exclusively from memory, either after having looked at a natural scene through binoculars, or after studying landscape photographs in brochures, catalogues, and books. The paintings are compared with the models from which they were derived, and the resulting generative changes are accounted for by an interaction between impaired visual input and memory transformations.
Asunto(s)
Trastorno Autístico/psicología , Trastornos del Conocimiento/psicología , Pinturas , Trastornos de la Visión/psicología , Niño , Personas con Discapacidad , Humanos , Masculino , Memoria , Percepción VisualRESUMEN
BACKGROUND: Savant calendar calculators can supply with speed the day of the week of a given date. Although memory is suggested to be an important component of this unusual ability, memory function has never been systematically investigated in these skilled yet learning impaired individuals. METHODS: Eight savant calendrical calculators, most of whom had autism, were compared with eight verbal IQ, age and diagnosis matched controls on digit and word span tests and measures of long-term memory for words and calendrical information (individual years). In an analogue to the 'generation effect', the savants' memory for dates was also compared following calculation and study/read tasks. RESULTS: The savants did not differ from controls on measures of general short- and long-term memory. They did, however, show a clear recall superiority for the long-term retention of calendrical material. They also remembered calculated dates better than those that were only studied. CONCLUSIONS: A general mnemonic advantage cannot explain savant date calculation skills. Rather, through exposure to date information, the savants are suggested to develop a structured calendar-related knowledge base with the process of calculation utilizing the interrelations within this knowledge store. The cognitive processing style characteristic of autism may also play a role in the acquisition of this savant ability.
Asunto(s)
Trastorno Autístico , Memoria/fisiología , Percepción del Tiempo/fisiología , Adulto , Análisis de Varianza , Cognición/fisiología , Humanos , Pruebas del Lenguaje , Vocabulario , Escalas de WechslerRESUMEN
BACKGROUND: Children with autistic spectrum disorders typically show impairments in processing affective information within social and interpersonal domains. It has yet to be established whether such difficulties persist in the area of music; a domain which is characteristically rich in emotional content. METHODS: Fourteen children with autism and Asperger syndrome and their age and intelligence matched controls were tested for their ability to identify the affective connotations of melodies in the major or minor musical mode. They were required to match musical fragments with schematic representations of happy and sad faces. RESULTS: The groups did not differ in their ability to ascribe the musical examples to the two affective categories. CONCLUSIONS: In contrast to their performance within social and interpersonal domains, children with autistic disorders showed no deficits in processing affect in musical stimuli.
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Afecto , Síndrome de Asperger/psicología , Percepción Auditiva , Trastorno Autístico/psicología , Música , Adolescente , Síndrome de Asperger/diagnóstico , Trastorno Autístico/diagnóstico , Niño , Femenino , Humanos , Masculino , Percepción SocialRESUMEN
The aim of my work was the answer to the following questions: how often does the deficiency of magnesium, copper, zinc, calcium, iron occur among hyperactive children in comparison with healthy children, deficiency of which of the considered bioelements is the most frequent, what is the effect of supplementation of deficit element on hyperactivity and does it depend on other certain disorders that coexist with hyperactivity? In a process of establishing the subject diagnosis I have followed the DSM IV criteria recognizing ADHD among examined ones. I have determined the deficiency of magnesium, copper, zinc, calcium, iron in the group of 116 children with diagnosed ADHD. Consequently, as a result, I have found out that shortage of above-mentioned bioelements occurs more often among hyperactive children than among those being healthy, and deficiency of magnesium is the most frequent in this respect. Further, I have divided the group of 110 children with magnesium deficiency into two groups according to the other mental disorders that coexist with ADHD: 1) the group where hyperactivity coexists with disorders typical for developmental age such as enuresis, tics, separation anxiety, stuttering, selective mutism (63 children); 2) the group where hyperactivity coexists with disruptive behaviour disorders: conduct disorder and oppositional defiant disorder (47 children). The content of magnesium, copper, zinc, calcium, iron has been determined respectively in blood (serum and red cells) and in hair by atomic absorption spectroscopy method in both groups accordingly. At the same time, the hyperactivity tests were carried out using Conner's Rating Scales for Parents and Teachers, Wender's Scale as well as Quotient of Development to Freedom from Distractibility. During the statistical analysis the inparametric tests have been used taking as a significance level p < 0.05. On the ground of obtained findings I have not stated any significant differences in bioelements content among hyperactive children in relation to other coexisting disorders, except for zinc. The zinc content in hair was higher among children with ADHD and disruptive behaviour disorder. The assessment of hyperactivity indicated the remarkably higher coefficient among children with coexisting behaviour disorders as compared to hyperactive children among whom, additionally, disorders typical for developmental age have occurred. The analysis of influence exerted by magnesium supplementation on hyperactivity has been carried out in the group of total 75 children with ADHD jointly with magnesium deficiency. The group of 50 children actually tested, apart from standard treatment have received the specified doses of magnesium preparations for 6 months on regular basis. The group of 25 children was left with standard treatment without additional magnesium. In both above-mentioned groups the content of bioelements and respectively ADHD level have been determined just before and after the test. The obtained results have clearly disclosed significant increase of magnesium, zinc, calcium content (Tab. 1) and respectively essential decrease of hyperactivity in the group of children treated with magnesium. At the same time, however, among the children given standard treatment without magnesium, hyperactivity has intensified (Tab. 3, 4). The findings herein presented indicate that it is necessary to take into consideration a possible bioelements deficiency among children with ADHD. Consequently, the accomplished study proves that there is a need of magnesium supplementation in ADHD children irrespectively of other mental disorders. The supplementation of that kind of magnesium supplementation together with standard traditional mode of treatment gives us the opportunity to extend the methods of therapy of ADHD children who are the "children of the risk" in connection with their educational, emotional and social problems.
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Trastorno por Déficit de Atención con Hiperactividad/etiología , Calcio/deficiencia , Cobre/deficiencia , Deficiencias de Hierro , Deficiencia de Magnesio/complicaciones , Trastorno por Déficit de Atención con Hiperactividad/prevención & control , Calcio/administración & dosificación , Calcio/análisis , Niño , Cobre/administración & dosificación , Cobre/análisis , Suplementos Dietéticos , Femenino , Cabello/química , Humanos , Hierro/administración & dosificación , Hierro/análisis , Deficiencia de Magnesio/diagnóstico , Deficiencia de Magnesio/terapia , Masculino , Trastornos Mentales/complicacionesRESUMEN
The relative immunity of the concept of size constancy in the face of changes to the retinal image as well as the pictorial device of linear perspective were investigated with 9 savant artists and 9 controls. For drawing use of pictorial rules seemed independent of levels of intelligence; however, when a construction instead of a drawing task had to be carried out, diagnosis rather than the presence or absence of talent was the decisive factor.
Asunto(s)
Aptitud , Arte , Niño Superdotado/psicología , Discapacidad Intelectual/psicología , Percepción del Tamaño , Percepción Espacial , Adulto , Niño , Humanos , InteligenciaRESUMEN
A positive influence of magnesium in the prevention and treatment of hyperactivity in children is more and more frequently raised in the literature. The aim of our work was to estimate magnesium contents in children with attention deficit hyperactivity disorder, (ADHD). The investigations comprised 116 children (94 boys and 20 girls), aged 9-12 years, with recognized ADHD. In 68 out of 116 patients examined ADHD occurred with other coexisting disorders specific to the developmental age and in the remaining 48 patients it occurred together with disruptive behaviour. Magnesium levels have been determined in blood serum, red blood cells and in hair with the aid of atomic absorption spectroscopy. Magnesium deficiency was found in 95 per cent of those examined, most frequently in hair (77.6 per cent), in red blood cells (58.6 per cent) and in blood serum (33.6 per cent) of children with ADHD. The conclusion from the investigations is that magnesium deficiency in children with ADHD occurs more frequently than in healthy children. Analysis of the material indicated the correlation between levels of magnesium and the quotient of development to freedom from distractibility.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/metabolismo , Magnesio/metabolismo , Trastorno por Déficit de Atención con Hiperactividad/sangre , Niño , Eritrocitos/metabolismo , Estudios de Evaluación como Asunto , Femenino , Cabello/metabolismo , Humanos , Magnesio/sangre , MasculinoRESUMEN
Children with ADHD are 'a group at risk' as far as their further emotional and social development and educational possibilities are concerned, and the consequences of the lack of an appropriate therapy appears to be serious. Some of these children do not respond to prevailing therapy methods. It is reported that dietetic factors can play a significant role in the etiology of ADHD syndrome, and magnesium deficiency can help in revealing hyperactivity in children. The aim of our work was to assess the influence of magnesium supplementation on hyperactivity in patients with ADHD. The examination comprised 50 hyperactive children, aged 7-12 years, who fulfilled DSM IV criteria for ADHD syndrome, with recognized deficiency of magnesium in the blood (blood serum and red blood cells) and in hair using atomic absorption spectroscopy. In the period of 6 months those examined regularly took magnesium preparations in a dose of about 200 mg/day. 30 of those examined with ADHD showed coexisting disorders specific to developmental age, and 20 of them showed disruptive behaviour. The control group consisted of 25 children with ADHD and magnesium deficiency, who were treated in a standard way, without magnesium preparations. 15 members of this group showed coexisting disorders specific for developmental age, and 10 members showed disruptive behaviour. Hyperactivity was assessed with the aid of psychometric scales: the Conners Rating Scale for Parents and Teachers, Wender's Scale of Behavior and the Quotient of Development to Freedom from Distractibility. In the group of children given 6 months of magnesium supplementation, independently of other mental disorders coexisting with hyperactivity, an increase in magnesium contents in hair and a significant decrease of hyperactivity of those examined has been achieved, compared to their clinical state before supplementation and compared to the control group which had not been treated with magnesium.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/dietoterapia , Suplementos Dietéticos , Deficiencia de Magnesio/dietoterapia , Magnesio/uso terapéutico , Administración Oral , Trastorno por Déficit de Atención con Hiperactividad/complicaciones , Niño , Humanos , Deficiencia de Magnesio/complicaciones , Resultado del TratamientoRESUMEN
Transfer of the SV40 large-T (LT) oncogene into isolated human and murine intestinal epithelial cells induced alterations of the ultrastructural organization and polarization of the resulting immortalized cell lines. We now demonstrate that the functional expression of the SV40 LT antigen in Caco-2 cells did not alter phenotypic markers of differentiation, including expression of villin, sucrase-isomaltase, brush border and dome formation. As compared to parental cells, the transfected Caco-2 LT9 cells exhibited similar growth curves and no invasive properties in vitro. The major oncogenic function of the SV40 LT antigen in transfected Caco-2 cells is associated with reduced latency times necessary for the manifestation of tumors in athymic nude mice. The Caco-2 cell line contained deleted and mutant p53 alleles (stop codon in position 204) and has no detectable truncated p53 protein by Western blot. Molecular complexes between the SV40 LT antigen and the retinoblastoma-related proteins pRb1 and Rb2 were clearly identified at the different phases of the growth curve. When compared to normal human colonic crypts, Caco-2 cell differentiation is related to partial redistribution of pRb1 into hypophosphorylated, antiproliferative forms. The pRb2 protein is found elevated in a subset of human colorectal tumors and their corresponding liver metastases. We conclude that: (1) Caco-2 cells exert a dominant control against the oncogenic functions of the LT antigen; (2) loss of p53 function is not restrictive for the establishment of polarity and differentiation of the enterocyte lineage; (3) the levels and phosphorylation status of the Rb1 and Rb2 proteins may play important roles in the proliferation and differentiation of normal and neoplastic human colonic mucosa.
Asunto(s)
Antígenos Transformadores de Poliomavirus/genética , Neoplasias del Colon/patología , Genes p53 , Mucosa Intestinal/citología , Oncogenes , Proteína de Retinoblastoma/metabolismo , Animales , Antígenos Transformadores de Poliomavirus/metabolismo , Células CACO-2 , Diferenciación Celular , División Celular , Línea Celular Transformada , Polaridad Celular , Transformación Celular Neoplásica , Neoplasias del Colon/metabolismo , Expresión Génica , Humanos , Mucosa Intestinal/metabolismo , Ratones , Ratones Desnudos , Trasplante de Neoplasias , Fosforilación , Virus 40 de los Simios/inmunología , Transfección , Proteína p53 Supresora de Tumor/metabolismoRESUMEN
We analysed the frequency of p53 mRNA overexpression in a series of 109 primary colorectal carcinomas and its association with p53 gene mutation, which has been correlated with short survival. Sixty-nine of the 109 cases (63%) demonstrated p53 mRNA overexpression, without any correlation with stage or site of disease. Comparison with p53 gene mutation indicated that, besides cases in which p53 gene mutation and p53 mRNA overexpression were either both present (40 cases) or both absent (36 cases), there were also cases in which p53 mRNA was overexpressed in the absence of any mutation (29 cases) and those with a mutant gene in which the mRNA was not overexpressed (four cases). Moreover, the mutant p53 tumours exhibited an increase of p53 mRNA expression, which was significantly higher in tumours expressing the mutated allele alone than in tumours expressing both wild- and mutated-type alleles. These data (1) show that p53 mRNA overexpression is a frequent event in colorectal tumours and is not predictive of the status of the gene, i.e. whether or not a mutation is present; (2) provide further evidence that p53 protein overexpression does not only result from an increase in the half-life of mutated p53 and suggest that inactivation of the p53 function in colorectal cancers involves at least two distinct mechanisms, including p53 overexpression and/or mutation; and (3) suggest that p53 mRNA overexpression is an early event, since it is not correlated with Dukes stage.
Asunto(s)
Neoplasias del Colon/genética , Genes p53/genética , Mutación , ARN Mensajero/metabolismo , Neoplasias del Recto/genética , Proteína p53 Supresora de Tumor/metabolismo , Neoplasias del Colon/patología , Femenino , Amplificación de Genes , Humanos , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , ARN Mensajero/genética , Neoplasias del Recto/patología , Proteína p53 Supresora de Tumor/genéticaRESUMEN
Poems by an individual with a diagnosis of Asperger's Syndrome were analysed and compared with those of a comparison poet. Though the savant poet performed less efficiently on formal language tests supposed to tap creativity, there were few differences between the two poets in regard to the poems' content and the use of various structural devices. The poems by the savant referred more often to aspects of self-analysis, while descriptions of people not related to the self were less frequent. Both poets made use of similes and metaphors. The results are discussed in terms of different modular domains within the language system.
Asunto(s)
Aptitud , Trastorno Autístico/psicología , Barreras de Comunicación , Creatividad , Poesía como Asunto , Trastorno de la Conducta Social/psicología , Escritura , Estudios de Casos y Controles , Femenino , Humanos , Lenguaje , Pruebas del Lenguaje , Persona de Mediana Edad , Autoevaluación (Psicología) , SíndromeRESUMEN
Variability in the expression of monogenic lipid disorders may be observed in patients carrying the same DNA mutation, suggesting possible genetic or environmental interactions. Our objective was to investigate the genotype-phenotype relationships in two unrelated French patients with an aggravated expression of a dominantly inherited hypercholesterolemia. In probands, segregation analysis complemented by DNA sequencing identified heterozygous defective alleles and mutations on two nonallelic loci for two monogenic lipid disorders: familial hypercholesterolemia at the low density lipoprotein (LDL) receptor locus and familial defective apolipoprotein B-100 at the locus encoding its ligand, apolipoprotein B-100. The LDL-receptor missense mutations had been reported in French Canadians. The apolipoprotein B mutation was the Arg3500Gln founder mutation in Northern Europe. Probands had an unusual phenotype of aggravated hypercholesterolemia that was complicated with premature coronary arterial disease, although remaining responsive to lipid-lowering drugs. This phenotype was distinct from that observed in their heterozygous relatives and distinct from those observed in FH or FDB homozygotes. These cases refer to a new class of patients with digenic lipid disorders, defined by specific clinical features that result from the combined effects of two independent loci. Moreover, the observed phenotype of aggravated hypercholesterolemia gives further evidence that receptor and ligand play distinct roles in regulating LDL metabolism. Although uncommon, these cases give insight into the molecular mechanisms that underly the clinical variability of inherited hypercholesterolemia.
Asunto(s)
Apolipoproteínas B/genética , Heterocigoto , Hiperlipoproteinemia Tipo II/genética , Fenotipo , Adulto , Apolipoproteína B-100 , Secuencia de Bases , Niño , Femenino , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Datos de Secuencia Molecular , LinajeRESUMEN
This study describes two experiments which investigate pattern construction by graphically gifted, autistic savants. We explore whether the notion of weak central coherence in autism might be extended to account for the relatively high frequency of savants among the autistic population. We also suggest that an awareness of constituent segments in wholes may be relevant to artistic talent in general.
Asunto(s)
Aptitud , Arte , Trastorno Autístico/psicología , Creatividad , Desempeño Psicomotor , Adolescente , Adulto , Niño , Niño Superdotado/psicología , Femenino , Humanos , Masculino , Orientación , Reconocimiento Visual de Modelos , Solución de Problemas , Psicometría , Valores de Referencia , Escalas de Wechsler/estadística & datos numéricosRESUMEN
The molecular basis of familial hypercholesterolemia (FH) in three families of Spanish descent from La Habana was investigated by the candidate gene approach. The Arg3500Gln mutation of apolipoprotein B-100 was not found. Identification of low density lipoprotein receptor (LDLR) gene haplotypes segregating with FH guided the characterisation of three point mutations by automated sequencing. One, a Val408-->Met missense mutation, a founder mutation in Afrikaner FH patients, was recurrent, being associated with a distinct DNA haplotype. The other two, Glu256-->Lys and Val776-->Met missense mutations, were novel and modified highly conserved residues. These mutations were absent in normolipidemic subjects and were associated in heterozygous carriers with twice the cholesterol levels observed in non-carriers. Noticeably, cardiovascular complications were rarely observed in older heterozygotes, even in those with the Afrikaner FH-2 mutation. These findings confirm the molecular heterogeneity of LDLR gene mutations causing FH and the variability of their expression across different populations.
Asunto(s)
Hiperlipoproteinemia Tipo II/genética , Mutación Puntual , Receptores de LDL/genética , Adolescente , Adulto , Anciano , Preescolar , Cuba , Femenino , Genes Recesivos , Haplotipos , Heterocigoto , Humanos , Lipoproteínas/sangre , Masculino , Persona de Mediana Edad , Linaje , Triglicéridos/sangreRESUMEN
The mode of Pneumocystis carinii transmission is controversial. Recent studies point to exogenous inoculation rather than reactivation, and person-to-person transmission has also been suggested. Comparison of nucleotide sequences of the large-subunit mitochondrial rRNA gene of P. carinii from human immunodeficiency virus-seropositive patients showed strain differences.
Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Pneumocystis/genética , Neumonía por Pneumocystis/microbiología , Secuencia de Bases , ADN de Hongos/análisis , Variación Genética , Seropositividad para VIH , Humanos , Datos de Secuencia Molecular , Pneumocystis/aislamiento & purificación , Reacción en Cadena de la Polimerasa , ARN de Hongos/genética , ARN Ribosómico/genéticaRESUMEN
Savant artists represent a conundrum to our understanding of the nature of high level specific talents as well as to the concept of general intellectual impairment. In the present paper, we are particularly concerned with the relationship between general perceptual-motor functions in relation to drawing aptitude. Drawing is by definition a perceptual-motor operation, yet mental handicap tends to be associated with some degree of impairment in this area. The following study seeks to isolate such aspects of performance on general perceptual-motor skills that might be associated with drawing ability, and may thus be regarded as building blocks underlying the manifestation of graphic talent. The results are discussed in terms of the relationships between graphic talent, non-verbal intelligence and visual-motor functions.
Asunto(s)
Aptitud , Arte , Trastorno Autístico/psicología , Inteligencia , Desempeño Psicomotor , Adolescente , Adulto , Percepción de Profundidad , Aprendizaje Discriminativo , Femenino , Área de Dependencia-Independencia , Humanos , Masculino , Recuerdo Mental , Destreza Motora , Pruebas Neuropsicológicas , Orientación , Reconocimiento Visual de Modelos , Solución de ProblemasRESUMEN
Two young autistic children of normal intelligence were tested repeatedly for their reading ability. Their comprehension was appropriate for their developmental status, however, they had reading speeds that were considerably faster than those of their age-matched normal controls. Randomizing word order, and thereby reducing meaningfulness, resulted in an equivalent reduction in relative reading speeds for the younger autistic subject and his control. For the older of the normal children, the effect of randomizing word order was very marked, whereas its effect was minimal for the older of the two autistic boys. The results are regarded as an indication that efficient grapheme-phoneme conversion is a modular component of the reading skill and this transcoding process is primarily responsible for the fast reading of the autistic children.