RESUMEN
ABSTRACT The objectives of this study were to report two cases of nasopalatine duct cyst and to review the relevant literature. In the first case, the lesion was approximately 1.5 cm in size and in the second case 3 cm, both characterized by localized swelling in the hard palate. The two cases presented a radiolucent unilocular image in the region of the incisive foramen. The diagnosis was nasopalatine duct cyst, established by excisional biopsy and anatomopathological examination. The second patient presented a late postoperative infection, four weeks after surgery, and was submitted to antibiotic therapy and drainage. Both patients were followed for more than 30 months, with no signs of recurrence.
RESUMO Os objetivos deste estudo foram relatar dois casos de cisto do ducto nasopalatino e rever a literatura pertinente. No primeiro caso, a lesão media aproximadamente 1,5 cm e, no segundo, 3 cm, ambas caracterizadas por tumefação localizada no palato duro. Os dois casos apresentaram imagem radiolúcida unilocular na região do forame incisivo. O diagnóstico foi cisto do ducto nasopalatino, realizado por meio de biópsia excisional e exame anatomopatológico. O segundo paciente apresentou infecção pós-operatória tardia, quatro semanas após a cirurgia, sendo submetido a antibioticoterapia e drenagem. Os dois pacientes foram acompanhados por mais de 30 meses, sem sinais de recidiva.
RESUMEN
O adenoma canalicular é uma neoplasia benigna incomum de glândulas salivares, que acomete principalmente as glândulas menores, com acentuada predileção pelo lábio superior. Essa neoplasia é mais prevalente em pacientes do sexo feminino, acima de 50 anos de idade. O objetivo deste trabalho é relatar um caso clínico de adenoma canalicular no lábio superior de uma paciente de 68 anos de idade, bem como rever a literatura pertinente. As características clínicas, hipóteses de diagnóstico, histopatologia, tratamento e prognóstico dessa neoplasia são apresentados e discutidos.
The canalicular adenoma is a rare benign salivary gland tumor that affects mainly the minor glands, with a marked predilection for the upper lip. This tumor is more prevalent in female patients above 50 years old. The objective of this study is to report on a case of canalicular adenoma in the upper lip of a 68 years old female patient and to review the pertinent literature. The clinical features, diagnostic hypotheses, histopathology, treatment and prognosis of this tumor are presented and discussed.
RESUMEN
The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC.