The comfort and functional performance of personal protective equipment for police officers: a systematic scoping review.

This scoping review aimed to identify and summarise evidence on the comfort and functional performance of police officer personal protective equipment (PPE). The Arksey and O'Malley (2005) five-stage framework for scoping reviews was followed. PubMed, CINAHL, Scopus, and Web of Science were searched, and 35 articles were included in the review. The findings show that increased police PPE mass increases heart rate, metabolic energy expenditure, and perceived exertion in response to exercise. Unisex armour designs cause increased discomfort for females with larger bra sizes. PPE reduces joint-specific range of motion, with the design and location impairing movement more than mass. Jumping and sprinting performance is decreased with heavy PPE but unaffected by lighter protection, while agility is compromised with most forms of protection. Future research is needed on the fit and function of PPE for specialist police units, such as mounted police, along with further investigations on how fit can affect functional performance.

This paper identifies and reviews existing evidence on the comfort and functional performance of police officer personal protective equipment (PPE). This is significant because it summarises and categorises key concepts that underpin research in this area, whilst highlighting gaps in the current knowledge and areas for future research.

Monitoring the physical demands of training in Rugby League: the practices and perceptions of practitioners.

The physical demands of elite sport are often monitored with the aim of making evidence-based decisions to enhance performance and reduce injury risk. However, there is limited evidence in rugby league of the monitoring practices and perspectives of practitioners. This study provides a cross-sectional view of practices and perspectives of rugby league practitioners engaged in monitoring the physical demands of training. Practitioners from the Super League, Championship and National Rugby League competitions completed an online survey. Questions related to the tools and measures used to monitor training, along with perceptions of monitoring effectiveness. 'Enhancing performance' was considered the most important factor for monitoring training demands with most practitioners using some form of time motion analysis (e.g., GPS) or accelerometers. Nearly all practitioners combined objective external measures of exercise intensity with subjective measures, of which RPE was most common. The monitoring parameters considered most useful were running metrics (high-speed running, total distance covered, and the number of accelerations). Findings suggest that current practices are mostly supported by evidence from research. There was a preference for internal load monitoring tools that are quick and simple, such as RPE. The extent to which training load was monitored was lesser in some Championship teams compared to those in the other competitions, which might be explained by discrepancies in funding and access to players.

The Physical and Physiological Match-Play Locomotor Activity Profiles of Elite Domestic Male Field Hockey.

A new four-quarter match format in field hockey has meant that the locomotor activity profiles of the sport are inconsistent with the literature. The aim of this investigation was to identify the physical and physiological demands of national-level male hockey players. Thirty-two male players participated in the study. Participants were monitored with GPS and heart rate monitors. Variables analysed were total time, total distance (m), relative total distance (m.min-1), total distance in velocity bands (m), and activity intensity (m.min-1). Mean and maximum heart rate were calculated as well as total time and percentage time spent in heart rate zones relative to HRmax. Players spent 52 ± 11 min in play. The total distance covered was 5986 ± 1105 m (116 ± 12 m.min-1) with 21.4 ± 6.8 m.min-1 of high intensity activity. Defenders covered the lowest relative total distance (p < 0.001) and attackers the highest (p < 0.001). Relative total distance in Q4 was 5% lower than in Q1and Q2 (p < 0.05) with moderate intensity exercise (8.1-15.5 km.h-1) being 11% lower in Q4 compared to Q1 and Q2. The mean HR and HRmax of players were 167 ± 10 and 194 ± 11 bpm respectively. Players had a lower mean HR in Q3 (164bpm) and Q4 (164bpm) compared to Q1 (169bpm) and Q2 (168bpm; p < 0.001). The current study provides novel data outlining the physical and physiological activity profiles of national-level male field hockey players across playing positions as well as quarters of play. The results highlight a need to consider positional differences when implementing a training programme for players at national level.

Lower-Limb Muscle Excitation, Peak Torque, and External Load Responses to a 120-Minute Treadmill-Based Soccer-Specific Simulation.

Purpose: The aim of this study was to investigate thigh musculature excitation and torque generation in response to soccer-specific exercise incorporating an extra-time (ET) period. Methods: Twelve semiprofessional soccer players performed 120-min treadmill-based soccer-specific exercise. Surface electromyography (EMG) signals for the rectus femoris (EMGRF) and biceps femoris (EMGBF) were measured as the mean response across a pre-determined 10-second sprint bout during each 15-min block of exercise. Peak eccentric torque of the knee flexors (eccKF) and concentric torque of the knee extensors (conKE) were recorded across angular velocities of 60, 180, and 270 deg∙s-1 immediately pre- and post-exercise. Tri-axial PlayerLoad™ (PL-T) was monitored throughout exercise and defined across vertical (PL-V), anterior-posterior (PL-AP), and medial-lateral (PL-ML) planes of motion. Results: A reduction in normalized EMGRF amplitude was evident at 105‒120 min, versus 0‒15 min (-12.5%; p = .037), 15‒30 min (-12.5%; p = .047), and 45‒60 min (-14%; p = .030). Peak torque of the eccKF was significantly reduced from pre- to post-exercise at 60 (-7.7%; p = .018), 180 (-10.5%; p = .042), and 270 deg∙s-1 (-7.5%; p = .034). A main effect for time was identified for PL-T (p < .010), PL-V (p = .033), and PL-AP (p < .010). Conclusions: These findings suggest that muscle excitation of the rectus femoris is reduced during ET, accompanied with a deficit in the torque generation of the knee flexors following 120 min of soccer-specific activity. Practitioners should adequately condition players for the additional ET period by incorporating exercises into training schedules that develop fatigue-resistant eccentric hamstring strength to minimize injury risk.

The energetic, kinematic and kinetic responses to load carried on the back, on the head and in a doublepack.

The determinants of energy saving phenomena reported for load carried on the head, back and in a doublepack remain unclear. This study compared the energetic, kinematic and kinetic responses to head (H), back (B) and doublepack (DP) loading. Fifteen volunteers walked on an instrumented treadmill at 3 km.h-1 with 0, 3, 12 and 20 kg in each loading method. Whole body motion, ground reaction forces (GRF) and metabolic cost were measured. H was less economical than B (p = 0.014) and DP (p = 0.010). H was also associated with increased step length (p = 0.045), decreased cadence (p = 0.001), greater trunk (p < 0.001) and hip (p < 0.001) extension and greater minimum vertical GRF (p = 0.001) than B and DP. In conclusion, no energy saving was found for head- or back-loading but economy may be improved with methods that cause smaller perturbations from unloaded walking. Practitioner summary: Energy saving phenomena have been reported for load carried on the head, back and in a doublepack, yet the determinants are unclear. This study shows that smaller perturbations from unloaded to loaded walking are associated with improved economy for certain load carriage conditions, such as the doublepack.

An error in the analysis of "An eye for the I".

Reports an error in "An eye for the I: Preferential attention to the eyes of ingroup members" by Kerry Kawakami, Amanda Williams, David Sidhu, Becky L. Choma, Rosa Rodriguez-Bailón, Elena Cañadas, Derek Chung and Kurt Hugenberg (Journal of Personality and Social Psychology, 2014[Jul], Vol 107[1], 1-20). Kawakami and colleagues (Kawakami et al., 2014) conducted a series of studies in which participants saw pairs of faces (e.g., one Black and one White, or one ingroup and one outgroup) while eye tracking data were recorded. Because two faces were presented simultaneously, participants were allowed to choose how to allocate attention between the two faces. Often, they attended to one type of face more the other, creating a difference in base rates. The original analysis suggested that (a) preferential attention to the eyes was more pronounced for same-race faces than for cross-race faces, (b) preferential attention to the eyes was more pronounced for a novel ingroup than a novel outgroup, (c) preferential attention to the eyes was responsive to manipulations of motivation, and (d) preferential attention to the eyes was related to subsequent recognition accuracy. Although the first conclusion seems justified, the last three conclusions are either incorrect or unjustified based on the analyses reported in the article. When we correct for base rates, we see that most of the effects disappear. At the date of this writing, Kawakami and colleagues' article has 64 citations in Google scholar, including several that base their arguments on analyses we have shown to be incorrect (e.g., Xiao, Coppin, & Van Bavel, 2016). It is important for the field to acknowledge the error in these analyses and ensure that future theoretical and empirical work rests on a solid foundation. It is also important for researchers to understand the issues that gave rise to this mistake and ensure that, in future work, methods avoid this kind of confound or analyses appropriately adjust for it. (The following abstract of the original article appeared in record 2014-25638-001.) Human faces, and more specifically the eyes, play a crucial role in social and nonverbal communication because they signal valuable information about others. It is therefore surprising that few studies have investigated the impact of intergroup contexts and motivations on attention to the eyes of ingroup and outgroup members. Four experiments investigated differences in eye gaze to racial and novel ingroups using eye tracker technology. Whereas Studies 1 and 3 demonstrated that White participants attended more to the eyes of White compared to Black targets, Study 2 showed a similar pattern of attention to the eyes of novel ingroup and outgroup faces. Studies 3 and 4 also provided new evidence that eye gaze is flexible and can be meaningfully influenced by current motivations. Specifically, instructions to individuate specific social categories increased attention to the eyes of target group members. Furthermore, the latter experiments demonstrated that preferential attention to the eyes of ingroup members predicted important intergroup biases such as recognition of ingroup over outgroup faces (i.e., the own-race bias; Study 3) and willingness to interact with outgroup members (Study 4). The implication of these findings for general theorizing on face perception, individuation processes, and intergroup relations are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Inter-individual variability in load carriage economy and comparisons between different load conditions.

Equivocal findings exist for the economy associated with load carried close to the body's centre of mass. Individual variation could explain some of the equivocal findings. This research aimed to examine the extent of individual variation in loaded walking economy. Eighteen females carried load on the back, head and split between the front and back. Individual variation in relative load carriage economy (ELI) was primarily assessed using standard deviation, coefficients of variation (CV) and intraclass correlation coefficients (ICC). There was large inter-individual variation in ELI values with highest mean CV's of 16%, 12% and 10% for head-, back- and combined front and back-loading. Mean ELI values were not significantly different between methods. The large amount of individual variation found here suggests future load carriage research should account for individual variation, particularly when considering sample size and when making inferences on the economy associated with different types of load carriage using group mean data.

A comparison of economy and sagittal plane trunk movements among back-, back/front- and head-loading.

It has been suggested that freedom of movement in the trunk could influence load carriage economy. This study aimed to compare the economy and sagittal plane trunk movements associated with three load carriage methods that constrain posture differently. Eighteen females walked at 3 km.h-1 with loads of 0, 3, 6, 9, 12, 15 and 20 kg carried on the back, back/front and head. Load carriage economy was assessed using the Extra Load Index (ELI). Change in sagittal plane trunk forward lean and trunk angle excursion from unloaded to loaded walking were assessed. Results show no difference in economy between methods (p = .483), despite differences in the change in trunk forward lean (p = .001) and trunk angle excursion (p = .021) from unloaded to loaded walking. We conclude that economy is not different among the three methods of load carriage, despite significant differences in sagittal plane trunk movements. Practitioner summary: This article shows, based on mean data, that there is no difference in economy among back, back/front and head-loading, despite differences in trunk movement. It is possible a combination of factors align to influence individual economy, rather than a single set of factors, applicable to all individuals for each method.

Phenoseasonal subcanopy light dynamics and the effects of light on the physiological ecology of a common understory shrub, Lindera benzoin.

The purpose of this work was to quantify the variation of subcanopy spatiotemporal light dynamics over the course of a year and to link it to the physiological ecology of the understory shrub, Lindera benzoin L. Blume (northern spicebush). Covering all seven phenoseasons of a deciduous forest, this work utilized a line quantum sensor to measure the variation in subcanopy light levels under all sky conditions at different times of the day. A total of 4,592 individual subcanopy measurements of photosynthetic photon flux density (PPFD, µmol m-2 s-1) were taken as 15-second spatially-integrated one-meter linear averages to better understand the dynamism of light exposure to L. benzoin. Both open (n = 2, one continuous and one instantaneous) and subcanopy location (n = 25) measurements of PPFD were taken on each sampling date in and near the forested plot (Maryland, USA). In addition, we explored the effect of four photointensity-photoperiod combinations on the growth of L. benzoin under controlled conditions to compare to field conditions. On average, understory PPFD was less than 2% of open PPFD during the leafed months and an average of 38.8% of open PPFD during leafless winter months, indicating that: (1) often overlooked woody surfaces intercept large amounts of light; and (2) spicebush within the plot receive limited light even in early spring before canopy leaf-out. Statistical results suggested phenoseason accounted for nearly three-quarters of the variation in incident radiation between the three plant canopy heights. Spicebush under controlled conditions exhibited the highest fitness levels at an intensity of 164.5 µmol m-2 s-1 for 12-hour duration. Similarly, spicebush growth in the field occurred at subcanopy locations receiving higher incidence of PPFD (i.e., >128 µmol m-2 s-1). Results suggest that the ecological niche for these plants is very specific in terms of light intensity.

The reliability of the Extra Load Index as a measure of relative load carriage economy.

The aim of this study was to measure the reliability of the extra load index (ELI) as a method for assessing relative load carriage economy. Seventeen volunteers (12 males, 5 females) performed walking trials at 3 km·h-1, 6 km·h-1 and a self-selected speed. Trial conditions were repeated 7 days later to assess test-retest reliability. Trials involved four 4-minute periods of walking, each separated by 5 min of rest. The initial stage was performed unloaded followed in a randomised order by a second unloaded period and walking with backpacks of 7 and 20 kg. Results show ELI values did not differ significantly between trials for any of the speeds (p = 0.46) with either of the additional loads (p = 0.297). The systematic bias, limits of agreement and coefficients of variation were small in all trial conditions. We conclude the ELI appears to be a reliable measure of relative load carriage economy. Practitioner Summary: This paper demonstrates that the ELI is a reliable measure of load carriage economy at a range of walking speeds with both a light and heavy load. The ELI, therefore, represents a useful tool for comparing the relative economy associated with different load carriage systems.

Of Kith and Kin: Perceptual Enrichment, Expectancy, and Reciprocity in Face Perception.

Race powerfully affects perceivers' responses to faces, promoting biases in attention, classification, and memory. To account for these diverse effects, we propose a model that integrates social cognitive work with two prominent accounts of visual processing: perceptual learning and predictive coding. Our argument is that differential experience with a racial ingroup promotes both (a) perceptual enrichment, including richer, more well-integrated visual representations of ingroup relative to outgroup faces, and (b) expectancies that ingroup faces are normative, which influence subsequent visual processing. By allowing for "top-down" expectancy-based processes, this model accounts for both experience- and non-experience-based influences, such as motivation, context, and task instructions. Fundamentally, we suggest that we treat race as an important psychological dimension because it structures our social environment, which in turn structures mental representation.

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.

The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced a 100-fold improvement in binding affinity, yielding lead compound 2 (KD = 15 µM). Deconstruction of 2 into its component retrofragments allowed the group efficiency of structural motifs to be assessed, the identification of more LE scaffolds for optimization and highlighted binding affinity hotspots. Structure-guided addition of a metal-binding pharmacophore onto LE retrofragment scaffolds produced low nanomolar (KD = 15 nM) CYP121 ligands. Elaboration of these compounds to target binding hotspots in the distal active site afforded compounds with excellent selectivity against human drug-metabolizing P450s. Analysis of the factors governing ligand potency and selectivity using X-ray crystallography, UV-vis spectroscopy, and native mass spectrometry provides insight for subsequent drug development.

Childhood contact predicts hemispheric asymmetry in cross-race face processing.

Participants typically process same-race faces more quickly and more accurately than cross-race faces. This deficit is amplified in the right hemisphere of the brain, presumably due to its involvement in configural processing. The present research tested the idea that cross-race contact tunes cognitive and perceptual systems, influencing this asymmetric race-based deficit in face processing. Participants with high and low levels of contact performed a lateralized recognition task with same- and cross-race faces. Replicating prior work, participants with minimal contact showed cross-race deficits in processing that were larger in the right hemisphere. For participants with more contact, this lateralized deficit disappeared. This effect of contact seems to be independent of race-based attitudes (e.g., prejudice).

Biofragments: an approach towards predicting protein function using biologically related fragments and its application to Mycobacterium tuberculosis CYP126.

We present a novel fragment-based approach that tackles some of the challenges for chemical biology of predicting protein function. The general approach, which we have termed biofragments, comprises two key stages. First, a biologically relevant fragment library (biofragment library) can be designed and constructed from known sets of substrate-like ligands for a protein class of interest. Second, the library can be screened for binding to a novel putative ligand-binding protein from the same or similar class, and the characterization of hits provides insight into the basis of ligand recognition, selectivity, and function at the substrate level. As a proof-of-concept, we applied the biofragments approach to the functionally uncharacterized Mycobacterium tuberculosis (Mtb) cytochrome P450 isoform, CYP126. This led to the development of a tailored CYP biofragment library with notable 3D characteristics and a significantly higher screening hit rate (14%) than standard drug-like fragment libraries screened previously against Mtb CYP121 and 125 (4% and 1%, respectively). Biofragment hits were identified that make both substrate-like type-I and inhibitor-like type-II interactions with CYP126. A chemical-fingerprint-based substrate model was built from the hits and used to search a virtual TB metabolome, which led to the discovery that CYP126 has a strong preference for the recognition of aromatics and substrate-like type-I binding of chlorophenol moieties within the active site near the heme. Future catalytic analyses will be focused on assessing CYP126 for potential substrate oxidative dehalogenation.

Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions.

Nondenaturing nanoelectrospray ionization mass spectrometry (nanoESI MS) of intact protein complexes was used to study CYP121, one of the 20 cytochrome P450s in Mycobacterium tuberculosis (Mtb) and an enzyme that is essential for bacterial viability. The results shed new light on both ligand-free and ligand-bound states of CYP121. Isolated unbound CYP121 is a predominantly dimeric protein, with a minor monomeric form present. High affinity azoles cause the dissociation of dimeric CYP121 into monomer, whereas weaker azole binders induce partial dimer dissociation or do not significantly destabilize the dimer. Complexes of CYP121 with azoles were poorly detected by nanoESI MS, indicating kinetically labile complexes that are easily prone to gas-phase dissociation. Unlike with the azoles, CYP121 forms a stable complex with its natural substrate cYY that does not undergo gas-phase dissociation. In addition, a series of potential ligands from fragment-based studies were used as a test for nanoESI MS work against CYP121. Most of these ligands formed stable complexes with CYP121, and their binding did not promote dimer dissociation. On the basis of binding to the monomer and/or CYP121 dimer it was possible to determine the relative order of their CYP121 binding affinities. The top nanoESI MS screening hit was confirmed by heme absorbance shift assay to have a Kd of 40 µM.

Kite skier's toe: an unusual case of frostbite.

Frostbite is a well-known occurrence in outdoor winter activity and exploration. We report the first documented case of frostbite associated with kite skiing. Kite skiing is an emerging sport that uses a kite to harness wind power for recreation and to travel long distances on skis. Certain characteristics of this sport may predispose athletes to frostbite injury. The stance required to resist and redirect the force created by the wind and kite puts constant pressure and repetitive trauma on the downwind great toe. This can compromise blood flow and increase risk of cold injury. Future kite skier expeditions should focus on specific prevention methods including properly fitting boots, adequate boot insulation, and frequent rest periods to inspect and warm toes.

Fragment-based approaches in drug discovery and chemical biology.

Fragment-based approaches to finding novel small molecules that bind to proteins are now firmly established in drug discovery and chemical biology. Initially developed primarily in a few centers in the biotech and pharma industry, this methodology has now been adopted widely in both the pharmaceutical industry and academia. After the initial success with kinase targets, the versatility of this approach has now expanded to a broad range of different protein classes. Herein we describe recent fragment-based approaches to a wide range of target types, including Hsp90, ß-secretase, and allosteric sites in human immunodeficiency virus protease and fanesyl pyrophosphate synthase. The role of fragment-based approaches in an academic research environment is also examined with an emphasis on neglected diseases such as tuberculosis. The development of a fragment library, the fragment screening process, and the subsequent fragment hit elaboration will be discussed using examples from the literature.

Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets.

TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability.