RESUMEN
BACKGROUND: Hair loss is a side effect of many chemotherapeutic agents, and patients have even refused possibly palliative or lifesaving drugs because they could not accept temporary or prolonged baldness. Topical minoxidil has been shown to be effective for androgenetic alopecia and alopecia areata. OBJECTIVE: Our purpose was to investigate the value and safety of minoxidil in chemotherapy-induced hair loss. METHODS: Twenty-two women who were facing adjuvant chemotherapy after breast surgery were registered in a protocol that used a 2% minoxidil topical solution or a placebo in a randomized double-blind trial. RESULTS: There was a statistically significant difference (favoring minoxidil) in the interval from maximal hair loss to first regrowth. Thus the period of baldness was shortened (mean, 50.2 days) in the minoxidil group. CONCLUSION: Minoxidil decreased the duration of alopecia caused by chemotherapy. There were no significant side effects.
Asunto(s)
Alopecia/inducido químicamente , Alopecia/tratamiento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias de la Mama/tratamiento farmacológico , Minoxidil/uso terapéutico , Administración Cutánea , Adulto , Antibióticos Antineoplásicos/administración & dosificación , Antibióticos Antineoplásicos/efectos adversos , Antimetabolitos Antineoplásicos/administración & dosificación , Antimetabolitos Antineoplásicos/efectos adversos , Antineoplásicos Alquilantes/administración & dosificación , Antineoplásicos Alquilantes/efectos adversos , Neoplasias de la Mama/cirugía , Quimioterapia Adyuvante , Ciclofosfamida/administración & dosificación , Ciclofosfamida/efectos adversos , Método Doble Ciego , Doxorrubicina/administración & dosificación , Doxorrubicina/efectos adversos , Femenino , Fluorouracilo/administración & dosificación , Fluorouracilo/efectos adversos , Cabello/efectos de los fármacos , Cabello/crecimiento & desarrollo , Humanos , Persona de Mediana Edad , Minoxidil/administración & dosificación , Proyectos Piloto , Placebos , Factores de TiempoRESUMEN
A variety of pharmacologic agents have been known to induce pustular psoriasis. We describe a patient with a positive personal and family history of psoriasis who developed an extensive annular pustular eruption 3 weeks after starting hydroxychloroquine (Plaquenil) for arthritis. The drug was discontinued, and she received 3 weeks of systemic and topical corticosteroids; in spite of the therapeutic intervention, showers of new lesions appeared daily, and progressed to involve 75% of the body. The development of new lesions stopped, and the older lesions began to clear after one dose of 7.5 mg of methotrexate. Subsequently, methotrexate therapy was stopped because of mild transaminase elevation; the pustular lesions then flared. New lesions stopped appearing after four doses of weekly methotrexate. The patient remains clear of lesions 6 months later.
Asunto(s)
Antirreumáticos/efectos adversos , Hidroxicloroquina/efectos adversos , Psoriasis/inducido químicamente , Adulto , Artritis Reumatoide/tratamiento farmacológico , Femenino , Humanos , Metotrexato/uso terapéutico , Psoriasis/tratamiento farmacológicoRESUMEN
Minocycline can cause hyperpigmentation of the conjunctiva, oral mucosa, and skin. Pigmentation of the oral mucosa may also be associated with a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, Peutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred. Minocycline-induced pigmentation should be added to the differential diagnosis of isolated lingual hyperpigmentation.
Asunto(s)
Hiperpigmentación/inducido químicamente , Minociclina/efectos adversos , Enfermedades de la Lengua/inducido químicamente , Acné Vulgar/tratamiento farmacológico , Adulto , Femenino , Humanos , Persona de Mediana Edad , Mucosa Bucal/efectos de los fármacos , Rosácea/tratamiento farmacológicoAsunto(s)
Dermatosis Facial/patología , Granuloma/patología , Complicaciones Posoperatorias , Trasplante de Piel , Adulto , Carcinoma Basocelular/cirugía , Dermatosis Facial/etiología , Femenino , Granuloma/etiología , Humanos , Recurrencia Local de Neoplasia , Complicaciones Posoperatorias/patología , Piel/patología , Neoplasias Cutáneas/cirugíaRESUMEN
A 17-year-old girl had linear and dermatomal lichenoid chronic graft-versus-host disease (GVHD) 18 months after receiving an allogeneic bone marrow transplantation for aplastic anemia. The cutaneous GVHD lesions appeared on previously normal skin.
Asunto(s)
Trasplante de Médula Ósea/efectos adversos , Enfermedad Injerto contra Huésped/etiología , Enfermedades de la Piel/etiología , Aciclovir/administración & dosificación , Adolescente , Anemia Aplásica/terapia , Femenino , Herpes Zóster/tratamiento farmacológico , Herpes Zóster/etiología , Humanos , Erupciones Liquenoides/etiología , Erupciones Liquenoides/patología , Enfermedades de la Piel/patologíaRESUMEN
A person who had previously been treated for laryngeal carcinoma presented with the new onset of asymptomatic nodular skin lesions. The preliminary differential diagnosis included cutaneous metastasis. Examination of a biopsy specimen of the lesions and results of subsequent laboratory investigation ruled out the possibility of recurrent metastatic disease and established a diagnosis of secondary syphilis. The differential diagnosis of nodular lesions that resemble a lymphoid neoplasm or a cutaneous metastasis in a patient treated for cancer should also include secondary syphilis.
Asunto(s)
Carcinoma de Células Escamosas/secundario , Neoplasias Cutáneas/secundario , Sífilis Cutánea/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Humanos , Neoplasias Laríngeas/patología , Masculino , Persona de Mediana Edad , Neoplasias Cutáneas/diagnóstico , Sífilis Cutánea/patologíaRESUMEN
A 17-year-old black man suddenly developed an unilateral eruption of clinically apparent lesions of idiopathic atrophoderma of Pasini and Pierini (IAPP) and concomitant lesions of morphea. Histologically the lesions are indistinguishable. IAPP appears to be a variant of morphea.
Asunto(s)
Tejido Elástico/patología , Esclerodermia Localizada/patología , Piel/patología , Adolescente , Factores de Edad , Atrofia , Dorso , Humanos , Masculino , Esclerodermia Sistémica/patologíaRESUMEN
Chronic cutaneous LE is a diverse disease, characterized by predominantly cutaneous disease with few systemic complications. Discoid lesions are commonly seen, but they are not specific for chronic cutaneous LE. These scarring and disfiguring changes are also present in neonatal LE, SLE, and complement deficiency LE. Because definitive diagnosis cannot be made by cutaneous examination alone, all patients should initially be evaluated for systemic disease. A small percentage of patients with chronic cutaneous LE will ultimately develop SLE, and therefore, patients should be re-evaluated periodically. The pathogenesis of the cutaneous lesions is not definitively known. There is suggestive evidence implicating T-cell mediated injury, especially in discoid LE. Antibody-dependent cellular cytotoxicity may also play a significant role in cellular damage in subacute cutaneous LE and neonatal LE, especially in the presence of anti-Ro antibody. Immunoglobulin deposition in association with membrane attack complex, has been associated with epidermal injury in some cases. Treatment of chronic cutaneous LE is largely symptomatic and nonspecific, focusing on reduction of inflammation. Further knowledge of pathogenesis will, hopefully, provide for specific immunologic therapy.
Asunto(s)
Lupus Eritematoso Discoide , Humanos , Lupus Eritematoso Discoide/etiología , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Discoide/patología , Paniculitis de Lupus Eritematoso/etiología , Paniculitis de Lupus Eritematoso/inmunología , Paniculitis de Lupus Eritematoso/patologíaRESUMEN
Lupus erythematosus represents a wide spectrum of diseases. Within this heterogeneity, however, several clinically relevant subsets have been found that may unite differing aspects of the disease and that may have pathogenic implications for the problem as a whole. Exciting links between genetic phenotypes, certain immune responses, and related cutaneous findings in neonatal, complement-deficient, subacute cutaneous, and ANA-negative lupus erythematosus and Sjögren's syndrome have been found. The increased frequency of the anti-Ro(SSA) antibody in these groups is notable. The ultraviolet light-altered immune system found in vivo and in vitro may also be relevant to disease pathogenesis. Even if the mechanisms elaborated are not the precise aberrations in lupus erythematosus, they may serve as an operational model for further research. Continued investigations into mechanisms of photoexacerbations in lupus erythematosus, as well as into genetically mediated immune response, may further our understanding of these disorders.
Asunto(s)
Lupus Eritematoso Sistémico , Trastornos por Fotosensibilidad/complicaciones , ARN Citoplasmático Pequeño , Ribonucleoproteínas , Adolescente , Adulto , Complejo Antígeno-Anticuerpo/genética , Autoantígenos/genética , Niño , Preescolar , Enfermedad Crónica , ADN/efectos de la radiación , Humanos , Lactante , Recién Nacido , Lupus Eritematoso Discoide/diagnóstico , Lupus Eritematoso Sistémico/diagnóstico , Lupus Eritematoso Sistémico/etiología , Lupus Eritematoso Sistémico/inmunología , Lupus Eritematoso Sistémico/fisiopatología , Linfocitos/efectos de la radiación , Trastornos por Fotosensibilidad/diagnóstico , Trastornos por Fotosensibilidad/inmunología , Rayos Ultravioleta/efectos adversosAsunto(s)
Anticuerpos Antinucleares , Antígenos , Autoantígenos , ARN Citoplasmático Pequeño , Ribonucleoproteínas , Factores de Edad , Animales , Anticuerpos Antinucleares/análisis , Anticuerpos Antinucleares/genética , Antígenos/análisis , Antígenos/genética , Autoantígenos/análisis , Autoantígenos/genética , Complemento C2/deficiencia , Femenino , Antígenos HLA/análisis , Antígenos HLA/genética , Humanos , Lactante , Recién Nacido , Lupus Eritematoso Sistémico/genética , Lupus Eritematoso Sistémico/inmunología , Lupus Eritematoso Sistémico/patología , Ratones , Embarazo , Síndrome de Sjögren/inmunología , Síndrome de Sjögren/patología , Piel/patologíaRESUMEN
Cutaneous sclerodermalike changes are a well-documented manifestation of chronic cutaneous graft-vs-host reaction. We describe a patient with chronic cutaneous graft-vs-host reaction who developed vesicles and bullae on sclerodermoid skin 18 months after bone marrow transplantation. The vesicles and bullae were subepidermal in location by light microscopy and were associated with dilated lymphatics and a sparse perivascular mononuclear cell infiltrate. No deposition of immunoreactants was seen by immunofluorescent microscopy. Electron microscopy confirmed the presence of a subepidermal blister beneath an intact basement membrane zone and surrounded by marked dermal edema. We postulate that localized lymphedema may play a role in the development of these vesicles and bullae.
Asunto(s)
Enfermedad Injerto contra Huésped/complicaciones , Esclerodermia Sistémica/etiología , Enfermedades Cutáneas Vesiculoampollosas/etiología , Adolescente , Trasplante de Médula Ósea , Enfermedad Crónica , Femenino , Humanos , Esclerodermia Sistémica/patología , Piel/patología , Enfermedades Cutáneas Vesiculoampollosas/patologíaRESUMEN
Epidermal keratinocytes with abnormally large nuclei were found in 12 of 13 patients who received high-dose busulfan and cyclophosphamide prior to receiving bone-marrow transplantation for treatment of hematological malignancies. These cells were similar to those previously described in the lungs, cervix and bladder of patients on long-term busulfan therapy. Marked keratinocyte nuclear abnormalities were not observed in bone-marrow transplant recipients who received a preparatory regimen of cyclophosphamide and total-body irradiation. This histologic cutaneous busulfan effect was transient and was unrelated to the development of graft-versus-host reaction.
Asunto(s)
Trasplante de Médula Ósea , Busulfano/efectos adversos , Piel/efectos de los fármacos , Adulto , Biopsia , Busulfano/uso terapéutico , Núcleo Celular/efectos de los fármacos , Ciclofosfamida/uso terapéutico , Femenino , Humanos , Terapia de Inmunosupresión , Leucemia Linfoide/terapia , Leucemia Mieloide Aguda/terapia , Masculino , Piel/patología , Irradiación Corporal TotalRESUMEN
Acute graft-versus-host disease (GVHD) is a severe complication of bone marrow transplantation. The diagnosis may be made and its course followed by serial skin biopsies. The degree of epidermal change has been used as a guideline in grading each biopsy, but great variation may be found within each grade, especially grade 2 (basal cell vacuolization and dyskeratosis). To find a histologic parameter that is prognostic of more severe acute GVHD, we examined retrospectively the serial biopsies of 54 patients. When we studied early cutaneous graft-versus-host reaction (GVHR), represented by the grade 2 biopsies, the number of dermal and epidermal mononuclear inflammatory cells correlated positively with the probability of developing more severe acute GVHD. In addition, the patients who had more severe acute GVHD tended to have an earlier appearance of cutaneous histologic changes. None of the other histologic parameters examined in these grade 2 biopsies were found to be predictive of GVHD progression. In addition, no histopathologic parameters in these grade 2 biopsies were predictive of the subsequent development of chronic GVHD.
Asunto(s)
Enfermedad Injerto contra Huésped/patología , Reacción Injerto-Huésped , Enfermedades de la Piel/patología , Biopsia , Femenino , Humanos , Masculino , PronósticoRESUMEN
Chronic cutaneous graft-versus-host reaction following bone marrow transplantation has been difficult to manage in some patients because of poor response to immunosuppressive agents or because of toxicity to these drugs. We recently used methoxsalen and ultraviolet A therapy and found it to be successful in controlling chronic cutaneous lichenoid graft-versus-host reaction in a bone marrow transplant patient. Although there was an initial flare of an eruption resembling acute cutaneous graft-versus-host reaction, both this acute eruption and the lichenoid lesions subsided and cleared with continued treatment. The skin lesions recurred when treatment was discontinued but responded promptly when it was initiated for the second time. Other than mild phototoxicity, there were no other significant side effects.