RESUMEN
The allogenic tumour extracts were studied as immunogens for the prevention of cattle infection with BLV. Immunization did not induce both the production of antibodies against the virus and spontaneous viral infection. Experimental infection of immunized animals with living leukocytes of a leukemic donor caused a BLV infection in 100% of cases.
Asunto(s)
Enfermedades de los Bovinos/prevención & control , Leucemia Experimental/prevención & control , Extractos de Tejidos/inmunología , Animales , Anticuerpos Antineoplásicos/análisis , Anticuerpos Antivirales/análisis , Bovinos , Enfermedades de los Bovinos/etiología , Enfermedades de los Bovinos/inmunología , Pruebas Inmunológicas de Citotoxicidad , Inmunización/métodos , Virus de la Leucemia Bovina/inmunología , Virus de la Leucemia Bovina/patogenicidad , Leucemia Experimental/etiología , Leucemia Experimental/inmunología , Transfusión de Leucocitos , Ganglios Linfáticos/inmunología , Trasplante de Neoplasias , Extractos de Tejidos/administración & dosificación , Trasplante Homólogo , Proteínas del Envoltorio Viral/inmunologíaRESUMEN
The role of bovine leukemia virus (BLV) expression was demonstrated in normal, BLV-infected and leukemic cattle. The studies established the changeable character of viremia on the basis of BLV p24 expression in blood plasma and native leukocyte lysates. The experiment revealed a marked regularity: a decrease of antibody titer in blood serum--the appearance of the virus in the body--lymphocytosis. The development of lympholeukemia shortly after experimental infection was detected in animals with an antigen regularly detectable in the plasma.