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1.
Neuroimage ; 43(1): 81-9, 2008 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-18644243

RESUMEN

Probability mapping of connectivity is a powerful tool to determine the fibre structure of white matter in the brain. Probability maps are related to the degree of connectivity to a chosen seed area. In many applications, however, it is necessary to isolate a fibre bundle that connects two areas. A frequently suggested solution is to select curves, which pass only through two or more areas. This is very inefficient, especially for long-distance pathways and small areas. In this paper, a novel probability-based method is presented that is capable of extracting neuronal pathways defined by two seed points. A Monte Carlo simulation based tracking method, similar to the Probabilistic Index of Connectivity (PICo) approach, was extended to preserve the directional information of the main fibre bundles passing a voxel. By combining two of these extended visiting maps arising from different seed points, two independent parameters are determined for each voxel: the first quantifies the uncertainty that a voxel is connected to both seed points; the second represents the directional information and estimates the proportion of fibres running in the direction of the other seed point (connecting fibre) or face a third area (merging fibre). Both parameters are used to calculate the probability that a voxel is part of the bundle connecting both seed points. The performance and limitations of this DTI-based method are demonstrated using simulations as well as in vivo measurements.


Asunto(s)
Algoritmos , Encéfalo/anatomía & histología , Imagen de Difusión por Resonancia Magnética/métodos , Interpretación de Imagen Asistida por Computador/métodos , Imagenología Tridimensional/métodos , Fibras Nerviosas Mielínicas/ultraestructura , Reconocimiento de Normas Patrones Automatizadas/métodos , Simulación por Computador , Interpretación Estadística de Datos , Humanos , Aumento de la Imagen/métodos , Modelos Neurológicos , Modelos Estadísticos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
2.
AJNR Am J Neuroradiol ; 28(4): 773-6, 2007 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-17416837

RESUMEN

BACKGROUND AND PURPOSE: After an early progression of signal intensity changes in T2-weighted MR images, also known as "neurofibromatosis bright objects," in patients with neurofibromatosis type 1 (NF-1), there is a tendency toward regression or even disappearance in early adulthood. The purpose of this study was to investigate whether adult patients with NF-1 exhibit generalized microstructural alterations even in normal-appearing brain regions. MATERIALS AND METHODS: Conventional and diffusion tensor MR imaging of the brain was obtained in 10 adult patients with NF-1 and 10 age-matched healthy volunteers. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in brain stem, basal ganglia, thalamus, corpus callosum, and frontal and parietooccipital white matter regions. RESULTS: Significantly increased ADC and decreased FA values were found in all regions of interest and in all patients with NF-1, irrespective of their scholastic achievement and subsequent professional performance, compared with control subjects (P < .001). There were no significant correlations with the age (P > .1) or with the lateralization between brain hemispheres (P > .05). CONCLUSION: Diffusion tensor imaging reveals globally elevated FA and decreased ADC values in the mature brains of patients with NF-1, which is most likely a consequence of diffuse and basic alterations in cerebral microstructure that result from the underlying gene mutation.


Asunto(s)
Encéfalo/patología , Imagen de Difusión por Resonancia Magnética , Neurofibromatosis 1/patología , Adolescente , Adulto , Anisotropía , Núcleo Caudado/patología , Corteza Cerebral/patología , Cuerpo Estriado/patología , Femenino , Humanos , Masculino , Tálamo/patología
3.
Magn Reson Med ; 54(5): 1216-25, 2005 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-16200554

RESUMEN

A multidiffusion-tensor model (MDT) is presented containing two anisotropic and one isotropic diffusion tensors. This approach has the ability to detect areas of fiber crossings and resolve the direction of crossing fibers. The mean diffusivity and the ratio of the tensor compartments were merged to one independent parameter by fitting MDT to the diffusion-weighted intensities of a two-point data acquisition scheme. By an F-test between the errors of the standard single diffusion tensor and the more complex MDT, fiber crossings were detected and the more accurate model was chosen voxel by voxel. The performance of crossing detection was compared with the spherical harmonics approach in simulations as well as in vivo. Similar results were found in both methods. The MDT model, however, did not only detect crossings but also yielded the single fiber directions. The FACT algorithm and a probabilistic connectivity algorithm were extended to support the MDT model. For example, a mean angular error smaller than 10 degrees was found for the MDT model in a simulated fiber crossing with an SNR of 80. By tracking the corticospinal tract the MDT-based tracks reached a significantly greater area of the gyrus precentralis.


Asunto(s)
Encéfalo/citología , Imagen de Difusión por Resonancia Magnética/métodos , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Imagenología Tridimensional/métodos , Fibras Nerviosas Mielínicas/ultraestructura , Reconocimiento de Normas Patrones Automatizadas/métodos , Algoritmos , Anisotropía , Inteligencia Artificial , Simulación por Computador , Imagen de Difusión por Resonancia Magnética/instrumentación , Humanos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Transductores
4.
Neuroradiology ; 46(4): 258-66, 2004 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-14999435

RESUMEN

We investigated the isotropic diffusion coefficient (D') and fractional anisotropy (FA) in white matter (WM) during brain development, using an optimised diffusion-tensor imaging (DTI) method with whole brain coverage in a clinically acceptable time. We images 52 children with no evident neurological abnormality (30 boys, 22 girls aged 1 day-16 years) using high-angle DTI with optimised temporal gradient performance. D' and FA were calculated in 10 regions of interest in white matter. We saw that the age-related reduction in D' and increase in FA follow a mono- or biexponential model in white matter, probably depending on the compactness and myelination rate of the fibre tracts. In contrast to other areas, in which adult values were reached during the third year, there is a trend to continuous increase in FA in all deep white-matter areas, suggesting continuing maturation and organisation of deep tracts not detected on conventional MRI.


Asunto(s)
Encéfalo/diagnóstico por imagen , Encéfalo/crecimiento & desarrollo , Desarrollo Infantil , Imagen de Difusión por Resonancia Magnética , Adolescente , Anisotropía , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Radiografía , Estudios Retrospectivos
5.
Acad Radiol ; 7(12): 1107-15, 2000 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11131055

RESUMEN

RATIONALE AND OBJECTIVES: Magnetic resonance (MR) imaging-based temperature monitoring has gained interest for use in general hyperthermia treatment of tumors. Such therapy requires an accurate control of the temperature, which should range from 41 degrees to 45 degrees C. A novel type of thermosensitive MR agent is proposed: liposome-encapsulated gadolinium chelates whose temperature response is linked to the phase-transition properties of the liposome carrier. In vitro relaxometry and MR imaging were used to evaluate the thermosensitivity of the contrast properties of liposomal gadolinium diethylenetriaminepentaacetic acid bis(methylamide) (Gd-DTPA-BMA). MATERIALS AND METHODS: T1 relaxivity (rl) measurements of liposomal Gd-DTPA-BMA were undertaken at 0.47 T and at temperatures of 20 degrees-48 degrees C. MR imaging was performed at 2.0 T with a gel phantom containing inserts of liposomes. Diffusion-weighted and T1-weighted gradient-recalled echo images were acquired as the phantom was heated from 22 degrees to about 65 degrees C. RESULTS: At ambient temperature, the r1 of liposomal Gd-DTPA-BMA was exchange limited due to slow water exchange between the liposome interior and exterior. A sharp, marked increase in r1 occurred as the temperature reached and exceeded the gel-to-liquid crystalline phase-transition temperature (Tm) of the liposomes (42 degrees C). The relaxation enhancement was mainly attributable to the marked increase in transmembrane water permeability, yielding fast exchange conditions. There was good correlation between the relaxometric and imaging results; the signal intensity on T1-weighted gradient-recalled echo images increased markedly as the temperature approached Tm. The temperature sensitivity of the diffusion-weighted technique differed from that of the liposome-based T1-weighted approach, with an apparent water diffusion coefficient increasing linearly with temperature. CONCLUSION: Since the transition from low to high signal intensity occurred in the temperature range of 38 degrees - 42 degrees C, the investigated paramagnetic liposomes have a potential role as "off-on" switches for temperature control during hyperthermia treatment.


Asunto(s)
Medios de Contraste , Gadolinio DTPA , Liposomas , Imagen por Resonancia Magnética/métodos , Espectroscopía de Resonancia por Spin del Electrón , Estudios de Factibilidad , Hipertermia Inducida
6.
MAGMA ; 10(1): 27-34, 2000 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-10697223

RESUMEN

The purpose of this study was to scrutinize the ability of magnetic resonance imaging (MRI)-performed measurements to compare arterial flow patterns in patients with peripheral arterial occlusive disease (PAOD), healthy volunteers (HV) and endurance athletes (EA). MRI blood flow data were partially repeated with Doppler ultrasound (DUS) with a view to a methodical comparison. Additionally, pulse wave velocity was assessed with the MUFF technique. For this purpose, MRI-performed flow measurements were performed in the common femoral artery in 21 patients with PAOD, in 34 HV and in 12 EA. The analysis included maximum flow velocities (MFV), velocity/time profile (VTP), pulse wave velocity (Vpulse), and vessel diameter (VD). In addition, MFV and VD were observed by DUS in most individuals. The results revealed a significant change regarding arterial blood flow characteristics in patients compared with HV and EA, with respect to the span between the peak positive and negative blood flow velocity in the femoral artery. The pulse wave velocity in patients was markedly elevated compared with healthy individuals. Furthermore, a complete, characteristic change in the VTP could be observed in patients. The methodical comparison between DUS and MRI showed a good correlation. Multi-slice Fourier flow data have indicated markedly increased pulse wave velocity in PAOD patients. Changes in the arterial blood flow can be clearly observed with MRI. In the future, this might offer a noninvasive possibility not only for the evaluation of the stage of the disease, but also for the detection of early, pre-clinical stages of atherosclerosis.


Asunto(s)
Arteriopatías Oclusivas/fisiopatología , Arterias/fisiología , Arteriosclerosis/fisiopatología , Imagen por Resonancia Magnética/métodos , Deportes/fisiología , Adulto , Anciano , Arterias/fisiopatología , Velocidad del Flujo Sanguíneo , Diástole , Femenino , Análisis de Fourier , Frecuencia Cardíaca , Humanos , Masculino , Persona de Mediana Edad , Resistencia Física , Valores de Referencia , Análisis de Regresión , Sístole , Ultrasonografía Doppler
7.
J Magn Reson Imaging ; 8(6): 1296-305, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9848742

RESUMEN

A diffusion-sensitive single-shot RARE (rapid acquisition with relaxation enhancement) sequence was implemented on a 2T whole-body MRI system. The sequence was optimized for diffusion-based MR thermometry, both on a conventional whole-body gradient system and on a high-performance gradient insert. The use of spin-echo versus stimulated-echo diffusion weighting is discussed as a function of gradient performance. Diffusion-based temperature mapping was used to observe the effect of the geometry of the antenna used for radiofrequency (RF) hyperthermia on the temperature distribution. Temperature changes of +/-.5 degrees C in gel and +/-2 degrees C in a muscle sample in vitro could be detected within 16 seconds (gel) or 1 minute (muscle) at a spatial resolution of 2 x 2 x 8 mm. Temperature changes in vivo were also observed on human muscle cooled with ice with comparable sensitivity for the measured apparent diffusion coefficient (ADC) values.


Asunto(s)
Temperatura Corporal/fisiología , Fiebre/fisiopatología , Aumento de la Imagen , Imagen por Resonancia Magnética , Músculo Esquelético/fisiología , Animales , Bovinos , Humanos , Hipertermia Inducida , Monitoreo Fisiológico/métodos , Fantasmas de Imagen , Sensibilidad y Especificidad
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