[The immunomodulating activity of a transfer-factor preparation transflavin, specific to tick-borne encephalitis virus]. / Immunomoduliruiushchaia aktivnost' transferfaktornogo preparata transflavina, spetsifichnogo virusu kleshchevogo entsefalita.

Transflavin, a transfer-factor preparation specific to tick-borne encephalitis virus, was experimentally shown to possess immunomodulating action. The immunomodulating action of this preparation could be observed in a dose of 1 D (1 D being equivalent to 5 x 10(8) lymphocytes), which was manifested by an increase in the phagocytic activity of neutrophils and macrophages, a rise in the amount of T-lymphocytes, an increase in rosette formation, the number of antibody-forming cells, increased proliferation on T- and, to a lesser extent, B-cell mitogens, the restoration of the T-dependent expression of lymphocyte receptors, inhibited by trypsin. Transflavin in doses of 0, 1 and 10 D suppressed primary immune response. The probable mechanisms of the immunomodulating action of the Transflavin under study is discussed.

[Immunotropic effects of molokin]. / Immunotropnye éffekty molokina.

The immunopharmacological properties of Molokin, a polypeptide preparation obtained from the milt of fish of the salmon family, were studied. The Molokin was shown to activate the phagocytosis of macrophages, to increase the number of antibody-forming cells, to elevate antibody titers in mice with high reactivity (CBA) and low reactivity (C57BL).

[The characteristics of the immune and neuromediator homeostasis in patients with borderline neuropsychic disorders in chronic poisoning by higher fatty-series aliphatic amines]. / Kharakteristika immunnogo i neiromediatornogo gomeostaza u bol'nykh s pogranichnymi nervno-psikhicheskimi rasstroistvami pri khronicheskoi intoksikatsii vysshimi alifaticheskimi aminami zhirnogo riada.

The authors provide the data on the etiological role played by higher aliphatic amines of the fatty series in the development of borderline neuropsychic disorders. The dopamine system was shown to play the leading part in their genesis. Activation of that system goes in parallel with disorders in immune and neuromediator homeostasis. Leukopenia, lymphocytosis, inhibition of T system immunity, a rise of the B lymphocyte count, beta-lysine, expression, of acetylcholine, dopamine, noradrenaline, adrenaline, histamine, serotonin, GABA, opiate and benzodiazepine receptors by immunocompetent cells were revealed. It has been demonstrated that the changes in the count of rosette-forming cells immune to neuromediators reflect the disease development and can be used as objective criteria for the diagnosis and treatment policy for borderline neuropsychic disorders caused by higher aliphatic amines of the fatty series.