Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature.

A review of the literature concerning psychogenic purpura is presented. The diagnosis is usually based on typical anamnestic data, clinical presentation (painful inflammatory skin lesions, which progressed to ecchymoses during the next 24 h) and positive diagnostic tests with intracutaneous injections of 80% solution of washed autologous erythrocytes. No pathological findings of blood coagulation parameters are usually detected. Histopathological evaluations of lesional biopsies revealed non-specific changes. Taking into account the high frequency of psychic disorders and stress dependence of skin symptoms, therapy with psychotropic drugs (according to indications) and psychotherapy are pathogenetically grounded methods of treatment in psychogenic purpura, and should be provided together with symptomatic therapy.

[Psychodermatology: current state of the problem]. / Psikhodermatologiia: sovremennoe sostoianie problemy.

An analysis of comorbidity of psychiatric and dermatological pathology in historical, epidemiological and clinical aspects is presented. Psychocutaneous disorders (delusional parasitosis, hypochondria circumscripta, obsessive-compulsive disorders with self-mutilations, pathomimia) play a central role in systematics elaborated in the present study. The authors suggest that delusional parasitosis is a subtype of paranoiac psychosis (paranoia, paranoiac schizophrenia). Psychiatric disorders triggered by dermatological pathology were specified as nosogenous reactions, depressive reactions with sociophobia, pathologic personality development (paranoiac, sensitive, hypochondriac). Atopic dermatitis, eczema, urticaria, psoriasis, herpes simplex, alopecia areata, rosacea, etc, are regarded among dermatological psychosomatic disorders with psychogenic manifestation/exacerbation.

[Skin microbiocenosis in patient with chronic dermatoses]. / Mikrotsenoz kozhi bol'nykh khronicheskimi dermatozami.

The skin microflora of patients with chronic dermatoses (atopic dermatitis and psoriasis) have been studied by the original "Bactotests" method. The data thus obtained indicate that the clinical picture of the disease is related to the severity of skin dysbacteriosis. The electron-microscopic study of 2 staphylococcal strains isolated from patients has revealed the presence of the immunoglobulin cover (capsule-like outer sheath consisting of immunoglobulins and other humoral protective factors) on the cell wall of these bacteria.

[Clinical significance of hyperuricemia in psoriasis]. / Klinicheskoe znachenie giperurikemii pri psoriaze.

After analysis of 1146 psoriasis patients, high incidence of asymptomatic hyperuricemia (18.8%) and elevated average levels of uric acid in these patients' blood were confirmed (346.8 +/- 2.4 mumol/l). More severe forms of uric acid disbolism lead to aggravated skin affections (psoriatic erythrodermia, exudative psoriasis), arthritis, occur in familial predisposition to psoriasis. Advanced psoriasis patients are at risk to develop apparent gout.

[Proliferative activity of peripheral blood lymphocytes and evaluation of the effectiveness of drugs in lichen ruber planus]. / Proliferativnaia aktivnost' limfotsitov perifericheskoi krovi i otsenka éffektivnosti lekarstvennykh preparatov pri krasnom ploskom lishae.

A total of 106 patients with lichen planus were examined for proliferative activity of peripheral blood lymphocytes and exogenous interleukin-2 effect on recovery of cyclosporin A suppressed proliferative response to mitogen. Lymphocyte proliferative activity was assessed by the level of 3H thymidine incorporation in cellular DNA. This parameter was found reduced in patients with lichen planus in comparison with healthy donors and dependent on the disease stage but not degree of dissemination. No disorders were detected in lymphocyte capacity to express receptors for interleukin-2 in the course of their activation. Tigason, prednisolone, and delagil had a marked in vitro antiproliferative effect on the lymphocytes of patients with lichen planus, tigason exerting the highest effect and prednisolone the lowest.

[Role of herpes simplex virus in the development of exudative erythema multiforme]. / Rol' virusa prostogo gerpesa v razvitii mnogoformnoi ékssudativnoi éritemy.

The paper presents analysis of current knowledge on etiology and immunopathogenesis of multiform exudative erythema (MEE). Among a variety of pathogenetic actions of herpes simplex on immune system are those relevant to MEE onset. These variants are dealt with in detail. The view on MEE as resultant from herpes simplex infection promises appearance of new prospective modes of etiotropic therapy.