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1.
Sci Rep ; 8(1): 14508, 2018 Sep 28.
Artículo en Inglés | MEDLINE | ID: mdl-30266967

RESUMEN

The combination of ceramic hardness with high crack resistance is a major challenge in the design of protective thin films. High entropy alloys have shown in earlier studies promising mechanical properties with a potential use as thin film materials. In this study, we show that small amounts of carbon in magnetron-sputtered multicomponent CrNbTaTiW films can lead to a significant increase in hardness. The film properties were strongly dependent on the metal composition and the most promising results were observed for TaW-rich films. They crystallised in a bcc structure with a strong (110) texture and coherent grain boundaries. It was possible to deposit films with 8 at.% C in a supersaturated solid-solution into the bcc structure without carbide formation. A major effect of carbon was a significant grain refinement, reducing the column diameter from approximately 35 to 10 nm. This resulted in an increase in hardness from 14.7 to 19.1 GPa while the reduced E-modulus stayed constant at 322 GPa. The carbon-containing films exhibited extremely little plastic deformation around the indent and no cracks were observed. These results show that supersaturation of carbon into high entropy films can be a promising concept to combine superior hardness with high crack resistance.

2.
J Phys Condens Matter ; 29(15): 155402, 2017 Apr 20.
Artículo en Inglés | MEDLINE | ID: mdl-28192279

RESUMEN

Combining theory with experiments, we study the phase stability, elastic properties, electronic structure and hardness of layered ternary borides AlCr2B2, AlMn2B2, AlFe2B2, AlCo2B2, and AlNi2B2. We find that the first three borides of this series are stable phases, while AlCo2B2 and AlNi2B2 are metastable. We show that the elasticity increases in the boride series, and predict that AlCr2B2, AlMn2B2, and AlFe2B2 are more brittle, while AlCo2B2 and AlNi2B2 are more ductile. We propose that the elasticity of AlFe2B2 can be improved by alloying it with cobalt or nickel, or a combination of them. We present evidence that these ternary borides represent nanolaminated systems. Based on SEM measurements, we demonstrate that they exhibit the delamination phenomena, which leads to a reduced hardness compared to transition metal mono- and diborides. We discuss the background of delamination by analyzing chemical bonding and theoretical work of separation in these borides.

3.
Ultramicroscopy ; 159 Pt 2: 217-22, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25667171

RESUMEN

A magnetron sputtered amorphous Cr-B-C thin film was investigated by means of atom probe tomography (APT). The film is constituted of two phases; a Cr-rich phase present as a few nanometer large regions embedded in a Cr-poor phase (tissue phase). The Cr-rich regions form columnar chains oriented parallel to the growth direction of the film. It was found that the Cr-rich regions have a higher B:C ratio than the Cr-poor regions. The composition of the phases was determined as approximately 35Cr-33B-30C and 15Cr-40B-42C (at%), respectively. The results suggest that this type of nanocomposite films has a more complex structure than previously anticipated, which may have an importance for the mechanical and electrical properties.

4.
J Pediatr Urol ; 9(6 Pt A): 700-6, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23759503

RESUMEN

OBJECTIVES: To study outcomes of early potty training in a population of healthy children with a tradition of early potty training and to compare these findings with a group of children to whom potty training was applied later. SUBJECTS AND METHODS: Mothers and their 47 healthy children in Vietnam participated in this longitudinal study. The voiding pattern and emptying ability were followed by the 4-h voiding observation method from 3 months to 3 years of age. A comparison is made with a group of 57 Swedish children investigated in a similar manner. RESULTS: In the group of Vietnamese children, 89% were on daily potty training at the age of 6 months. At the age of 24 months, potty training was complete for 98%. In the Swedish group, just a few (5%) had started daily potty training by the age of 24 months (p < 0.001). The Vietnamese group had fewer voidings and lower voided volumes than the Swedish group. In the Vietnamese children, bladder emptying could be regarded as having been completed, with no residual urine at 9 months, compared with the Swedish group, which first showed complete emptying at the age of 36 months. CONCLUSION: Potty training performed daily affects the emptying ability positively. In the Vietnamese group, no residual urine was found at the age of 9 months. These results differ significantly from those of the group of Swedish children.


Asunto(s)
Control de Esfínteres , Vejiga Urinaria/fisiología , Micción/fisiología , Factores de Edad , Preescolar , Comparación Transcultural , Femenino , Humanos , Lactante , Masculino , Valores de Referencia , Suecia , Vietnam
5.
J Urol ; 174(1): 289-93, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15947669

RESUMEN

PURPOSE: We describe the voiding pattern and acquisition of bladder control in healthy children up to age 6 years. MATERIALS AND METHODS: We determined age for daytime and nighttime dryness, voiding patterns, voiding volumes and post-void residual volume per 4 hours individually and noninvasively every 3 months up to age 3 years and every 6 months up to age 6 years in 36 female and 23 male patients using 4-hour voiding observation and uroflowmetry/ultrasound. RESULTS: Median age for attaining daytime and nighttime dryness was 3.5 and 4 years, respectively. No significant difference was found between girls and boys. All but 1 child attained daytime dryness an average of 10 months before attaining nighttime dryness. Bladder sensation was reported in 31%, 79% and 100% of patients at ages 2, 3 and 4 years, respectively. Median bladder capacity was 67 ml, 123 ml and 140 ml at years 1, 3 and 6, respectively. Median post-void residual volume was 5.5 ml, 0 ml and 2 ml at ages 1, 3 and 6 years, respectively. CONCLUSIONS: Today bladder control is acquired at a later stage despite earlier awareness of bladder function. The occurrence of bladder sensation from age 1.5 years motivates an earlier start with toilet training. Infants with small post-void residual volume at age 6 months or large bladder capacity will probably attain daytime dryness earlier than those with large post-void residual volume at age 6 months or small bladder capacity.


Asunto(s)
Vejiga Urinaria/fisiología , Micción , Factores de Edad , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Estudios Longitudinales , Masculino , Control de Esfínteres
6.
Science ; 293(5539): 2434-7, 2001 Sep 28.
Artículo en Inglés | MEDLINE | ID: mdl-11577231

RESUMEN

A mechanism to enhance hardness in multilayer coatings is proposed. Using the technologically important hard transition metal carbides as prototypes, although the principle is transferable also to other systems, we demonstrate, from first-principles calculations, that by suitable alloying the energy difference between several competing structures in the transition metal carbides is small or tunable. This creates multiphase/polytypic compounds with a random or controllable layer stacking sequence, systems in which the propagation of dislocations can be strongly suppressed by a large number of interfaces between structures with different glide systems, accordingly allowing the possibility of a greatly enhanced hardness. With modern thin-film technologies, it should therefore be possible to deposit such materials that will express multilayer characteristics with only minor changes in the chemical constitution of the material, which is in contrast to conventional superlattices.

7.
Acta Paediatr ; 90(3): 255-9, 2001 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-11332163

RESUMEN

UNLABELLED: In order to study dose-dependency in histopathological reactions and in changes of serological markers of mucosal relapse, gluten challenge was performed with two defined amounts of gluten in 54 children with earlier enteropathy. Gluten was provided in the form of powder and the patients were randomly allotted to either 0.2 (group A, n = 27) or 0.5 (group B, n = 27) grams per kg body weight per day. At the start and after 4 wk of challenge a small intestinal biopsy was performed. Biopsy specimens were evaluated, in accordance with defined criteria, graded and summarized in an enteropathy score. Blood was sampled at the start and after 2 and 4 wk of challenge. Serum levels of anti-gliadin antibodies (AGA) and anti-endomysium antibodies (EmA) were measured. Within 4 wk of challenge, 24 out of 27 patients in group A and all patients in group B had relapsed. After increasing the gluten dose to 0.5 g/kg/d during the subsequent 4 wk, the three non-relapsing patients also relapsed. CONCLUSION: The severity of mucosal inflammation was significantly higher for group B (p = 0.04) indicating a dose-related severity of the enteropathy. No significant difference was found for maximum AGA level, or in the proportion of patients that converted to pathological values for AGA or EmA.


Asunto(s)
Enfermedad Celíaca/fisiopatología , Glútenes/administración & dosificación , Biomarcadores/sangre , Biopsia , Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/patología , Preescolar , Relación Dosis-Respuesta Inmunológica , Femenino , Gliadina/inmunología , Humanos , Mucosa Intestinal/patología , Intestino Delgado/patología , Masculino , Recurrencia
8.
Lakartidningen ; 98(3): 160-4, 2001 Jan 17.
Artículo en Sueco | MEDLINE | ID: mdl-11271576

RESUMEN

DU90%--the number of drugs that account for 90% of DDDs--and adherence to guidelines in this segment were proposed by the Swedish Medical Quality Council (MKR) as indicators for assessing the quality of drug prescribing. We tested these indicators at a primary health care (PHC) center in Stockholm. Bar-coded prescriptions purchased at pharmacies were compared with the guidelines issued by the regional drug committee. The data were presented and discussed at the PHC center. Although the DU90% method neither examines the appropriateness of use nor provides outcome data, it was shown to be an inexpensive, flexible and simple method for assessing the general quality of drug prescribing.


Asunto(s)
Centros Comunitarios de Salud/normas , Prescripciones de Medicamentos/normas , Garantía de la Calidad de Atención de Salud , Centros Comunitarios de Salud/economía , Centros Comunitarios de Salud/estadística & datos numéricos , Costos de los Medicamentos , Prescripciones de Medicamentos/estadística & datos numéricos , Utilización de Medicamentos , Comité Farmacéutico y Terapéutico , Guías de Práctica Clínica como Asunto , Indicadores de Calidad de la Atención de Salud , Suecia
9.
Eur J Endocrinol ; 144(4): 417-23, 2001 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11275953

RESUMEN

OBJECTIVE: In children with coeliac disease, the ingestion of gluten causes small intestinal inflammation and a clinical picture of malabsorption, weight reduction and short stature. Decreased alkaline phosphatase (ALP) during gluten challenge was found in a previous study. ALP is a marker of bone formation and ALP activities are correlated with growth velocity. The aim of this study was to characterise the previously observed decrease of total ALP by investigating three specific bone ALP isoforms (bone/intestinal, B1 and B2) and three specific liver ALP isoforms (L1, L2 and L3) and, moreover, to correlate these ALP isoforms with other growth factors and growth markers. In addition, we also studied the association with possible weight changes, small intestinal mucosa inflammation, sex, age and gluten dose during gluten challenge. MATERIALS AND METHODS: Bone and liver ALP isoforms, IGF-I, IGF-binding protein (IGFBP)-3 and serum cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) were measured together with change in weight and small intestinal mucosa histopathology in 54 children with earlier enteropathy who participated in a 4-week gluten challenge. RESULTS: We observed a decreased total ALP activity after 4 weeks of gluten challenge, 7.8+/-1.8 to 6.5+/-1.7 microkat/l (means +/- s.d.), which was mainly due to a reduction of the bone ALP isoforms. The sum of all three bone ALP isoforms decreased from 6.3+/-1.7 to 5.1+/-1.6 microkat/l. The decreased activities of the bone ALP isoforms correlated with the observed reductions of IGF-I (r=0.74, P<0.001), IGFBP-3 (r=0.51, P<0.001) and ICTP (r=0.57, P<0.001). The decrease of the growth factors and growth markers correlated with weight reduction, but when influences from the change in weight were adjusted for, the partial correlation of the small intestinal mucosa inflammation was significant for IGF-I (r=-0.56, P<0.001) and IGFBP-3 (r=-0.55, P<0.001). CONCLUSION: The decrease of total ALP was due to a reduction of bone ALP. The decrease of IGF-I and IGFBP-3 was independently correlated with weight change and small intestinal inflammation.


Asunto(s)
Fosfatasa Alcalina/metabolismo , Huesos/enzimología , Enfermedad Celíaca/enzimología , Gastroenteritis/enzimología , Glútenes , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo , Factor I del Crecimiento Similar a la Insulina/metabolismo , Intestino Delgado/enzimología , Fosfatasa Alcalina/sangre , Biomarcadores , Enfermedad Celíaca/patología , Niño , Femenino , Gastroenteritis/patología , Sustancias de Crecimiento/sangre , Humanos , Intestino Delgado/patología , Isoenzimas/metabolismo , Hígado/enzimología , Masculino
10.
J Urol ; 164(6): 2050-4, 2000 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11061923

RESUMEN

PURPOSE: We describe the development of voiding patterns and bladder control in healthy children during the first 3 years of life. MATERIALS AND METHODS: We determined voiding patterns, bladder capacity and post-void residual urine volume per 4 hours individually and noninvasively every 3 months in 36 female and 23 male healthy infants using the 4-hour voiding observation. RESULTS: Voiding frequency decreased slowly from 5 to 2 voiding episodes per 4 hours from ages 3 months to 3 years. We noted interrupted voiding in 33% of subjects at age 3 months but this condition was rare after age 2 years. Voiding during sleep occurred mainly during the first 7 months of life and did not continue after age 18 months. Bladder capacity increased from a median of 52 to 67, 68 and 123 ml. during years 1 to 3, respectively. As measured by post-void residual urine volume, bladder emptying was unchanged during years 1 and 2 but it decreased during year 3 (median 6 versus 0 and mean 4 versus 3 ml. per 4 hours). CONCLUSIONS: During the first 3 years of life the number of voiding episodes, including interrupted voiding, post-void residual urine and voiding during sleep, decreased while bladder capacity increased.


Asunto(s)
Micción , Preescolar , Femenino , Humanos , Lactante , Estudios Longitudinales , Masculino , Valores de Referencia , Vejiga Urinaria/fisiología , Orina , Urodinámica
11.
Acta Paediatr ; 89(4): 465-70, 2000 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-10830461

RESUMEN

The same questionnaire and study design was used in two surveys of asthma among all the children attending the 9-y compulsory school in Sundsvall in 1985 (n = 10527) and 1995 (n = 9165). A detailed questionnaire was distributed by post to the parents of all children who had answered in the affirmative to a simple screening question on asthmatic symptoms at the beginning of the autumn term. The questionnaire contained detailed questions on symptoms and asthma management. Our findings indicated a moderate increase in reported asthma-like symptoms and physician-diagnosed asthma between 1985 and 1995. The severity of symptoms was unchanged, despite a large community-based asthma campaign and a tenfold increase in the number of children receiving inhaled steroids. A validation analysis included an interview by a physician, a skin prick test, determination of specific IgE antibodies and spirometry. The oral interviews suggested that undertreatment was common. Many children had adequate medication at home, but this medication was not used properly. Finally, all 13-14-y-old children also replied to written and video questionnaires from the International Study of Asthma and Allergies in Childhood (ISAAC). It is likely that differences in study design explained the much higher prevalence of wheezing in this part of the study.


Asunto(s)
Asma/epidemiología , Adolescente , Humanos , Prevalencia , Ruidos Respiratorios , Índice de Severidad de la Enfermedad , Espirometría , Encuestas y Cuestionarios , Suecia/epidemiología
12.
Thromb Res ; 82(5): 409-15, 1996 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-8771701

RESUMEN

The influence of haemorrhage and blood transfusion on primary haemostasis, coagulation and fibrinolysis was investigated in ten healthy male volunteers. Acute loss of 10% of the blood volume did not give any significant alteration in thrombin- antithrombin III (TAT) complex and plasmin-alpha 2-antiplasmin (PAP) complex levels compared with a control series. The skin bleeding time with the Simplate II device was not altered after the 10% blood loss. Acute loss of 10% of blood volume followed by transfusion of packed red cells or stored plasma did not resulted in any significant change in bleeding time, TAT and PAP complex levels. It could be concluded that a controlled haemorrhage does not give any detectable changes of the platelet dependent primary haemostasis, blood coagulation and fibrinolysis. Transfusion of one unit of packed red cells or stored plasma does not seem to adversely affect the haemostasis.


Asunto(s)
Antifibrinolíticos , Antitrombina III/metabolismo , Transfusión de Componentes Sanguíneos , Fibrinolisina/metabolismo , Hemorragia/fisiopatología , Péptido Hidrolasas/metabolismo , alfa 2-Antiplasmina/metabolismo , Adulto , Tiempo de Sangría , Coagulación Sanguínea , Fibrinólisis , Hemostasis , Humanos , Masculino
13.
J Trop Pediatr ; 41(6): 360-3, 1995 12.
Artículo en Inglés | MEDLINE | ID: mdl-8606445

RESUMEN

The effects of medically-orientated labour ward routines were studied during the the first hour after birth, in 48 vaginal, single deliveries. All infants were immediately separated from their mothers and left on a resuscitation table. There was no significant difference in onset of crying if the infant received cutaneous stimulation or not. It was found that 17 infants, not showing hand-to-mouth activity, were bathed at an average time of 17 min (12-23 min) after birth, while those who did were bathed at 28.5 (24.5-41.5) min (P = 0.002). One infant was breastfed during the first hour. Being separated from its mother, bathed early, and swaddled after birth seemed to interfere with the infant's inborn ability to signal hunger. Forty-one infants were hypothermic at 1 hour. According to a multiple regression analysis infant body temperature at 60 min of age corresponded positively with birth weight (P = 0.0001) and time of oxygen administration (P = 0.0002). A plausible explanation for the effect of oxygen exposure is that there is brown fat inactivation in normal newborn infants and administration of oxygen activates the brown fat. It might be advantageous to let the mother keep the baby warm, rather than manipulate the baby's metabolism with oxygen.


Asunto(s)
Regulación de la Temperatura Corporal/fisiología , Salas de Parto/organización & administración , Conducta Alimentaria/fisiología , Peso al Nacer , Femenino , Humanos , Recién Nacido , Masculino , Pakistán , Factores de Tiempo
14.
J Pediatr Gastroenterol Nutr ; 21(4): 443-5, 1995 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-8583297

RESUMEN

Down syndrome is associated with immune-related disorders such as hypothyroidism, insulin-dependent diabetes mellitus, and celiac disease. In this study we determined antigliadin antibodies (AGA) in 54 patients with Down syndrome; 22 had AGA values above the cutoff limit. Nineteen patients underwent intestinal biopsy, and total or subtotal villous atrophy was found in nine. There was a total of 65 patients with Down syndrome in our area of southern Sweden; two were already known to have celiac disease. The minimum prevalence of celiac disease in Down syndrome in this area in southern Sweden was 11 of 65 or 16.9%.


Asunto(s)
Enfermedad Celíaca/complicaciones , Síndrome de Down/complicaciones , Adolescente , Anticuerpos/sangre , Biopsia , Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/epidemiología , Femenino , Gliadina/inmunología , Glútenes/administración & dosificación , Humanos , Mucosa Intestinal/patología , Intestinos/patología , Masculino , Suecia
15.
J Lab Clin Med ; 123(4): 561-4, 1994 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-8145004

RESUMEN

Regular blood donors were enrolled in a double-blind, parallel group study to evaluate the side effects of two iron supplements, one containing both heme iron and non-heme iron (Hemofer, 2 tablets = 18 mg iron/day), the other non-heme iron only (Erco-Fer; 1 tablet = 60 mg iron/day). No differences were found between the two alternatives in regaining predonation iron status as measured by serum ferritin and hemoglobin levels. Despite this therapeutic equivalence, participants' symptom diaries showed substantial differences in the side effects for the two treatments. The frequency of constipation (p < 0.05) and the total incidence of all side effects (p < 0.01) were significantly higher for non-heme iron when compared with the heme iron-non-heme iron combination and a placebo. The study demonstrates that a low-dose iron supplement containing both heme iron and non-heme iron (Hemofer) has fewer side effects when compared with an equipotent, traditional non-heme iron supplement.


Asunto(s)
Anemia Hipocrómica/prevención & control , Donantes de Sangre , Compuestos Ferrosos/efectos adversos , Adulto , Análisis de Varianza , Método Doble Ciego , Femenino , Ferritinas/sangre , Hemoglobinas/metabolismo , Humanos , Masculino , Persona de Mediana Edad
17.
J Pediatr Gastroenterol Nutr ; 6(5): 707-9, 1987.
Artículo en Inglés | MEDLINE | ID: mdl-3694364

RESUMEN

Within a defined population in southeast Sweden, celiac disease was diagnosed in 167 children born between 1970 and 1982. The diagnosis was based on the criteria of the European Society for Paediatric Gastroenterology and Nutrition. Another six children had an initial flat small intestinal mucosa but do not yet fulfill the criteria for the diagnosis of celiac disease. The incidence of celiac disease was 1.27/1,000 live births for the years 1970-1976 and 1.43/1,000 for 1977-1982. In contrast to our findings, a decline in the disorder during the late 1970s was reported from other countries. We discuss the observation that the incidences of celiac disease in children are moving discrepantly in different populations.


Asunto(s)
Enfermedad Celíaca/epidemiología , Adolescente , Femenino , Humanos , Masculino , Suecia
18.
Eur J Pediatr ; 145(3): 185-6, 1986 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-3769972

RESUMEN

Eighty-seven children with short stature (height more than 2 SD below the mean for age and sex) were investigated by small intestinal biopsy. There was no obvious reason for their growth retardation found by routine examination and they had no gastrointestinal symptoms. Coeliac disease was found in two children and probable coeliac disease in two children. Although the prevalence of coeliac disease was comparatively low in this study of Swedish children with short stature, it emphasizes the fact that coeliac disease must be considered in a child with short stature even in the absence of gastrointestinal symptoms.


Asunto(s)
Estatura , Enfermedad Celíaca/diagnóstico , Adolescente , Biopsia , Enfermedad Celíaca/patología , Niño , Preescolar , Femenino , Humanos , Lactante , Intestino Delgado/patología , Masculino
19.
J Pediatr Gastroenterol Nutr ; 4(6): 917-22, 1985 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-4067780

RESUMEN

Serum immunoglobulin (Ig) A and IgG gliadin antibodies were determined with a simple, rapid, and inexpensive method--diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA)--and the results were related to small intestinal mucosal morphology in 234 children suspected of having malabsorption. Fifty-six of 58 children with flat intestinal mucosa had increased IgA and/or IgG gliadin antibody levels (sensitivity 97%). Fifty-four of the 58 children had celiac disease (CD) (n = 25) or probable CD (n = 29). Four children with flat mucosa had cow's milk protein and/or soy protein intolerance and three of these had increased gliadin antibody levels. Seventeen percent of 132 children with normal intestinal mucosa had increased IgA and/or IgG gliadin antibody levels. IgA and IgG gliadin antibody levels decreased significantly in the celiac children on a gluten-free diet and increased significantly after gluten challenge. Determination of serum IgA and IgG gliadin antibodies by means of DIG-ELISA is a sensitive test for small intestinal mucosal damage in children. When malabsorption is suspected, we suggest that this assay be used to select children for a small intestinal biopsy. It is also very useful for the follow-up of adherence to a gluten-free diet and to determine the effect of gluten challenge in celiac children.


Asunto(s)
Enfermedad Celíaca/diagnóstico , Gliadina/inmunología , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Intestino Delgado/patología , Proteínas de Plantas/inmunología , Adolescente , Enfermedad Celíaca/inmunología , Enfermedad Celíaca/patología , Niño , Preescolar , Proteínas en la Dieta/administración & dosificación , Glútenes/administración & dosificación , Humanos , Lactante , Mucosa Intestinal/patología , Factores de Tiempo
20.
Monatsschr Kinderheilkd ; 128(9): 620-2, 1980 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-6107850

RESUMEN

ACTH in high doses and over long periods of time is the treatment of choice in infantile spasm. Serious side effects can occur, but are not so often described. Two cases are published with hypertonia and immunosuppression. Control of blood pressure and electrolytes is mandatory. The importance of rather careful control of infections is stressed, as symptoms during ACTH-therapy are somewhat altered.


Asunto(s)
Hormona Adrenocorticotrópica/efectos adversos , Espasmos Infantiles/tratamiento farmacológico , Hormona Adrenocorticotrópica/uso terapéutico , Humanos , Hipertensión/inducido químicamente , Terapia de Inmunosupresión , Lactante , Masculino
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