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@#ObjectiveTo explore the expression of Pannexin1 in patients with acute ischemic stroke（AIS）and its association with severity and prognosis. MethodsA total of 113 patients with AIS admitted to our hospital from January 2017 to January 2020 were selected as case group，who were divided into mild impairment group（NIHSS<4 points，n=42），moderate impairment group（NIHSS 4～15 points，n=45），severe impairment group（NIHSS>15 pointe，n=26）according to the degree of neurological impairment. Also，the patients were divided into small infarction group（infarction volume<5 cm3，n=37），moderate infarction group（infarction volume 5～10cm3，n=51）and large infarction group（infarction volume>10cm3，n=25）according to the volume of cerebral infarction. 90 days after treatment，the patients were divided into good prognosis group（mRS<=2 points，n=81）and poor prognosis group（mRS 3～5 points，n=32）according to the modified Rankin Scale（mRS）. At the same time，58 healthy volunteers were randomly selected as control group. The Pannexin1 level were detected by enzyme-linked immunosorbent assay. ResultsThe level of Pannexin1 in case group was higher than that in control group（P<0.05）. With the aggravation of neurological impairment and the increase of cerebral infarction volume，the level of Pannexin1 in AIS patients increased gradually（P<0.05）. The level of Pannexin1 in good prognosis group was lower than that in bad prognosis group（P<0.05）. The Pearson’s product moment correlation analysis showed that Pannexin1 was positively associated with NIHSS score，infarct volume and mRS score（r=0.632，0.598，0.671；P<0.05）. The AUC of Pannexin1 in predicting poor prognosis was 0.865，the sensitivity and specificity were 87.50% and 86.42% respectively. ConclusionSerum Pannexin1 highly express in patients with AIS，which is closely related to the severity of the disease and prognosis. Early detection of Pannexin1 can be used as a biochemical index to judge the severity of disease and predict poor prognosis.
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Objective To investigate the correlation between onset frequencies and duration of symptoms and early stroke risk in patients with transient ischemic attack (TIA).Methods From January 2013 to July 2017,inpatients with TIA at the Department of Neurology,Lu'an People's Hospital were enrolled retrospectively.According to the findings of head CT or MRI reexaminations within 72 h after the first TIA,the patients were divided into non-stroke group and stroke group.The demographic and clinical data of both groups were compared.Results A total of 171 patients with TIA were enrolled,including 54 in the stroke group and 117 in the non-stroke group.There were significant differences in sex,atrial fibrillation,using anticoagulant drug before onset,baseline blood pressure (systolic and diastolic blood pressure),lowdensity lipoprotein cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,TIA etiology (cardiogenic embolism),TIA frequency (≥2 times),duration of TIA symptoms,ABCD2 score (6 and 7),and using antihypertensive drugs after onset in both groups.Multivariable logistic regression analysis indicated that high diastolic blood pressure (odds ratio [OR] 1.121,95％ confidence interval [CI] 1.016-1.238;P =0.023),high fasting glucose (OR 10.866,95％ CI 3.658-30.945;P =0.001),ABCD2 score 6 (OR 4.221,95％ CI 1.906-9.352;P ＜ 0.001),ABCD2 score 7 (OR 4.207,95％ CI 2.040-9.961,P ＜ 0.001),duration of symptoms ≥ 60 min(OR 3.682,95 ％ CI 1.961-9.989;P ＜ 0.001),and frequency of TIA onset ≥2 (OR 4.220,95％ CI 1.953-9.118;P＜0.001) were the independent risk factors for early TIA,and the use of anticoagulants before onset was an independent protective factor (OR 0.300,95％ CI 0.097-0.923;P =0.036).Conclusion TIA patients with recurrent onset (≥2 times) and duration of symptoms longer than 60 min are more likely to develop ischemic stroke in a short term.
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As a key aspect of quality of life in patients w ith stroke, the clinical research of sexual function and sexual satisfaction is stil rare. The rehabilitation goals in patients w ith stroke usualy include recovering functional activities and improving quality of life, how ever, it is not yet know n about the recovery of sexual function. This article review s the epidemiology, etiology, risk factors, clinical manifestations, treatment and rehabilitation of sexual dysfunction in male patients w ith stroke.
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Objective The aim of this study was to investigate the prevalence of erectile dysfunction (ED) and to assess the risk factors of ED in male post‐stroke patients .Methods One hundred and twenty six male post‐stroke patients were invited to par‐ticipate in this study .Patients were divided into ED group and non‐ED group according to the erectile function evaluated by Interna‐tional Index of Erectile Function‐5 (IIEF‐5) .The neurological impairment was measured using the National Institute of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS) .Depressive symptoms was measured using the Hamilton Depression Scales (HAMD) .The global cognitive function was measured using the Mini mental Status Examination (MMSE) .The clinical and psychosocial factors were compared between the ED and non‐ED groups .Univariate and multivariate Logistic regression analyses were employed to assess the risk factors with ED .Results There were 38 patients (30 .2% ) with ED in all the 126 male post‐stroke patients .Univariate Logistic regression analyses revealed that hypertension ,diabetes ,ACEI ,and depression were significantly related to ED in male post‐stroke patients (P<0 .05) .Multivariate Logistic regression analyses revealed that ACEI and depression were independently associated with ED in male post‐stroke patients (P<0 .05) .Conclusion ED is common in Chinese male post‐stroke patients .ACEI and depression are the major determinants of ED .
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Postprandial hyperglycemia is a risk factor for atherosclerosis and cerebro-vascular diseases. This article reviews the mechanisms of cerebrovascular diseases caused by postprandial hyperglycemia from aspects of postprandial hyperglycemia participating in the pathophysiological mechanisms of atherosclerosis, and the relations between postprandial hyperglycemia and cerebrovascular diseases.
