[Enzymatic activity of some tissues and blood serum from animals and humans exposed to microwaves and hypothesis on the possible role of free radical processes in the nonlinear effects and modification of emotional behavior of animals]. / Fermentnaia aktivnost' nekotorykh tkanei i syvorotki krovi zhivotnykh i cheloveka pri vozdeistvii mikrovoln i gipoteza o vozmozhnoi roli svobodnoradikal'nykh protesssov v nelineinykh éffektakh i modifikatsii émotsional'nogo povedeniia zhivotnykh.

The dependence of activities of actomyosin ATPase, alkaline phosphatase, aspartataminotranspherase, monoaminoxidase and that of affective rat behavior on frequency of modulation of microwaves (0.8-10 microW/cm2) was explored at short-time actions. Series of nonlinear phenomenons, inexplicable from positions of the energy approaches are revealed, The working hypothesis explaining opportunity of high performance of weak and super-weak microwaves and other revealed phenomena by resonance interaction of such electromagnetic radiofrequency radiation with paramagnetic molecules of biological tissues was proposed. This resonance interaction activate free radicals and initiate auto-supporting and auto-intensifying of chain chemical reactions. The spontaneous autocatalytic oxidation of catecholamines enlarges a common pool of free radicals, capable to participate in such enhanced generating. The protective role of monoaminoxidase is postulated. Monoaminoxidase is basically located on an outer surface of mitochondrias and it is deaminating monoamines. The deaminating prevents penetration of catecholamines inside of mitochondrias and their quinoid oxidation there with formation of free-radical semi-quinons, capable to destroy system of ATP synthesis. These inferences are obliquely confirmed by the experimentally revealed correlation between activity of monoaminoxidase and integrative activity of the rat brain.

[Effect of the preparation baliz-2 on the integrative brain activity and biogenic amine metabolism in rats under stress]. / Vliianie preparata baliz-2 na integrativnuiu deiatel'nost' mozga i obmen biogennykh aminov u stressirovannykh krys.

Effects of balis-2 on exploratory activity in the open field and elevated plus-maze, attention to sensory stimuli of different modalities, elaboration and retention of conditioned reflexes with food reinforcement, were studied in rats under stress. Prolonged treatment of rats with balis-2 seems to normalise integrative activity and metabolism of serotonine and dopamine in the animal brain.

[Learning in rats with differing emotional responsiveness and its relation to brain monoamines]. / Obuchenie krys s razlichnoi émotsional'noi reaktivnost'iu i ee s monoaminami mozga.

The ability for learning was studied in two groups of Wistar line rats divided by susceptibility to the audiogenic stress-stimulation as compared with the monoamines level in various brain structures. The best ability to learn avoidance reaction in a shuttlebox was shown by animals non-resistant to the stress stimulus as compared with the resistant rats, which correlated positively with the exploratory activity in "the open field". The distinct feature of the animals non-resistant to the stress stimulation consisted in a higher reactivity of the monoamine systems, mainly of the noradrenergic system. This group of animals was also characterized by a higher dopamine content and a lower noradrenaline content in the brain-stem. Decreased activity of the brain dopamine-beta-hydroxylase in animals non-resistant to the stress stimulus, has been suggested.

[Change in the biogenic amine level in the rat brain in ethanol poisoning]. / Izmenenie urovnia biogennykh aminov v mozge krys pri intoksikatsii étanolom.

Variations in the content of biogenic amines were studied by fluorometry in the brain of rats administered ethanol at a single dose (1.5 and 6 g/kg, intraperitoneally) and chronically at a concentration raised from 10 to 40% for 2 months, and after ethanol withdrawal. In acute ethanol poisoning the serotonin concentration grows abruptly while the content of noradrenalin and dopamine drops down. On the contrary, in chronic ethanol poisoning the content of dopamine and noradrenalin rises, while that of serotonin does not differ from the control level. Ethanol withdrawal entails a decrease in the serotonin level apart from noradrenalin and dopamine accumulation by the brain. It is suggested that interrelated variations in the content of biogenic amines in the central nervous system may underlie the mechanism of depression development in acute ethanol poisoning and convulsant activity after it is discontinued.