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1.
Clin Genitourin Cancer ; 7(1): 62-3, 2009 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19213671

RESUMEN

A 62-year-old woman was treated with sunitinib as a second-line therapy for metastatic clear-cell renal carcinoma. She was given oral sunitinib 50 mg once daily, 4 weeks on followed by 2 week off. During the fourth week of her first cycle, the patient was admitted to our hospital because of an acute-onset, right upper quadrant pain associated with nausea and vomiting. She was diagnosed with acute acalculous cholecystitis, which was treated with broad-spectrum antibiotics, and sunitinib therapy was discontinued. A follow-up computed tomography scan of the abdomen revealed a complete resolution of gallbladder changes. Our patient did not have major risk factors for developing an acalculous cholecystitis except for a relative immunosuppressed state secondary to her advanced renal cancer. The Naranjo Adverse Drug Reaction Probability Scale score for this event was 5, indicating a probable association of the event with sunitinib. Because the use of sunitinib is expanding in clinical practice, we want to alert the oncology community about this uncommon and life-threatening complication in patients receiving sunitinib or another agent with antiangiogenic activity.


Asunto(s)
Colecistitis Alitiásica/inducido químicamente , Antineoplásicos/efectos adversos , Carcinoma de Células Renales/tratamiento farmacológico , Indoles/efectos adversos , Neoplasias Renales/tratamiento farmacológico , Pirroles/efectos adversos , Colecistitis Alitiásica/tratamiento farmacológico , Carcinoma de Células Renales/patología , Carcinoma de Células Renales/cirugía , Femenino , Humanos , Neoplasias Renales/patología , Neoplasias Renales/cirugía , Persona de Mediana Edad , Sunitinib , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
2.
La Rioja; IUCS - Fundacion H. A. Barcelo; 1997. 17 p. fotog. (63126).
Monografía en Español | BINACIS | ID: bin-63126
3.
La Rioja; IUCS - Fundacion H. A. Barcelo; 1997. 11 p. (62981).
Monografía en Español | BINACIS | ID: bin-62981
4.
La Rioja; IUCS - Fundacion H. A. Barcelo; 1997. 11 p.
Monografía en Español | BINACIS | ID: biblio-1190687
5.
La Rioja; IUCS - Fundacion H. A. Barcelo; 1997. 17 p. ^efotog.
Monografía en Español | BINACIS | ID: biblio-1190815
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