1.
Bioorg Med Chem Lett
; 8(7): 871-4, 1998 Apr 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9871557
RESUMEN
The first demonstration of DNA cleavage by an organic radical generated via homolysis of a metal-alkyl bond in a Cp-metal complex is presented. Irradiation of CpW(CO)3CH3 (1.5 molecules/base pair) produced methyl radical, giving single-strand cleavage of pBR322 DNA. This process was inhibited by the general radical trap cysteine and by TEMPO, which traps carbon radicals but not oxygen-centered radicals.
