[Measles antibodies in exocrine secretions]. / Issledovanie protivokorevykh antitel vo vneshnikh sekretakh.

The results of the analysis of saliva samples taken from 157 persons aged 1-48 years for the presence of antimeasles antibodies in the neutralization test, the hemagglutination inhibition test and the passive hemagglutination test are presented. The data obtained in this study suggest that antimeasles antibodies can be detected in saliva for many years after the formation of immunity, but quickly disintegrate after a saliva sample is taken.

[Antiviral immunity in disseminated sclerosis]. / Izuchenie protivovirusnogo immuniteta pri rasseiannom skleroze.

Titres of antibodies to various viral antigens, levels of immunoglobulins, and the rate of detection of specific IgM to measles virus were studied in the blood sera of 50 patients with multiple sclerosis and 50 normal subjects. High antibody titres to measles, mumps, rubella and parainfluenza type 3 virus antigens were revealed. Specific IgM to measles virus were detected in 50% of multiple sclerosis patients and in none of the normal subjects. The patients with multiple sclerosis showed no significant differences in the levels of immunoglobulins of the three main classes (G, A, M).

[Protective effect of a commercial vaccine, poludan and their combinations in an experimental herpes infection]. / Izuchenie zashchitnogo éffekta kommercheskoi vaktsiny, poludana i ikh kombinatsii pri éksperimental'noi gerpeticheskoi infektsii.

The antiviral action of herpes vaccine and poludan, an interferon-inducing agent, has been studied in experimental herpes infection, and the synergic effect of these preparations has been obtained. The best result (survival rate equal to 100% after the intraperitoneal inoculation of herpes simplex virus and 85.7% after its intracerebral inoculation) has been registered after the multiple vaccination of experimental animals and the injection of poludan 1 day before the challenge of the animals with the virus. The protective effect of the synergic action of the preparations under study coincides with the period of the maximum content of antibodies in the blood sera of the animals.

[Interferon production in multiple sclerosis]. / Izuchenie interferonoobrazovaniia pri rasseiannom skleroze.

The interferon-synthesizing activity of the peripheral blood leukocytes and serum interferon in the blood of patients with multiple sclerosis were studied. A reverse relationship was found between antibody production (high titers of measles antibody) and the interferon-synthesizing activity of peripheral blood leukocytes in these patients. A 3-fold decline in serum interferon titers was observed in patients with multiple sclerosis as compared with the control group.

[Antiviral immunity study in systemic diseases]. / Issledovanie protivovirusnogo immuniteta pri nekotorykh sistemnykh zabolevaniiakh.

The investigation of antiviral antibody titers to 8 different antigens: measles, influenza A2 and B, parainfluenza types 1, 2, 3, adenovirus and smallpox, of interferon in the blood serum, the interferon-synthesizing activity of the peripheral blood leukocytes in patients with autoimmune diseases in the period of the disease exacerbation revealed a number of immunological features. Thus, in all groups of patients antibody titers were high to measles, influenza, parainfluenza type 3 viruses, and titers of leukocyte interferon and interferon in the blood serum were 3-4-fold lower than in the control group.