RESUMEN
The effects of a new derivative of benzimidazole (K-134) in doses of 5 and 50 mg/kg on the spermatogenesis and fertilizing ability of spermatozoa were studied on male rats. It was found that 2-month course treatment with the studied substance enhances the producing ability of the spermatogenic epithelium and improves fertilizing ability of spermatozoa.
Asunto(s)
Fertilidad/efectos de los fármacos , Quinolinas/farmacología , Epitelio Seminífero/efectos de los fármacos , Urea/análogos & derivados , Animales , Animales no Consanguíneos , Bencimidazoles/farmacología , Citoprotección/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Masculino , Ratas , Epitelio Seminífero/fisiología , Espermatogénesis/efectos de los fármacos , Testículo/efectos de los fármacos , Urea/farmacologíaRESUMEN
Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.
Asunto(s)
Ansiolíticos/efectos adversos , Bencimidazoles/efectos adversos , Exposición Materna/efectos adversos , Morfolinas/efectos adversos , Efectos Tardíos de la Exposición Prenatal/etiología , Animales , Animales Recién Nacidos , Reacción de Prevención/efectos de los fármacos , Conducta Animal/efectos de los fármacos , Femenino , Aprendizaje por Laberinto/efectos de los fármacos , Memoria/efectos de los fármacos , Actividad Motora/efectos de los fármacos , Fuerza Muscular/efectos de los fármacos , Músculo Esquelético/efectos de los fármacos , Músculo Esquelético/crecimiento & desarrollo , Embarazo , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Ratas , Reflejo Pupilar/efectos de los fármacos , Maduración Sexual/efectos de los fármacos , Aumento de Peso/efectos de los fármacosRESUMEN
It is experimentally established that afobazole produces no damaging action on the organogenesis and fetogenic processes registered in the postnatal period of rat offspring development. It was noted that, in rat babies in lactation age, the dynamics of body weight gain was lower on average by 7.4% (p < 0.05) in males and 17.0% (p < 0.001) in females; the rate of muscular force maturing was lower by 2.7% (p < 0.05); and the locomotive activity was lower (by 19.4% for ver- tical standings and by 50% for looking into floor holes, p < 0.05) compared to control values. For the same offspring passed to definitive food, the body weight gain and behavioral activity did not differ from control indicators, while the terms of sexual development were delayed in females and did not change in males. By two-month age, the physical development of rat offspring was completely created and met physiological standards.
Asunto(s)
Ansiolíticos/farmacología , Conducta Animal/efectos de los fármacos , Bencimidazoles/farmacología , Lactancia/efectos de los fármacos , Morfolinas/farmacología , Actividad Motora/efectos de los fármacos , Animales , Animales Recién Nacidos , Femenino , Lactancia/fisiología , Masculino , Embarazo , Efectos Tardíos de la Exposición Prenatal/diagnóstico , Efectos Tardíos de la Exposición Prenatal/patología , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Factores SexualesRESUMEN
The effects of a new thietanylbenzimidazole derivative (K-134) on estrous cycles, conception processes, and sexual behavior of female rats were studied. Two-week oral treatment with K-134 in doses of 5 and 50 mg/kg shortened the estrus phase and prolonged proestrus. Changes in sexual behavior were presented by activation of receptive sexual motivations without affecting proceptive motivations. The pregnancy and fertility indexes in experimental females after mating with intact males increased and pre- and postimplantation embryonic death decreased.
Asunto(s)
Bencimidazoles/farmacología , Ciclo Estral/efectos de los fármacos , Fármacos para la Fertilidad Femenina/farmacología , Fertilización/efectos de los fármacos , Aptitud Genética/efectos de los fármacos , Conducta Sexual Animal/efectos de los fármacos , Animales , Animales no Consanguíneos , Ciclo Estral/fisiología , Femenino , Fertilización/fisiología , Mortalidad Fetal , Aptitud Genética/fisiología , Libido/efectos de los fármacos , Tamaño de la Camada/efectos de los fármacos , Tamaño de la Camada/fisiología , Masculino , Embarazo , Ratas , Conducta Sexual Animal/fisiologíaRESUMEN
Experiments on pregnant rats have demonstrated the absence of damaging effect of Afobazole administered during the antenatal period on organogenesis in fetuses. Afobazole in a dose of 5 mg/kg given to pregnant rats on gestation days 6-16 reduced pre- and post-implantation fetal mortality and improved fertility; 20-day-old embryos had no developmental abnormalities and did not differ from controls by craniocaudal size, body weight, and skeleton ossification. Afobazole in a dose of 100 mg/kg reduced pre- and post-implantation fetal mortality, but had no effect on fertility. No congenital malformations were found in the fetuses, but they were characterized by lower craniocaudal size, body weight, and number of ossification foci in the sternum and spine.