[Functionally sparing surgery in locally spread malignant maxillary tumors and the use of local chemotherapy]. / Funktsional'no-shchadiashchie operatsii pri mestno-rasprostranennykh zlokachestvennykh opukholiakh verkhnei cheliusti s ispol'zovaniem lokal'noi khimioterapii.

53 patients underwent functionally sparing operations which imply electrosurgical maxillectomy with alveolar process and hard palate left intact as well as eyeball preserving resections. At termination of the surgical intervention cyanoacrylate glue compounds incorporating cytostatics bleomycin or carminomycin were applied to the walls of the postoperative cavity. Maxillary alveolar process and hard palate were preserved when the tumor arose from maxillary posterior superior segments, ethmoidal labyrinth and upper nasal cavity. In orbital direction of the tumor spread the eyeball was spared when the lesion was confined to orbital wall and if intraorbital fat was uninvolved. 3-year survival after the above operations made up 60.4%. The method is believed oncologically effective and functionally, cosmetically sparing.

[The current status of the problem and the treatment possibilities in disseminated malignant neoplasms of the maxilla]. / Sovremennoe sostoianie problemy i vozmozhnosti lecheniia rasprostranennykh zlokachestvennykh novoobrazovanii verkhnei cheliusti.

A study of the results of treatment of 170 patients makes a case for combined electrosurgical resection of the maxilla and local chemotherapy with deposited cytostatic drugs for localized malignant tumors of this site. No recurrences were detected within the first 12 months in 75.4% of patients and 52%--in control. Three-year survival in treated patients and controls was 67 and 48%, respectively.

[Use of cytostatics in polymer-drug complexes in the treatment of malignant neoplasms of the maxilla]. / Primenenie tsitostatikov v sostave polimerlekarstvennykh kompleksov pri lechenii zlokachestvennykh novoobrazovanii verkhnei cheliusti.

The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic complications and that wounds may be managed without tampons. Deposition of the drug and its regulated elimination from the composition helps create a high concentration of the agent at the operation site where the tumor elements remained after surgery; this permits expecting better late results.