RESUMEN
BACKGROUND: Aspirin is widely used to modify the risk of recurrent vascular events. It is, however, associated with increased upper gastrointestinal bleeding risk. The influence of Helicobacter pylori on this risk is uncertain. AIM: To determine the influence of H. pylori on upper gastrointestinal bleeding risk in patients taking aspirin. METHODS: MEDLINE and EMBASE databases were searched. All studies providing data regarding H. pylori infection in adults taking aspirin and presenting with upper gastrointestinal bleeding were included. RESULTS: A total of 13 studies that included 1 case-control, 10 cohort studies and 2 randomized-controlled trials (RCTs) were analysed. The case-control study (n = 245) determined H. pylori to be a significant independent risk factor for upper gastrointestinal bleeding. The cohort studies were heterogeneous, varying in inclusion criteria, doses and duration of aspirin used, mode of H. pylori testing and causative GI pathology considered. Comprising 5465 patients, H. pylori infection was tested for in 163 (0.03%) aspirin users with upper gastrointestinal bleeding. The RCTs yielded no significant results. CONCLUSIONS: The current data are not sufficient to allow meta-analyses. The widely held belief that H. pylori is a risk factor for upper gastrointestinal bleeding in regular aspirin users is not supported by the very limited evidence available.
Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Aspirina/efectos adversos , Hemorragia Gastrointestinal/inducido químicamente , Infecciones por Helicobacter/complicaciones , Helicobacter pylori/aislamiento & purificación , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Factores de Riesgo , Tracto Gastrointestinal SuperiorRESUMEN
Confluent and reticulated papillomatosis (CRP) is a rare skin disorder. To date its aetiology remains uncertain. The possibility of an infectious aetiology has been supported by case reports of therapeutic response to antibiotic therapy. We have isolated and identified a previously unknown Dietzia strain, an Actinomycete, from skin scrapings of a 17-year-old boy with CRP. We propose that this organism may be the aetiological agent of CRP. Further investigations are necessary to determine the potential role of this Actinomycete in the pathogenesis of CRP.
Asunto(s)
Infecciones por Actinomycetales/complicaciones , Actinomycetales/clasificación , Papiloma/microbiología , Neoplasias Cutáneas/microbiología , Actinomycetales/aislamiento & purificación , Adolescente , Humanos , Masculino , Papiloma/patología , Neoplasias Cutáneas/patologíaRESUMEN
In this study the quantitative adhesion of a strain of Staphylococcus epidermidis, Streptococcus mutans and Pseudomonas aeruginosa to and the ease of removal from different TiNOX coatings was investigated by means of a parallel plate flow chamber and in situ image analysis. Quality of adhesion was determined by counting bacteria which remained attached to the surface after exposure to an air-liquid interface. S. epidermidis and S. mutans showed a bipolar adhesion pattern with highest numbers of adhesion at low and high resistivity with lowest adhesions at a resistivity of 10(4) microohms cm. P. aeruginosa was the least adherent organism. These results indicate that the affinity of these three strains under the current experimental conditions is minimal for TiNOX coatings with a specific resistivity. TiNOX coatings with pre-adsorbed fibrinogen showed different numbers of S. epidermidis adhered to the different coatings. However, the affinity of this strain for fibrinogen-coated TiNOX remains low when the resistivity is around 10(4) microohms cm. This indicates that the specific influence of the resistivities of the TiNOX coatings is transferred through the adsorbed fibrinogen film to the interface with adhering bacteria.
Asunto(s)
Adhesión Bacteriana/fisiología , Materiales Biocompatibles/química , Pseudomonas aeruginosa/fisiología , Staphylococcus epidermidis/fisiología , Streptococcus mutans/fisiología , Titanio/química , Adsorción , Aleaciones/química , Fibrinógeno/metabolismo , Humanos , Propiedades de SuperficieRESUMEN
The conventional treatment of staphylococcal endocarditis requires in-patient administration, is inconvenient, and is potentially toxic. Increasing experience with well-absorbed, well-tolerated and highly active agents such as the new quinolones has prompted interest in their use as therapeutic alternatives for the treatment of such infections. We describe a case of staphylococcal endocarditis which failed to respond to conventional therapy, but where the addition of moxifloxacin, an 8-methoxyquinolone, was curative.
Asunto(s)
Antiinfecciosos/uso terapéutico , Compuestos Aza , Endocarditis Bacteriana/tratamiento farmacológico , Fluoroquinolonas , Quinolinas , Staphylococcus aureus/aislamiento & purificación , Adulto , Endocarditis Bacteriana/microbiología , Humanos , Masculino , Moxifloxacino , Infecciones Estafilocócicas/tratamiento farmacológicoAsunto(s)
Antiinfecciosos/farmacología , Ciprofloxacina/farmacología , Hematoma/microbiología , Trasplante de Riñón , Infecciones por Mycoplasma/tratamiento farmacológico , Mycoplasma hominis/aislamiento & purificación , Adolescente , Antibacterianos/farmacología , Antiinfecciosos/uso terapéutico , Ciprofloxacina/uso terapéutico , Farmacorresistencia Microbiana , Femenino , Humanos , Pruebas de Sensibilidad Microbiana , Mycoplasma hominis/efectos de los fármacos , NefrectomíaRESUMEN
An outbreak of Gram-negative septicaemia due to cross infection on an acute cardiology ward is reported. This outbreak was facilitated by two factors: first, an area originally designed for non-clinical purposes was converted into a clean utility area without consulting the infection control team, and second, changes in staff had taken place at the same time. This outbreak emphasizes the importance of continuous staff training in infection control, the involvement of the infection control team in all building alterations and the need to improve recommendations by the Department of Health in the design of clean utility areas.
Asunto(s)
Infección Hospitalaria/epidemiología , Brotes de Enfermedades , Enterobacter cloacae/aislamiento & purificación , Infecciones por Enterobacteriaceae/epidemiología , Sepsis/epidemiología , Cardiología , Infección Hospitalaria/etiología , Infección Hospitalaria/prevención & control , Infecciones por Enterobacteriaceae/etiología , Infecciones por Enterobacteriaceae/prevención & control , Contaminación de Equipos , Unidades Hospitalarias , Humanos , Control de Infecciones/normas , Infusiones Intravenosas/efectos adversos , Infusiones Intravenosas/instrumentación , Sepsis/etiología , Reino Unido/epidemiologíaRESUMEN
The contribution of ventilatory equipment to the pathogenesis of ventilator-associated pneumonia (VAP) is well-established but the design of endotracheal tubes has been improved only to reduce tracheal traumatization. However many factors, including the surface properties of the endotracheal tube, humidity of the ventilatory gases, ventilatory mode and nursing management result in the formation of an infective, highly viscous and adhesive layer inside of the endotracheal tube. Endotracheal tubes may contribute to the pathogenesis of VAP when infective particles of this adhesive layer are dislodged into the lower airways by shear forces imparted by the respiratory gasflow. The current state of research is reviewed and potential solutions to this problem are discussed.
Asunto(s)
Infección Hospitalaria/etiología , Intubación Intratraqueal/efectos adversos , Neumonía/etiología , Diseño de Equipo , Humanos , Humedad , Moco/microbiología , Ventilación Pulmonar , Respiración Artificial/efectos adversos , Respiración Artificial/instrumentación , Respiración Artificial/enfermería , Propiedades de SuperficieRESUMEN
Many automated blood culture reading systems monitor bacterial growth 24 hours a day but it is unclear if reacting to prompts indicating bacterial growth outside normal laboratory hours is of clinical benefit. An analysis of 50 blood cultures from 43 patients which had organisms seen on Gram films and had triggered positive out-of-hours showed that examination of the Gram film altered management of seven patients and the results of culture or sensitivity testing altered that of a further four. However, after review, it was felt the clinical outcome would not have been influenced by earlier intervention in any of these patients. We therefore consider that an out-of-hours service for dealing with positive blood cultures is not justified in our hospital. This conclusion may not apply universally, especially in hospitals where potential pathogens show less predictable antimicrobial sensitivity patterns.