[Etiology, clinical manifestations, and epidemiology in community-acquired respiratory infection in children in the Khabarovsk region]. / Etiologicheskaia kharakteristika, klinika i épidemiologiia gruppovogo zabolevaniia respiratornoi infektsiei u detei Khabarovskogo kraia.

Clinico-epidemiological analysis and etiological verification of the outbreak of respiratory infection among school children in a rural district of the Khabarovsk territory, registered in spring 1997, were made. According to clinical signs, one-third of the patients had whooping cough, while the rest of the children exhibited the signs of respiratory infection with the symptoms of longering bronchitis. A half of the children had not been vaccinated against whooping cough, as they had been given injections of adsorbed DT vaccine with reduced antigen content. Etiologically, the diagnosis of whooping cough was confirmed in 57% of the patients with 47.4% of them having Bordetella pertussis monoinfection and 52.6% having mixed infection, mainly in combination with chlamydiosis. Whooping cough took an abnormal course under these circumstances. Treatment with erythromycin produced a good effect.

[Prenatal diagnosis of cytomegalovirus infection]. / Prenatal'naia diagnostika tsitomegalovirusnoi infektsii.

Prognostic value of markers of cytomegalovirus infection (CMV) in pregnant women for the neonatal status was assessed. Detection of such markers as antiCMV IgM and CMV DNA in cervical secretion by DNA dot-spot hybridization in women with a complicated course of pregnancy indicates a 5.7% risk of delivery of children with stable symptoms. Studies of antibodies to pre-early proteins (IE CMV) showed that antiCMV IgG to IE are more incident in pregnant women than antiCMV IgM; moreover, antiCMV IgG to IE but not antiCMV IgM are detected in umbilical blood. The results of detection of antiCMV IgG and IgM to IE correlated with the clinical characteristics of newborns.

[Long-term persistence of coxsackieviruses in familial foci of infectious myocarditis patients]. / Dlitel'noe sokhranenie virusov Koksaki v semeinykh ochagakh v okruzhenii bol'nykh infektsionnym miokarditom.

Numerous examinations during 12-36 months of 16 children suffering from myocarditis and their 37 relatives revealed long-term persistence of Coxsackie A13/A18 viruses in the familial foci of infection in 13 cases. In addition, 9 families were found to have foci of Coxsackie B virus infection of which 2 were also persistent (Coxsackie B1 and B3) and 7 transitory. In 8 families, Coxsackie B viruses circulated simultaneously with Coxsackie A13/A18.

[Persistence of Coxsackie A13 virus in the families of children ill with rheumocarditis]. / Persistentsiiia virusa Koksaki A13 v semiakh bol'nykh revmokarditom detei.

Virological and clinico-instrumental examinations were carried out three times during one year in 13 patients with rheumatic carditis and 34 of their relatives from 13 families. Besides, probands from 5 families had been examined 1-3 years before this study during treatment for rheumocarditis. Among 62 virus strains isolated from feces, blood, and nasopharyngeal washings in the family foci 40 were Coxsackie A13, 12: Coxsackie B1, B2, B5; 10 viruses were not identified. Coxsackie A13 virus was isolated from probands, siblings and parents in 11 out of 13 families. Virus-neutralizing antibodies to it were demonstrated in the great majority of probands and relatives, including those families where no virus had been isolated. Coxsackie A13 virus and antibodies to it were shown to persist throughout the observation period in most families.

[Experimental study of Coxsackie-streptococcal infection]. / Eksperimental'noe izuchenie koksaki-streptokokkovoi infektsii.

The pathological process due to Coxsackie A18 virus and hemolytic streptococcus infection was studied in adult white mice. Their synergistic effect was established as manifested by longer periods of virus detection in the blood and heart and the detection of the streptococcus in animals infected with an 8-fold lower dose. In cases of combined infection, signs of dystrophy, destruction and proliferation developed in the myocardium reaching the highest intensity when the virus and the microbe had been inoculated simultaneously.