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OBJECTIVES: The accuracy and precision of two new methods of model-based radiostereometric analysis (RSA) were hypothesised to be superior to a plain radiograph method in the assessment of polyethylene (PE) wear. METHODS: A phantom device was constructed to simulate three-dimensional (3D) PE wear. Images were obtained consecutively for each simulated wear position for each modality. Three commercially available packages were evaluated: model-based RSA using laser-scanned cup models (MB-RSA), model-based RSA using computer-generated elementary geometrical shape models (EGS-RSA), and PolyWare. Precision (95% repeatability limits) and accuracy (Root Mean Square Errors) for two-dimensional (2D) and 3D wear measurements were assessed. RESULTS: The precision for 2D wear measures was 0.078 mm, 0.102 mm, and 0.076 mm for EGS-RSA, MB-RSA, and PolyWare, respectively. For the 3D wear measures the precision was 0.185 mm, 0.189 mm, and 0.244 mm for EGS-RSA, MB-RSA, and PolyWare respectively. Repeatability was similar for all methods within the same dimension, when compared between 2D and 3D (all p > 0.28). For the 2D RSA methods, accuracy was below 0.055 mm and at least 0.335 mm for PolyWare. For 3D measurements, accuracy was 0.1 mm, 0.2 mm, and 0.3 mm for EGS-RSA, MB-RSA and PolyWare respectively. PolyWare was less accurate compared with RSA methods (p = 0.036). No difference was observed between the RSA methods (p = 0.10). CONCLUSIONS: For all methods, precision and accuracy were better in 2D, with RSA methods being superior in accuracy. Although less accurate and precise, 3D RSA defines the clinically relevant wear pattern (multidirectional). PolyWare is a good and low-cost alternative to RSA, despite being less accurate and requiring a larger sample size.
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PURPOSE: This study tested the hypothesis that serial dilation of the tibial tunnel could provide a stronger anchorage of the graft-fixation-device complex compared to traditional extraction drilling. METHODS: Forty patients (22 men and 18 women) undergoing ACL reconstruction were randomized to either extraction drilling (group ED) or compaction by serial dilation (group SD) of the tibial tunnel. Tantalum beads were placed in the tibia, femur, and in the hamstring graft. Radiostereometric analysis (RSA) was performed postoperatively and again after 6, 12, and 24 weeks. Migration of graft in the bone tunnels as well as knee laxity was assessed using RSA and a TELOS stress device. RESULTS: Six patients (three men and three women) were excluded during follow-up, which resulted in 17 patients in group ED [median age 30 years (range 20-50)] and 17 patients in group SD [median age 32 years (range 20-49)]. The mean migration of the graft in the tibial bone canal after 3 months was 1.3 (SD 0.6) mm in group ED and 0.8 (SD 0.5) mm in group SD (P = 0.02). The overall knee laxity after 3 months was 13.0 (SD 4.0) mm in group ED and 10.9 (SD 3.1) mm in group SD. CONCLUSION: This study found less slippage of the hamstring graft in the tibial bone canal in the serial dilated group compared to the extraction drilling group. The clinical relevance of the difference is unknown. No difference in stress radiographic knee laxity was found between the two groups.
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Lesiones del Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/cirugía , Inestabilidad de la Articulación/prevención & control , Procedimientos Ortopédicos/métodos , Procedimientos de Cirugía Plástica/métodos , Transferencia Tendinosa/métodos , Adulto , Ligamento Cruzado Anterior/diagnóstico por imagen , Fenómenos Biomecánicos , Dilatación/métodos , Femenino , Estudios de Seguimiento , Rechazo de Injerto , Humanos , Puntaje de Gravedad del Traumatismo , Traumatismos de la Rodilla/diagnóstico por imagen , Traumatismos de la Rodilla/cirugía , Masculino , Persona de Mediana Edad , Procedimientos Ortopédicos/instrumentación , Fotogrametría , Cuidados Posoperatorios/métodos , Radiografía , Rango del Movimiento Articular/fisiología , Procedimientos de Cirugía Plástica/instrumentación , Recuperación de la Función , Valores de Referencia , Medición de Riesgo , Estadísticas no Paramétricas , Transferencia Tendinosa/efectos adversos , Resistencia a la Tracción , Resultado del Tratamiento , Adulto JovenRESUMEN
PURPOSE: Several devices for measuring knee laxity following anterior cruciate ligament ACL reconstruction exist, but the precision of the methods has never been optimal. Therefore, a new standardized protocol (NSP) was made, aiming at ensuring a reliable positioning of the Telos Stress Device (TSD) which theoretically could result in precise knee laxity measurements when using radiostereometric analysis (RSA) in combination with TSD. METHOD: The TSD was applied to the knee of 30 healthy persons, using both the NSP and the official company instructions. The position of the stress arms of the TSD was marked following each measurement. The reliability of each protocol was calculated as the difference in length between the first and second markings. The NSP for the TSD was then used in a clinical study. Thirty-five patients underwent ACL reconstruction. Double measurements of knee laxity by RSA were performed at a 3-month follow-up. RESULTS: Using the NSP for TSD positioning, the prediction interval at the marking sites ranged from ±0.4 to ±1.1 mm. Following the company instructions, the prediction interval ranged from ±0.8 to ±3.9 mm depending on marking site. Thus, the precision of positioning the stress arms of the TSD was improved at all marking sites using the NSP compared with the original company protocol. The double measurements of the knee laxity in the clinical study resulted in a mean difference of 0.0 mm and a prediction interval of ±5.2 mm. CONCLUSION: Even though the NSP improved the positioning of the TSD on patients' extremities, the combination of NSP-TSD and RSA was not able to provide acceptable knee laxity measurements in a clinical setting compared with published precision data for other devices on the market. Therefore, the Telos Stress Device is not recommendable for use in knee laxity measurements following ACL reconstruction.
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Lesiones del Ligamento Cruzado Anterior , Inestabilidad de la Articulación/diagnóstico , Fotogrametría , Procedimientos de Cirugía Plástica/instrumentación , Procedimientos de Cirugía Plástica/métodos , Adulto , Ligamento Cruzado Anterior/cirugía , Fenómenos Biomecánicos , Estudios de Cohortes , Diseño de Equipo , Femenino , Humanos , Traumatismos de la Rodilla/diagnóstico por imagen , Traumatismos de la Rodilla/cirugía , Articulación de la Rodilla/fisiología , Masculino , Valor Predictivo de las Pruebas , Radiografía , Rango del Movimiento Articular/fisiología , Valores de Referencia , Sensibilidad y Especificidad , Estrés Mecánico , Adulto JovenRESUMEN
The hamstring tendon graft has become increasingly popular in anterior cruciate ligament reconstruction because of low donor-site morbidity. However, the tibial fixation is considered difficult, mainly because of low tibial mineral bone density. Therefore, we tested whether preparation of the tibial tunnel with compaction by serial dilation provided a stronger anchorage of the graft-fixation-device complex than does traditional extraction drilling of the tibial tunnel. In 20 bovine tibiae, the bone tunnels were created with either extraction drilling (group 1) or compaction by serial dilation (group 2). Twenty bovine digital extensor tendons were fixated in the bone tunnel with an Intrafix tibial fastener. The graft-fixation-device complexes were mounted in a hydraulic test machine. The fixation strength was evaluated after cyclic loading. The difference between the serial dilation group and the extraction drilling group ranged from a mean slippage of 0 mm at 70-220 N, to a mean slippage of 0.1 mm at 70-520 N. We found no significant difference in slippage of the graft-fixation-device complex after 1,600 cycles. This study failed to show a significant difference between compaction by serial dilation and extraction drilling of the tibia bone tunnel in anterior cruciate ligament reconstruction.
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Lesiones del Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/cirugía , Plastía con Hueso-Tendón Rotuliano-Hueso/métodos , Animales , Ligamento Cruzado Anterior/fisiopatología , Fenómenos Biomecánicos , BovinosRESUMEN
REASONS FOR PERFORMING STUDY: There is limited knowledge available of factors influencing response to treatments of the DIP-joint in horses with lameness responding to diagnostic analgesia of the DIP-joint. For this reason a multivariable statistical analysis was performed. HYPOTHESIS: Horses with lameness reduced by > or = 75% 10 min after intra-articular analgesia of the DIP-joint, can be treated successfully by intra-articular medication of the joint. Multiple factors influence the response to treatment. METHODS: The study was performed retrospectively based on clinical records of horses treated with either polysulphated glycosaminoglycan (PSGAG) or methylprednisolone acetate (MPA) in the DIP-joint between January 1996 and January 2003. Information was collected from clinical records and from the owners of the horses via a detailed questionnaire, in which they described their perception of the outcome a minimum of one year after treatment. Allocation of the horses to the 2 treatment groups was done mainly because of a change in treatment policy. In Regime A all horses received 3 intra-articular injections of PSGAG approximately 8 days apart, whereas in Regime B all horses received a single intra-articular injection of MPA as a first treatment. If the horse did not improve sufficiently to return to work by 4 weeks, a series of 3 intra-articular PSGAG injections was administered. RESULTS: Of the horses receiving Regime A, 67% had a successful outcome, compared with 46% of the group receiving Regime B. A significantly better result was obtained in dressage horses than in jumping horses (eventing and showjumping). Other variables such as age, duration of lameness, distribution of lameness, degree of lameness, response to DIP-joint analgesia and radiographic observations were also associated with success of treatment. CONCLUSIONS AND POTENTIAL RELEVANCE: There is a rationale for using either PSGAG or MPA intra-articularly in the treatment of lameness, reduced > or = 75% within 10 min of analgesia of the DIP-joint.
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Analgesia/veterinaria , Enfermedades del Pie/veterinaria , Enfermedades de los Caballos/tratamiento farmacológico , Inyecciones Intraarticulares/veterinaria , Articulación del Dedo del Pie , Analgesia/métodos , Anestesia Local/métodos , Anestesia Local/veterinaria , Animales , Antiinflamatorios/uso terapéutico , Femenino , Enfermedades del Pie/tratamiento farmacológico , Enfermedades del Pie/prevención & control , Glicosaminoglicanos/uso terapéutico , Enfermedades de los Caballos/prevención & control , Caballos , Artropatías/tratamiento farmacológico , Artropatías/prevención & control , Artropatías/veterinaria , Cojera Animal/tratamiento farmacológico , Cojera Animal/prevención & control , Masculino , Metilprednisolona/análogos & derivados , Metilprednisolona/uso terapéutico , Acetato de Metilprednisolona , Análisis Multivariante , Dolor/prevención & control , Dolor/veterinaria , Estudios Retrospectivos , Factores de Tiempo , Articulación del Dedo del Pie/efectos de los fármacos , Articulación del Dedo del Pie/patología , Resultado del TratamientoRESUMEN
Change of the hip joint centre location during preparation of the acetabular cavity for the acetabular component can affect the outcome of total hip arthroplasty. Deviations from the preoperative geometry can compromise an otherwise successful operation with regard to hip dislocations, leg length inequality and range of motion of the hip joint. Eighteen acetabula from pelvic specimens were measured before and after acetabular reaming to determine the change of hip centre location. Two different acetabular reamers were applied to the acetabular cavity: a chamfered reamer intended for minimal invasive hip surgery (MIS) and a conventional hemispherical reamer. An optical 3D scanning system created 3D models of the cavities prior to and after the reaming procedure. The two 3D models were merged into a single 3D model and displacements in all three dimensions were calculated The results showed no significant difference between MIS and conventional reaming with regard to transition vector length (p=0.9). The mean length of the transition vector was 3.6 mm (SD. 2.4 mm). Our findings suggest that the alteration of the hip centre location is not influenced by the changes made to the MIS reamers in comparison with conventional reamers. In comparison with previous studies the drift of the hip centre caused by the acetabular reaming is reduced due to new reaming techniques and prosthesis designs.
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Bone on-growth and peri-implant migration of polyethylene particles were studied in an experimental setting using trabecular metal and solid metal implants. Cylindrical implants of trabecular tantalum metal and solid titanium alloy implants with a glass bead blasted surface were inserted either in an exact surgical fit or with a peri-implant gap into a canine knee joint. We used a randomised paired design. Polyethylene particles were injected into the knee joint. In both types of surgical fit we found that the trabecular metal implants had superior bone ongrowth in comparison with solid metal implants (exact fit: 23% vs. 7% [p=0.02], peri-implant gap: 13% vs. 0% [p=0.02]. The number of peri-implant polyethylene particles was significantly reduced around the trabecular metal implants with a peri-implant gap compared with solid implants.
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Migración de Cuerpo Extraño , Prótesis de la Rodilla/efectos adversos , Polietileno/efectos adversos , Cicatrización de Heridas/fisiología , Aluminio , Animales , Materiales Biocompatibles Revestidos , Perros , Tamaño de la Partícula , Falla de Prótesis , Distribución Aleatoria , Estadísticas no Paramétricas , Propiedades de Superficie , Tantalio , TitanioRESUMEN
The aim of this study was to evaluate the identification of polyethylene (PE) particles in relatively thick methylmethacrylate (MMA) sections widely used in bone implant research. The sensitivity and specificity were compared between decalcified paraffin-embedded oil red O (ORO) stained and MMA-embedded sections using polarized light. Furthermore, we introduced a grading system to semiquantify the level of PE particles in peri-implant tissue. Paraffin-embedded and MMA-embedded sections were compared concerning intra-observer agreement of the grading system. Moreover, the semiquantitative assessment of particle level was compared between the two section types. We found a sensitivity and specificity of polarized light of 100% for both paraffin ORO-stained and MMA sections. The intra-observer agreement on both types was comparable and acceptable. The ratings of differently processed blocks (MMA- and paraffin-embedded) originating from the same bone implant specimen showed good correlation. Our study showed that relatively thick MMA sections were just as suitable as ORO-stained paraffin sections concerning peri-implant PE particle migration analysis. MMA sections do not allow analysis at cellular level, but unbiased estimation of bone ingrowth into the implant surface based on stereological principles is possible.
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Metilmetacrilato , Microscopía de Polarización/métodos , Adhesión en Parafina , Polietileno/análisis , Prótesis e Implantes , Animales , Compuestos Azo , Huesos , Perros , Prótesis Articulares , Sensibilidad y EspecificidadRESUMEN
The influence of wear debris on bone healing around orthopedic implants is debated. Hydroxyapatite (HA) particles and polyethylene (PE) particles have been shown to have a negative effect on osteoblast cultures in vitro. The present study investigated the in vivo effects of HA and PE particles on the mechanical fixation and gap healing around experimental HA implants. Nonloaded implants (n = 30) were inserted bilaterally into the proximal tibia of 15 dogs with a 2-mm gap to the bone. The peri-implant gap was either (1) empty (n = 6) or filled with (2) hyaluronic acid (n = 8), (3) hyaluronic acid and HA particles (n = 8), or (4) hyaluronic acid and PE particles (n = 8). After 4 weeks, the animals were killed. The implant interface was evaluated by pushout testing until failure and by histomorphometry. Both HA and PE particles were found to be phagocytosed by macrophage-like cells in the interfacial tissue. HA particles were also integrated in newly formed bone. We found no negative effect of the particulate material on mechanical fixation of the implants or on bone formation around the implants.
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Materiales Biocompatibles/farmacología , Durapatita/farmacología , Fagocitosis/efectos de los fármacos , Prótesis e Implantes , Análisis de Varianza , Animales , Regeneración Ósea/efectos de los fármacos , Regeneración Ósea/fisiología , Perros , Ácido Hialurónico/metabolismo , Microscopía Electrónica de Rastreo , Polietileno/metabolismoRESUMEN
We used an experimental model producing a tissue response with a sclerotic endosteal neo-cortical rim associated with implant loosening in humans: a 6 mm PMMA cylinder pistoned 500 m concentrically in a 7.5 mm hole, with polyethylene particles. At a second operation at eight weeks, the standard revision procedure removed the fibrous membrane in one knee, and the crack revision procedure was used to crack the sclerotic endosteal rim in the contralateral knee. Once stability was achieved following the revision procedures, loaded Ti plasma sprayed implants were inserted into the revision cavities of 8 dogs for an additional 4 weeks. Revision implant fixation (ultimate shear strength and energy absorption) was significantly enhanced by cracking the sclerotic endosteal rim. In conclusion, we demonstrated a simple technique of cracking the sclerotic endosteal rim as an additional method for improving revision fixation. (Hip International 2002; 2: 77-9).
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A sagittal fracture of the medial aspect of the patella was identified in 15 horses, 2 of which had been kicked and 12 of which had hit a fixed fence while jumping. Eight horses showed concurrent fragmentation of the base of the patella, and 2 had sustained a concurrent fracture of the distal end of the lateral trochlear ridge of the femur. A cranioproximal-craniodistal oblique radiographic view was essential to identify the site of the medial patellar fracture and to determine its configuration. Fourteen horses were treated by surgical removal of the medial patellar fracture fragment(s). Of 12 horses (83%) without evidence of pre-existing degenerative joint disease, 10 were treated successfully with return to full athletic function.
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Fracturas Óseas/veterinaria , Caballos/lesiones , Rótula/lesiones , Animales , Fracturas del Fémur/complicaciones , Fracturas del Fémur/veterinaria , Estudios de Seguimiento , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/cirugía , Cojera Animal/etiología , Rótula/cirugía , Complicaciones Posoperatorias/veterinaria , Radiografía , Resultado del TratamientoRESUMEN
The incorporation of autogenous cancellous bone graft was studied in eight yearling ponies. The site for the defect to be grafted was chosen so that the effect on the graft, of both the host cortical and trabecular bone, could be assessed. To obtain information concerning the vitality of the graft and the dynamic aspects of the modelling and remodelling processes of graft incorporation, a double and treble tetracycline intravital labelling technique was used. Radiographs of the graft and host tissues of all ponies were obtained regularly, but were of little assistance in assessing graft incorporation. The ponies were destroyed humanely at regular intervals between nine and 241 days after installation of the graft, followed by histological examination of undecalcified sections. The study revealed that all installed graft trabeculae showed signs of non-vitality at nine days after installation and gradually disintegrated. Two processes of new bone formation were observed. First, finger-like projections of immature new trabeculae were found to originate from the graft/host interfaces. Second, a gradual process of accretion of osteoid and woven bone upon disintegrating graft trabeculae occurred uniformly throughout the graft. The graft adapted to the structure of opposing host bone by corticalisation and trabecularisation. The present study confirmed clinical observations relating to convalescence time following grafting of large osseous defects in horses and indicated that equine bone reacts to autogenous bone grafts in a similar manner to other mammals.
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Trasplante Óseo , Caballos/cirugía , Metacarpo/cirugía , Animales , Huesos/anatomía & histología , Trasplante AutólogoRESUMEN
The quantitative aspects of equine cancellous bone graft incorporation and the possibility of influencing graft incorporation by daily exposure to a pulsed electromagnetic field (PEMF) was studied in eight yearling ponies. In order to be able to quantify formative aspects of graft remodelling, a double and treble tetracycline intravital labelling technique was used. Intravital radiographs were obtained at regular intervals throughout the trial, but were found to be of little assistance in assessing any differences between stimulated and non-stimulated grafts. The ponies were humanely destroyed at regular intervals between nine and 241 days after installation of the graft. Light microscopy and fluorescent light microscopy were used to evaluate quantitative aspects of graft incorporation and to compare PEMF-stimulated grafts with control grafts. There was a small but statistically significant effect of PEMF-stimulation on cancellous bone graft incorporation. In view of this, these observations can only be considered as indicative of a possible trend, but should encourage further studies using different signal modalities.
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Trasplante Óseo , Campos Electromagnéticos , Fenómenos Electromagnéticos , Extremidades/cirugía , Caballos/cirugía , Animales , Huesos/anatomía & histología , Huesos/efectos de la radiación , Extremidades/efectos de la radiación , Radiación no IonizanteRESUMEN
Four full thickness cartilage defects, two linear and two elliptical, and four subchondral cavity defects were created at the point of weightbearing of the medial femoral condyle in four experimental ponies. This study showed that subchondral bone cysts can develop following full thickness (cartilage only) linear cartilage defects at a weightbearing location. Subchondral bone cysts did not develop following the removal of an elliptical piece of cartilage, exposing the subchondral bone. Primary subchondral defects created in communication with the joint cavity did not heal by replacement with bone over a six-month period. Fibrous and cartilaginous repair occurred which appeared to be unrelated to the size or depth of the subchondral defect. Irrespective of the size of the defects, the surrounding bone showed marked woven bone formation with remodelling of existing and newly formed bone. The resulting osteosclerosis indicated a positive balance and a natural limitation of cavity expansion. The positive balance affected only the surrounding bone and did not lead to re-establishment of the bone within the cavity during the period studied.
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Quistes Óseos/veterinaria , Desarrollo Óseo , Cartílago Articular/fisiopatología , Enfermedades de los Caballos/fisiopatología , Cicatrización de Heridas , Animales , Quistes Óseos/fisiopatología , Caballos , MasculinoAsunto(s)
Cementos para Huesos/uso terapéutico , Enfermedades Óseas/veterinaria , Enfermedades de los Caballos/terapia , Ortopedia/métodos , Absceso/cirugía , Absceso/terapia , Absceso/veterinaria , Animales , Quistes Óseos/cirugía , Quistes Óseos/terapia , Quistes Óseos/veterinaria , Enfermedades Óseas/cirugía , Enfermedades Óseas/terapia , Femenino , Fémur , Miembro Posterior , Enfermedades de los Caballos/cirugía , Caballos , Cojera Animal/cirugía , Cojera Animal/terapia , Tarso AnimalRESUMEN
The results of surgical treatment of 10 subchondral bone cysts, all located in the medial femoral condyle, are presented. A cancellous bone graft was used in nine cases and a two component acrylic bone cement was used in the case of an extremely large cyst. Eight out of the 10 cases made a satisfactory clinical recovery.
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Quistes Óseos/veterinaria , Trasplante Óseo , Fémur/cirugía , Enfermedades de los Caballos/cirugía , Cojera Animal/cirugía , Animales , Cementos para Huesos , Quistes Óseos/complicaciones , Quistes Óseos/diagnóstico por imagen , Quistes Óseos/cirugía , Femenino , Enfermedades de los Caballos/diagnóstico por imagen , Caballos , Cojera Animal/diagnóstico por imagen , Cojera Animal/etiología , Masculino , RadiografíaRESUMEN
The gross and histological appearance of subchondral bone cysts in six Thoroughbred or partbred horses is described. The lesions were all situated in the centre of the medial femoral condyle and were not associated with any other damage to the articular surface of the femorotibial or femoropatellar joints. In three cases the cysts were unilateral but had an early non-cystic lesion present in the opposite stifle. All the cysts had a narrow channel at their distal extremity which communicated with the femorotibial joint. The more recently developed ones were fluid filled and contained fibrous strands, while those in the older horses contained dense fibrotic detritus. No signs of significant ossification of the cysts were detected. The likely pathogenesis of these lesions is discussed in the light of the pathological findings.