Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
1.
Infect Genet Evol ; 43: 245-51, 2016 09.
Artículo en Inglés | MEDLINE | ID: mdl-27223631

RESUMEN

Paracoccidioidomycosis (PCM) is a systemic chronic mycosis, endemic in Latin America, especially Brazil, and is the eighth leading cause of death among chronic and recurrent infectious diseases. PCM infection is characterized by the presence of Th1 immune response; the acute form, by a mixed Th2/Th9, while the chronic form is characterized by Th17/Th22 profiles. The occurrence and severity of human PCM may also be associated with genetic factors such as single nucleotide polymorphisms (SNP) on cytokines encoding genes. We investigated the association between these polymorphisms and the different clinical forms of PCM. We included 156 patients with PCM (40 with the acute form, 99 with the chronic multifocal and 17 with the chronic unifocal form) and assayed their DNA samples for IFNG +874 T/A SNP by PCR-ARMS (Amplification Refractory Mutational System), IL12B +1188 A/C SNP on 3' UTR and IL12RB1 641 A/G SNP on exon 7 by PCR-RFLP (Restriction Fragment Length Polymorphism). We found similar genotypic and allelic frequencies of the investigated SNPs among the clinical forms of PCM. Considering male patients, the IL12RB1 641 AA genotype was more frequent in the chronic multifocal form while heterozygosis was in the chronic unifocal form of PCM (p=0.048). Although our data suggest that the AA genotype (IL12RB1) may be associated with the more disseminated chronic disease, more patients of the chronic unifocal PCM group need to be analyzed as well as the secretion patterns of IFN-γ combined with the IL-12Rß1 expression for a better comprehension of this association.


Asunto(s)
Interacciones Huésped-Patógeno , Interferón gamma/genética , Subunidad p40 de la Interleucina-12/genética , Paracoccidioidomicosis/genética , Polimorfismo de Nucleótido Simple , Receptores de Interleucina-12/genética , Regiones no Traducidas 3' , Enfermedad Aguda , Adolescente , Adulto , Anciano , Alelos , Brasil , Niño , Enfermedad Crónica , Femenino , Expresión Génica , Frecuencia de los Genes , Genotipo , Humanos , Interferón gamma/inmunología , Subunidad p40 de la Interleucina-12/inmunología , Masculino , Persona de Mediana Edad , Paracoccidioides/crecimiento & desarrollo , Paracoccidioidomicosis/inmunología , Paracoccidioidomicosis/microbiología , Paracoccidioidomicosis/patología , Polimorfismo de Longitud del Fragmento de Restricción , Receptores de Interleucina-12/inmunología , Factores Sexuales
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA