A JPEG variable quantization method for compound documents.

In this paper, we present a JPEC-compliant method for the efficient compression of compound documents using variable quantization. Based on the DCT activity of each 8 x 8 block, our scheme automatically adjusts the quantization scaling factors so that test blocks are compressed at higher quality than image blocks. Results from three different quantization mappings are also reported.

Image sharpening in the JPEG domain.

We present a new technique for sharpening compressed images in the discrete-cosine-transform domain. For images compressed using the JPEG standard, image sharpening is achieved by suitably scaling each element of the encoding quantization table to enhance the high-frequency characteristics of the image. The modified version of the encoding table is then transmitted in lieu of the original. Experimental results with scanned images show improved text and image quality with no additional computation cost and without affecting compressibility.

Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide.

Integrins are cell-surface glycoproteins found in different forms on all cells except erythrocytes. Integrins bind to cell adhesion molecules and to proteins found in the extracellular matrix. A tripeptidic sequence Arg-Gly-Asp (RGD) is often the primary site of recognition by integrins which are expressed on tumour cells and are responsible for tumour invasion and metastasis. A synthetic decapeptide designated alpha P2 containing two RGD sequences radiolabelled with technetium-99m was used to image malignant melanoma in vivo. Fourteen patients previously diagnosed with metastatic melanoma underwent gamma camera imaging 20-180 min following intravenous administration of the radiolabelled synthetic decapeptide alpha P2. Six out of eight (6/8) of the lymph node metastases (75%) and all other neoplastic sites (11 sites) were successfully imaged, with the exception of three sites in the mediastinal area which were not positively imaged. In two cases there was false positive uptake in the rounded pigmented areolar/nipple area. In three cases (seven sites) the peptide scan confirmed the absence of disease in suspected lesions (true-negative). The synthetic peptide was rapidly removed from the circulation by filtration through the kidneys and excretion in the urine. No toxicity or adverse events were recorded. Radiolabelled alpha P2 peptide, which binds specifically to adhesion molecules on tumours, can be used for the in vivo detection of neoplastic metastases.

Noise estimation and filtering using block-based singular value decomposition.

Preprocessing of image and video sequences with spatial filtering techniques usually improves the image quality and compressibility. We present a block-based, nonlinear filtering algorithm based on singular value decomposition and compression-based filtering. Experiments show that the proposed filter preserves edge details and can significantly improve the compression performance.

Breast cancer imaging with radiolabelled peptide from complementarity-determining region of antitumour antibody.

Specific tumour imaging with radiolabelled monoclonal antibodies has been extensively investigated. Although some success has been reported, there are many limitations due to the slow kinetics, poor extravasation, catabolism by the reticuloendothelial system, and non-specific uptake of macromolecules such as antibodies. We have tried to overcome some of the problems associated with monoclonal antibodies while retaining their specificity by using an antibody-derived synthetic peptide. A synthetic pentadecapeptide (alpha M2) derived from the third heavy-chain complementarity-determining region (CDR-3H) of a tumour-associated monoclonal antibody was produced and shown to retain its specificity against the pan-carcinoma cell-surface antigen, polymorphic epithelial mucin, detected by the parent antibody. The peptide was radiolabelled with technetium-99m and injected intravenously to image malignant lesions in 26 women with primary, recurrent, or metastatic breast cancer. Visualisation of breast tumours and their metastases was obtained shortly after administration of alpha M2, and was optimum by 3 h. Overall, 57 (77%) of 74 sites were visualised. Successful imaging was achieved in 14 of 15 primary tumour sites and all of eight local recurrences. Five of six metastases in the opposite breast, eight of 15 metastatic axillary lymph nodes, and all of six metastatic supraclavicular lymph nodes were imaged. Metastatic sites in the lungs, mediastinum, chest wall, and liver were poorly visualised because of background cardiac blood pool. alpha M2 detected small lesions ( < 2 cm) as efficiently as larger ones. The peptide was rapidly (3 h) cleared from the circulation. No acute or chronic adverse reactions due to the alpha M2 were observed. Specific tumour targeting with the radiolabelled anticancer peptide alpha M2 offers new opportunities for breast cancer imaging and possibly therapy.

The Khoros software development environment for image and signal processing.

Data flow visual language systems allow users to graphically create a block diagram of their applications and interactively control input, output, and system variables. Khoros is an integrated software development environment for information processing and visualization. It is particularly attractive for image processing because of its rich collection of tools for image and digital signal processing. This paper presents a general overview of Khoros with emphasis on its image processing and DSP tools. Various examples are presented and the future direction of Khoros is discussed.

Beam transformation techinques for ultrasonic medical imaging.

Data acquisition rates in pulsed ultrasound scanners are limited by the speed of sound in the human body. This poses severe limitations to the design of future ultrasound equipment, such as 3-D imaging scanners. The authors describe a technique for higher data acquisition rates based on the simultaneous transmission of multiple beams. By using a linear combination of the received beams, interbeam interference due to the sidelobe energy of the transmitting beams can be significantly reduced. The transformation coefficients are found by using a least squares minimization criterion. A simulation environment used for the evaluation of the authors' methodologies and various simulation results are presented.