[Professional risk assessment for modern pesticides during their application in the horticulture].

The work conditions on application of modern pesticides Masai, Regalis and Bellis for apple orchards protection have been researched. We show that total risk of hazard influence of tebufenpyrad, prohexadione-calcium, pyraclostrobin and boscalid on agricultural workers under condition of complex entry in body through skin and respiratory tracts is permissible. We proved that application of studied preparations is not dangerous for workers in case of abidance of agrotechnical and hygienic regulations.

[An experimental study of the mechanism of the combined action on the body of ionizing radiation, pesticides, nitrates and lead and cadmium salts]. / Eksperymental'ne vyvchennia mekhanizmu kombinovanoï diï na orhanizm ionizuiuchoho vyprominiuvannia, pestytsydiv, nitrativ, solei svintsiu i kadmiiu.

The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals. Combined action of chemical factors and gamma radiation was found out to make for increasing in lipid peroxidation and involving of ceruloplasmin in the LPO inhibition. Depletion of the antioxidant system in repeated irradiations against the background of chemical loading was accompanied by accumulation of the LPO products. We conclude that in the pathogenesis of the revealed changes in associated effects of ionizing radiation, pesticides, nitrates, Plumbum and Cadmium salts, the LPO activation in the presence of the antioxidant system depletion is most important, in view of which fact the specific criteria for the studied factors combined effects on the organism appear to be the activity of the oxidation-reduction enzymes and the level of the-active products, with the chief preventive measures being directed towards increasing of radioresistance of the organism through correction of the antioxidant deficiency.

[Evaluation of Ricide-P pesticide toxicity using the experimental model mother-fetus-newborn]. / Otsenka toksichnosti pestitsida Ritsid-P s pomoshchíu éksperimentalnoi modeli mat-plod-novorozhdennyi.

Necessity of the mother-fetus-newborn model usage in toxicological experiments for the xenobiotics environmental content standardization was shown in the toxicological study of Ricid-P pesticide.

[Morphological changes of stomach innervation after vagotomy]. / Morfologicheskie izmeneniia innervatsionnogo apparata zheludka posle vagotomii.

The morphologic signs of response of the peripheric neural system of the stomach to vagotomy in animals and in patients with the ulcer disease were compared. The innervative apparatus of the stomach was studied in 4 intact dogs (control), 6 animals who underwent selective proximal vagotomy (SPV) and in 13 patients with the ulcer disease reoperated after SPV performance in connection with the development of a recurrent ulcer. Compensatory possibilities of the innervative apparatus of the stomach in human are lower than those in animals.

[Role of soil air in the development of acute pesticide poisoning in agricultural workers]. / O roli pochvennogo vozdukha v vozniknovenii ostrykh otravlenii sel'skokhoziaistvennykh rabochikh pestitsidami.

The mechanism of the high concentrations of pesticides in overground air is described. Equivocation and computer program for the pesticides concentration to calculations are worked out.

[Assessment of the toxic effects of a combination of chemicals contained in the soil]. / Otsenka stepeni toksicheskogo vozdeistviia kombinatsii khimicheskikh veshchestv, soderzhashchikhsia v pochve.

A technique of the assessment of toxic effect of a combination of chemicals in soil on the organism of mammals has been developed. It is based on the investigation of the damaging effect of components of the combination when they get into the organism through the soil-contiguous media on the level of summary 24-hour doses, as well as when their residues get into the organism with food, water, air and through the skin. A method calculating the threshold dose of each component of the combination in soil according to the toxicological harm index is suggested.