RESUMEN
We investigated 3 agents with antiserotoninergic activity (oral trazodone, ketanserin and mianserin) in a double-blind randomized placebo controlled design in terms of the effectiveness in erectile dysfunction. Positive response rates to 30 days of treatment were 65.2% with trazodone, 19.1% with ketanserin, 31.6% with mianserin and 13.6% with placebo. Response to trazodone treatment was significantly better than with placebo (p = 0.0004) and the other 2 agents (p = 0.03 and p = 0.002 for mianserin and ketanserin, respectively). The effectiveness of ketanserin and mianserin seemed to be greater than that of placebo but the differences did not reach statistical significance (p = 0.63 and p = 0.17, respectively).
Asunto(s)
Disfunción Eréctil/tratamiento farmacológico , Ketanserina/uso terapéutico , Mianserina/uso terapéutico , Trazodona/uso terapéutico , Adulto , Anciano , Método Doble Ciego , Humanos , Masculino , Persona de Mediana EdadAsunto(s)
Leiomiosarcoma/patología , Neoplasias de la Próstata/patología , Preescolar , Humanos , MasculinoRESUMEN
In an experimental study on 36 male guinea pigs testicular torsion was induced in 10, epididymitis in 10, surgical trauma in 6 and only ether anaesthesia was given to 10 animals. Serum creatine phosphokinase (CPK) levels at 0, 4, 8, 20, 28 and 40 hours were determined in each group. Serum CPK levels were found to rise significantly in the torsion group. Determination of serum CPK levels may be an auxiliary alternative in the diagnosis of testicular torsion.
