[Preliminary assessment of felbamate effect on the cerebral bioelectrical activity in children with refractory epilepsy]. / Wstepna ocena wplywu preparatu Felbamate na czynnosc bioelektryczna mózgu u dzieci z padaczka oporna na leczenie.

Influence Felbamate on the cerebral bioelectric activity (EEG) in the group of 31 children (18 with syndrome Lennox-Gastaut, 13 with partial epilepsy) with refractory epilepsy was investigated. In the waking EEG was visually analysed: 1. Abnormalities distribution and morphology with special consideration of slow waves, sharp elements and paroxysmal character of discharges. 2. Influence of Felbamate on the duration time of discharges. 3. Range dominant frequency and length of segments (with non-disturbed topographic differentiation) of background activity EEG. During therapy the results showed more often EEG improvement among children with syndrome Lennox-Gastaut (near 70%) than in children with partial refractory epilepsy (near 30%). The EEG results correlated positively with the clinical improvement. In the both group of epilepsy background activity improvement had a statistical significance. In sleep EEG any influence of Felbamate on the sleep spindles was observed. No observation about increase beta activity in waking and sleep EEG records was noted.

Comparative investigations of in vitro and in vivo scalding of mouse skin.

Mouse skin was scalded in vitro by the wet (immersion) method and dry (metal stamp) method. For in vivo scalding only the dry method was used. The content of dry mass of skin was investigated. In extracts of scalded skin the content of soluble components: protein, collagen, albumin and IgG was determined. The analyses and statistic estimation revealed that with respect to the observed effects the in vivo scalding of skin is similar to the ion vitro dry scalding but different from the in vitro wet method. Moreover, it is suggested that protein substances which are products of thermic denaturation of skin can penetrate from scalded skin into the surrounding tissues.