RESUMEN
OBJECTIVES: This study aims to investigate the effect of teicoplanin on fracture healing stereologically and histopatologically. MATERIALS AND METHODS: Twenty male Wistar albino rats were separated into two as the study (teicoplanin) and control groups. After intramedullary fixation of the right tibia of all the rats with 0.5 mm Kirschner wire under general anesthesia, standard closed shaft fractures were created using fracture formation apparatus. Teicoplanin (10 mg/kg) and saline were administered intraperitoneally to the study and control groups, respectively. Control radiographs were taken at the end of the procedure and the rats were sacrificed after 28 days. New bone and connective tissue volumes were calculated on obtained tissue samples using unbiased stereological and histopathological techniques. RESULTS: It was observed that teicoplanin increased the formation of bone, vascularization, and connective tissue. There was a statistically significant difference between the two groups in respect of bone and vascular total volume (p<0.05). Although an increase was observed in connective tissue total volume, no statistically significant difference was detected between the two groups (p>0.05). CONCLUSION: In addition to its antibacterial effect, teicoplanin may increase new bone formation; thus, it may be used safely in the treatment of bone defects accompanied with infection.
Asunto(s)
Fijación Intramedular de Fracturas/métodos , Curación de Fractura/efectos de los fármacos , Fracturas Cerradas/tratamiento farmacológico , Teicoplanina/farmacología , Animales , Antibacterianos/farmacología , Regeneración Ósea/efectos de los fármacos , Fracturas Cerradas/patología , Fracturas Cerradas/fisiopatología , Fracturas Cerradas/cirugía , Masculino , Radiografía , Ratas , Ratas Wistar , Tibia/diagnóstico por imagen , Tibia/patología , Resultado del TratamientoRESUMEN
CASE: A thirty-one-year-old woman was diagnosed with a minimally displaced medial femoral condyle (Hoffa) fracture. Reduction and retrograde percutaneous screw fixation were performed under arthroscopic visualization. At three months postoperatively, she was able to walk without support, had no pain, and had full range of movement of the knee. CONCLUSION: In Hoffa fractures, arthroscopy-assisted fixation is an option for treatment. It is advantageous because it allows the ability to evaluate other intra-articular structures, decreases blood loss, shortens surgical time, decreases soft-tissue dissection, and facilitates a shorter postoperative rehabilitation period.