[Clinical anatomy of the Bernasconi-Cassinari artery]. / Klinicheskaya anatomiya arterii Bernaskoni­Kassinari.

The article provides a comprehensive overview of the Bernasconi-Cassinari's artery (marginal tentorial branch of internal carotid artery, r. marginalis tentorii a. carotis internae). It includes information on the history of its discovery, anatomical features, and topography. The interrelation between the anatomical features of this artery and the presence of neurological pathology in patients is discussed, along with neurosurgical treatment methodologies.

Silatrane-Sulfonamide Hybrids as Promising Antibacterial Agents.

At the A. E. Favorsky Irkutsk Institute of Chemistry, a series of silatrane-sulfonamide hybrids 1a-d and 2a-d was synthesized. The antibacterial activity of 1a, 1b, 1d, 2a, and 2b against test strains of bacteria Yersinia pestis EV NIIEG, Yersinia enterocolitica 628/1, Listeria monocytogenes 766, and Starhylococcus aureus ATCC 6538-P (FDA 209-Р) was evaluated. The minimum inhibitory concentration for silatrane-sulfonamide hybrids was 100-200 mg/liter. Silatrane-sulfonamide hybrid 1d was the most active against all tested strains: minimum inhibitory concentration 100 mg/liter. Exposure to silatrane-sulfonamide hybrids in a doses of 100-200 mg/liter inhibited culture growth by 50-75%.

The Influence of Comorbid Endemic Goiter on the Quality of Life of Patients with Gastrointestinal Pathology.

The impairment of adaptive mechanisms of functional systems of the body plays an important role in the occurrence of gastrointestinal diseases. This impairment is caused by unfavorable ecological and radiation conditions, external stress factors, food containing carcinogens, macro - and microelements deficiency. Technogenic environmental pollution contributes to decrease in the level of iodine in the body and more severe course of thyroid pathology. Diseases of the digestive and endocrine systems and their combination will occupy one of the leading places among the existing pathologies according to the forecasts of WHO experts in the XXI century. Adaptation of the body to various environmental influences is the most important factor in the quality of life. The relevance of the study was determined by the high incidence of psychological disadaptation, borderline personality disorders and, as a consequence, decrease in the quality of life in patients with gastrointestinal pathology and hypothyroidism. The article presents the results of comparative analysis of the quality of life indications of patients with gastric ulcer and / or gastroesophageal reflux disease in combination with hypothyroidism. The Russian-language analogue of the international questionnaire SF36 was used to analyze the indicatoions of patients' quality of life. The results of the study will allow to formulate the diagnosis exactly and organize adequate, comprehensive multidisciplinary treatment.

[Intelligent distributed system of population cancer screening].

This review summarizes data dedicated to improving the efficiency of screening of malignant tumors through the use of modern information and telecommunication technologies. It is showed that currently available software solutions in the field of medical imaging is not enough adapted for population screening. So far there is no single standard that defines checking algorithms of data processing at certain controlled conditions. The most expected result will be the organization of information centralized storage, sharing diagnostic data, providing broad access to them, automated analysis and selection of diagnostically significant results through the software. The basic requirements for the development of self-learning systems for intelligent processing array of heterogeneous data through the use of technologies of semantic networks are provided.

[Automated identification, interpretation and classification of focal changes in the lungs on the images obtained at computed tomography for lung cancer screening].

This review article analyzes data of literature devoted to the description, interpretation and classification of focal (nodal) changes in the lungs detected by computed tomography of the chest cavity. There are discussed possible criteria for determining the most likely of their character--primary and metastatic tumor processes, inflammation, scarring, and autoimmune changes, tuberculosis and others. Identification of the most characteristic, reliable and statistically significant evidences of a variety of pathological processes in the lungs including the use of modern computer-aided detection and diagnosis of sites will optimize the diagnostic measures and ensure processing of a large volume of medical data in a short time.

[Current principles in the chemoprophylaxis of acute respiratory viral infections].

AIM: To evaluate the preventive efficacy of the Russian antiviral drug ingavirin (vitaglutam) in the epidemiological foci with the peak incidence of acute respiratory viral infections (ARVI). SUBJECTS AND METHODS: Four hundred men and women aged 18 to 65 years from the epidemic foci of ARVI who had been in close daily contact with the patients whose diagnosis was verified by laboratory tests were examined. Two hundred persons received prophylaxis with ingavirin (a 90-mg oral capsule once daily for 7 days) and 200 took placebo according to the same scheme. The efficiency index and coefficient were calculated and the relative risk of the disease was estimated to evaluate the efficiency of ARVI prevention. A pharmacoeconomic analysis was made. RESULTS: There is evidence that the administration of 90-mg ingavirin capsules (OAO "Valenta Farm", Russia) caused a reduction in morbidity rates among those who had been in contact by 63% and in the risk of ARVI by 2.7 times. There was a reduction in the duration of fever by one day and a milder course of respiratory disease in the ingavirin-treated contact persons who developed ARVI. CONCLUSION: Ingavirin meets all requirements for current drugs for the nonspecific prevention of ARVI at the peak of its incidence. It has a pronounced protective effect and broad-spectrum activity, low toxicity and high safety, which allows it to be recommended for the emergency intrafocal prevention at the peak of the incidence of influenza and ARVI in adults.

[Distance methods of cardiologic monitoring in diagnostics of high loading effects on organism of sportsman and cosmonaut].

Increase of cardiovascular tension is a common thing for professional athletic training. Cardiovascular pathologies can be prevented by permanent physiological monitoring using, among others, the methods of cardiologic monitoring so far available in stationary diagnostic centers. On-line remote diagnostics during training is potent to enhance effectiveness and efficiency of sporting people's health management. In addition, RD will also enable extensive investigations of the bodily responses of individually determined training loads. The paper gives an overview of the current RM technologies.

[Hemodynamic indices of children's cardio-vascular system with due regard for their constitutional differences].

The paper presents the study of adaptation of cardio-vascular system of children from 5 to 7 to heightened physical activity with due regard for somatic peculiarities of human organism. A careful account is given to reographic and cyclo-ergometic methods of research under the physical load of heightened power capacities 1 and 1.5 watt per 1 kg body weight. The dosage of physical loads with regard for somatic peculiarities of human organism assists the rise in the standarts of children's functional training. Considerable increase of functional potentialities of children of different somatic types is revealed in the exponents of absolute physical efficiency, transient and systolic amount of blood. Bigger rise of hemodynamic indices have girls in comparison with boys of the same age.

[Pathogenetic implications of lipid spectrum in some infectious diseases].

AIM: To estimate concentrations of blood serum lipids and erythrocytic membranes in the conditions of intoxication syndrome. MATERIAL AND METHODS: Lipids were studied in the serum and erythrocytic membranes of 48 patients with oropharyngeal diphtheria and 67 patients suffering from hemorrhagic fever with renal syndrome (HFRS) in different forms and severity of the disease. RESULTS: Various correlations were found between structural and serum lipids. This is pathogenetically important for characterizing biomembranes and variants of activation of lipid metabolism in conditions of intoxication syndrome in diphtheria and HFRS. CONCLUSION: At the height of diphtheria and HFRS organization of biomembrane phospholipids conformation creates conditions for cell disorganization.

[Vestibulo-ocular reflexes in patients with chronic impairment of cerebral circulation].

Vestibular dysfunction was studied in 95 patients with initial cerebral circulatory insufficiency (CCI) stage I and II. Sinusoidal rotation proved highly effective in staging the disease, as initial CCI responses with vestibular hyperreflexia to sinusoidal rotation with closed eyes. With CCI progression, some patients demonstrated inhibition of vestibular excitability while other patients had enhanced excitability. This shows clinical heterogeneity of CCI stage II. P-waves correlating with marked vestibulocerebellar symptoms and high vestibular excitability evidence for CCI stage II. It is established that severity of impairment of nystagmus suppression with glance fixation on a moving object depends on the disease stage.

[The phospholipid spectrum of erythrocyte membranes in hemorrhagic fever with renal syndrome].

The subjects of the study--patients with severe hemorrhagic fever with renal syndrome--were divided into two groups: those who were on hemodialysis, and those who were not. The study included evaluation of the phospholipid spectrum of erythrocyte membranes in the acute period and during recovery. The results revealed conformational shifts in the structure of the bilipid membrane layer, which were maximal during the acute phase of the disease, as well as less prominent and varied changes in the phospholipid spectrum during recovery. This allows determination of the terms of rehabilitation of the patients and substantiates administration of membrane stabilizers as a part of complex therapy of residual syndrome.

Effect of Buerger's thromboangiitis activity on the outcomes of vascular reconstructions.

Altogether 39 patients suffering from thromboangiitis obliterans were under observation. The vasculitis activity score (VAS) developed by R.A. Luqmain et al. (1994) was used as a criterion for thromboangitis activity. The patients were distributed into 2 groups: the first group included patients in the period of remission and the second, group comprised patients in the period of exacerbation. The patients underwent different types of vascular reconstructions. On examination of hemostasis and hemorheology the second group patients demonstrated potentiation of platelet function, inhibition of antiaggregation activity of the arterial wall, the rise of aggregation activity of red blood cells, and inhibition of blood fibrinolytic activity. The tendency toward hypercoagulation and hyperaggregation revealed in the second group patients led to deterioration of the immediate outcomes of reconstructive operations. Thrombosis of the reconstructed area was recorded in 5 (26.31%) first group patients and in 7 (35%) second group patients. In the first group, the high limb amputation was accomplished in one (5.26%) patient whereas in the second group, amputation was performed in 6 (30%) cases. So, the VAS according to R. A. Luqmain et al. (1994) is a reliable predictor which allows to carry out the screening of patients with Buerger's thromboangiitis for vascular reconstructions. The presence of the clinical signs of vasculitis activity in Buerger's thromboangitis requires preliminary preliminary preparation aimed at the removal of inflammation and correction of hemorheologic and hemostatic disorders.

[Sickle cell anemia (HBSS) in an adult patient from Tanzania]. / Serpovidnaia kletochnaia anemiia (HBSS) u vzroslogo bol'nogo iz Tanzanii.

There is a description of an observation of patient N., aged 29, (a student of Russian University for Peoples' Friendship and a citizen of Tanzania) suffering from sickle-cell anemia--SCA--(HbSS), homozygous type, which was detected at screening of abnormal Hb by electrophoresis on the cellulose acetate strips. The results of clinical-and-biological examinations of the patients are described. The patient had anemia (Hb 98-83 g/L); thrombotic (pain) crises with dark urination were periodically observed. HbS accounted for the bulwark (98%) of Hb, while small fractions of Hb (HbF and HbA2) were within the normal limits. This was a comparatively mild form of the disease; the patient had minor changes in the heart and lungs with other internal bodies being intact. Patient N. received, from childhood, an appropriate therapy including antibiotics, folic acid, analgesics etc. Obviously, this provides for an explanation to that he lived up to 29 years, withstood the acclimatization in Russia and could get education. A comparison of the clinical-and-laboratory indices of patient N. with the data of patients with SCA of other types (HbS-thalassemia, HbSC and HbSK) is presented.

[Prevention of early thrombotic complications after reconstructive operations in occlusions of the aorto-iliac segment]. / Profilaktika rannikh tromboticheskikh oslozhnenii posle rekonstruktivnykh operatsii pri okkliuziiakh aortopodvzdoshnogo segmenta.

108 patients with atherosclerosis of aorto-iliac segment have undergone various reconstructive operations on this segment. Depending on the treatment all the patients were divided in 2 groups (test group--54 patients, control group--54 patients). The patients of the control group received aspirin, rheopolyglucin and trental for correction of hemorheology and hemocoagulation disorders. In patients of the test group at the same time as this treatment, the indirect electrochemical blood oxidation by intravenous infusion of 0.03% sodium hypochlorite was applied. Regional hemodynamics, hemorheology and hemostasis indices were studied in all the patients. It was established that indirect electrochemical blood oxidation permits to significantly improve the hemorheology indices, to diminish thrombophilia phenomenon during the treatment and early postoperative period. It was noted that early thrombotic reocclusion and amputations rates were reduced in the test group.

[Hemoglobinopathies in students at the Russian University of the Friendship of Peoples]. / Gemoglobinopatii u studentov Rossiuskogo universiteta druzhby narodov.

Screening of the university students for hemoglobinopathies detected 153 patients with various hemoglobin abnormalities; 69 with Hb AS, 3 with Hb S-beta-thalassemia, 4 with Hb S-alpha-thalassemia, 3 with hb SC, 1 with Hb SK, 1 with Hb CC, 38 with Hb AC, 1 with Hb A O Arab, 4 with Hb EE, 25 with Hb AE, 1 with Hb AD, 1 with Hb AI, 1 with beta-thalassemia major, and 1 with beta-thalassemia minor. The most grave disease was observed in a child with Hb S-beta-thalassemia and in a youth with beta-thalassemia major. The patterns of Hb SC disease varied. The majority of heterozygote carriers of Hb S, Hb C, Hb E, etc. were healthy. A total of 7000 students were screened by express electrophoresis on cellulose acetate films. more than 400 subjects with abnormal hemoglobins were detected, the most numerous of which were heterozygote carriers of Hb S (Hb AS).

[Reaction of the brain receptor system to the effect of low intensity microwaves]. / Reaktsii retseptornykh sistem mozga na deistvie mikrovoln nizkoi intensivnosti.

We have found that two important brain synaptic receptor systems are very sensitive to the influence of low intensity microwaves. Both the excitatory glutamatergic and the inhibitory GABAergic are affected by microwave exposure. Power densities higher 50 microW/cm2 caused changes in the binding properties of these receptors to agonists. Low frequence modulation of microwaves was essential for these effects. Statistically significant effects on mean value of binding were observed at 16 Hz modulation. Exposure to microwave radiation changes the binding of agonists to glutamate and GABA receptors in different ways. An increase was observed for glutamate and a decrease for GABA. We suppose that the effect of microwaves is related to the stress reactions of the organism.

[Medical technology: the leading trend in the conversion of an enterprise]. / Meditsinskoe priborostroenie--vedushchee napravlenie konversii predpriiatiia.

The Izhevsky motozavod (Aksion Public stock company) is one of the Russia's largest production associations (PA), which manufactures a wide range of products for various purposes, including those for implementation of space programmes. Medical engineering is close to space instrument making as it required special technologies, high quality and reliability for its manufacture. The development and introduction of medical equipment into production of the Izhevsky motozavod PA are under way along several basic lines: electrocardiographic equipment and defibrillators, devices for maternity and child care, ambulances, reanimobiles, etc. The most interesting produce, such as one-channel EK1 TTSSP-01 (for emergency care) and EK1T-04 electrocardiographs, DKI-H-04 defibrillator, Oksipuls-01 pulsoximeter, a DLTB-01 unit for diagnosis and treatment of tubal sterility in females, a KPH-01 unit for neonatal resuscitation, an ambulance, a Nadezhda reanimobile, etc. are briefly described.