RESUMEN
Following an operational research study in Zomba Central Prison, Malawi, in 1996, the National Tuberculosis Control Programme (NTP) and the Prison Medical Services worked together to improve the diagnosis and treatment of tuberculosis (TB) in prisoners. Prisoners are screened for TB on admission and during their prison sentences. A system was established of treating patients, according to NTP guidelines, while in prison and on discharge from prison. Monitoring and evaluation is undertaken using TB officers at district and regional level, and 6-monthly meetings are held with all stakeholders and the central unit to collate data and review prison TB control activities.
Asunto(s)
Política de Salud , Prisiones , Desarrollo de Programa , Práctica de Salud Pública , Tuberculosis Pulmonar/prevención & control , Terapia por Observación Directa , Humanos , Malaui/epidemiología , Prisiones/estadística & datos numéricos , Resultado del Tratamiento , Tuberculosis Pulmonar/diagnóstico , Tuberculosis Pulmonar/epidemiologíaRESUMEN
Forty-four tuberculosis (TB) officers who attended the National TB Seminar were given a multiple choice questionnaire (MCQ), based on information in the TB manual. They were asked to complete the MCQ in their hospitals, using the manual, and return it within 6 weeks to the Central Unit. Thirty-one (70%) officers returned completed MCQs. There was negative marking for incorrect answers. The mean mark was 69%. Twelve (39%) officers scored 80% or higher and four (13%) scored below 50%. MCQ assessments may be a useful way of stimulating TB officers to read TB manuals and other guidelines.
Asunto(s)
Competencia Clínica , Personal de Salud/psicología , Manuales como Asunto , Encuestas y Cuestionarios , Tuberculosis Pulmonar , Humanos , Malaui , Motivación , Guías de Práctica Clínica como Asunto , Lectura , Tuberculosis Pulmonar/diagnóstico , Tuberculosis Pulmonar/terapiaRESUMEN
SETTING: Five districts in Malawi. OBJECTIVE: A new oral anti-tuberculosis treatment regimen with different directly observed treatment (DOT) choices in the initial phase of treatment was introduced for new patients in the five districts. The objectives were to determine 1) the site of DOT during the initial phase of treatment, and 2) the effectiveness of the new regimen. DESIGN: Prospective data collection on all tuberculosis (TB) patients registered in a phased approach between 1 July 1997 and 31 December 1998, including site of DOT option in initial phase of treatment, 2-month and 8-month treatment outcomes, 2-month sputum smear conversion in smear-positive pulmonary tuberculosis (PTB) patients and in-patient hospital bed days. RESULTS: There were 6335 new patients: 2671 (42%) with smear-positive PTB, 2211 (35%) with smear-negative PTB and 1453 (23%) with extra-pulmonary TB. The site of the initial phase of treatment was determined in 5790 patients: 1759 (30%) received DOT from guardians, 1465 (25%) from a health centre, 753 (13%) as out-patients from the hospital TB ward and 1813 (32%) remained in hospital. Eight-month treatment completion was 67% for smear-positive PTB patients, 51% for smear-negative PTB patients and 56% for extra-pulmonary TB patients. Two-month outcomes and 8-month treatment outcomes for all out-patient sites of supervision were satisfactory, except that a higher proportion of smear-positive PTB patients under guardian DOT failed to smear convert at 2 months. Over two-thirds of patients received ambulatory treatment out of hospital during the initial phase. CONCLUSION: The new treatment strategy, tested in five districts, was associated with a reduction in hospital bed days and satisfactory treatment outcomes. The results of these studies were vital in helping the National TB Control Programme make an informed decision about phased expansion of the strategy countrywide.
Asunto(s)
Antituberculosos/uso terapéutico , Tuberculosis Pulmonar/tratamiento farmacológico , Administración Oral , Adulto , Atención Ambulatoria , Antituberculosos/administración & dosificación , Centros Comunitarios de Salud/estadística & datos numéricos , Femenino , Política de Salud , Hospitalización , Humanos , Tiempo de Internación , Malaui , Masculino , Cooperación del Paciente , Población Rural , Resultado del TratamientoRESUMEN
OBJECTIVE: Following the introduction of guidelines for the control of tuberculosis (TB) infection in all hospitals in Malawi, a study was carried out to determine whether the guidelines were being implemented, the time between admission to hospital and the diagnosis of pulmonary TB had been reduced, and the annual case notification rates among health workers had fallen and were comparable to those of primary-school teachers. METHODS: The study involved 40 district and mission hospitals. Staff and patients were interviewed in order to determine whether the guidelines had been adopted. In four hospitals the diagnostic process in patients with smear-positive pulmonary TB was evaluated before and after the introduction of the guidelines, with the aid of case notes and TB registers. In all hospitals the proportion of health workers registered with TB before and after the guidelines were introduced, in 1996 and 1999, respectively, was determined by conducting interviews and consulting staff lists and TB registers. A similar method was used to determine the proportion of primary-school teachers who were registered with TB in 1999. FINDINGS: The guidelines were not uniformly implemented. Only one hospital introduced voluntary counselling and testing for its staff. Most hospitals stated that they used rapid systems to diagnose pulmonary TB. However, there was no significant change in the interval between admission and diagnosis or between admission and treatment of patients with smear-positive pulmonary TB. The TB case notification rate for 2979 health workers in 1999 was 3.2%; this did not differ significantly from the value of 3.7% for 2697 health workers in 1996 but was significantly higher than that of 1.8% for 4367 primary-school teachers in 1999. CONCLUSION: The introduction of guidelines for the control of TB infection is an important intervention for reducing nosocomial transmission of the disease, but rigorous monitoring and follow-up are needed in order to ensure that they are implemented.
Asunto(s)
Adhesión a Directriz/estadística & datos numéricos , Control de Infecciones/normas , Enfermedades Profesionales/prevención & control , Personal de Hospital/normas , Guías de Práctica Clínica como Asunto , Tuberculosis Pulmonar/prevención & control , Adolescente , Adulto , Distribución por Edad , Países en Desarrollo , Notificación de Enfermedades , Femenino , Hospitales de Distrito , Hospitales Privados , Humanos , Control de Infecciones/estadística & datos numéricos , Malaui/epidemiología , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/epidemiología , Admisión del Paciente , Personal de Hospital/estadística & datos numéricos , Sistema de Registros , Misiones Religiosas , Distribución por Sexo , Tuberculosis Pulmonar/diagnóstico , Tuberculosis Pulmonar/epidemiologíaRESUMEN
SETTING: All 43 non-private hospitals in Malawi which in 1999 registered and treated patients with tuberculosis (TB). OBJECTIVE: To determine the proportion of TB patients who transferred from one reporting unit to another and their treatment outcome, and to compare outcome results between the main TB register and the transfer-in register. DESIGN: Retrospective data collection, using the main TB register and transfer-in register, on all patients registered in Malawi in 1999. RESULTS: There were 24,908 patients, of whom 3249 (13%) in total were transfers. Significantly more patients transferred from mission hospitals (23%) compared with central (8%) or district (5%) hospitals (P < 0.001). The date of transfer was recorded for 1406 patients, of whom 1170 (83%) transferred in the first 10 weeks. Respectively 45% and 58% of transfer patients had unknown outcomes in the main TB register and transfer-in register; these rates were significantly lower in smear-positive pulmonary TB (PTB) patients. A total of 1357 patients were entered into transfer-in registers; 694 patients had matched names and/or registration numbers in both registers. Of the matched patients, 373 (54%) had similar treatment outcomes. CONCLUSION: It is common for patients to transfer between treatment units, but the quality of the data for patients who transfer is poor, and needs to be improved.
Asunto(s)
Transferencia de Pacientes , Tuberculosis/epidemiología , Adulto , Recolección de Datos , Femenino , Humanos , Malaui/epidemiología , Masculino , Transferencia de Pacientes/estadística & datos numéricos , Sistema de Registros , Resultado del Tratamiento , Tuberculosis/tratamiento farmacológicoRESUMEN
High death rates are reported in health care workers (HCWs) and teachers in urban areas of Malawi. The present study was carried out to determine the annual death rate in HCWs and primary school teachers working in semi-urban and rural areas of Malawi, and to try to ascertain the main causes of death. Forty district and mission hospitals in Malawi were visited. A record was made of the number of clinical and nursing-based HCWs in each hospital in 1999, the number of deaths in that calendar year and reported causes of death. A record was also made of the number of teachers working in 4 primary schools nearest to each hospital in 1999, the number of deaths in that calendar year and reported causes of death. There were 2979 HCWs, of whom 60 (2.0%) died. There were 4367 teachers of whom 101 (2.3%) died. Annual death rates, calculated per 100,000 people, were significantly higher in male HCWs compared with female HCWs (2495 versus 1770, RR 1.17, 95% CI 1.14-1.20, P < 0.001), and significantly higher in female teachers compared with male teachers (2521 versus 1934, RR 1.14, 95% CI 1.11-1.17, P < 0.001). In male HCWs and teachers the highest death rates were in those aged 35-44 years. In female HCWs and teachers, the highest death rates were in those aged 25-34 years and 35-44 years, respectively. Reported causes of death in HCWs were tuberculosis (TB) in 47%, chronic illness in 45% and acute illness in the remainder, while in teachers the causes were TB in 27%, chronic illness in 49% and acute illness in 25%. Chronic illness, thought to be due to AIDS, and TB were the common causes of death. The current high death rates from AIDS and TB will have a crippling toll on the health and education sectors, and effective ways of reducing these death rates must be found.
Asunto(s)
Enfermedad Aguda/mortalidad , Enfermedad Crónica/mortalidad , Personal de Salud/estadística & datos numéricos , Enseñanza/estadística & datos numéricos , Adolescente , Adulto , Anciano , Causas de Muerte , Distribución de Chi-Cuadrado , Femenino , Humanos , Malaui/epidemiología , Masculino , Persona de Mediana Edad , Salud Rural , Distribución por Sexo , Tasa de Supervivencia , Tuberculosis/mortalidad , Salud UrbanaRESUMEN
SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books. RESULTS: A total of 16,004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.
Asunto(s)
Tuberculosis/mortalidad , Adolescente , Adulto , Anciano , Antituberculosos/administración & dosificación , Femenino , Humanos , Malaui/epidemiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Tiempo , Tuberculosis/diagnóstico , Tuberculosis/tratamiento farmacológicoRESUMEN
A cross-sectional study was carried out in all 43 hospitals in Malawi that register and treat tuberculosis (TB) patients to determine whether there is care and treatment for human immunodeficiency virus (HIV) complications in TB patients. Of 1,416 adults with TB, 861 (61%) had HIV complications, 627 (44%) patients had received no ward round, and of 1,142 patients who had been on anti-tuberculosis treatment for more than 7 days, 294 (26%) had not had a clinical review. Of patients with HIV complications, only 139 (16%) were receiving treatment. There is a lack of regular care and treatment for HIV complications in TB patients in Malawi.
Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/complicaciones , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Antituberculosos/uso terapéutico , Tuberculosis/tratamiento farmacológico , Tuberculosis/etiología , Adulto , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/etiología , Estudios Transversales , Femenino , VIH/efectos de los fármacos , Humanos , Malaui/epidemiología , Masculino , Persona de Mediana EdadRESUMEN
The Malawi Tuberculosis Programme has evaluated an oral ambulatory treatment regimen (2R3H3Z3E3/6HE) in five districts, and observed a mortality rate of 23% in 2671 new patients with smear-positive pulmonary tuberculosis (PTB). Three studies were performed comparing treatment outcomes between patients treated with 2R3H3Z3E3/6HE and 2SRHZ/6HE using historical data in the same districts and concurrent data in different districts. Using historical comparisons, mortality was significantly higher with 2R3H3Z3E3/6HE than 2SRHZ/6HE. Using concurrent comparisons, mortality was similar, although there was a higher death rate in the first month with the intermittent regimen. The intermittent regimen may be inferior to the established regimen.
Asunto(s)
Antituberculosos/administración & dosificación , Tuberculosis Pulmonar/tratamiento farmacológico , África del Sur del Sahara/epidemiología , Estudios de Casos y Controles , Estudios de Cohortes , Quimioterapia Combinada , Humanos , Periodicidad , Riesgo , Tuberculosis Pulmonar/mortalidadRESUMEN
OBJECTIVE: To document resources for controlling tuberculosis (TB) in Malawi. METHODS: We performed a countrywide study of all 43 hospitals (3 central, 22 district and 18 mission) which register and treat patients with TB. To collect data for 1998 on the TB-related workload, diagnostic facilities, programme staff and treatment facilities, we used laboratory, radiographic and TB registers, conducted interviews and visited hospital facilities. FINDINGS: The data show that in 1998, 88,257 TB suspects/patients contributed approximately 230,000 sputum specimens for smear microscopy, 55,667 chest X-rays were performed and 23,285 patients were registered for TB treatment. There were 86 trained laboratory personnel, 44 radiographers and 83 TB programme staff. Of these, about 40% had periods of illness during 1998. Approximately 20% of the microscopes and X-ray machines were broken. Some 16% of the hospital beds were designated for TB patients in special wards, but even so, the occupancy of beds in TB wards exceeded 100%. Although stocks of anti-TB drugs were good, there was a shortage of full-time TB ward nurses and 50% of district hospitals conducted no TB ward rounds. In general, there was a shortage of facilities for managing associated HIV-related disease; central hospitals, in particular, were underresourced. CONCLUSION: Malawi needs better planning to utilize its manpower and should consider cross-training hospital personnel. The equipment needs regular maintenance, and more attention should be paid to HIV-related illness. The policies of decentralizing resources to the periphery and increasing diagnostic and case-holding resources for central hospitals should be continued.
Asunto(s)
Control de Enfermedades Transmisibles/organización & administración , Recursos en Salud/organización & administración , Tuberculosis Pulmonar/prevención & control , Antituberculosos/uso terapéutico , Costo de Enfermedad , Recolección de Datos , Humanos , Malaui/epidemiología , Tuberculosis Pulmonar/tratamiento farmacológico , Tuberculosis Pulmonar/epidemiologíaRESUMEN
SETTING: Thirty-seven hospitals in Malawi. OBJECTIVE: To audit the hospital practice of clinically diagnosing adults with smear-negative pulmonary tuberculosis (PTB). DESIGN: A cross-sectional survey of adults aged 15 years or above who were registered and receiving inpatient treatment for smear-negative PTB. An assessment of each patient was carried out to determine 1) the number of recommended diagnostic guidelines (cough >3 weeks, no response to antibiotics, negative sputum smears and a chest radiograph compatible with PTB) used by hospital staff in making the diagnosis of PTB, and 2) whether the clinical diagnosis of smear-negative PTB was correct according to criteria set by the study. RESULTS: There were 259 patients, 127 men and 132 women, with a mean age of 37 years; 93% had a cough >3 weeks, 95% had received one or more courses of antibiotics, 92% had submitted sputum samples for smear examination and 97% had chest radiographs performed. In 148 (57%) patients, all four diagnostic guidelines were used, and in 238 (92%) patients three or more were used. The diagnosis of smear-negative PTB was considered correct by study criteria in 203 (78%) patients. In the remainder, 22 (8%) were considered to have extrapulmonary TB and 34 (14%) another diagnosis. CONCLUSION: Hospital practices in the diagnosis of smear-negative PTB are reasonable, although there is room for improvement with in-service training and regular audits of practice.
Asunto(s)
Mycobacterium tuberculosis/aislamiento & purificación , Esputo/microbiología , Tuberculosis Pulmonar/diagnóstico , Adulto , Estudios Transversales , Femenino , Hospitales , Humanos , Malaui/epidemiología , Masculino , Auditoría Médica , Guías de Práctica Clínica como Asunto , Sistema de Registros , Tuberculosis Pulmonar/epidemiologíaRESUMEN
Sub-Saharan Africa is bearing the brunt of the human immunodeficiency virus (HIV) pandemic, and HIV-associated tuberculosis (TB) has become a major clinical and public health problem. There is evidence that HIV-infected patients not uncommonly develop disseminated TB, and that this diagnosis is often not made ante mortem because of limited diagnostic facilities and other factors. Where diagnostic facilities are limited, a trial of anti-tuberculosis treatment with drugs specific for Mycobacterium tuberculosis may be a useful way of diagnosing disseminated TB. The case for and against 'a trial of treatment' is presented, and a suggestion is made that 'a trial of treatment' can be incorporated into the case finding package of a National TB Control Programme.
Asunto(s)
Antituberculosos/administración & dosificación , Tuberculosis/diagnóstico , Tuberculosis/tratamiento farmacológico , Infecciones Oportunistas Relacionadas con el SIDA/epidemiología , Infecciones Oportunistas Relacionadas con el SIDA/prevención & control , Adulto , África del Sur del Sahara/epidemiología , Algoritmos , Humanos , Masculino , Prevalencia , Tuberculosis/epidemiología , Tuberculosis/prevención & controlRESUMEN
The proportion of patients with recurrent tuberculosis (TB) is reported to be increased in TB patients with human immunodeficiency virus (HIV) infection after they have completed treatment. Despite rising HIV seroprevalence amongst TB patients in Malawi, notifications of patients with relapse smear-positive pulmonary TB (PTB) and recurrent smear-negative TB have remained stable during the past 12 years. We suspected that patients with recurrent or relapse TB were being missed under routine programme conditions. Forty-three hospitals in Malawi were visited in 1999, and TB inpatients who had been registered as 'new' cases in the TB register and treatment card were interviewed about previous episodes of TB. A previous history of TB was elicited in 94 (7.5%) of 1254 patients who were being treated as new cases. Compared with patients with smear-positive PTB, a previous episode of TB was significantly more common in patients with smear-negative PTB (OR 3.5, [95% CI 2.1-5.7], P < 0.001) and patients with extrapulmonary TB (OR 2.0, [95% CI 1.1-3.7], P < 0.05). Of 94 patients with a previous episode of TB, 76 had completed treatment and 18 had defaulted from treatment during this episode. Patients with recurrent or relapse TB are being incorrectly registered within the Malawi TB Control Programme, and in the case of smear-positive PTB patients this is associated with administration of incorrect treatment. Measures have been put in place to rectify the situation, and further operational research is planned to monitor treatment outcomes of patients with recurrent smear-negative TB.
Asunto(s)
Tuberculosis Pulmonar/prevención & control , Adulto , Control de Enfermedades Transmisibles/organización & administración , Femenino , Humanos , Incidencia , Malaui/epidemiología , Masculino , Prevalencia , Recurrencia , Tuberculosis Pulmonar/epidemiologíaRESUMEN
The time between sputum examination and commencement of treatment in patients registered with smear-negative pulmonary tuberculosis (PTB) in four hospitals in Malawi was investigated. Information was obtained in 701 of 887 patients who were registered over a 12-month period between 1997 and 1998: 86% were started on treatment within 3 weeks of sputum examination, 14% were started after a 3-week interval and 6% after a 6-week interval. Such delays are unacceptable, for a number of reasons. Recommendations will go to programme staff to repeat sputum examination in PTB suspects with an abnormal chest radiograph whose negative sputum smears were examined more than 3 weeks previously.
Asunto(s)
Esputo/microbiología , Tuberculosis Pulmonar/diagnóstico , Adolescente , Adulto , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Factores de Tiempo , Tuberculosis Pulmonar/tratamiento farmacológicoRESUMEN
SETTING: Ntcheu district hospital, Malawi. OBJECTIVE: To assess a screening strategy for tuberculosis (TB) suspects using two sputum smears. DESIGN: A strategy of screening all TB suspects with two sputum smears for 6 months (1 July-31 December 1998) was compared with the period 1 January to 30 June 1998 during which the strategy of screening TB suspects with three sputum smears was in use. All chest radiographs of patients with negative sputum smears were assessed, and in those with pulmonary cavities and extensive disease a third sputum smear was examined. Data were collected from the laboratory sputum register and the TB register. The two 6-month periods were compared. RESULTS: In the laboratory register, using a two-sputum strategy, 186 (16%) of 1152 TB suspects were smear-positive, a result that was no different than when the three-sputum strategy was used, where 173 (16%) of 1106 TB suspects were smear-positive. The clinical pattern of TB using the different screening strategies was similar, with 58% of registered patients smear-positive with the two-sputum strategy and 54% smear-positive with the three-sputum strategy. In the first 6 months 3177 sputum smears were examined compared to 2266 smears in the second 6 months, a 29% reduction in the number of smears examined. The cost of consumables using the strategy of three sputum smears was USD $731 compared with USD $521 using the strategy of two sputum smears. C O N C L U S I O N S: Screening TB suspects using two sputum smears is as effective as screening using three sputum smears, and is associated with less laboratory work and savings in costs.
Asunto(s)
Tamizaje Masivo/métodos , Esputo/microbiología , Tuberculosis Pulmonar/diagnóstico , Control de Costos , Costos y Análisis de Costo , Humanos , Malaui/epidemiología , Tamizaje Masivo/economía , Sistema de Registros/estadística & datos numéricos , Manejo de Especímenes/economía , Tuberculosis Pulmonar/epidemiologíaRESUMEN
Within the National Tuberculosis Control Programme of Malawi, misunderstandings sometimes occur about the diagnosis and management of recurrent tuberculosis (TB). Patients with smear-positive pulmonary tuberculosis (PTB) who have had a previous, treated episode of smear-negative TB may be registered as 'new cases' rather than relapse cases, and thus denied the benefits of a retreatment regimen. Patients with a recurrent episode of smear-negative PTB or extra-pulmonary TB (EPTB) may also be wrongly registered as 'new cases' rather than recurrent cases. International guidelines about the treatment of recurrent smear-negative PTB and EPTB are not explicit, resulting in confusion about how best to manage these cases. It is suggested that all such cases be considered for re-treatment regimen because of concerns about acquired drug resistance. WHO and IUATLD guidelines on the diagnosis and management of recurrent and relapse TB need to be improved, and operational research studies should be conducted to provide answers to some outstanding questions.