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Humanos , Femenino , Persona de Mediana Edad , Médula Ósea , Hialohifomicosis , Trasplantes , Sistema Respiratorio , HongosRESUMEN
No disponible
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Humanos , HDL-Colesterol/deficiencia , Dislipidemias/fisiopatología , LDL-Colesterol/análisis , Factores de RiesgoAsunto(s)
HDL-Colesterol/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de ReferenciaRESUMEN
BACKGROUND AND OBJECTIVE: Rheumatoid arthritis (RA) is characterized by high cardiovascular (CV) mortality, which seems related to systemic inflammation. Our aim was to quantify carotid atherosclerosis in RA and its relationship with the disease. PATIENTS AND METHOD: 73 RA patients and the same number of sex and age matched controls were enrolled, without history of cardiovascular events. Carotid intima-media thickness (IMT) and plaques were measured by ultrasonography. Its relationship with risk factors (RF), rheumatic disease characteristics, and inflammatory markers were analysed. RESULTS: Controls showed higher body mass index (BMI) and dyslipidemia. There were no differences in other risk factors or IMT. Age (p = 0.001), sex (p = 0.02), BMI (p = 0.002), waist perimeter (p = 0.001), and hypertension (p = 0.005) had a relationship with IMT. Among disease characteristics, only time elapsed since RA diagnosis was associated with IMT. CONCLUSIONS: There was not an increased carotid subclinical atherosclerosis in patients with RA, beyond the effects of classical RF.
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Artritis Reumatoide/complicaciones , Enfermedades de las Arterias Carótidas/epidemiología , Enfermedades de las Arterias Carótidas/etiología , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , PrevalenciaRESUMEN
No disponible
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Humanos , Artritis Reumatoide/complicaciones , Resistencia a la Insulina , Enfermedades Vasculares/complicaciones , Factores de Riesgo , Artritis Reumatoide/fisiopatología , Enfermedades Vasculares/fisiopatologíaRESUMEN
Fundamento y objetivo: En la artritis reumatoide (AR) hay un aumento de la morbimortalidad cardiovascular. Nuestro objetivo fue cuantificar la arteriosclerosis subclínica carotídea en pacientes con AR y su relación con la enfermedad. Pacientes y método: En 73 pacientes con AR y 73 controles, emparejados por edad y sexo, sin enfermedad vascular, se midió el grosor íntima-media (GIM) carotídeo y la presencia de placas mediante ecografía. Se analizó su relación con los factores de riesgo vascular (FRV), las características de la enfermedad y los parámetros inflamatorios. Resultados: Los controles presentaban mayor índice de masa corporal (IMC) y dislipemia, sin diferencias significativas entre ambos grupos en el resto de los FRV o en los valores del GIM. La edad (p = 0,001), el sexo (p = 0,02), el IMC (p = 0,002), el perímetro abdominal (p = 0,001) y la hipertensión arterial (p = 0,005) se relacionaron con el GIM. El tiempo desde el diagnóstico fue la única característica de la AR que se relacionó con el GIM. Conclusiones: No se ha encontrado un incremento de ateromatosis carotídea en pacientes con AR más allá del efecto atribuible a los FRV clásicos
Background and objective: Rheumatoid arthritis (RA) is characterized by high cardiovascular (CV) mortality, which seems related to systemic inflammation. Our aim was to quantify carotid atherosclerosis in RA and its relationship with the disease. Patients and method: 73 RA patients and the same number of sex and age matched controls were enrolled, without history of cardiovascular events. Carotid intima-media thickness (IMT) and plaques were measured by ultrasonography. Its relationship with risk factors (RF), rheumatic disease characteristics, and inflammatory markers were analysed. Results: Controls showed higher body mass index (BMI) and dyslipidemia. There were no differences in other risk factors or IMT. Age (p = 0.001), sex (p = 0.02), BMI (p = 0.002), waist perimeter (p = 0.001), and hypertension (p = 0.005) had a relationship with IMT. Among disease characteristics, only time elapsed since RA diagnosis was associated with IMT. Conclusions: There was not an increased carotid subclinical atherosclerosis in patients with RA, beyond the effects of classical RF