Early neonatal cutaneous candidiasis.

A premature female presented cutaneous lesions caused by Candida albicans at 12 h after delivery. Her mother carried Candida in the vagina. The lesions extended to face, both sides of the trunk and extremities, including palms and soles, and later to the mouth. The cutaneous manifestations healed in four weeks. It is proposed to use the term "early neonatal cutaneous candidiasis" to designate the forms of candidiasis which appear within the first hours after delivery, and "congenital cutaneous candidiasis" when lesions are present at delivery.

[Serum theophylline levels after oral administration in a group of asthmatic children]. / Niveles séricos de teofilina tras administración oral en un grupo de niños asmáticos.

Serum levels of theophylline were determined in 54 asthmatics children aged 3,92 +/- 2,45 years, who were taken oral theophylline at doses of 4,99 +/- 0,45 mg. The serum levels at 0 hours (9,22 +/- 4,90 mcg/ml) and at 2 hours (15,22 +/- 5,5 mcg/ml) showed a great variation, although they were taken similar doses. Two hours after ingestion, 34 patients showed levels between 10-20 mcg/ml in 10 children were less than 10 mcg/ml, and another 10 shown serum levels over 20 mcg/ml without symptoms. There was a good correlation between levels at 0 and 2 hours (p less than 0,002). These data may support the utility of doses employed. It is advisable knowing the individual response to theophylline for managing episodes of asthma in children, that can be made by only one determination 2 hours after ingestion.

Autoimmunity to insulin in a child with hypoglycemia.

Plasma insulin antibodies were present in a 5-year-old boy who had been suffering from frequent hypoglycemic episodes during a year without exogenous insulin administration. The antibodies were of low titre one month after the last hypoglycemic episode, although a possible previous higher titre could have been responsible for the child's symptoms. After 17 months, during which the child remained asymptomatic, insulin antibodies could not be detected in his plasma. This is a new case of insulin autoimmunity associated with hypoglycemia.

[Clinical manifestations of juvenile chronic arthritis (author's transl)]. / Manifestaciones clínicas de la artritis crínica juvenil.

The most outstanding clinical, laboratory and evolutive features of 119 patients with juvenile chronic arthritis were studied. According to the onset of the disease, these patients have bee divided into three subtypes, following the criteria set-up by the EULAR for the diagnosis and classification of patients with juvenile chronic arthritis. Among the 119 patients studied, 29.4% had a systemic onset, 37.8% a polyarticular onset and 32.7% a pauciarticular onset. The relationship between female and male was 0.8/1 in he group with systemic onset, 4/1 in the group with polyarticular onset and 1.1/1 in the group with pauciarticular onset. The patients with systemic onset seem to constitute a homogeneous clinical group. The group with polyarticular onset is made up of two subtypes of different evolutive seriousness, one seropositive and another seronegative. In the pauciarticular group, two subtypes are present: one presenting with chronic iridocyclitis and another with sacroilitis (some in this subtype shall develop subsequently ankylosing spondylitis), leaving aside a non-homogeneous group of patients unable to be classified at the present time.