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J Pediatr Endocrinol Metab ; 22(12): 1127-35, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-20333872

RESUMEN

Serum IGF-I and IGFBP-3 assays are used to monitor rhGH treatment. Some discrepancies in results obtained by means of different assays have been reported. The aim of this study was to establish normal ranges for circulating IGF-I and IGFBP-3 in children and adolescents of Hispanic and Italian origin. Circulating levels of IGF-I and IGFBP-3 were measured in 169 Hispanic and Italian prepubertal children and 66 adolescents of both sexes, using a chemiluminescent assay. Serum levels of IGF-I and IGFBP-3 increased from early childhood into adolescence. After pubertal peaks of IGF-I and IGFBP-3, slight decreases were observed with increasing age. Furthermore, serum IGF-I levels were significantly higher in girls than in boys, suggesting a sexual dimorphism in serum IGF-I values in late prepuberty and early puberty. Differences in IGF-I and IGFBP-3 absolute values between our study and previous studies suggest the need to establish reference ranges for each ethnic group.


Asunto(s)
Química Clínica/normas , Proteínas de Unión a Factor de Crecimiento Similar a la Insulina/sangre , Factor I del Crecimiento Similar a la Insulina/metabolismo , Mediciones Luminiscentes/normas , Caracteres Sexuales , Adolescente , Factores de Edad , Argentina , Química Clínica/métodos , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina , Italia , Masculino , Valores de Referencia , Factores Sexuales
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