RESUMEN
Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, (1)H- and (13)C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity.
Asunto(s)
Antifúngicos/química , Antifúngicos/farmacología , Antiprotozoarios/química , Antiprotozoarios/farmacología , Basidiomycota/química , Triterpenos/química , Triterpenos/farmacología , Animales , Antifúngicos/aislamiento & purificación , Antiprotozoarios/aislamiento & purificación , Candida albicans/efectos de los fármacos , Candidiasis/tratamiento farmacológico , Cristalografía por Rayos X , Humanos , Leishmania donovani/efectos de los fármacos , Leishmaniasis Visceral/tratamiento farmacológico , Ratones , Ratones Endogámicos BALB C , Modelos Moleculares , Triterpenos/aislamiento & purificaciónRESUMEN
Phytochemical investigation of the gum resin of Ferula assafoetida resulted in the isolation and characterization of a new sesquiterpenoid coumarin, Saradaferin (1) named as [Decahydro-(3-alpha-hydroxy-4,4,10-trimethyl-8-methylene-9-naphthenyl)-alpha-hydroxymethyl] ether of umbelliferone.
