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PURPOSE: The development of optics-based wearables for bladder volume monitoring has emerged as a significant topic in recent years. Given the innovative nature of this technology, there is currently no bladder phantom available to effectively validate these devices against more established gold standards, such as ultrasound. In this study, we showcase and demonstrate the performance of our hybrid bladder phantom by using an optical device and making comparisons with ultrasound. METHODS: A series of validation tests, including phantom repeatability, ultrasound scanning, and an optical test, were performed. A near-infrared optical device was utilized to conduct diffuse optical spectroscopy (DOS). Machine learning models were employed to construct predictive models of volume using optical signals. RESULTS: The size and position of an embedded balloon, serving as an analog for the bladder, were shown to be consistent when infused with 100 mL to 350 mL of water during repeatability testing. For DOS data, we present 7 types of machine learningbased models based on different optical signals. The 2 best-performing models demonstrated an average absolute volume error ranging from 12.7 mL to 19.0 mL. CONCLUSION: In this study, we introduced a hybrid bladder phantom designed for the validation of near-infrared spectroscopy-based bladder monitoring devices in comparison with ultrasound techniques. By offering a reproducible and robust validation tool, we aim to support the advancement of next-generation optical wearables for bladder volume monitoring.
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Background and Objective: Current guidelines for patients with neurogenic bladder (NB) dysfunction suggest the use of self-intermittent catheterization with adherence to catheterization timers. Due to biorhythmic variability, unpredictable voiding times may occur. As a result, many patients abstain from extended social or work activities, turn to more secluded lifestyles, and generally experience a decrease in quality of life. Being able to know when to void is essential for patients with NB dysfunction. To solve the problem of variable void timings, wearable devices using near-infrared spectroscopy (NIRS) have been emergent and showed potential for bladder volume monitoring. Therefore, in this review, we provided a comprehensive overview of research which implemented NIRS for bladder volume monitoring, and discussed how the researchers validated their device by in-vitro methods and suggested a potential validation approach. Methods: A literature search using PubMed and Google Scholar was conducted on February 2023. Publications involving bladder volume monitoring incorporating NIRS technique with in-vitro validation was considered for review. Key Content and Findings: Due to the novelty of NIRS being applied to bladder monitoring, there are a few possibilities to effectively validate this technique through in-vitro methods. Ballistics gel, which has been proven to be a versatile material for applications involving ultrasound, could be a suitable material when constructing a bladder phantom for in-vitro validation of NIRS technology. Conclusions: By outlining a more standardized in-vitro validation model based on ballistics gel, we hope to facilitate development in this field towards a more accurate and robust NIRS-based bladder monitoring device.
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Significance: Light emitting diodes (LEDs) are commonly utilized for tissue spectroscopy due to their small size, low cost, and simplicity. However, LEDs are often approximated as single-wavelength devices despite having relatively broad spectral bandwidths. When paired with photodiodes, the wavelength information of detected light cannot be resolved. This can result in errors during chromophore concentration calculations. These errors are particularly apparent when analyzing water and fat in the 900 to 1000 nm window where the spectral bandwidth of LEDs can encompass much of the analysis region, resulting in intense crosstalk. Aim: We utilize and present a spectral correction (SC) algorithm to correct for the spectral bandwidth of LEDs. We show the efficacy using a narrowband technique of spectrally broad and overlapping LEDs. Approach: Narrowband diffuse reflectance spectroscopy (nb-DRS), a technique capable of quantifying the hydration ratio (RH2O) of turbid media, was utilized. nb-DRS typically requires a broadband light source and spectrometer. We reduce the hardware to just five LEDs and a photodiode detector, relying on SC to compensate for spectral crosstalk. The effectiveness of our SC approach was tested in simulations as well as in an emulsion phantom and limited selection of human tissue. Results: In simulations, we show that calculated RH2O errors increased with the spectral bandwidth of LEDs but could be corrected using SC. Likewise, in emulsions, we found an average error of 8.7% (maximum error 14%) if SC was not used. By contrast, applying SC reduced the average error to 2.2% (maximum error of 6.4%). We show that despite utilizing multiple, spectrally broad, and overlapping LEDs, SC was still able to restore the performance of our narrowband method, making it comparable to a much larger full broadband system.
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Refractometría , Agua , Humanos , Análisis Espectral/métodos , Fantasmas de Imagen , AlgoritmosRESUMEN
We report a handheld, smartphone-based spatial frequency domain imaging device. We first examined the linear dynamic range of the smartphone camera sensor. We then calculated optical properties for a series of liquid phantoms with varying concentrations of nigrosin ink and Intralipid, demonstrating separation of absorption and scattering. The device was then tested on a human wrist, where optical properties and hemoglobin-based chromophores were calculated. Finally, we performed an arterial occlusion on a human hand and captured hemodynamics using our device. We hope to lay the foundation for an accessible SFDI device with mass-market appeal designed for dermatological and cosmetic applications.
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Frequency domain diffuse optical spectroscopy (fdDOS) is a noninvasive technique to estimate tissue composition and hemodynamics. While fdDOS has been established as a valuable modality for clinical research, comparison of fdDOS with direct chemical analysis (CA) methods has yet to be reported. To compare the two approaches, we propose a procedure to confirm accurate calibration by use of liquid emulsion and solid silicone phantoms. Tissue fat (FAT) and water (H2 O) content of two ex vivo porcine tissue samples were optically measured by fdDOS and compared to CA values. We show an average H2 O error (fdDOS minus CA) and SD of 1.9 ± 0.2% and -0.9 ± 0.2% for the two samples. For FAT, we report a mean error of -9.3 ± 1.3% and 0.8 ± 1.3%. We also measured various body sites of a healthy human subject using fdDOS with results suggesting that accurate calibration may improve device sensitivity.
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Tejido Adiposo , Agua , Animales , Calibración , Humanos , Fantasmas de Imagen , Análisis Espectral , PorcinosRESUMEN
We report a narrow wavelength band diffuse reflectance spectroscopy (nb-DRS) method to determine water and fat ratios of scattering media in the 900-1000â nm range. This method was shown to be linearly correlated with absolute water and fat concentrations as tested on a set of turbid emulsion phantoms with a range of water and lipid compositions. Robustness to scattering assumptions was demonstrated and compared against measured scattering by a frequency-domain photon migration system. nb-DRS was also tested on ex-vivo porcine samples and compared against direct tissue water extraction by analytical chemistry methods. We speculate nb-DRS has potential applications in portable devices such as clinical and digital health wearables.
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OBJECTIVE: Diffuse optical spectroscopic imaging (DOSI) is a promising biophotonic technology for clinical tissue assessment, but is currently hampered by difficult wide area assessment. A co-integrative optical imaging system is proposed for dense sub-surface optical property spatial assessment. METHODS: The proposed system fuses a co-aligned set of camera frames and diffuse optical spectroscopy measurements to generate spatial sub-surface optical property maps. A 3D rigid body motion estimation model was developed by fitting automatically detected target features to an a priori geometric model using a single overhead camera. Point-wise optical properties were measured across the tissue using frequency domain photon migration DOSI. The 3D probe trajectory and temporal optical property data were fused to generate 2D spatial optical property maps, which were projected onto the tissue image using pre-calibrated camera parameters. RESULTS: The system demonstrated sub-millimeter positional accuracy (error 0.24 ± 0.35 mm) across different probe speeds (1.0-3.8 cm/s), and displacement accuracy in overhead ([Formula: see text] mm) and tilted (0.51 ± 0.51 mm) camera orientations. Unstructured scans on a tumor inclusion phantom showed strong contrast under different probe paths, and significant ( ) changes in optical properties in an in vivo leg cuff occlusion protocol with spatial anatomy localization. CONCLUSION: The proposed co-integrative optical imaging system generated dense sub-surface optical property distributions across wide tissue areas with sub-millimeter accuracy at different probe speeds and trajectories, and does not require pre-planned probe route for tissue assessment. SIGNIFICANCE: This system provides a valuable tool for real-time non-invasive tissue health and cancer screening, and enables longitudinal disease progression assessment through unstructured probe-based optical tissue assessment.
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Algoritmos , Diagnóstico por Imagen , Imagenología Tridimensional , Microcirugia , Imagen Óptica , Fantasmas de Imagen , Análisis EspectralRESUMEN
Objective: To quantitatively measure tissue composition and hemodynamics during resuscitative endovascular balloon occlusion of the aorta (REBOA) in two tissue compartments using non-invasive two-channel broadband diffuse optical spectroscopy (DOS). Methods: Tissue concentrations of oxy- and deoxyhemoglobin (HbO2 and HbR), water, and lipid were measured in a porcine model (n = 10) of massive hemorrhage (65% total blood volume over 1 h) and 30-min REBOA superior and inferior to the aortic balloon. Results: After hemorrhage, hemoglobin oxygen saturation (StO2 = HbO2/[HbO2 + HbR]) at both sites decreased significantly (-29.9% and -42.3%, respectively). The DOS measurements correlated with mean arterial pressure (MAP) (R2 = 0.79, R2 = 0.88), stroke volume (SV) (R2 = 0.68, R2 = 0.88), and heart rate (HR) (R2 = 0.72, R2 = 0.88). During REBOA, inferior StO2 continued to decline while superior StO2 peaked 12 min after REBOA before decreasing again. Inferior DOS parameters did not associate with MAP, SV, or HR during REBOA. Conclusions: Dual-channel regional tissue DOS measurements can be used to non-invasively track the formation of hemodynamically distinct tissue compartments during hemorrhage and REBOA. Conventional systemic measures MAP, HR, and SV are uncorrelated with tissue status in inferior (downstream) sites. Multi-compartment DOS may provide a more complete picture of the efficacy of REBOA and similar resuscitation procedures.