Demonstration of T lymphocytes in leprous granuloma using the acid alpha naphtyl acetate esterase activity. An attempt at quantitative analysis.

In nine leprosy patients (1 TT, 1 BT, 4 BL and 3 LLp), esterase positive lymphocytes (T Lymphocytes) were studied in frozen sections of skin biopsies by alpha naphtyl acetate esterase pH 5.8 method (ANAE) Four patients had never been treated previously and five patients exhibited clinical and bacteriological evidence of relapse for inadequate therapy at first biopsy. There was an increase in ANAE (+) lymphocyte density in granulomas when second biopsies were done after efficient treatment, evaluated by bacillary index for the eight bacilliferous patients, and clinical improvement. The significance of T cells in granulomas is discussed.

[A new type of sialidosis with kidney disease: nephrosialidosis. II. Anatomic study]. / Un nouveau type de sialidose avec atteinte rénale: la nephrosialidose. II.--Etude anatomique.

The anatomical, macroscopical, histological, histochemical and ultrastructural findings in nephrosialidosis have certain similarities to those found in mucolipidoses. (Excess of complex lipid in neural tissue and an excess of light coloured material in the reticulo-endothelial system that is not easily characterised). Several distinct features help to distinguish nephrosialidosis from closely related conditions (renal lesions, storage of material in sympathetic ganglia).

[Thymic and parathyroid agenesia (DiGeorge's syndrome). Apropos of a case with abnormal vena caval return]. / L'agenesie thymique et parathyroidienne (syndrome de Di George). A propos d'un cas comportant un retour veineux cave anormal

A child with a complete absence of thymus and parathyroids (Di George's syndrome) associated with a cardiac malformation (truncus arteriosus and abnormal caval venous return) is described ; the child died at the age of 1 month. An exchange-transfusion, performed at 4 days of age induced a mild graft versus host reaction which could only be recognized histologically and distorted the results of immunological tests. On this occasion, the main clinical, anatomical and immunological features of the Di George's syndrome are reviewed. They suggest a possible relationship between the severity of the cardiac malformation and the more or less complete character of the dysgenesia of the thymus and the parathyroids.