Asunto(s)
Anticuerpos Antibacterianos/fisiología , Cromosomas Humanos Par 1 , Mosaicismo/genética , Polisacáridos Bacterianos/inmunología , Trisomía , Preescolar , Femenino , Haemophilus influenzae/inmunología , Humanos , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Lactante , Recién Nacido , Mosaicismo/inmunología , Familia de Multigenes , Streptococcus pneumoniae/inmunologíaRESUMEN
All of 16 infants with neonatal meningitis treated during a 30-month period were found to have accompanying ventriculitis at the time of the initial ventricular puncture. Fifteen of these infants were caused by gramm-negative organisms. All infants received antibiotics systemically and intraventricularly via an implanted ventriculostomy reservoir or by direct ventricular injection. Antibiotic concentrations within the ventricular fluid were monitored during chemotherapy; the complications encountered during treatment are discussed. Fifteen infants survived the infection; of these, seven infants were normal at follow-up examinations. In our experience intraventricular chemotherapy as an adjunct to systemic administration of antibiotics has greatly reduced the mortality rate in neonatal meningitis.