RESUMEN
Several treatments have been used to induce ovulation in the polycystic ovary. In the following study, estradiol and testosterone plasma concentration were measured and evaluated in 18 women with polycystic ovaries, as one of the factors involved in the antiestrogenic response to Clomiphene Citrate. An estrogen plasma concentration baseline of 50 pg/ml is proposed in order to obtain the antiestrogenic effects. Nevertheless, induction of ovulation was achieved when the estradiol/testosterone ratio was 0.09 or higher (P less than 0.001).
Asunto(s)
Anovulación , Clomifeno/uso terapéutico , Quistes Ováricos/sangre , Ovario/fisiopatología , Testosterona/sangre , Adolescente , Adulto , Anovulación/tratamiento farmacológico , Femenino , Humanos , Quistes Ováricos/tratamiento farmacológico , Ovulación/efectos de los fármacosRESUMEN
In the present study, the changes observed in the length of the cycle, basal body temperatures, endometrial histology and plasma progesterone in a group of 18 patients with polycystic ovaries, treated with Clomiphene Citrate, is reported. Two distinctive responses were observed depending on the estradiol/testosterone mean concentration found. Regardless of the induction of ovulation, a clear change in the length of the cycle was observed. Progesterone concentration of 2.1-2.9 ng/ml gave a definite rise in BBT, but no endometrial secretory changes were found in parallel with that concentration. Progesterone concentration above 6.1 ng/ml did induce secretory changes in the endometrium.
