RESUMEN
Evidence-based clinical practice guidelines are essential to ensure that childhood cancer survivors at risk of chronic health conditions receive effective long-term follow-up care. However, adult survivors of childhood cancer are not always engaged in recommended health promotion and follow-up practices, as many centres do not have a formal transition programme that prepares survivors and their families for successful transfer from child-centred to adult-oriented healthcare. The need for a specific pan-European guideline for the transition of care for childhood cancer survivors has been recognised. The first step is to define the concept of transition of care for survivors of childhood cancer based on existing evidence.
Asunto(s)
Cuidados a Largo Plazo/normas , Neoplasias/terapia , Sobrevivientes , Transición a la Atención de Adultos/normas , Cuidado de Transición/normas , Adolescente , Adulto , Factores de Edad , Niño , Humanos , Cuidados a Largo Plazo/clasificación , Guías de Práctica Clínica como Asunto , Terminología como Asunto , Factores de Tiempo , Transición a la Atención de Adultos/clasificación , Cuidado de Transición/clasificación , Resultado del Tratamiento , Adulto JovenRESUMEN
PURPOSE: Head and neck rhabdomyosarcoma (HNRMS) survivors are at increased risk of developing pituitary dysfunction as an adverse event of radiotherapy. Our aim was to investigate the frequency and risk factors for pituitary dysfunction in these survivors. Secondly, we aimed to compare the prevalence of pituitary dysfunction between survivors treated with external beam radiation therapy (EBRT) and survivors treated with the ablative surgery, moulage technique after loading brachytherapy, and surgical reconstruction (AMORE) procedure. METHODS: Eighty HNRMS survivors treated in London (EBRT based) and Amsterdam (AMORE based: AMORE if feasible, otherwise EBRT) in the period 1990-2010 and alive ≥ 2 years post-treatment were evaluated. Survivors were evaluated in multidisciplinary late-effects clinics, with measurement of linear growth, determination of thyroid function, and growth hormone parameters. Additional data, such as baseline characteristics, anthropometrics, pubertal stage, and the results of additional laboratory investigations, were retrieved from patient charts. RESULTS: Pituitary dysfunction was diagnosed in 24 in 80 (30%) survivors, after a median follow-up time of 11 years. Median time to develop pituitary dysfunction after HNRMS diagnosis was 3.0 years. Risk factors were EBRT-based therapy (odds ratio [OR] 2.06; 95% confidence interval [CI] 1.79-2.46), parameningeal tumour site (OR 1.83; 95% CI 1.60-2.17) and embryonal RMS histology (OR 1.49; 95% CI 1.19-1.90). CONCLUSIONS: Radiotherapy used for the treatment of HNRMS confers a significant risk of the development of pituitary dysfunction. AMORE-based treatment in children with HNRMS resulted in less pituitary dysfunction than treatment with conventional EBRT. Our findings underscore the importance of routine early endocrine follow-up in this specific population.
Asunto(s)
Braquiterapia/efectos adversos , Irradiación Craneana/efectos adversos , Neoplasias de Cabeza y Cuello/radioterapia , Enfermedades de la Hipófisis/epidemiología , Traumatismos por Radiación/epidemiología , Rabdomiosarcoma/radioterapia , Sobrevivientes , Adolescente , Desarrollo del Adolescente , Adulto , Factores de Edad , Niño , Desarrollo Infantil , Preescolar , Estudios Transversales , Femenino , Neoplasias de Cabeza y Cuello/cirugía , Humanos , Incidencia , Lactante , Recién Nacido , Estimación de Kaplan-Meier , Modelos Logísticos , Londres/epidemiología , Masculino , Análisis Multivariante , Países Bajos/epidemiología , Oportunidad Relativa , Enfermedades de la Hipófisis/diagnóstico , Pruebas de Función Hipofisaria , Prevalencia , Traumatismos por Radiación/diagnóstico , Radioterapia Adyuvante , Estudios Retrospectivos , Rabdomiosarcoma/cirugía , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: The randomised findings of the UKW3 trial were that preoperative chemotherapy was associated with a more advantageous stage distribution and reduction in therapy burden versus immediate nephrectomy without compromising outcome in localised Wilms' tumour (WT). We analysed outcome in all WT registered in UKW3. PATIENTS AND METHODS: Seven hundred and eighteen WT cases (7% anaplastic) were registered in UKW3. We assigned a treatment stage and conducted survival analysis. RESULTS: Five-year event-free survival (EFS) and overall survival (OS) were 77.2% [95% confidence interval (CI) 73.9-80.2] and 87.5% (95% CI 84.8-89.7) after median follow-up of 9.5 years and 10.0 years, respectively. Five-year OS in localised non-anaplastic cases was 92.9% (95% CI 90.2-94.9). Anaplasia was associated with adverse outcome compared with non-anaplastic cases: 5-year EFS of 42.0% (95% CI 28.3-55.1) versus 79.8% (95% CI 76.5-82.7) and 5-year OS of 60% (95% CI 45.1-72.0) versus 89.6% (95% CI 87.0-91.7), respectively. Outcomes were similar for non-anaplastic stage I or II but significantly poorer in stage III cases than stage I. Five-year OS after relapse was 54.1% (95% CI 44.5-62.8). Forty-seven percent of non-anaplastic WT received anthracycline; 27% were treated with radiotherapy first line. CONCLUSION: These outcomes provide a baseline for future comparisons of WT treatment approach, burden and patient outcome.
Asunto(s)
Neoplasias Renales/terapia , Recurrencia Local de Neoplasia , Tumor de Wilms/terapia , Preescolar , Terapia Combinada , Supervivencia sin Enfermedad , Femenino , Humanos , Neoplasias Renales/mortalidad , Masculino , Modelos de Riesgos Proporcionales , Ensayos Clínicos Controlados Aleatorios como Asunto , Estudios Retrospectivos , Estadísticas no Paramétricas , Análisis de Supervivencia , Resultado del Tratamiento , Tumor de Wilms/mortalidadRESUMEN
This report illustrates a rare genetic disorder, Currarino syndrome, in association with an unusual malignant transformation to a peripheral primitive neuroectodermal tumour within a sacral teratoma. The triad of features consists of a presacral mass, partial sacral agenesis and anorectal anomalies. The most common presentation is constipation. In this case there was a history of constipation, teratomas and spinal abnormalities in many of the family members over three generations. Detailed family history taken at time of initial presentation may have prevented delay in diagnosis and averted the need for intensive treatment, which may well cause late sequelae.
Asunto(s)
Estreñimiento/genética , Neoplasias Primarias Múltiples/patología , Tumores Neuroectodérmicos Periféricos Primitivos/patología , Región Sacrococcígea , Teratoma/patología , Preescolar , Estreñimiento/complicaciones , Femenino , Humanos , Tumores Neuroectodérmicos Periféricos Primitivos/complicaciones , Síndrome , Teratoma/complicacionesRESUMEN
AIM: To evaluate the effectiveness of cardiac markers to quantify anthracycline-induced cardiotoxicity in children with cancer. METHODS: Systematic review using a priori methods. RESULTS: Seven studies, all with methodological limitations, were identified. One RCT suggests that cardiac troponin can be used to assess the effectiveness of the cardio-protective agent dexrazoxane. Cohort studies suggest that atrial natriuretic peptide and brain (B-type) natriuretic peptide are elevated in some subgroups of patients compared with healthy children; NT-pro-BNP levels are significantly elevated in children with cardiac dysfunction compared with those without; serum lipid peroxide is higher in children who have received doxorubicin compared with children not receiving doxorubicin; there are no differences in carnitine levels between children treated with doxorubicin and a healthy control group. CONCLUSIONS: The limited evidence makes conclusions difficult. Research is needed to fill this important evidence gap and link short-term changes in cardiac markers to longer-term cardiac damage.
Asunto(s)
Antraciclinas/efectos adversos , Antibióticos Antineoplásicos/efectos adversos , Biomarcadores/metabolismo , Cardiopatías/prevención & control , Neoplasias/tratamiento farmacológico , Preescolar , Estudios de Cohortes , Corazón/efectos de los fármacos , Cardiopatías/inducido químicamente , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , SobrevivientesRESUMEN
OBJECTIVES: To evaluate the technologies used to reduce anthracycline-induced cardiotoxicity in children. Also to evaluate cardiac markers to quantify cardiotoxicity, and identify cost-effectiveness studies and future research priorities. DATA SOURCES: Eight electronic databases were searched from inception to January 2006. Bibliographies of related papers were assessed for relevant studies and experts contacted to identify additional published references. REVIEW METHODS: A systematic review of the evidence was undertaken using a priori methods. RESULTS: Four randomised controlled trials (RCTs) met the inclusion criteria of the review, each considering a different cardioprotective intervention; all trials included children with acute lymphoblastic leukaemia, and one also included children with non-Hodgkin's lymphoma. However, all had methodological limitations. No cost-effectiveness studies were identified. One RCT and six cohort studies on the use of cardiac markers met the inclusion criteria of the review, but also had methodological limitations. Of the two RCTs that considered continuous infusion versus bolus (rapid) infusion, one found that continuous infusion of doxorubicin did not offer any cardioprotection over bolus; the other suggested that continuous infusion of daunorubicin had less cardiotoxicity than bolus. Two studies considered cardioprotective agents, one concluded that dexrazoxane prevents or reduces cardiac injury without compromising the antileukaemic efficacy of doxorubicin and the other reported a protective effect of coenzyme Q10 on cardiac function during anthracycline therapy. One RCT suggested that cardiac troponin T can be used to assess the effectiveness of the cardioprotective agent dexrazoxane. Two cohort studies considering atrial natriuretic peptide and two considering brain (B-type) natriuretic peptide suggested that these chemicals are elevated in some subgroups of children treated with anthracyclines for cancer. N-terminal B-type natriuretic peptide levels were significantly elevated in children treated with anthracyclines who had cardiac dysfunction. One cohort study found that serum lipid peroxide was higher in younger children treated with doxorubicin than correspondingly aged children not receiving doxorubicin. No differences in carnitine levels were found in children treated with doxorubicin and a group of healthy children in one cohort study. CONCLUSIONS: It is difficult to draw conclusions about the effectiveness of technologies for reducing or preventing cardiotoxicity and about the use of cardiac markers in children as the evidence is limited in quantity and quality. The lack of standardisation for monitoring and reporting cardiac performance is problematic. Not all studies report effectiveness in terms of cardiac outcomes and event-free survival with supporting statistical analyses. Studies are mostly small and of short duration, making generalisation difficult. Increasing numbers of survivors of childhood cancer treated with anthracyclines will experience cardiac damage and require long-term surveillance and management. This will have an impact on cardiac services and costs. Diverse medical problems and other late sequelae that affect cardiac outcome will have an impact on other specialist services. Mechanisms to reduce or prevent cardiotoxicity from anthracycline therapy and cardiac markers to improve monitoring could alter the extent of this impact on service provision. RCTs of the different methods for reducing or preventing cardiotoxicity in children treated with anthracyclines for cancer with long-term follow-up are needed to determine whether the technologies influence the development of cardiac damage. Cost-effectiveness research is also required.
Asunto(s)
Antraciclinas/efectos adversos , Antraciclinas/economía , Antibióticos Antineoplásicos/efectos adversos , Antibióticos Antineoplásicos/economía , Fármacos Cardiovasculares/uso terapéutico , Cardiopatías/prevención & control , Linfoma no Hodgkin/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Antraciclinas/uso terapéutico , Antibióticos Antineoplásicos/uso terapéutico , Biomarcadores/sangre , Niño , Esquema de Medicación , Cardiopatías/inducido químicamente , Cardiopatías/diagnóstico , Insuficiencia Cardíaca/inducido químicamente , Insuficiencia Cardíaca/prevención & control , HumanosRESUMEN
This review systematically assessed the evidence on the clinical and cost-effectiveness of cardioprotection against the toxic effects of anthracyclines given to children with cancer. We searched eight electronic databases, including Medline and the Cochrane Library, from inception to January 2006 for systematic reviews and randomised controlled trials that reported death, heart failure, arrhythmias or measures of cardiac performance associated with cardioprotective technologies compared with standard treatment in children treated for cancer with anthracyclines. Economic evaluations were also sought. Inclusion criteria, data extraction and quality assessment were undertaken by standard methodology. Four randomised controlled trials met the inclusion criteria of the review; each had methodological limitations. No economic evaluations were identified. Studies were combined through narrative synthesis. One trial found that continuous infusion of doxorubicin did not offer any cardioprotection over rapid infusion. One suggested that continuous infusion of daunorubicin provoked less cardiotoxicity than rapid infusion. One concluded that dexrazoxane reduces cardiac injury during doxorubicin therapy and one reported a protective effect of coenzyme Q(10) on cardiac function during anthracycline therapy. The evidence on the effectiveness of cardioprotective technologies in children is limited in quality and quantity thus making conclusions difficult. This is surprising given the importance of anthracycline use in children with cancer. Further long-term research, which includes relevant outcome measures, is needed to determine whether technologies influence the development of cardiac damage without limiting the antitumour efficacy of anthracyclines.
Asunto(s)
Antraciclinas/efectos adversos , Cardiotónicos/uso terapéutico , Antraciclinas/uso terapéutico , Niño , Humanos , Medicina EstatalRESUMEN
BACKGROUND: Most Wilms tumours occur in otherwise healthy children, but a small proportion occur in children with genetic syndromes associated with increased risks of Wilms tumour. Surveillance for Wilms tumour has become widespread, despite a lack of clarity about which children are at increased risk of these tumours and limited evidence of the efficacy of screening or guidance as to how screening should be implemented. METHODS: The available literature was reviewed. RESULTS: The potential risks and benefits of Wilms tumour surveillance are finely balanced and there is no clear evidence that screening reduces mortality or morbidity. Prospective evidence-based data on the efficacy of Wilms tumour screening would be difficult and costly to generate and are unlikely to become available in the foreseeable future. CONCLUSIONS: The following pragmatic recommendations have been formulated for Wilms tumour surveillance in children at risk, based on our review: (1) Surveillance should be offered to children at >5% risk of Wilms tumour. (2) Surveillance should only be offered after review by a clinical geneticist. (3) Surveillance should be carried out by renal ultrasonography every 3-4 months. (4) Surveillance should continue until 5 years of age in all conditions except Beckwith-Wiedemann syndrome, Simpson-Golabi-Behmel syndrome and some familial Wilms tumour pedigrees where it should continue until 7 years. (5) Surveillance can be undertaken at a local centre, but should be carried out by someone with experience in paediatric ultrasonography. (6) Screen-detected lesions should be managed at a specialist centre.
Asunto(s)
Tumor de Wilms/prevención & control , Trastornos de los Cromosomas/complicaciones , Trastornos de los Cromosomas/diagnóstico , Anemia de Fanconi/complicaciones , Anemia de Fanconi/diagnóstico , Humanos , Práctica Profesional , Derivación y Consulta , Factores de Riesgo , Síndrome , Tumor de Wilms/complicaciones , Tumor de Wilms/genéticaAsunto(s)
Antraciclinas/efectos adversos , Antineoplásicos/efectos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Disfunción Ventricular Izquierda/inducido químicamente , Adolescente , Factores de Edad , Antraciclinas/uso terapéutico , Antineoplásicos/uso terapéutico , Niño , Diástole , Esquema de Medicación , Ecocardiografía Doppler , Humanos , Neoplasias Renales/complicaciones , Neoplasias Renales/tratamiento farmacológico , Análisis Multivariante , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Estudios Prospectivos , Sobrevivientes , Disfunción Ventricular Izquierda/diagnóstico por imagen , Tumor de Wilms/complicaciones , Tumor de Wilms/tratamiento farmacológicoRESUMEN
BACKGROUND: Stage 4S neuroblastoma is associated with a high rate of spontaneous maturation and involution, with survival rates of 70-90%. There is little long-term follow-up data describing the disease status or late effects. The aim of this study was to assess the clinical outcome and imaging findings in long-term survivors of 4S neuroblastoma. METHODS: The patient population was identified from a single centre over 26 years. Twenty-five of 31 consecutive patients were long-term survivors. Five died from disease progression and one from cerebral palsy related complications. All survivors underwent clinical examination. Abdominal ultrasound scanning, liver function tests, hepatitis viral screen, and urinary catecholamines were performed. RESULTS: The mean age at diagnosis was 8 +/- 9 weeks with a mean age when studied of 11 years and 10 months +/- 8 years. Twenty of 25 had no significant clinical findings, three had disease associated clinical abnormalities (neurological, multiple subcutaneous nodules). Three patients had treatment related effects (small testes, urethral stricture, radiation induced soft tissue hypoplasia, post-surgical Horners syndrome). Persistant adrenal enlargement and calcification was noted in three patients. Twelve patients had abnormal liver ultrasound findings ranging from mildly coarse echotexture to structural changes without evidence of hepatic dysfunction or infection. Treatment did not correlate with abnormal hepatic ultrasound findings. CONCLUSIONS: The majority of long-term survivors of stage 4S neuroblastoma have no clinically or radiologically significant sequelae but do have residual abnormalities. These findings have implications for subsequent management of unrelated medical conditions in this patient group.
Asunto(s)
Hepatopatías/epidemiología , Neuroblastoma/terapia , Estudios de Seguimiento , Humanos , Lactante , Hígado/diagnóstico por imagen , Hígado/patología , Hepatopatías/etiología , Neuroblastoma/epidemiología , Neuroblastoma/patología , Resultado del Tratamiento , Ultrasonografía , Reino Unido/epidemiologíaRESUMEN
The objective of the present study was to review the presentation, management, outcome and morbidity of paediatric patients presenting to a single centre with rhabdomyosarcoma of the ear and temporal region. All patients diagnosed with rhabdomyosarcoma of the ear and temporal region between 1980 and 2000 were entered into this retrospective study. Fourteen patients were identified. The median age at presentation was 4.5 years with a mean time of onset of symptoms to diagnosis of 21 weeks. In many patients, the presentation mimicked that of chronic otitis media, delaying diagnosis. Histological subtype was embryonal in 13 patients and alveolar in 1. All patients underwent multimodality treatment. The 5-year disease-free survival rate was 81%. Regional post-treatment morbidity included chronic aural discharge (6/14), facial palsy (8/14), growth disturbance (4/14) and maxillo-facial deformity occurring in four children. From the results, we conclude that these patients should usually present to an ENT surgeon who should keep the diagnosis in mind when dealing with children with chronic otitis media as early diagnosis with referral to a specialist multidisciplinary team will optimize the chance of survival. Discharge, hearing loss and aural polyp, although commonly because of chronic otitis media, should prompt urgent investigation and biopsy, particularly if associated with facial palsy, lymphadenopathy or an obvious mass.
Asunto(s)
Neoplasias Óseas , Neoplasias del Oído , Rabdomiosarcoma Embrionario , Hueso Temporal , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/epidemiología , Neoplasias Óseas/terapia , Niño , Preescolar , Enfermedad Crónica , Estudios de Cohortes , Terapia Combinada/métodos , Diagnóstico Diferencial , Supervivencia sin Enfermedad , Neoplasias del Oído/diagnóstico , Neoplasias del Oído/epidemiología , Neoplasias del Oído/terapia , Parálisis Facial/etiología , Femenino , Humanos , Lactante , Masculino , Morbilidad , Otitis Media con Derrame/diagnóstico , Complicaciones Posoperatorias , Estudios Retrospectivos , Rabdomiosarcoma Embrionario/diagnóstico , Rabdomiosarcoma Embrionario/epidemiología , Rabdomiosarcoma Embrionario/terapiaRESUMEN
The severity of late cardiotoxicity after anthracycline treatment for childhood cancer relates mainly to the cumulative anthracycline dose received, but all dose ranges cause some cardiac dysfunction. Anthracycline administration by infusion in order to lower peak drug concentration has been used in an attempt to reduce cardiotoxicity. Cardiac performance was assessed by echocardiography in children who were relapse-free survivors of treatment for acute lymphoblastic leukaemia (ALL). They received the same cumulative anthracycline dose (daunorubicin 180 mg/m2) either by bolus injection (UKALL X protocol, n = 40) or by infusion (UKALL XI protocol, n = 71) with a follow-up duration of 5.3 +/- 2.0 and 5.4 +/- 1.0 years respectively. On analysis, both the bolus administration and infusion groups showed similar mild impairment of cardiac performance, characterized by increased left ventricular end systolic stress and impaired left ventricular function. In conclusion, subclinical abnormality of left ventricular performance was confirmed in both groups despite the relatively modest cumulative anthracycline dose received. We were unable to demonstrate an advantage of anthracycline administration by 6-h infusion with respect to late cardiotoxicity at this dose.
Asunto(s)
Antibióticos Antineoplásicos/administración & dosificación , Daunorrubicina/administración & dosificación , Cardiopatías/inducido químicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Adolescente , Antibióticos Antineoplásicos/efectos adversos , Niño , Daunorrubicina/efectos adversos , Esquema de Medicación , Femenino , Estudios de Seguimiento , Cardiopatías/fisiopatología , Humanos , Infusiones Intravenosas , Inyecciones Intravenosas , Masculino , Función Ventricular Izquierda/efectos de los fármacosAsunto(s)
Neoplasias/terapia , Calidad de Vida , Sobrevivientes , Adaptación Psicológica , Factores de Edad , Antineoplásicos/efectos adversos , Niño , Empleo , Sistema Endocrino/efectos de la radiación , Cardiopatías/inducido químicamente , Humanos , Infertilidad/etiología , Relaciones Interpersonales , Esperanza de Vida , Trastornos Mentales/etiología , Neoplasias/psicología , Osteoporosis/inducido químicamente , Pubertad , Radioterapia/efectos adversos , Factores de Riesgo , Sobrevivientes/psicologíaRESUMEN
PURPOSE: This study sought to determine whether the identification of minimal pulmonary metastatic disease by chest computed tomography (CT) performed at diagnosis in patients with Wilms' tumor and normal chest x-rays (CXR) could predict a subgroup of children at increased risk of pulmonary relapse. PATIENTS AND METHODS: A retrospective analysis was carried out of the records of 449 children entered onto the United Kingdom Childrens' Cancer Study Group Second Wilms' Tumor Study between July 1986 and September 1991. The imaging protocol did not stipulate chest CT at diagnosis, but 141 children who had normal frontal and lateral CXRs and a chest CT scan performed at diagnosis were eligible for analysis. After surgery, children with stage I Wilms' tumor received single-agent chemotherapy (vincristine), whereas children with stages II, III, and bilateral Wilms' tumor received combination chemotherapy. Most children with stage III tumors were also treated with abdominal radiotherapy (20 Gy). RESULTS: In 31 patients (22%), pulmonary nodules were visible on chest CT; eight experienced relapse, four (15%) in the lungs. When only stage I patients were analyzed, there was a significant difference between the pulmonary relapse rate of 43% (three of seven) in the CT-positive group and 10% (five of 48) in the CT-negative group (P =.02). Four of eight patients with stage I disease with pulmonary relapse died. CONCLUSION: CT seemed to identify a subgroup of stage I patients who were at increased risk of pulmonary relapse. These children had received only single-agent chemotherapy. A prospective randomized trial is needed to clarify whether these children would benefit from combination chemotherapy.
Asunto(s)
Neoplasias Renales/patología , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/secundario , Estadificación de Neoplasias , Tomografía Computarizada por Rayos X , Tumor de Wilms/diagnóstico por imagen , Tumor de Wilms/secundario , Antineoplásicos Fitogénicos/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Neoplasias Renales/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Masculino , Valor Predictivo de las Pruebas , Pronóstico , Recurrencia , Estudios Retrospectivos , Factores de Riesgo , Vincristina/uso terapéutico , Tumor de Wilms/tratamiento farmacológicoAsunto(s)
Neoplasias/terapia , Sobrevivientes , Enfermedades Cardiovasculares/inducido químicamente , Medicina Basada en la Evidencia , Medicina Familiar y Comunitaria , Estudios de Seguimiento , Humanos , Neoplasias/tratamiento farmacológico , Neoplasias/radioterapia , Enfermeras Practicantes , Estudios RetrospectivosRESUMEN
AIMS: To assess the impact of treatment for embryonal rhabdomyosarcoma on spinal growth and limb length and examine the response of these parameters to growth hormone (GH) treatment. METHODS: We conducted a retrospective case note review of 17 survivors of head and neck rhabdomyosarcoma followed up at a single institution. All children had been treated with chemotherapy and local radiotherapy. Growth velocity, height, sitting height, and subischial limb length SDS scores were analysed. RESULTS: Growth failure secondary to isolated GH deficiency (GHD) developed in 7/17 patients. GHD occurred at a median (range) of 3.4 (1.3-9.9) years after radiotherapy tumour doses of 46 (40-50) Gy. Growth velocity, height, and subischial limb length SDS were significantly reduced in the GHD group and improved with GH therapy. CONCLUSIONS: GH treatment resulted in a significant improvement in sitting height SDS. We discuss the unexpected improvement in spinal growth in survivors with GHD.
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Trastornos del Crecimiento/tratamiento farmacológico , Hormona del Crecimiento/uso terapéutico , Neoplasias de Cabeza y Cuello/radioterapia , Rabdomiosarcoma Embrionario/radioterapia , Estatura/efectos de los fármacos , Estatura/efectos de la radiación , Niño , Preescolar , Femenino , Estudios de Seguimiento , Trastornos del Crecimiento/etiología , Hormona del Crecimiento/deficiencia , Humanos , Lactante , Huesos de la Pierna/crecimiento & desarrollo , Huesos de la Pierna/efectos de la radiación , Masculino , Estudios Retrospectivos , Columna Vertebral/crecimiento & desarrollo , Columna Vertebral/efectos de la radiación , SobrevivientesRESUMEN
We report the presence of basilar invagination, an unexpected and previously undescribed abnormality of the skull base, in 7 of 38 long-term survivors of multisystem Langerhans' cell histiocytosis. The abnormality is acquired, but its pathogenesis is uncertain.
Asunto(s)
Enfermedades Óseas/etiología , Histiocitosis de Células de Langerhans/complicaciones , Hueso Occipital/patología , Adolescente , Adulto , Enfermedades Cerebelosas/etiología , Niño , Estudios de Cohortes , Encefalocele/etiología , Femenino , Estudios de Seguimiento , Foramen Magno/patología , Humanos , Estudios Longitudinales , Imagen por Resonancia Magnética , Masculino , Apófisis Odontoides/patología , Platibasia/etiología , SobrevivientesAsunto(s)
Infertilidad Femenina/etiología , Infertilidad Masculina/etiología , Neoplasias/terapia , Medicina Reproductiva , Antineoplásicos/efectos adversos , Niño , Preescolar , Femenino , Humanos , Masculino , Neoplasias/tratamiento farmacológico , Neoplasias/radioterapia , Embarazo , Complicaciones del Embarazo/etiología , Radioterapia/efectos adversos , Sobrevivientes , Enfermedades Uterinas/etiologíaRESUMEN
BACKGROUND: Current treatment of stage III favorable histology (FH) Wilms tumor is surgery, radiotherapy to residual disease, and "triple" chemotherapy (vincristine, dactinomycin, and doxorubicin) for 12 months. This study tests the hypothesis that some stage III patients, especially very young children with minimal residual abdominal disease, might be successfully treated without radiotherapy, thereby avoiding the adverse late effects associated with radiotherapy. PROCEDURE: From 1984, radiotherapy was omitted from the treatment of 8 carefully selected children who were younger than 3 years of age at diagnosis with stage III Wilms tumor by virtue of microscopic residual disease after surgery and whose lymph nodes were not involved by tumors. They were followed with bimonthly abdominal ultrasound examinations to assess local control. RESULTS: Follow-up is now from 2 to 12 years (median 6 years) and 7 of the 8 children are alive and well with no abdominal recurrence. One child relapsed in the lungs and despite further treatment died of progressive disease. The disease-free survival (DFS) and overall survival (OS) are therefore both 87.5%. CONCLUSIONS: The DFS and OS in this admittedly small sample are consistent with the survival rates for stage III FH Wilms tumor in the first United Kingdom Children's Cancer Study Group (UKCCSG), North American (NWTS), and European (SIOP) Wilms Tumor studies, Larger numbers of patients are needed to determine whether or not this treatment approach is generally applicable, but we conclude that some children in this stage III "substage" may be treated successfully without radiotherapy.