1.
Guang Pu Xue Yu Guang Pu Fen Xi
; 24(1): 15-7, 2004 Jan.
Artículo
en Chino
| MEDLINE
| ID: mdl-15768965
RESUMEN
A novel flow injection chemiluminescence method has been developed for the determination of doxycycline (DC) based on the inhibition of chemiluminescence reaction of Luminol-KMnO4 by using DC in sodium hydroxide medium. Using different concentrations of KMnO4, a series of good linear regression equations of decreased chemiluminescence intensity and the concentration of DC were obtained with different subsections in the concentration range of 0.005-5.0 microg x mL(-1). The detection limit (3sigma) is 2.0 x 10(-3) microg x mL(-1). The method has been successfully applied to the determination of DC in a pharmaceutical preparation.