RESUMEN
Recovering phosphorus (P) and nitrogen (N) from wastewater not only contributes to environmental protection but also aligns with sustainable development goals. This study employed a magnesium-air fuel cell (Mg-O2-FC) to extract P and N from wastewater in the form of struvite (MgNH4·6H2O), based on the removal efficiency of ammonia and phosphate, electricity generation capacity and struvite purity to determine the optimal operation parameters. These parameters included hydraulic retention time (HRT), service life of magnesium sheet, and precipitation discharge frequency. The results showed that the removal efficiency of ammonia from 0 to 4h was 55.99%, and that from 4 to 12h was only 15.74%. The phosphate removal efficiency in the initial cycle was 97.68% but decreased to 63.25% after 24h. The phosphate removal rate in 2 min increased by 145% when the precipitation discharge frequency increased from 4 h/time to 24 h/time. Consequently, the HRT, service life of the magnesium sheet, and precipitation discharge frequency were selected as 4 h, 24 h, and 24 h/time. These optimized conditions provide valuable insights for the practical implementation of Mg-O2-FC in recovering N and P from wastewater.
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Magnesio , Nitrógeno , Fósforo , Aguas Residuales , Fósforo/química , Fósforo/análisis , Aguas Residuales/química , Nitrógeno/análisis , Magnesio/química , Magnesio/análisis , Eliminación de Residuos Líquidos/métodos , Amoníaco/química , Fosfatos/química , Fosfatos/análisisRESUMEN
Quercetin, an abundant flavonoid compound in plants, is considered a novel antidepressant; however, its mechanisms of action are poorly understood. This study aimed to investigate the therapeutic effects of quercetin on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors in rats and explore the underlying mechanisms by combining untargeted metabolomics and 16S rRNA sequencing analysis of brain tissue metabolites and gut microbiota. Gut microbiota analysis revealed that at the phylum level, quercetin reduced Firmicutes and the Firmicutes/Bacteroidetes (F/B) ratio and enhanced Cyanobacteria. At the genus level, quercetin downregulated 6 and upregulated 14 bacterial species. Metabolomics analysis revealed that quercetin regulated multiple metabolic pathways, including glycolysis/gluconeogenesis, sphingolipid metabolism, the pentose phosphate pathway, and coenzyme A biosynthesis. This modulation leads to improvements in depression-like phenotypes, anxiety-like phenotypes, and cognitive function, highlighting the therapeutic potential of quercetin in treating depression.
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Egg yolk texture affects consumer egg preference. The sensory characteristics of eggs are affected by not only the cooking method but also the maternal breed. In this study, we investigated the texture, structure, and nutritional differences between the cooked yolks of eggs obtained from Hetian Dahei (HTDH) and Rhode Island Red (RIR) chickens. The springiness, cohesiveness, gumminess, chewiness, and resilience of HTDH egg yolks were lower, and the hardness was higher than those of RIR egg yolks. Moreover, scanning electron microscopy revealed that HTDH egg yolk particles were smaller and that HTDH egg yolks had a denser protein network than those of RIR egg yolks. Lipid and protein levels were higher, whereas water contents were lower in uncooked HTDH egg yolks than in uncooked RIR egg yolks. Liquid chromatography tandem mass spectrometry further revealed that lower cohesiveness was associated with higher levels and greater variety of lipids in egg yolks. Moreover, increased phospholipid levels reduced egg yolk cohesiveness. Thus, the eggs of local Chinese chicken breeds were superior to those of a highly selected broiler chicken breed in terms of texture, structure, and nutritional composition, which may influence egg variety selection.
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Pollos , Óvulo , Animales , Pollos/genética , China , Yema de Huevo/química , Huevos/análisis , Lípidos/análisis , Óvulo/químicaAsunto(s)
Hemorragia Cerebral , Impresión Tridimensional , Ventrículos Cardíacos , Humanos , PuncionesRESUMEN
Recently, the function of nanofiber membranes prepared from electrospinning in accelerating wound healing has attracted wide attention. In this study, novel nanofiber membranes consisted of cellulose acetate (CA) and zein were fabricated to provide efficient delivery vehicles for sesamol, and then the effect of sesamol-loaded composite nanofiber membranes on the wound healing of diabetic mice was studied. It was found the critical concentration of CA was between 15% and 25% (w/v), and the most suitable concentration of stabilizing fibers was 22.5%. When the CA/zein ratio was 12:8, the fiber obtained small diameter and uniform distribution, stable intermolecular structure, low infiltration speed and high stability in water. The composite nanofiber membrane with high-dose sesamol (5% of total polymer concentration, w/w) promoted formation of myofibroblasts by enhancing TGF-ß signaling pathway transduction, and promoted keratinocyte growth by inhibiting chronic inflammation in wounds, thus enhancing wound healing in diabetic mice. This study can further broaden the application range of sesamol, CA and zein, and provide reference for the design and development of new wound dressings in the future.
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Celulosa/análogos & derivados , Celulosa/farmacología , Membranas Artificiales , Nanofibras/química , Nanofibras/uso terapéutico , Cicatrización de Heridas/efectos de los fármacos , Zeína/farmacología , Animales , Vendajes , Benzodioxoles , Diabetes Mellitus Experimental , Masculino , Ratones , Ratones Endogámicos C57BL , Nanofibras/ultraestructura , Fenoles , Agua/químicaRESUMEN
BACKGROUND: Cerebral cavernous malformations (CCMs) are present in up to 0.5% of the general population. Although CCMs have been considered congenital lesions, numerous reports have observed de novo formations in patients with the familial form of CCM and in patients after cranial radiotherapy. Outside of these circumstances, there is scant evidence as to the potential etiologies of CCM. CASE DESCRIPTION: We present a 48-year-old woman with a medical history of endometrial hyperplasia concomitant endometrial polyps demonstrating a large de novo CCM, which grew to a large size in a period of 20 months. A previous magnetic resonance imaging scan showed no abnormalities. This CCM exhibited aggressive biological behavior characterized by recurrent overt bleeding and seizure. Histopathologic analysis confirmed the diagnosis of CCM. Here, we discuss the growth mechanisms of these lesions. CONCLUSIONS: Given the patient's medical history and imaging findings, we propose that de novo CCMs can arise directly from angiogenic proliferation, secondary to BCL-2 overexpression from underlying causes. We hypothesize that inappropriate secretion of estrogen could have set off a genetic cascade with attendant endothelial proliferation. Thus, female hormones may play an important role in influencing the biological behavior of CCMs. The relationship between estrogen and CCM needs further investigation.
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Ganglios Basales/cirugía , Neoplasias Encefálicas/cirugía , Craneotomía , Hemangioma Cavernoso del Sistema Nervioso Central/cirugía , Ganglios Basales/diagnóstico por imagen , Ganglios Basales/patología , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/patología , Neoplasias Encefálicas/fisiopatología , Femenino , Hemangioma Cavernoso del Sistema Nervioso Central/diagnóstico por imagen , Hemangioma Cavernoso del Sistema Nervioso Central/patología , Hemangioma Cavernoso del Sistema Nervioso Central/fisiopatología , Humanos , Persona de Mediana EdadRESUMEN
6-Gingerol and 6-shogaol are the main bioactive compounds in ginger. Although 6-shogaol has more and better bioactivities than its precursor 6-gingerol, the low content of 6-shogaol in ginger restricts its bioactive effects in functional foods. The traditional preparation methods of 6-shogaol are defective because of the environmental hazards and low efficiency of the processes. In this study, an efficient, easy and eco-friendly dehydration conversion of 6-gingerol to 6-shogaol is presented using an acidic ionic liquid 1-butyl-3-methylimidazolium hydrosulfate ([Bmim]HSO4) under ultrasound irradiation. The key parameters, including reaction temperature, reaction time, mass ratio of catalyst to substrate and ultrasonic power in each reaction process, were investigated. The yield of 6-shogaol reached as high as 97.16% under optimized condition. The catalyst could be separated from the reaction mixture and reused five times with only a slight loss of activity.