Asunto(s)
Aminofilina/farmacocinética , Animales Recién Nacidos/metabolismo , Cabras/metabolismo , Inhibidores de Fosfodiesterasa/farmacocinética , Administración Oral , Aminofilina/administración & dosificación , Aminofilina/farmacología , Animales , Peso al Nacer/efectos de los fármacos , Femenino , Semivida , Inyecciones Intravenosas/veterinaria , Masculino , Inhibidores de Fosfodiesterasa/administración & dosificación , Inhibidores de Fosfodiesterasa/farmacologíaAsunto(s)
Enfermedades de los Perros/diagnóstico , Disnea/veterinaria , Acalasia del Esófago/veterinaria , Neumonía por Aspiración/veterinaria , Animales , Perros , Disnea/diagnóstico , Disnea/etiología , Acalasia del Esófago/diagnóstico , Esófago/patología , Humanos , Pulmón/patología , Neumonía por Aspiración/diagnóstico , Neumonía por Aspiración/patologíaRESUMEN
We describe a new deafness mutant found in the Zucker rat. The mutant phenotype appears to be caused by an autosomal recessive gene, tentatively named stargazer, gene symbol stg. The phenotype is characterized by stargazing, head tossing, drawing back, circling, and hyperactivity, all of which are apparent by the third week of life. Although the affected animals sire or bear normal-sized litters, mortality is high for litters of affected dams, apparently due to trampling or neglect by the hyperactive dams. Affected animals are unable to swim and, when lifted by the tail, they are likely to curl ventrally, rather than extending their paws downward. These behaviors are consistent with a disorder of the vestibular system. Auditory evoked potential recordings were attempted as a hearing test. The failure of audible clicks up to 90 decibels to stimulate the auditory tract indicates that stargazers are profoundly deaf. These disruptions of vestibular and auditory systems suggest that the stargazer phenotype may be caused by disordered development of the inner ear. Histologic examination of the inner ear revealed progressive degeneration of cells in the acoustic ganglion and of hair cells. The stargazer rat may be useful as a model for hereditary deafness or hyperactivity.
Asunto(s)
Sordera/veterinaria , Mutación , Ratas Zucker/genética , Enfermedades de los Roedores/genética , Animales , Conducta Animal , Cóclea/patología , Cruzamientos Genéticos , Sordera/genética , Sordera/patología , Modelos Animales de Enfermedad , Potenciales Evocados Auditivos , Femenino , Masculino , Fenotipo , RatasAsunto(s)
Enfermedades de las Aves/etiología , Columbidae , Enteritis/veterinaria , Complejo Vitamínico B/uso terapéutico , Deficiencia de Vitamina B/veterinaria , Animales , Enfermedades de las Aves/tratamiento farmacológico , Enfermedades de las Aves/patología , Quistes/tratamiento farmacológico , Quistes/veterinaria , Enteritis/tratamiento farmacológico , Enteritis/etiología , Femenino , Deficiencia de Vitamina B/complicaciones , Deficiencia de Vitamina B/patologíaRESUMEN
Seven purebred Toggenburg fetuses in four does, six purebred Nubian fetuses in four does, and eight Angora fetuses in six does were repeatedly measured using transabdominal real-time ultrasound with a 5 MH(z) linear-array transducer from 40 d to 100 d gestational age (GA) and their biparietal diameters (BPD) were determined. For Toggenburg goats the GA = 27.9 + 1.64 BPD; for Nubian goats the GA = 26.8 + 1.74 BPD; for Angora goats the GA = 28.6 + 1.77 BPD. The breed differences in GA for equal BPD are insignificant at the beginning of the second trimester but are +3 d for Nubian and +6 d for Angora fetuses by the end of the second trimester.
