Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 10 de 10
Filtrar
1.
Br J Dermatol ; 184(6): 1113-1122, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33236347

RESUMEN

BACKGROUND: The lack of uniformity in the outcomes reported in clinical studies of the treatment of cutaneous squamous cell carcinoma (cSCC) complicates efforts to compare treatment effectiveness across trials. OBJECTIVES: To develop a core outcome set (COS), a minimum set of agreed-upon outcomes to be measured in all clinical trials of a given disease or outcome, for the treatment of cSCC. METHODS: One hundred and nine outcomes were identified via a systematic literature review and interviews with 28 stakeholders. After consolidation of this long list, 55 candidate outcomes were rated by 19 physician and 10 patient stakeholders, in two rounds of Delphi exercises. Outcomes scored 'critically important' (score of 7, 8 or 9) by ≥ 70% of patients and ≥ 70% of physicians were provisionally included. At the consensus meeting, after discussion and voting of 44 international experts and patients, the provisional list was reduced to a final core set, for which consensus was achieved among all meeting participants. RESULTS: A core set of seven outcomes was finalized at the consensus meeting: (i) serious or persistent adverse events, (ii) patient-reported quality of life, (iii) complete response, (iv) partial response, (v) recurrence-free survival, (vi) progression-free survival and (vii) disease-specific survival. CONCLUSIONS: In order to increase the comparability of results across trials and to reduce selective reporting bias, cSCC researchers should consider reporting these core outcomes. Further work needs to be performed to identify the measures that should be reported for each of these outcomes.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias Cutáneas , Carcinoma de Células Escamosas/terapia , Técnica Delphi , Humanos , Calidad de Vida , Proyectos de Investigación , Neoplasias Cutáneas/terapia , Resultado del Tratamiento
2.
J Pediatr Ophthalmol Strabismus ; 44(6): 379-81, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-18062498

RESUMEN

A 17-year-old boy with a growth in the medial right lower eyelid obliterating the lower punctum and canaliculus underwent incisional biopsy, which revealed fibrous histiocytoma. The remaining tumor was excised and the eyelid was reconstructed. No recurrence was noted after 1 year of follow-up.


Asunto(s)
Neoplasias de los Párpados/patología , Histiocitoma Fibroso Benigno/patología , Adolescente , Biopsia , Diagnóstico Diferencial , Neoplasias de los Párpados/cirugía , Párpados/patología , Párpados/cirugía , Estudios de Seguimiento , Histiocitoma Fibroso Benigno/cirugía , Humanos , Masculino , Procedimientos Quirúrgicos Oftalmológicos/métodos , Procedimientos de Cirugía Plástica/métodos
3.
J Clin Oncol ; 11(4): 690-7, 1993 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-8478662

RESUMEN

PURPOSE: Since the only three cases of granulocytic sarcoma among patients with acute myeloid leukemia (AML) seen at our institution during the last 12 years were each associated with the 8;21 translocation [t(8;21)], we sought to determine if this association is specific and more frequent than previously recognized. PATIENTS AND METHODS: We report three patients with AML and t(8;21) who developed granulocytic sarcomas, and review the world literature. RESULTS: Between 1980 and 1992, 53 cases of AML French-American-British (FAB) M2 were identified at our institution. Eight (15%) patients had t(8;21). Three of these eight patients (38%) developed granulocytic sarcoma. All three of our patients received conventional intensive antileukemic chemotherapy yet had short relapse-free survival durations. Several series of patients with t(8;21) report that granulocytic sarcomas occur in approximately 18% of this population, which is four times the expected incidence in AML. Thirty-seven cases have been previously reported. Although karyotype analyses were not reported in many cases of granulocytic sarcoma in the literature, the vast majority of abnormal karyotypes in patients with AML involved t(8;21). Recent work with a cell line derived from a patient with t(8;21) indicates that such cells are unusually adherent to culture bottles and are aggregable CONCLUSION: Our data suggest that this association is more common than generally recognized and may be specific. Patients with t(8;21) should be observed closely for signs and symptoms of granulocytic sarcoma. These patients may have a less favorable prognosis than other patients with t(8;21). Cooperative oncology groups should retrospectively identify patients with AML and t(8;21) who had a poor outcome to determine if they had a disproportionate incidence of granulocytic sarcoma. If so, aggressive therapy such as bone marrow transplantation may be warranted early in the therapeutic strategy.


Asunto(s)
Cromosomas Humanos Par 21 , Cromosomas Humanos Par 8 , Leucemia Mieloide/genética , Translocación Genética , Enfermedad Aguda , Adulto , Femenino , Humanos , Leucemia Mieloide/diagnóstico , Imagen por Resonancia Magnética , Masculino , Neoplasias Orbitales/diagnóstico , Neoplasias Orbitales/genética , Neoplasias Orbitales/patología
4.
Ophthalmic Surg ; 22(12): 745-8, 1991 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-1787941

RESUMEN

Silicone tubes removed from patients who underwent intubation of the nasolacrimal system for acquired or congenital obstruction were studied to determine the cellular reaction on the tubes and to assess the relationship between the length of intubation and the cellular response. Twenty-one tubes were available for analysis. Length of intubation varied from 39 to 415 days; patient ages varied from 10 months to 75 years. All patients had undergone dacryocystorhinostomy or closed intubation of the nasolacrimal system. No patient had clinical signs of infection at the time of tube removal. All tubes were mounted on glass slides and stained with hematoxylin and eosin. The reactions seen, together with the location and type of cells present, were graded by a masked observer. There were varying numbers of inflammatory cells, predominantly polymorphonuclear leukocytes. As the length of intubation increased, the number of inflammatory cells also increased. The proximal portion of the tubing showed the least amount of cellular reaction at all lengths of intubation.


Asunto(s)
Reacción a Cuerpo Extraño/patología , Intubación , Obstrucción del Conducto Lagrimal/terapia , Conducto Nasolagrimal , Elastómeros de Silicona/efectos adversos , Adolescente , Adulto , Anciano , Niño , Preescolar , Dacriocistorrinostomía , Femenino , Reacción a Cuerpo Extraño/etiología , Humanos , Lactante , Leucocitos/patología , Masculino , Persona de Mediana Edad , Elastómeros de Silicona/química
5.
Ophthalmology ; 98(6): 925-7, 1991 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-1866146

RESUMEN

Hemangiopericytomas of the orbit are rare tumors with low malignancy potential. To the authors' knowledge, only three previous cases of these tumors occurring in the lacrimal sac have been reported. The authors report a fourth case. Follow-up was obtained on the first reported case, and the patient in that case had a recurrence after 15 years. These tumors should be totally excised and followed for long periods of time.


Asunto(s)
Hemangiopericitoma/patología , Enfermedades del Aparato Lagrimal/patología , Adulto , Dacriocistorrinostomía , Femenino , Estudios de Seguimiento , Hemangiopericitoma/cirugía , Humanos , Enfermedades del Aparato Lagrimal/cirugía , Recurrencia Local de Neoplasia
6.
J Pediatr Ophthalmol Strabismus ; 24(3): 141-4, 1987.
Artículo en Inglés | MEDLINE | ID: mdl-3598835

RESUMEN

Several months after a fall down a flight of stairs, a one-year-old girl developed downward displacement and pulsation of the left eye. Vision and ocular motility were not impaired and the child remained neurologically normal. Computed tomography with metrizamide cisternography demonstrated herniation of brain tissue through a traumatic defect in the roof of the orbit. The orbital rim and other craniofacial bones were intact. Repair of the growing fracture found at operation restored normal appearance without disturbing function. To our knowledge, this is the first documented case of encephalocele associated with an isolated fracture of the orbital roof due to blunt head trauma.


Asunto(s)
Encefalocele/etiología , Fracturas Orbitales/complicaciones , Fracturas Craneales/complicaciones , Encefalocele/diagnóstico por imagen , Encefalocele/cirugía , Femenino , Humanos , Lactante , Fracturas Orbitales/diagnóstico por imagen , Fracturas Orbitales/cirugía , Tomografía Computarizada por Rayos X
7.
Pediatr Neurosci ; 13(4): 210-3, 1987.
Artículo en Inglés | MEDLINE | ID: mdl-3454443

RESUMEN

A sphenoid wing meningioma causing a progressive painless proptosis is reported in a 5-year-old boy. The diagnostic evaluation and surgical management of this case are reported. A review of the literature indicates this is the youngest patient with sphenoid wing meningioma.


Asunto(s)
Exoftalmia/etiología , Neoplasias Meníngeas/complicaciones , Meningioma/complicaciones , Preescolar , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico por imagen , Neoplasias Meníngeas/cirugía , Meningioma/diagnóstico por imagen , Meningioma/cirugía , Hueso Esfenoides/diagnóstico por imagen , Hueso Esfenoides/cirugía , Tomografía Computarizada por Rayos X
8.
Postgrad Med ; 78(8): 121-33, 1985 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-3840890

RESUMEN

Several pathologic processes can disturb the complex structures of the eyelids and orbital tissues and the muscles that enable their proper function. Some disorders, such as entropion and ectropion, are usually acquired in later years from laxity of supporting structures. Blepharoptosis has a range of causes, from aging to an intracranial aneurysm, and its severity varies, from mild to almost complete closure of the lid fissures. Graves' orbitopathy can produce lid retraction, lid lag, and proptosis and can cause vision-threatening conditions. Orbital cellulitis produces pain, swelling, proptosis, and redness of the lids and conjunctivae and, if severe, can compromise ocular motility and visual acuity. Early recognition of the specific disorder and prompt and adequate treatment are essential to spare the patient discomfort and ensure preservation of vision.


Asunto(s)
Enfermedades de los Párpados , Enfermedades Orbitales , Anciano , Antibacterianos/uso terapéutico , Blefaroptosis/diagnóstico , Blefaroptosis/patología , Celulitis (Flemón)/tratamiento farmacológico , Celulitis (Flemón)/etiología , Celulitis (Flemón)/patología , Diagnóstico Diferencial , Ectropión/patología , Ectropión/fisiopatología , Ectropión/cirugía , Entropión/patología , Entropión/cirugía , Enfermedades de los Párpados/diagnóstico , Enfermedades de los Párpados/patología , Enfermedades de los Párpados/cirugía , Enfermedad de Graves/diagnóstico , Enfermedad de Graves/patología , Enfermedad de Graves/terapia , Humanos , Enfermedades Orbitales/etiología , Enfermedades Orbitales/patología , Enfermedades Orbitales/terapia , Atención Primaria de Salud , Sinusitis/complicaciones
9.
Am J Ophthalmol ; 88(4): 708-13, 1979 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-389051

RESUMEN

A premature infant with acute necrotizing enterocolitis, Escherichia coli sepsis, and disseminated intravascular coagulation developed spontaneous bilateral hyphemas at 3 days of age. The necrotizing enterocolitis was associated with gas bubbles in the intestinal walls. The anterior chambers of both eyes also contained bubbles of gas, formed possibly by a mechanism similar to those in the intestine.


Asunto(s)
Aire , Oftalmopatías/etiología , Hipema/etiología , Neumatosis Cistoide Intestinal/etiología , Cámara Anterior , Coagulación Intravascular Diseminada/complicaciones , Enterocolitis Seudomembranosa/complicaciones , Infecciones por Escherichia coli , Humanos , Recién Nacido , Enfermedades del Prematuro/complicaciones , Masculino , Sepsis/complicaciones
10.
Am J Ophthalmol ; 86(3): 388-94, 1978 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-362928

RESUMEN

A 60-year-old man receiving antituberculous and corticosteroid therapy for a granulomatous disease of uncertain etiology was found to have a chorioretinal mass in his right eye. Fluorescein angiography showed blockage of fluorescence by the mass and late leakage. Autopsy findings were compatible with Hodgkin's disease with disseminated nocardiosis caused by Nocardia asteroides. Organisms typical of Nocardia were found in the choroid and subretinal space. The patient's history, ophthalmic examination, and fluorescein angiographic findings suggested a type of chorioretinal involvement.


Asunto(s)
Oftalmopatías/complicaciones , Enfermedad de Hodgkin/complicaciones , Nocardiosis/complicaciones , Corticoesteroides/uso terapéutico , Ojo/patología , Oftalmopatías/diagnóstico , Oftalmopatías/patología , Enfermedad de Hodgkin/tratamiento farmacológico , Enfermedad de Hodgkin/patología , Humanos , Masculino , Persona de Mediana Edad , Nocardiosis/diagnóstico , Nocardiosis/patología , Nocardia asteroides
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...