[Electron microscopic research in non-A, non-B viral hepatitis with a fecal-oral mechanism of infection transmission]. / Elektronno-mikroskopicheskie issledovaniia pri virusnom gepatite ni A ni B s fekal'no-oral'nym mekhanizmom peredachi infektsii.

Fecal specimens collected in the early stage of the disease from hepatitis patients classified by serological, clinical, and epidemiological data as non-A-non-B hepatitis were examined by means of cross immune electron microscopy. Extracts of feces from such patients were found to contain full, semi-empty, and empty virus particles without envelopes, 27-30 nm in size, forming immune complexes only in the presence of acute and convalescent sera from patients with this type of hepatitis. The lack of serological crosses with hepatitis A and non-A-non-B viruses isolated in other regions suggests that this virus is antigenically distinct. The final solution requires further studies in which methods of molecular biology of viruses should be used.

[Clinico-epidemiological characteristics and diagnosis of viral non-A, non-B hepatitis with fecal and oral mechanisms of transmission of the infection]. / Kliniko-épidemiologicheskie osobennosti i diagnostika virusnogo gepatita ni A, ni B s fekal'no-oral'nym mekhanizmom peredachi infektsii.

The paper deals with observations of the patients with non-A-non-B hepatitis (NANBH) transmitted by the fecal-oral mode. The disease was diagnosed by ruling out other similar diseases of the liver, primarily viral A (HA) and B (HB) hepatitides, using clinical and epidemiological data and highly sensitive methods of laboratory diagnosis of HA and HB. Cases of NANBH occurred in one of Central Asia regions in the period of the usual seasonal rise of incidence. The disease was more frequent in adults, running a mild course in most patients, although there were also severe forms with fatal outcomes observed only in pregnant women in the second half of pregnancy. The lethality among the pregnant women was 15.7%. Immune electron microscopy of fecal specimens collected from the patients in the early days of jaundice revealed virus-like particles of 27-30 nm in diameter, morphologically similar to HA virus but forming no immune complexes upon treatment with blood sera containing antibody to HA virus antigen.