Biomolecular condensates can function as inherent catalysts.

We report the discovery that chemical reactions such as ATP hydrolysis can be catalyzed by condensates formed by intrinsically disordered proteins (IDPs), which themselves lack any intrinsic ability to function as enzymes. This inherent catalytic feature of condensates derives from the electrochemical environments and the electric fields at interfaces that are direct consequences of phase separation. The condensates we studied were capable of catalyzing diverse hydrolysis reactions, including hydrolysis and radical-dependent breakdown of ATP whereby ATP fully decomposes to adenine and multiple carbohydrates. This distinguishes condensates from naturally occurring ATPases, which can only catalyze the dephosphorylation of ATP. Interphase and interfacial properties of condensates can be tuned via sequence design, thus enabling control over catalysis through sequence-dependent electrochemical features of condensates. Incorporation of hydrolase-like synthetic condensates into live cells enables activation of transcriptional circuits that depend on products of hydrolysis reactions. Inherent catalytic functions of condensates, which are emergent consequences of phase separation, are likely to affect metabolic regulation in cells.

An Experimental Field Comparison of Wi-Fi HaLow and LoRa for the Smart Grid.

IEEE 802.11ah, or Wi-Fi HaLow, is a long-range Internet of Things (IoT) communication technology with promising performance claims. Being IP-based makes it an attractive prospect when interfacing with existing IP networks. Through real-world performance experiments, this study evaluates the network performance of Wi-Fi HaLow in terms of throughput, latency, and reliability against IEEE 802.11n (Wi-Fi n) and a competing IoT technology LoRa. These experiments are enabled through three proposed network evaluation architectures that facilitate remote control of the devices in a secure manner. The performance of Wi-Fi HaLow is then assessed against the network requirements of various smart grid applications. Wi-Fi HaLow offers promising performance when compared to rival technology LoRa. This study is the first to evaluate Wi-Fi HaLow in an authentic experimental way, providing performance data and insights that are not possible through simulation and modelling alone. This work provides the basis for further evaluation and implementation of this emerging technology.

Utilizing SELinux to mandate ultra-secure access control of medical records.

Ongoing concerns have been raised over the effectiveness of information technology products and systems in maintaining privacy protection for sensitive data. The aim is to ensure that sensitive health information can be adequately protected yet still be accessible only to those that "need-to-know". To achieve this and ensure sustainability over the longer term, it is advocated that an alternative, stable and secure system architecture is required. This paper considers the adoption of a model targeted at health information that provides much higher degrees of protection. A purpose built demonstrator that was developed based on enterprise-level systems software products is detailed. The long term aim is to provide a viable solution by utilizing contemporary, commercially supported operating system and allied software. The advantages and limitations in its application with a medical database are discussed. The future needs in terms of research, software development and changes in organizational policy for healthcare providers, are outlined.