RESUMEN
Early cognitive changes due to Alzheimer's disease (AD) include difficulties in semantic access and working memory. Using a computerized cognitive test developed by our group, called the Memory for Semantically Related Objects test (MESERO), we evaluated if cognitively unimpaired carriers of an autosomal dominant AD (ADAD) mutation performed worse on this test than non-carrier family members. 35 cognitively unimpaired ADAD mutation carriers and 26 non-carrier family members from a Colombian ADAD cohort took the MESERO on a laptop computer. Cognitively unimpaired ADAD carriers had significantly worse MESERO total scores than non-carrier family members, driven by worse performance in semantically-related object sets; group performances did not differ on semantically unrelated object sets. Findings suggest that MESERO performance may be sensitive to subtle cognitive changes associated with AD. Future MESERO research should examine performances between healthy older adults and people at risk for sporadic AD.
Asunto(s)
Enfermedad de Alzheimer , Humanos , Anciano , Enfermedad de Alzheimer/psicología , Mutación/genética , Pruebas Neuropsicológicas , ColombiaRESUMEN
Experimental high-quality optical vortices of different topological charges are generated by using a vortex producing lens with two phase levels. In our setup, the lens is displayed on a liquid-crystal spatial light modulator that only attains phase modulation of around 1.2π. This achievement opens the real possibility of creating high-quality optical vortices with devices of very low phase modulation capacity. The experimental setup is fully described, and the considerations to set the optimal parameters to obtain high-quality optical vortices are discussed and experimentally established. The phase and intensity of the optical vortices are recovered. The phase is obtained through a phase-shifting method that is directly programmed onto the modulator avoiding any class of mechanical displacement.