RESUMEN
A case is described in which the short-acting glycoprotein IIb/IIIa receptor antagonist tirofiban was used in combination with heparin, aspirin and prasugrel to successfully treat extensive intracoronary thrombus in a delayed presentation STEMI, illustrating the utility of this approach.
Asunto(s)
Abciximab , Aspirina/administración & dosificación , Trombosis Coronaria/tratamiento farmacológico , Heparina/administración & dosificación , Clorhidrato de Prasugrel/administración & dosificación , Infarto del Miocardio con Elevación del ST/tratamiento farmacológico , Tirofibán/administración & dosificación , Anciano , Trombosis Coronaria/complicaciones , Humanos , Masculino , Complejo GPIIb-IIIa de Glicoproteína Plaquetaria/antagonistas & inhibidores , Infarto del Miocardio con Elevación del ST/complicacionesAsunto(s)
Estenosis de la Válvula Aórtica/cirugía , Dolor en el Pecho/complicaciones , Depresión/epidemiología , Vigilancia de la Población , Autoinforme , Centros de Atención Terciaria , Reemplazo de la Válvula Aórtica Transcatéter/efectos adversos , Anciano , Estenosis de la Válvula Aórtica/diagnóstico , Dolor en el Pecho/epidemiología , Depresión/etiología , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Nueva Zelanda/epidemiología , Estudios Retrospectivos , Tomografía Computarizada por Rayos XAsunto(s)
Angiografía Coronaria/efectos adversos , Vasoespasmo Coronario/diagnóstico por imagen , Arteria Radial/diagnóstico por imagen , Cardiomiopatía de Takotsubo/diagnóstico por imagen , Trombosis/diagnóstico por imagen , Adulto , Vasoespasmo Coronario/complicaciones , Femenino , Humanos , Cardiomiopatía de Takotsubo/complicaciones , Trombosis/etiologíaAsunto(s)
Angina Inestable/cirugía , Braquiterapia/métodos , Reestenosis Coronaria/patología , Vasos Coronarios/patología , Procedimientos Endovasculares/métodos , Stents , Tomografía de Coherencia Óptica/métodos , Anciano , Angina Inestable/diagnóstico por imagen , Angina Inestable/patología , Partículas beta/uso terapéutico , Angiografía Coronaria , Reestenosis Coronaria/radioterapia , Vasos Coronarios/efectos de la radiación , Vasos Coronarios/cirugía , Estudios de Seguimiento , Humanos , Masculino , Falla de Prótesis , Factores de TiempoRESUMEN
BACKGROUND: Patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) are known to have poorer short-term prognosis compared to stable coronary artery (CAD) patients undergoing elective PCI. Few studies have made direct comparison of long-term mortality between ACS and stable CAD patients undergoing PCI. The aim of our study was to compare the long-term mortality following PCI between patients with ACS and those with stable CAD. METHODS: We examined consecutive patients undergoing PCI with stenting at a tertiary referral hospital. Clinical, angiographic and biochemical data were collected and analysed. The primary outcome was all-cause mortality retrieved from the Statewide Death Registry database. RESULTS: Included were 1923 consecutive PCI patients (970 stable CAD and 953 ACS). The mean follow-up time was 4.1 years ± 1.8 years. In-hospital mortality was 1.4% overall, seen exclusively in patients with ACS (n=28, 2.9%). Post-discharge mortality was 6.7% among patients with stable CAD and 10.5% for ACS (P<0.01). Multivariate predictors of post-discharge deaths for both groups included age (HR 1.08 per year, P<0.001) and impaired renal function (HR 2.49, P<0.001). Following adjustment for these factors, an ACS indication for PCI was not associated with greater post-discharge mortality (adjusted HR 1.18: 0.85-1.64, P=0.32). CONCLUSIONS: Patients undergoing PCI following an ACS have higher long-term mortality to those with stable CAD, which is potentially explained by a greater prevalence of comorbidities. This suggests that for the ACS population, contemporary interventional and medical management strategies may effectively and specifically counter the adverse prognostic impact of coronary instability and myocardial damage.
Asunto(s)
Síndrome Coronario Agudo/mortalidad , Síndrome Coronario Agudo/cirugía , Enfermedad de la Arteria Coronaria/mortalidad , Enfermedad de la Arteria Coronaria/cirugía , Intervención Coronaria Percutánea/mortalidad , Síndrome Coronario Agudo/diagnóstico , Anciano , Estudios de Cohortes , Enfermedad de la Arteria Coronaria/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Nueva Gales del Sur/epidemiología , Intervención Coronaria Percutánea/tendencias , Sistema de Registros , Factores de Tiempo , Resultado del TratamientoRESUMEN
Imaging the coronary vasculature using Optical Coherence Tomography (OCT) is now possible using motorised pullback during contrast injection.
Asunto(s)
Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Vasos Coronarios/diagnóstico por imagen , Tomografía de Coherencia Óptica/métodos , Medios de Contraste/administración & dosificación , Procedimientos Endovasculares , Humanos , Tomografía de Coherencia Óptica/instrumentación , UltrasonografíaRESUMEN
We describe a case of native coronary percutaneous coronary intervention (PCI) in which a probable thrombus following ST elevation myocardial infarction (STEMI) was managed using a combined Export catheter (Medtronic, Minneapolis, MN, USA) and Filterwire (Boston Scientific, Natick, MA, USA) approach. The two devices were compatible, with the Export catheter passing over the Filterwire wire, resulting in an excellent clinical outcome. This novel combination approach is feasible for cases with thrombotic burden.
Asunto(s)
Trombosis Coronaria/terapia , Infarto del Miocardio/complicaciones , Stents , Succión/instrumentación , Adulto , Anticoagulantes/uso terapéutico , Terapia Combinada , Angiografía Coronaria , Trombosis Coronaria/etiología , Ecocardiografía , Humanos , MasculinoRESUMEN
Gene silencing techniques are gaining increasing popularity in the literature, both as a tool for unravelling gene function and to potentially deliver therapeutic benefit, especially in the context of cardiovascular disease. Gene-specific catalytic DNA molecules, or DNAzymes, have shown promise in ameliorating the effects of myocardial ischaemia reperfusion injury and in-stent restenosis in various animal models, demonstrating that these agents may be useful in a clinical setting. A review of the recent advances in the use of DNAzymes in treating cardiovascular disease is therefore essential given the increasing clinical burden of cardiovascular disease worldwide. We have thus sought to firstly provide background into the construct and mechanism of action of DNAzymes, with a discussion of recent improvements in design. Secondly, we have examined the effects of DNAzyme-mediated gene inhibition in in vitro studies of both endothelial and smooth muscle migration and proliferation, as well as in vivo models of acute myocardial infraction and neointima formation. Lastly we compare DNAzymes with other gene silencing tools and discuss issues involved in successfully delivering these drugs in a clinical setting.
Asunto(s)
Enfermedades Cardiovasculares/terapia , ADN Catalítico/metabolismo , Marcación de Gen/métodos , Animales , Enfermedades Cardiovasculares/enzimología , Silenciador del Gen , Terapia Genética/métodos , HumanosRESUMEN
BACKGROUND: Mice lacking plasminogen (PG-/-) require alternative pathways of fibrinolysis for survival. This may depend on polymorphonuclear leukocytes (PMN) that can clear soluble and insoluble fibrin(ogen) through PG-independent processes. Our objective was to demonstrate that PMNs from PG-/- mice exhibit increased Mac-1 dependent phagocytic activity, which may explain their increased fibrin(ogen)lytic activity compared with wild type (PG+/+) mice. METHODS: Phagocytic activity of PMNs from PG-/- and PG+/+ mice was compared following exposure to Staphylococcus aureus (S. aureus) particles and the expression of Mac-1 was assessed in parallel by flow cytometric analysis. Resistance to phorbol-12-myristate-13-acetate (PMA)-induced cell death was compared between PMNs from the different genotypes. RESULTS: Stimulation of PG-/- PMNs by opsonized S. aureus diluted in PG-/- plasma significantly increased phagocytosis (15-fold) compared with stimulation of PG+/+ PMNs in PG+/+ plasma. Incubation of PG-/- PMNs with PG+/+ plasma (control) or PG-/- plasma supplemented with human PG inhibited this increased phagocytic activity. Mac-1 cell surface density increased 6.2+/-1.0-fold in PG-/- PMNs versus 2.9+/-0.6-fold in PG+/+ PMNs (P < 0.01) indicating that Mac-1 may be associated with increased phagocytic activity. Supporting this, treatment of PG-/- PMNs with an anti-Mac-1 antibody in PG-/- plasma inhibited phagocytic activity. In addition, physiologic PG blocked Mac-1 accessibility at the surface of PMNs. Addition of PMA resulted in 33% death of PMNs from PG-/- mice versus 68% in PG+/+ controls (P < 0.001). CONCLUSIONS: PMNs from PG-/- mice exhibit a Mac-1 dependent increase in phagocytic activity that is suppressed with human PG, an anti-Mac-1 antibody or the plasma from PG+/+ mice. The propensity for PMNs from PG-/- mice to be activated in response to PMA together with their relative resistance to PMA-toxicity may contribute to increased PMN half-life and enhanced fibrin(ogen) clearance in the setting of PG deficiency.
Asunto(s)
Neutrófilos/fisiología , Fagocitosis/fisiología , Plasminógeno/deficiencia , Animales , Apoptosis/efectos de los fármacos , Apoptosis/genética , Apoptosis/fisiología , Secuencia de Bases , Cartilla de ADN/genética , Femenino , Fibrinólisis/fisiología , Antígeno de Macrófago-1/metabolismo , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Neutrófilos/citología , Neutrófilos/efectos de los fármacos , Neutrófilos/inmunología , Fagocitosis/efectos de los fármacos , Fagocitosis/genética , Plasminógeno/genética , Plasminógeno/fisiología , Staphylococcus aureus/inmunología , Acetato de Tetradecanoilforbol/farmacologíaRESUMEN
sICAM-1 measurements are here shown to be independent of processing method (serum, platelet rich and platelet poor plasma) and sampling size (venous or arterial blood) in patients with coronary disease.
Asunto(s)
Enfermedad de la Arteria Coronaria/sangre , Molécula 1 de Adhesión Intercelular/sangre , Biomarcadores/sangre , Proteínas Sanguíneas/análisis , Enfermedad de la Arteria Coronaria/inmunología , Humanos , Plasma Rico en Plaquetas/química , Reproducibilidad de los Resultados , Manejo de EspecímenesRESUMEN
Particulate and histopathologic examination of atherosclerotic material collected during carotid artery stenting is presented, illustrating the limitations of current knowledge regarding the use of distal protection devices (DPD) during this novel vascular intervention.
Asunto(s)
Arteriosclerosis/patología , Estenosis Coronaria/patología , Estenosis Coronaria/terapia , Stents , Filtración/instrumentación , Humanos , Embolia Intracraneal/etiología , Embolia Intracraneal/prevención & control , Masculino , Persona de Mediana Edad , Tamaño de la PartículaRESUMEN
BACKGROUND AND AIM: The transcription factor and immediate-early gene Egr-1 is widely viewed as a key upstream activator in a variety of settings within cardiovascular pathobiology. The role that Egr-1 plays in myocardial ischemia-reperfusion (IR) injury is unknown. We hypothesized that Egr-1 upregulation is of pathophysiologic importance in myocardial IR injury. METHODS AND RESOURCES: First, abrogation of Egr-1 mRNA upregulation using Egr-1 targeting DNAzymes in a rat cardiomyocyte in vitro model was demonstrated. Egr-1 mRNA and protein upregulation following myocardial IR in rats were then selectively suppressed by locally delivered DNAzyme. Furthermore, myocardial neutrophil infiltration, intercellular adhesion molecule 1 mRNA and protein expression, and myocardial infarct size were all attenuated in DNAzyme-treated animals. CONCLUSIONS: These data support the hypothesis that Egr-1 is a key contributor to myocardial IR injury, and that Egr-1 targeting strategies have therapeutic potential in this context.
Asunto(s)
ADN Catalítico/uso terapéutico , Proteína 1 de la Respuesta de Crecimiento Precoz/fisiología , Infarto del Miocardio/prevención & control , Daño por Reperfusión/tratamiento farmacológico , Animales , Movimiento Celular/efectos de los fármacos , ADN Catalítico/administración & dosificación , Proteína 1 de la Respuesta de Crecimiento Precoz/efectos de los fármacos , Proteína 1 de la Respuesta de Crecimiento Precoz/genética , Molécula 1 de Adhesión Intercelular/genética , Infarto del Miocardio/tratamiento farmacológico , Infarto del Miocardio/etiología , Miocitos Cardíacos/patología , Neutrófilos/citología , ARN Mensajero/efectos de los fármacos , Ratas , Daño por Reperfusión/complicaciones , Regulación hacia Arriba/efectos de los fármacos , Regulación hacia Arriba/genéticaRESUMEN
In an era of percutaneous stenting for acute myocardial infarction (AMI), a case of thoracic spinal cord ischemia following AMI and cardiac arrest is presented, to highlight and discuss this rare but debilitating condition, well-documented within the neurological literature, but rarely encountered in cardiovascular practice.