Persistent symptoms and conditions among children and adolescents hospitalised with COVID-19 illness: a qualitative study.

OBJECTIVES: There is limited in-depth research exploring persistent symptoms and conditions among children and adolescents who contracted COVID-19 illness that required hospitalisation. The main objective of this study was to conduct qualitative interviews among families who had a child hospitalised with COVID-19 illness to elucidate their child's physical, mental and social health outcomes months after initial acute infection. DESIGN, SETTING AND PARTICIPANTS: A qualitative study that composed of in-depth interviews among families with a child hospitalised with COVID-19 illness in one large urban US paediatric healthcare system. Parents (N=25) were recruited from an ongoing quantitative study to estimate the prevalence of long COVID in children hospitalised with COVID-19 illness. During in-depth interviews, parents were invited to describe their child's post-COVID-19 symptoms and experiences. Interviews were audiotaped, transcribed and coded in NVivo. RESULTS: Seven themes were identified concerning the child's prolonged COVID-19 experiences: (1) post-traumatic stress disorder, (2) social anxiety, (3) severe symptoms on reinfection, (4) worsened pre-existing conditions, (5) lack of insurance coverage for costly treatments, (6) access and utilisation of support systems and (7) overall resilience and recovery. Four parent-specific themes were identified: (1) fear of COVID-19 unknowns, (2) mixed messaging from health information sources, (3) schools being both a support system and a hindrance and (4) desire for and access to support systems. CONCLUSIONS: A subset of children who were hospitalised with COVID-19 illness are experiencing a range of serious mental health impacts related to persistent COVID-19 symptoms. Clinical and public health support strategies should be developed to support these children and their families as they reintegrate in school, social and community activities.

Tratamientos y barreras de protección utilizadas antes y durante la pandemia en entidades de México / Treatments and protective barriers used before and during the pandemic in entities in Mexico

Introducción: los tratamientos bucodentales son procedimientos que requieren de un diagnóstico visual y táctil; existe alto riesgo de contagio por productos biológicos. Objetivo: determinar los tipos de tratamientos y barreras de protección implementados antes y durante la pandemia de COVID-19 en tres entidades de México. Material y métodos: estudio observacional, analítico y longitudinal en odontólogos de atención clínica privada, instituciones educativas y/o de salud, mediante un muestreo no probabilístico por cuotas de 100 odontólogos por entidad. La información fue recopilada en un formulario de Google distribuido vía WhatsApp y correos electrónicos. Los datos se procesaron en el SPSS v. 22. Resultados: los tratamientos implementados antes del periodo pandémico fueron los programados con 87.2%, durante la pandemia de COVID-19, la atención principal continuó programada (90.9%), las barreras de protección que más aumentaron fueron la protección ocular como gafas protectoras (84.8%) y careta facial (83.1%), presentando la sustitución de la mascarilla tricapa por ser de alta filtración KN95 (78.0%) y el traje aislante (53.0%). Conclusión: los tratamientos realizados antes y durante la pandemia fueron programados, las barreras que incrementaron fueron gafas protectoras, careta, mascarilla KN95 y traje aislante (AU)

Introduction: oral treatments are procedures that require a visual and tactile diagnosis, there is a high risk of infection by biological products. Objective: determine the types of treatments and protection barriers implemented before and during the COVID-19 pandemic in three states in Mexico. Material and methods: it was an observational, analytical and longitudinal study in private clinical care dentists, educational and/or health institutions, through a non-probabilistic sampling by quotas of 100 dentists per entity. The information was collected in a Google form distributed via WhatsApp and emails. The data was processed in SPSS v. 22. Results: the treatments implemented before the pandemic period were those scheduled with 87.2%, during the COVID-19 pandemic the main care continued as scheduled (90.9%) where the protection barriers that increased the most were eye protection such as goggles (84.8%) and facial mask (83.1%). Presenting the substitution of the three-layer mask for high filtration KN95 (78.0%) and the disposable suit (53.0%). Conclusion: the treatments carried out before and during the pandemic were programmed, the barriers that increased were googles, face shield, KN95 mask and insulating suit (AU)

Comparison of Long-Term Complications of COVID-19 Illness among a Diverse Sample of Children by MIS-C Status.

Most pediatric COVID-19 cases are asymptomatic; however, a small number of children are diagnosed with multisystem inflammatory syndrome in children (MIS-C), a rare but severe condition that is associated with SARS-CoV-2 infection. Persistent symptoms of COVID-19 illness in children diagnosed with/without MIS-C is largely unknown. A retrospective EHR review of patients with COVID-19 illness from one pediatric healthcare system to assess the presence of acute (<30 days) and chronic (≥30, 60-120, and >120 days) long-term COVID symptoms was conducted. Patients/caregivers completed a follow-up survey from March 2021 to January 2022 to assess the presence of long COVID. Results showed that non-MIS-C children (n = 286; 54.49% Hispanic; 19.23% non-Hispanic Black; 5.77% other ethnicity; 79.49% government insurance) were younger (mean age 6.43 years [SD 5.95]) versus MIS-C (n = 26) children (mean age 9.08 years, [SD 4.86]) (p = 0.032). A share of 11.5% of children with MIS-C and 37.8% without MIS-C reported acute long COVID while 26.9% and 15.3% reported chronic long COVID, respectively. Females were almost twice as likely to report long symptoms versus males and those with private insurance were 66% less likely to report long symptoms versus those with government insurance. In conclusion, a substantial proportion of ethnically diverse children from low resource backgrounds with severe COVID illness are reporting long-term impacts. Findings can inform pediatric professionals about this vulnerable population in post-COVID-19 recovery efforts.

Prostitución femenina y género en el contexto colombiano: un estado del arte (2010-2019) / Female prostitution and gender in the colombian context: a state of the art. (2010-2019)

Introducción: desde el enfoque de género, la prostitución de las mujeres se explica como una expresión del modelo patriarcal. Este enfoque puede aportar elementos sustanciales para la comprensión y el abordaje a la prostitución femenina, de cara a la realidad colombiana, donde se carece de estudios documentales en esta línea conceptual. Método: se realizó un estado del arte de la investigación teórica y aplicada sobre la prostitución femenina, con lectura de género, en el periodo 2010-2019. Resultados: de los estudios analizados, varios situados en Bogotá, se ocupa especialmente la academia. Los autores coinciden en que la prostitución se deriva de la intersección entre desigualdades de género e injusticia social, y causa violencias de género y estigmatización. Políticas sociales para erradicarla, legalización y empoderamiento de las mujeres surgen como opciones para hacerle frente. Conclusión: para nutrir la política pública se requiere avanzar en la comprensión de los aspectos subjetivos implicados en este estilo de vida, profundizar en los discursos, construcciones y significados de género, e incluir la realidad de quienes están inmersas en la modalidad "prepago"

Introduction: According to the gender perspective, the prostitution of women is explained as an expression of the patriarchal model. This approach can provide substantial elements for the understanding and approach to female prostitution, facing the Colombian reality, where there is a lack of documentary studies in this conceptual line. Method: a state of the art of theoretical and applied research on female prostitution was carried out, with a gender reading, in the period 2010-2019, based on 18 studies. Results: Rendering to the studies analyzed, several located in Bogotá, the academy is especially concerned. The authors agree that prostitution stems from the intersection between gender inequalities and social injustice and causes gender violence and stigmatization. Social policies to eradicate it, legalization, and empowerment of women emerge as options to face it. Conclusion: Concerning the above, to nurture public policy, it is necessary to advance in the understanding of the subjective aspects involved in this lifestyle, deepening the discourses, constructions, and gender meanings and including the reality of those who are immersed (women) in the "prepaid" modality

De curandis hominum morbis: An 18th century medical prescription for measles and smallpox in the Nuevo Reino de Granada / De curandis hominum morbis: una receta médica del siglo XVIII para el sarampión y las viruelas en el Nuevo Reino de Granada

A collection of more than one hundred medical recipes from the late 18th century was donated by Presbyter Cipriano Rodríguez Santa María, institutional eponym of the collection at the Historical Archive "Octavio Arizmendi Posada" of the library of the Universidad de La Sabana in Colombia. These texts represent an important historical and medical legacy and they constitute an important basis for understanding the colonial and traditional therapeutics related to various diseases. In this article, we describe one of these recipes for the treatment of smallpox and measles as a contribution to the history of medicine in Colombia.

En el Archivo Histórico de la Biblioteca "Octavio Arizmendi Posada" de la Universidad de La Sabana, se encuentra una colección de más de un centenar de recetas médicas de finales del siglo XVIII donadas por el presbítero Cipriano Rodríguez Santa María, epónimo institucional del archivo. Estos textos son un legado histórico médico y un fundamento para comprender la terapéutica colonial y tradicional de diversas enfermedades. En este artículo, se describen algunas recetas para el tratamiento de la viruela y el sarampión, como aporte a la historia de la medicina en Colombia.

De curandis hominum morbis: una receta médica del siglo XVIII para el sarampión y las viruelas en el Nuevo Reino de Granada / De curandis hominum morbis: An 18th century medical prescription for measles and smallpox in the Nuevo Reino de Granada

En el Archivo Histórico de la Biblioteca "Octavio Arizmendi Posada" de la Universidad de La Sabana, se encuentra una colección de más de un centenar de recetas médicas de finales del siglo XVIII donadas por el presbítero Cipriano Rodríguez Santa María, epónimo institucional del archivo. Estos textos son un legado histórico médico y un fundamento para comprender la terapéutica colonial y tradicional de diversas enfermedades. En este artículo, se describen algunas recetas para el tratamiento de la viruela y el sarampión, como aporte a la historia de la medicina en Colombia.

A collection of more than one hundred medical recipes from the late 18th century was donated by Presbyter Cipriano Rodríguez Santa María, institutional eponym of the collection at the Historical Archive "Octavio Arizmendi Posada" of the library of the Universidad de La Sabana in Colombia. These texts represent an important historical and medical legacy and they constitute an important basis for understanding the colonial and traditional therapeutics related to various diseases. In this article, we describe one of these recipes for the treatment of smallpox and measles as a contribution to the history of medicine in Colombia.

Occurrence of Salmonella typhimurium resistance under sublethal/repeated exposure to cauliflower infusion and infection effects on Caernohabditis elegans host test organism.

Resistant bacteria to antimicrobials are increasingly emerging in medical, food industry and livestock environments. The present research work assesses the capability of Salmonella enterica var Typhimurium to become adapted under the exposure to a natural cauliflower antimicrobial by-product infusion in consecutive repeated exposure cycles. Caenorhabditis elegans was proposed as in vivo host-test organism to compare possible changes in the virulent pattern of the different rounds treated S. enterica var Typhimurium and untreated bacterial cells. According to the obtained results, S. enterica var Typhimurium was able to generate resistance against a repeated exposure to cauliflower by-product infusion 5% (w/v), increasing the resistance with the number of exposed repetitions. Meanwhile, at the first exposure, cauliflower by-product infusion was effective in reducing S. enterica var Typhimurium (≈1 log10 cycle), and S. enterica var Typhimurium became resistant to this natural antimicrobial after the second and third treatment-round and was able to grow (≈1 log10 cycle). In spite of the increased resistance observed for repeatedly treated bacteria, the present study reveals no changes on C. elegans infection effects between resistant and untreated S. enterica var Typhimurium, according to phenotypic parameters evaluation (lifespan duration and egg-laying).

Serological and virological survey of hepatitis E virus (HEV) in animal reservoirs from Uruguay reveals elevated prevalences and a very close phylogenetic relationship between swine and human strains.

Hepatitis E virus (HEV) infection is an issue of public health concern in high-income and non-endemic countries. Increasing evidence supports the hypothesis of a zoonotic route as the main mode of infection in this epidemiological setting, since the transmission of genotypes HEV-3 and HEV-4 from reservoirs to humans has been demonstrated. In America, studies have confirmed the circulation of HEV in pig herds but the zoonotic role of wild boars has never been evaluated. Uruguay has a high burden of HEV- associated acute hepatitis, and a close phylogenetic relationship was observed among human HEV-3 strains and European isolates detected in swine. However in this context, swine herds have never been surveyed. Herein is reported a survey of HEV in swine herds, pigs at slaughter-house and free-living wild boar populations. Two-hundred and twenty sera and 150 liver tissue samples from domestic pigs, and 140 sera from wild boars were tested for HEV by ELISA and PCR-based approaches. All tested swine farms resulted seropositive with an overall rate of 46.8%. In turn, 22.1% of the wild boars had anti-HEV antibodies. HEV RNA was detected in 16.6% and 9.3% of liver samples from slaughter-age pigs and adult wild boars sera, respectively. Three strains from domestic pig were also amplified by nested-PCR approaches. By contrast, none of the positive samples obtained from wild boars could be confirmed by nested-PCR. Phylogenetic analysis revealed a very high nucleotide identity among swine strains and sequences obtained from humans in Uruguay. Results showed that HEV is widely distributed among swine herds in Uruguay. Additionally, this study evidences for the first time in the American continent that wild boar populations are a reservoir for HEV, though its zoonotic role remains to be elucidated. Altogether, data presented here suggest a high zoonotic risk of HEV transmission from swine to humans.

Molecular study of Porcine Circovirus type 2 in wild boars and domestic pigs in Uruguay from 2010 to 2014: Predominance of recombinant circulating strains.

Porcine Circovirus type 2 (PCV2) is a worldwide distributed pathogen and one of the most economically relevant swine infections. Four genotypes have been recognized and it is well known that PCV2a, PCV2b and PCV2d have a global distribution. However, the information about recombinant strains circulation and their influence in driving PCV2 evolution is a poorly studied area. In Uruguay, PCV2 associated symptoms began to be frequently observed in pigs from different farms since 2010. The main purpose of this study was to thoroughly investigate the molecular epidemiology of PCV2 in nationwide swine herds and free-living wild boars during the period 2010-2014, providing an extensive viral sequence dataset. Surprisingly, the findings revealed a predominance of recombinant strains circulation, evidencing for the first time in the field that PCV2 recombination can lead to the emergence of strains able to compete and potentially displace parental ones. In addition, the circulation of the genotypes PCV2d (29%), PCV2b (10.5%) and PCV2a (7.9%) were also observed. Since 2013, a high circulation of PCV2d was identified in the country and probably reflected the recent global scenario of the emergence of this genotype. In addition, fluctuations in the frequency of PCV2 infection in the period evaluated may suggest a limitation of biosecurity strategies implemented in Uruguay for the disease control, including the instability of vaccination practices. On the other hand, the sustained PCV2 infection observed in wild boar population and the similarity among circulating viral strains from these animals and domestic pigs, suggested that wild animals could serve as permanent reservoir of the disease. Altogether, this work put forward that many factors play a role in PCV2 heterogeneity including rapid viral spread and evolution, recombination, wide movement within national boundaries and multiples introduction events resulting of international trade. Continuous monitoring of viral epidemiology is needed to better understand the PCV2 population dynamics in Uruguay and the development of appropriate strategies are required for disease control.

Autochthonous Outbreak and Expansion of Canine Visceral Leishmaniasis, Uruguay.

We report an outbreak of canine visceral leishmaniasis in Uruguay. Blood specimens from 11/45 dogs tested positive for Leishmania spp. Specimens of Lutzomyia longipalpis sand flies were captured; typing revealed Leishmania infantum. Our findings document an expansion of visceral leishmaniasis to southern South America and risk for vectorborne transmission to humans.

Secundarismo sifilítico: un amplio espectro de manifestaciones dermatológicas / Syphilitic Secondaryism: A Wide Spectrum of Dermatological Manifestations

El artículo describe el caso de un paciente de 28 años de edad con antecedente de VIH, quien presentaba múltiples lesiones en la piel y las mucosas, producto de sífilis secundaria, y quien mostraba un amplio espectro de manifestaciones cutáneas características de esta enfermedad.

We describe the case of a 28-year-old patient with HIV history who has multiple skin and mucous lesions that showing a broad spectrum of cutaneous manifestations of secondary syphilis.