Asunto(s)
Neoplasias de la Mama , Carcinoma Neuroendocrino , Humanos , Carcinoma Neuroendocrino/patología , Carcinoma Neuroendocrino/cirugía , Carcinoma Neuroendocrino/diagnóstico por imagen , Carcinoma Neuroendocrino/diagnóstico , Femenino , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Carcinoma de Células Grandes/patología , Carcinoma de Células Grandes/cirugía , Carcinoma de Células Grandes/terapia , Persona de Mediana EdadRESUMEN
OBJECTIVE: The purpose of this study was to investigate the relationship between the expression of matrix metalloproteinase-9 (MMP-9) and pathological indexes in papillary thyroid carcinoma (PTC). EVIDENCE OBTAINED: The database was searched in PubMed, Embase, CNKI, and Web of Science databases for relevant clinical trials. The odds ratio (OR) and 95% confidence interval (CI) show the effect of MMP-9 expression and age, tumour size, gender, lymph node metastasis (LNM), and TNM (tumour, lymph node, metastasis) stage. Statistical analysis of the data was performed using Stata 17.0. EVIDENCE SYNTHESIS: A total of 1433 patients with PTC were included in this meta-analysis. MMP-9 expression was significantly correlated with LNM (OR = 3.92, 95% CI = 2.71-5.65, P = 0.000), tumour size (OR = 1.69, 95% CI = 1.13-2.52, P = 0.011), and TNM stage (OR = 2.95, 95% CI = 2.10-4.13, P = 0.000), but not with gender (OR = 0.90, 95% CI = 0.66-1.22, P = 0.487) and age (OR = 1.36, 95% CI = 0.93-1.98, P = 0.115). CONCLUSIONS: Our meta-analysis showed that MMP-9 was significantly associated with LNM, tumour size, and TNM stage; therefore, MMP-9 may be a reliable prognostic biomarker for patients with PTC. However, more high-quality studies are needed to support these findings further.
Asunto(s)
Neoplasias de la Tiroides , Humanos , Relevancia Clínica , Metástasis Linfática , Metaloproteinasa 9 de la Matriz , Cáncer Papilar Tiroideo/patología , Neoplasias de la Tiroides/patologíaRESUMEN
Unmerited authorship is a practice common to many countries around the world, but are there systematic cultural differences in the practice? We tested whether scientists from collectivistic countries are more likely to add unmerited coauthors than scientists from individualistic countries. We analyzed archival data from top scientific journals (Study 1) and found that national collectivism predicted the number of authors, which might suggest more unmerited authors. Next, we found that collectivistic scientists were more likely to add unmerited coauthors than individualistic scientists, both between cultures (Studies 2-3) and within cultures (Study 4). Finally, we found that priming people with collectivistic self-construal primes made them more likely to endorse questionable authorship attitudes (Study 5). These findings show that culture collectivism is related to unmerited authorship.
